PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25458686-2	2014	The stereo specific metabolic activity of human CYP-2B6 (cytochrome P450) on endosulfan has been well demonstrated.	Endosulfan	77-87	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	48-55	
25458686-4	2014	The functional similarity was studied at organism level by batch-scale studies and it was proved that B. megaterium could metabolize endosulfan to endosulfan sulfate, as CYP-2B6 does in human system.	Endosulfan	133-143	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	170-177	
24832206-0	2014	Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.	Endosulfan	16-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	65-71	
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Endosulfan	58-68	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	192-198	
16855053-7	2006	This study shows that endosulfan-alpha is metabolized by HLMs to a single metabolite, endosulfan sulfate, and that it has potential use, in combination with inhibitors, as an in vitro probe for CYP2B6 and 3A4 catalytic activities.	Endosulfan	22-32	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	194-200	
20361990-0	2010	Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.	Endosulfan	0-10	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-25	
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-98	
20361990-11	2010	These data support the role of endosulfan-alpha as a strong activator of PXR and inducer of CYP2B6 and CYP3A4, which may impact metabolism of CYP2B6 or CYP3A4 substrates.	Endosulfan	31-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-148	
16581944-5	2006	Correlation analysis between the known P450 enzyme activities and the rate of the formation of endosulfan sulfate in the 14 human liver microsomes showed that alpha-endosulfan metabolism is significantly correlated with CYP2B6-mediated bupropion hydroxylation and CYP3A-mediated midazolam hydroxylation, and that beta-endosulfan metabolism is correlated with CYP3A activity.	Endosulfan	159-175	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	220-226	
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	256-271	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	211-217	
16581944-8	2006	CYP2B6 enantioselectively metabolizes alpha-endosulfan, but not beta-endosulfan.	Endosulfan	38-54	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
16581944-9	2006	These findings suggest that the CYP2B6 and CYP3A enzymes are major enzymes contributing to the stereoselective disposition of endosulfan.	Endosulfan	126-136	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	32-38	
16581944-5	2006	Correlation analysis between the known P450 enzyme activities and the rate of the formation of endosulfan sulfate in the 14 human liver microsomes showed that alpha-endosulfan metabolism is significantly correlated with CYP2B6-mediated bupropion hydroxylation and CYP3A-mediated midazolam hydroxylation, and that beta-endosulfan metabolism is correlated with CYP3A activity.	Endosulfan	313-328	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	220-226	
16581944-6	2006	The P450 isoform-selective inhibition study in human liver microsomes and the incubation study of cDNA-expressed enzymes also demonstrated that the stereoselective sulfonation of alpha-endosulfan is mediated by CYP2B6, CYP3A4, and CYP3A5, and that that of beta-endosulfan is transformed by CYP3A4 and CYP3A5.	Endosulfan	179-195	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	211-217