PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21111848-3	2011	Early intervention with hemin, an HO-1 inducer, abrogated bleomycin-induced pulmonary fibrosis (fibrotic/reparative score decrease from 21.0+-2.4 to 13.8+-1.7, P<0.01), and early intervention with CrMP, an HO-1 inhibitor, worsened bleomycin-induced pulmonary fibrosis (fibrotic/reparative score increase from 21.0+-2.4 to 32.5+-2.9, P<0.01).	Bleomycin	58-67	heme oxygenase 1	Mus musculus	34-38	
29362432-7	2018	We found BLM-induced lung fibrosis were more severe in Nrf2-/- mice compared to WT mice with reduced expressions of HO-1 and NQO1.	Bleomycin	9-12	heme oxygenase 1	Mus musculus	116-120	
24854244-4	2014	RESULTS: We found that the expression of HO-1 was significantly decreased in lung fibroblasts isolated from bleomycin-challenged mice in comparison with control mice.	Bleomycin	108-117	heme oxygenase 1	Mus musculus	41-45	
21111848-3	2011	Early intervention with hemin, an HO-1 inducer, abrogated bleomycin-induced pulmonary fibrosis (fibrotic/reparative score decrease from 21.0+-2.4 to 13.8+-1.7, P<0.01), and early intervention with CrMP, an HO-1 inhibitor, worsened bleomycin-induced pulmonary fibrosis (fibrotic/reparative score increase from 21.0+-2.4 to 32.5+-2.9, P<0.01).	Bleomycin	58-67	heme oxygenase 1	Mus musculus	209-213	
33952237-11	2021	In addition, BLM-induced elevation of HO-1 (heme oxygenase-1) and 3-NT (3-nitrotyrosine) was alleviated by TUDCA.	Bleomycin	13-16	heme oxygenase 1	Mus musculus	38-42	
35148253-4	2022	In WT mice, bleomycin caused activation of ASK1, p38, and ERK1/2 in lung tissue, as well as changes in redox indicators (thioredoxin and heme-oxygenase-1), collagen content, and epithelial mesenchymal transition markers (EMT).	Bleomycin	12-21	heme oxygenase 1	Mus musculus	137-153	
12449100-0	2002	Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway.	Bleomycin	90-99	heme oxygenase 1	Mus musculus	51-67	
12449100-2	2002	Because enhanced expression of HO-1 confers protection against many types of cell and tissue damage by modulating apoptotic cell death or cytokine expression profiles, we hypothesized that adenovirus-mediated transfer of HO-1 cDNA and subsequent overexpression of the protein in lung would provide therapeutic benefit in a murine model of bleomycin-induced pulmonary fibrosis.	Bleomycin	339-348	heme oxygenase 1	Mus musculus	31-35	
12449100-2	2002	Because enhanced expression of HO-1 confers protection against many types of cell and tissue damage by modulating apoptotic cell death or cytokine expression profiles, we hypothesized that adenovirus-mediated transfer of HO-1 cDNA and subsequent overexpression of the protein in lung would provide therapeutic benefit in a murine model of bleomycin-induced pulmonary fibrosis.	Bleomycin	339-348	heme oxygenase 1	Mus musculus	221-225	
12449100-5	2002	Consistent with the concept that HO-1 overexpression prevents fibrosis via a pathway independent of Fas-FasL interaction, Ad.HO-1 administration prevented bleomycin-induced pulmonary fibrosis in gld/gld mice, which express nonfunctional FasL.	Bleomycin	155-164	heme oxygenase 1	Mus musculus	125-129	
33952237-11	2021	In addition, BLM-induced elevation of HO-1 (heme oxygenase-1) and 3-NT (3-nitrotyrosine) was alleviated by TUDCA.	Bleomycin	13-16	heme oxygenase 1	Mus musculus	44-60