PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26750154-0 2016 Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-gamma in colon. Bleomycin 26-35 hepatocyte growth factor Mus musculus 107-131 24959005-8 2014 The in vivo relevance of the interaction between the COX-2/PGE2 and HGF pathways through a positive feedback loop was shown in cultured alveolar macrophages following in vivo exposure of bleomycin-stimulated lungs to apoptotic cells. Bleomycin 187-196 hepatocyte growth factor Mus musculus 68-71 14982862-4 2004 Following bleomycin administration, we found that HGF protein levels were higher in bronchoalveolar lavage fluid from PAI-1-/- mice compared to wild-type (PAI-1+/+) mice. Bleomycin 10-19 hepatocyte growth factor Mus musculus 50-53 19448157-0 2010 Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice. Bleomycin 67-76 hepatocyte growth factor Mus musculus 21-45 18988920-3 2009 Hepatocyte growth factor (HGF) inhibits progression of bleomycin-induced pulmonary fibrosis in mice. Bleomycin 55-64 hepatocyte growth factor Mus musculus 0-24 18988920-3 2009 Hepatocyte growth factor (HGF) inhibits progression of bleomycin-induced pulmonary fibrosis in mice. Bleomycin 55-64 hepatocyte growth factor Mus musculus 26-29 16840775-5 2006 A recent study using bleomycin-exposed mice showed that manipulations of the plasminogen activation system influenced the amount of free HGF within bronchoalveolar lavage fluid without affecting total lung HGF mRNA or protein. Bleomycin 21-30 hepatocyte growth factor Mus musculus 137-140 15963921-3 2005 The exogenous source of hHGF gene expression increased the endogenous mouse HGF in the lungs and significantly decreased TNF-alpha, IL-6, and collagen synthesis after bleomycin injury. Bleomycin 167-176 hepatocyte growth factor Mus musculus 25-28 15197407-0 2004 Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice. Bleomycin 79-88 hepatocyte growth factor Mus musculus 59-62 15197407-3 2004 The aim of this study is to establish nonviral HGF gene therapy of bleomycin-induced lung fibrosis avoiding the viral vector-related side effects. Bleomycin 67-76 hepatocyte growth factor Mus musculus 47-50 15197407-10 2004 Our data indicate that HGF gene therapy with a single skeletal muscle-targeting electroporation has a therapeutic potential for bleomycin-induced lung fibrosis and this strategy can be applied as a practical gene therapy protocol for various organs. Bleomycin 128-137 hepatocyte growth factor Mus musculus 23-26 23922381-1 2013 Apoptotic cell instillation after bleomycin induces persistent HGF production and protects from pulmonary fibrosis, but the underlying mechanism remains unclear. Bleomycin 34-43 hepatocyte growth factor Mus musculus 63-66 15665032-7 2005 In bleomycin-treated mice, c-Met expression was found on interstitial myofibroblasts and HGF increased apoptosis in culture of myofibroblasts isolated from bleomycin-treated murine lungs. Bleomycin 3-12 hepatocyte growth factor Mus musculus 89-92 15665032-7 2005 In bleomycin-treated mice, c-Met expression was found on interstitial myofibroblasts and HGF increased apoptosis in culture of myofibroblasts isolated from bleomycin-treated murine lungs. Bleomycin 156-165 hepatocyte growth factor Mus musculus 89-92 15665032-8 2005 Furthermore, administration of recombinant HGF to bleomycin-treated mice increased lung MMP activities and enhanced myofibroblast apoptosis, while in vivo MMI270 injections together with HGF inhibited such MMP activation, leading to suppressed myofibroblast apoptosis. Bleomycin 50-59 hepatocyte growth factor Mus musculus 43-46 15665032-8 2005 Furthermore, administration of recombinant HGF to bleomycin-treated mice increased lung MMP activities and enhanced myofibroblast apoptosis, while in vivo MMI270 injections together with HGF inhibited such MMP activation, leading to suppressed myofibroblast apoptosis. Bleomycin 50-59 hepatocyte growth factor Mus musculus 187-190 14982862-6 2004 Conversely, intratracheal instillation of urokinase into bleomycin-injured PAI-1+/+ mice to activate plasminogen caused a significant increase in HGF within bronchoalveolar lavage and caused less collagen accumulation in the lungs. Bleomycin 57-66 hepatocyte growth factor Mus musculus 146-149 14982862-7 2004 Administration of an anti-HGF neutralizing antibody markedly increased collagen accumulation in the lungs of bleomycin-injured PAI-1-/- mice. Bleomycin 109-118 hepatocyte growth factor Mus musculus 26-29 32694760-6 2021 Furthermore, in bleomycin-treated mice, the upregulated protein level of HGF in lungs by oral curcumin was highly correlated with its anti-PF effect, which was further confirmed by coadministration of c-Met inhibitor SU11274. Bleomycin 16-25 hepatocyte growth factor Mus musculus 73-76 11112155-4 2000 We found that HGF significantly attenuated collagen accumulation induced by bleomycin as determined by quantitation of hydroxyproline content and by scoring of the extent of fibrosis. Bleomycin 76-85 hepatocyte growth factor Mus musculus 14-17 9412578-0 1997 Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. Bleomycin 139-148 hepatocyte growth factor Mus musculus 42-66 31115492-0 2019 NMDA receptor activation inhibits the protective effect of BM-MSCs on bleomycin-induced lung epithelial cell damage by inhibiting ERK signaling and the paracrine factor HGF. Bleomycin 70-79 hepatocyte growth factor Mus musculus 169-172 27388243-0 2016 Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis. Bleomycin 85-94 hepatocyte growth factor Mus musculus 0-24 27388243-5 2016 The role for hepatocyte growth factor (HGF) in MSC protection against bleomycin lung injury was examined using HGF knockdown MSC. Bleomycin 70-79 hepatocyte growth factor Mus musculus 39-42 27388243-15 2016 Furthermore, this study translates these findings demonstrating an important role for HGF in the protective effects mediated by MSC in vivo in the bleomycin model. Bleomycin 147-156 hepatocyte growth factor Mus musculus 86-89 29408570-0 2018 Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR-gamma and subsequent expression of HGF in colons. Bleomycin 42-51 hepatocyte growth factor Mus musculus 159-162