PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20536192-0 2010 DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. 10-decarbamoylmitomycin C 15-38 tumor protein p53 Homo sapiens 80-83 25565400-0 2015 Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. 10-decarbamoylmitomycin C 0-23 tumor protein p53 Homo sapiens 40-43 25565400-0 2015 Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. 10-decarbamoylmitomycin C 25-28 tumor protein p53 Homo sapiens 40-43 25565400-3 2015 We previously reported that the novel DMC induced beta-interstrand DNA crosslinks induce a p53-independent form of cell death. 10-decarbamoylmitomycin C 38-41 tumor protein p53 Homo sapiens 91-94 25565400-4 2015 The p53-independent DMC cytotoxicity associates with the activation, and subsequent depletion, of Chk1. 10-decarbamoylmitomycin C 20-23 tumor protein p53 Homo sapiens 4-7 25565400-10 2015 Our results suggest that DMC induces a p53-independent disassociation of ATR from chromatin that facilitates Chk1 checkpoint activation and Rad51 chromatin recruitment. 10-decarbamoylmitomycin C 25-28 tumor protein p53 Homo sapiens 39-42 24586407-5 2014 DNA damage was induced by ultraviolet type C (UVC) radiation, or 10-decarbamoyl mitomycin C (DMC, an agent known to induce mammalian p53-independent cell death). 10-decarbamoylmitomycin C 65-91 tumor protein p53 Homo sapiens 133-136 24586407-5 2014 DNA damage was induced by ultraviolet type C (UVC) radiation, or 10-decarbamoyl mitomycin C (DMC, an agent known to induce mammalian p53-independent cell death). 10-decarbamoylmitomycin C 93-96 tumor protein p53 Homo sapiens 133-136 24586407-9 2014 Consistent with DMC inducing p53-independent cell death in mammalian cells DMC induced a C. elegans p53-independent germline cell death pathway. 10-decarbamoylmitomycin C 16-19 tumor protein p53 Homo sapiens 29-32 24586407-9 2014 Consistent with DMC inducing p53-independent cell death in mammalian cells DMC induced a C. elegans p53-independent germline cell death pathway. 10-decarbamoylmitomycin C 75-78 tumor protein p53 Homo sapiens 29-32 24586407-9 2014 Consistent with DMC inducing p53-independent cell death in mammalian cells DMC induced a C. elegans p53-independent germline cell death pathway. 10-decarbamoylmitomycin C 75-78 tumor protein p53 Homo sapiens 100-103 20536192-1 2010 The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than mitomycin C (MC). 10-decarbamoylmitomycin C 25-51 tumor protein p53 Homo sapiens 83-86 20536192-1 2010 The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than mitomycin C (MC). 10-decarbamoylmitomycin C 53-56 tumor protein p53 Homo sapiens 83-86 20536192-9 2010 Thus, the mitosene-1-beta stereoisomeric DNA adducts produced by the DMC signal for a p53-independent mode of cell death correlated with reduced nuclear size, persistent DNA damage, increased ubiquitin proteolysis and reduced Chk1 protein. 10-decarbamoylmitomycin C 69-72 tumor protein p53 Homo sapiens 86-89 30091208-2 2018 MC analog, 10-decarbamoyl mitomycin C (DMC), unlike MC, has stronger effects on cancer with p53 mutation. 10-decarbamoylmitomycin C 11-37 tumor protein p53 Homo sapiens 92-95 20798760-5 2010 Specifically, 2,7-DAM is not cytotoxic and does not activate the p53 pathway while MC and DMC are cytotoxic and able to activate the p53 pathway. 10-decarbamoylmitomycin C 90-93 tumor protein p53 Homo sapiens 133-136 20798760-6 2010 DMC is more cytotoxic than MC and can also kill p53-deficient cells by inducing degradation of Checkpoint 1 protein, which is not seen with MC treatment of the p53-deficient cells. 10-decarbamoylmitomycin C 0-3 tumor protein p53 Homo sapiens 48-51 20798760-6 2010 DMC is more cytotoxic than MC and can also kill p53-deficient cells by inducing degradation of Checkpoint 1 protein, which is not seen with MC treatment of the p53-deficient cells. 10-decarbamoylmitomycin C 0-3 tumor protein p53 Homo sapiens 160-163 17530733-2 2007 DMC was previously shown in our laboratory to exceed the cytotoxicity of MC in a human leukemia cell line that lacks a functional p53 pathway (K562). 10-decarbamoylmitomycin C 0-3 tumor protein p53 Homo sapiens 130-133 17530733-5 2007 In cell lines lacking wild-type p53, DMC was reproducibly more cytotoxic than MC, but it generated barely detectable signal transduction markers associated with apoptotic death. 10-decarbamoylmitomycin C 37-40 tumor protein p53 Homo sapiens 32-35 17530733-7 2007 Alkylating agents can induce increased PARP activity associated with programmed necrosis, and the biological activity of DMC in p53-null cell lines fits this paradigm. 10-decarbamoylmitomycin C 121-124 tumor protein p53 Homo sapiens 128-131 17530733-8 2007 In cell lines with a functional p53 pathway, both MC and DMC induced apoptosis. 10-decarbamoylmitomycin C 57-60 tumor protein p53 Homo sapiens 32-35 17530733-9 2007 In the presence of p53, both MC and DMC activate procaspases; however, the spectrum of procaspases involved differs for the two drugs, as does induction of p73. 10-decarbamoylmitomycin C 36-39 tumor protein p53 Homo sapiens 19-22 30091208-2 2018 MC analog, 10-decarbamoyl mitomycin C (DMC), unlike MC, has stronger effects on cancer with p53 mutation. 10-decarbamoylmitomycin C 39-42 tumor protein p53 Homo sapiens 92-95 30091208-8 2018 This implied that the deactivated Akt caused by MC/DMC was p53-dependent. 10-decarbamoylmitomycin C 51-54 tumor protein p53 Homo sapiens 59-62 30091208-3 2018 We previously demonstrated that MC/DMC could activate p21WAF 1/ CIP 1 in MCF-7 (p53-proficient) and K562 (p53-deficient) cells in a p53-independent mode. 10-decarbamoylmitomycin C 35-38 tumor protein p53 Homo sapiens 80-83 30091208-13 2018 In summary, MC/DMC regulate Akt activation in a p53-dependent manner. 10-decarbamoylmitomycin C 15-18 tumor protein p53 Homo sapiens 48-51 30091208-3 2018 We previously demonstrated that MC/DMC could activate p21WAF 1/ CIP 1 in MCF-7 (p53-proficient) and K562 (p53-deficient) cells in a p53-independent mode. 10-decarbamoylmitomycin C 35-38 tumor protein p53 Homo sapiens 106-109 30091208-3 2018 We previously demonstrated that MC/DMC could activate p21WAF 1/ CIP 1 in MCF-7 (p53-proficient) and K562 (p53-deficient) cells in a p53-independent mode. 10-decarbamoylmitomycin C 35-38 tumor protein p53 Homo sapiens 106-109 27666201-0 2016 Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation. 10-decarbamoylmitomycin C 16-39 tumor protein p53 Homo sapiens 47-50 27666201-5 2016 In addition, DMC can provoke strong p53-independent cell death. 10-decarbamoylmitomycin C 13-16 tumor protein p53 Homo sapiens 36-39 27666201-6 2016 Our hypothesis is that the stereochemistry of the major unique beta-ICL generated by DMC is responsible for this p53-independent cell death signaling. 10-decarbamoylmitomycin C 85-88 tumor protein p53 Homo sapiens 113-116