PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24854244-4 2014 RESULTS: We found that the expression of HO-1 was significantly decreased in lung fibroblasts isolated from bleomycin-challenged mice in comparison with control mice. Bleomycin 108-117 heme oxygenase 1 Mus musculus 41-45 21111848-3 2011 Early intervention with hemin, an HO-1 inducer, abrogated bleomycin-induced pulmonary fibrosis (fibrotic/reparative score decrease from 21.0+-2.4 to 13.8+-1.7, P<0.01), and early intervention with CrMP, an HO-1 inhibitor, worsened bleomycin-induced pulmonary fibrosis (fibrotic/reparative score increase from 21.0+-2.4 to 32.5+-2.9, P<0.01). Bleomycin 58-67 heme oxygenase 1 Mus musculus 34-38 21111848-3 2011 Early intervention with hemin, an HO-1 inducer, abrogated bleomycin-induced pulmonary fibrosis (fibrotic/reparative score decrease from 21.0+-2.4 to 13.8+-1.7, P<0.01), and early intervention with CrMP, an HO-1 inhibitor, worsened bleomycin-induced pulmonary fibrosis (fibrotic/reparative score increase from 21.0+-2.4 to 32.5+-2.9, P<0.01). Bleomycin 58-67 heme oxygenase 1 Mus musculus 209-213 12449100-0 2002 Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway. Bleomycin 90-99 heme oxygenase 1 Mus musculus 51-67 12449100-2 2002 Because enhanced expression of HO-1 confers protection against many types of cell and tissue damage by modulating apoptotic cell death or cytokine expression profiles, we hypothesized that adenovirus-mediated transfer of HO-1 cDNA and subsequent overexpression of the protein in lung would provide therapeutic benefit in a murine model of bleomycin-induced pulmonary fibrosis. Bleomycin 339-348 heme oxygenase 1 Mus musculus 31-35 12449100-2 2002 Because enhanced expression of HO-1 confers protection against many types of cell and tissue damage by modulating apoptotic cell death or cytokine expression profiles, we hypothesized that adenovirus-mediated transfer of HO-1 cDNA and subsequent overexpression of the protein in lung would provide therapeutic benefit in a murine model of bleomycin-induced pulmonary fibrosis. Bleomycin 339-348 heme oxygenase 1 Mus musculus 221-225 12449100-5 2002 Consistent with the concept that HO-1 overexpression prevents fibrosis via a pathway independent of Fas-FasL interaction, Ad.HO-1 administration prevented bleomycin-induced pulmonary fibrosis in gld/gld mice, which express nonfunctional FasL. Bleomycin 155-164 heme oxygenase 1 Mus musculus 125-129 35148253-4 2022 In WT mice, bleomycin caused activation of ASK1, p38, and ERK1/2 in lung tissue, as well as changes in redox indicators (thioredoxin and heme-oxygenase-1), collagen content, and epithelial mesenchymal transition markers (EMT). Bleomycin 12-21 heme oxygenase 1 Mus musculus 137-153 33952237-11 2021 In addition, BLM-induced elevation of HO-1 (heme oxygenase-1) and 3-NT (3-nitrotyrosine) was alleviated by TUDCA. Bleomycin 13-16 heme oxygenase 1 Mus musculus 38-42 33952237-11 2021 In addition, BLM-induced elevation of HO-1 (heme oxygenase-1) and 3-NT (3-nitrotyrosine) was alleviated by TUDCA. Bleomycin 13-16 heme oxygenase 1 Mus musculus 44-60 29362432-7 2018 We found BLM-induced lung fibrosis were more severe in Nrf2-/- mice compared to WT mice with reduced expressions of HO-1 and NQO1. Bleomycin 9-12 heme oxygenase 1 Mus musculus 116-120