PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8993023-3	1997	O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	128-131	O-6-methylguanine-DNA methyltransferase	Mus musculus	0-38	
9269990-0	1997	The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.	1-(2-chloroethyl)-1-nitrosourea	126-148	O-6-methylguanine-DNA methyltransferase	Mus musculus	23-61	
9269990-2	1997	Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase (MGMT) protects against CNU-induced tumors.	1-(2-chloroethyl)-1-nitrosourea	234-237	O-6-methylguanine-DNA methyltransferase	Mus musculus	150-209	
9269990-2	1997	Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase (MGMT) protects against CNU-induced tumors.	1-(2-chloroethyl)-1-nitrosourea	234-237	O-6-methylguanine-DNA methyltransferase	Mus musculus	211-215	
9269990-6	1997	The results provide clear evidence that MGMT exerts protection against CNU-induced cancer.	1-(2-chloroethyl)-1-nitrosourea	71-74	O-6-methylguanine-DNA methyltransferase	Mus musculus	40-44	
9269990-7	1997	Our data also indicate that O6-chloroethylguanine, which is repaired by MGMT, is a main precarcinogenic CNU-induced DNA lesion.	1-(2-chloroethyl)-1-nitrosourea	104-107	O-6-methylguanine-DNA methyltransferase	Mus musculus	72-76	
9148943-3	1997	Exposure of mouse 3T3 cells to increasing concentrations of CNU, and subsequent selection of resistant cells, led to the isolation of clones with 5-10 times higher levels of MGMT activity than in the control.	1-(2-chloroethyl)-1-nitrosourea	60-63	O-6-methylguanine-DNA methyltransferase	Mus musculus	174-178	
8993023-3	1997	O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage.	1-(2-chloroethyl)-1-nitrosourea	128-131	O-6-methylguanine-DNA methyltransferase	Mus musculus	40-44	
8993023-4	1997	We have previously demonstrated that transplantation of murine bone marrow cells transduced with a recombinant retroviral vector expressing MGMT via the human phosphoglycerate kinase promoter (PGK-MGMT) protects animals in vivo from acute myelotoxicity associated with CNU treatment.	1-(2-chloroethyl)-1-nitrosourea	269-272	O-6-methylguanine-DNA methyltransferase	Mus musculus	140-144	
8993023-9	1997	Thus, long term immunodeficiency following CNU therapy may be prevented by genetic modification of murine hemopoietic stem cells with MGMT, leading to significant improvement in post-transplant immune function.	1-(2-chloroethyl)-1-nitrosourea	43-46	O-6-methylguanine-DNA methyltransferase	Mus musculus	134-138	
8552605-2	1996	Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions.	1-(2-chloroethyl)-1-nitrosourea	12-15	O-6-methylguanine-DNA methyltransferase	Mus musculus	178-216	
8552605-2	1996	Bone marrow CNU sensitivity is probably due to the inefficient repair of CNU-induced DNA damage; relative to other tissues, bone marrow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein that repairs cytotoxic O6-chloroethylguanine DNA lesions.	1-(2-chloroethyl)-1-nitrosourea	12-15	O-6-methylguanine-DNA methyltransferase	Mus musculus	218-222	
8552605-4	1996	Stable reconstitution of mouse bone marrow with genetically modified, MGMT-expressing hematopoietic stem cells conferred considerable resistance to the cytotoxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a CNU commonly used for chemotherapy.	1-(2-chloroethyl)-1-nitrosourea	212-215	O-6-methylguanine-DNA methyltransferase	Mus musculus	70-74	
7956741-1	1994	Tumor resistances to chloroethylnitrosourea (CENU) are mainly due to O6-alkylguanine-DNA alkyltransferase (AGT).	1-(2-chloroethyl)-1-nitrosourea	45-49	O-6-methylguanine-DNA methyltransferase	Mus musculus	69-105	
7956741-1	1994	Tumor resistances to chloroethylnitrosourea (CENU) are mainly due to O6-alkylguanine-DNA alkyltransferase (AGT).	1-(2-chloroethyl)-1-nitrosourea	21-43	O-6-methylguanine-DNA methyltransferase	Mus musculus	69-105