PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3923646-1 1985 Thrombin, histamine and ionophore A23187 stimulated human endothelial cells to release arachidonic acid and synthesize prostaglandins. Prostaglandins 119-133 coagulation factor II, thrombin Homo sapiens 0-8 3923646-8 1985 Like thrombin, both histamine and ionophore A23187 also stimulated release of arachidonic acid and synthesis of prostaglandins. Prostaglandins 112-126 coagulation factor II, thrombin Homo sapiens 5-13 6860783-2 1983 The second finding in this paper, that indomethacin blocks the stimulating effect of thrombin on bone resorption, is consistent with the concept that prostaglandin synthesis may be involved in this process. Prostaglandins 150-163 coagulation factor II, thrombin Homo sapiens 85-93 6810948-2 1982 Addition of arachidonic acid, bradykinin, the calcium ionophore A23187 or thrombin stimulated prostaglandin formation, whereas addition of angiotensin II did not. Prostaglandins 94-107 coagulation factor II, thrombin Homo sapiens 74-82 7167726-7 1982 The ability of platelets to produce prostaglandin metabolites, estimated from malondialdehyde formation after thrombin stimulation was also moderately, but significantly lower in coronary sinus blood. Prostaglandins 36-49 coagulation factor II, thrombin Homo sapiens 110-118 6256612-3 1980 A possible mechanism is suggested to explain how the body can maintain thrombin at a level too low to cause platelet aggregation but adequate to stimulate release of prostaglandins and enzymes for more than 24 hours from a single dose of the pineapple enzymes. Prostaglandins 166-180 coagulation factor II, thrombin Homo sapiens 71-79 7258182-4 1981 Stimulation of "myeloproliferative" platelets with thrombin after blocking the prostaglandin pathway with aspirin resulted in reduced aggregation, indicating either a deficiency of the storage pool of adenine nucleotides in the platelets or an abnormality of a membrane receptor for thrombin. Prostaglandins 79-92 coagulation factor II, thrombin Homo sapiens 51-59 6946268-1 1981 Prostaglandin (PG) production by human embryo lung fibroblasts (HELF) is stimulated by a number of effectors including angiotensin, thrombin, bradykinin and ascorbic acid. Prostaglandins 0-13 coagulation factor II, thrombin Homo sapiens 132-140 6946268-1 1981 Prostaglandin (PG) production by human embryo lung fibroblasts (HELF) is stimulated by a number of effectors including angiotensin, thrombin, bradykinin and ascorbic acid. Prostaglandins 15-17 coagulation factor II, thrombin Homo sapiens 132-140 7111236-0 1982 [Thrombin-induced prostaglandin synthesis by thrombocytes under different preservation conditions]. Prostaglandins 18-31 coagulation factor II, thrombin Homo sapiens 1-9 6779878-9 1981 This thrombin effect correlated with serotonin release and could be dissociated from platelet aggregation and prostaglandin synthesis. Prostaglandins 110-123 coagulation factor II, thrombin Homo sapiens 5-13 888085-3 1977 The three most vasoactive prostaglandins were E1, E2, and F2, alpha. Prostaglandins 26-40 coagulation factor II, thrombin Homo sapiens 58-67 7384555-2 1980 It inhibits platelet prostaglandin production induced by thrombin or collagen but not by arachidonic acid. Prostaglandins 21-34 coagulation factor II, thrombin Homo sapiens 57-65 399532-3 1979 Small doses of prostaglandins inhibited ADP- and thrombin-induced aggregation, but only prolonged aggregation time without affecting the extent of arachidonic acid (AA)-induced aggregation. Prostaglandins 15-29 coagulation factor II, thrombin Homo sapiens 49-57 399532-5 1979 Large doses of prostaglandins abolished platelet aggregation and prolonged the onset of thrombin-induced clotting. Prostaglandins 15-29 coagulation factor II, thrombin Homo sapiens 88-96 399532-9 1979 APG and prostaglandins showed additive inhibition of only thrombin-induced aggregation. Prostaglandins 8-22 coagulation factor II, thrombin Homo sapiens 58-66 476213-6 1979 It is concluded that the pathway of prostaglandins is normally stimulated by thrombin in newborn platelets. Prostaglandins 36-50 coagulation factor II, thrombin Homo sapiens 77-85 190267-11 1977 Higher thrombin concentrations are required to stimulate prostaglandin synthesis (0.05-2 U/ml) than are required to induce [14C]serotonin release (0.02-0.1 U/ml). Prostaglandins 57-70 coagulation factor II, thrombin Homo sapiens 7-15 32365105-7 2020 In addition, thrombin increased prostaglandin-endoperoxidase synthase-2 (PTGS2 or COX2) mRNA and prostaglandin E2 and F2alpha synthesis in human myometrial cells. Prostaglandins 32-45 coagulation factor II, thrombin Homo sapiens 13-21 5051706-0 1972 [Effect of F 2 prostaglandin on the placental vessels in vitro]. Prostaglandins 17-30 coagulation factor II, thrombin Homo sapiens 11-14 32858395-7 2020 Additionally, tissue factor, thrombin, and activated coagulation factors induce the release of pro-inflammatory cytokines such as prostaglandin and C reactive protein, which may further induce von Willebrand factor secretion. Prostaglandins 130-143 coagulation factor II, thrombin Homo sapiens 29-37 32365105-10 2020 Collectively, thrombin induces myometrial contractions by two mechanisms, including direct activation of myosin and indirect increases in prostaglandin synthesis. Prostaglandins 138-151 coagulation factor II, thrombin Homo sapiens 14-22 184521-0 1976 Thrombin-induced platelet prostaglandin and cyclic AMP production and a possible intrinsic modulation of platelet function. Prostaglandins 26-39 coagulation factor II, thrombin Homo sapiens 0-8 1258974-4 1976 The findings confirm the hypothesis that a prostaglandin produced endogenously by platelets initiates platelet contraction and suggests that ADP and thrombin have the ability to stimulate the platelet contractile apparatus by an alternate mechanism not dependent on prostaglandin synthesis. Prostaglandins 43-56 coagulation factor II, thrombin Homo sapiens 149-157 1258974-4 1976 The findings confirm the hypothesis that a prostaglandin produced endogenously by platelets initiates platelet contraction and suggests that ADP and thrombin have the ability to stimulate the platelet contractile apparatus by an alternate mechanism not dependent on prostaglandin synthesis. Prostaglandins 266-279 coagulation factor II, thrombin Homo sapiens 149-157 5497809-0 1970 Formation and release of prostaglandins by platelets in response to thrombin. Prostaglandins 25-39 coagulation factor II, thrombin Homo sapiens 68-76 32365105-8 2020 Thrombin significantly increased the mRNA level of interleukine-1beta, whereas it decreased the expressions of prostaglandin EP3 and F2alpha receptors. Prostaglandins 111-124 coagulation factor II, thrombin Homo sapiens 0-8 19460777-9 2009 CONCLUSIONS: This study provides the first evidence that NFAT2 contributes to the transcriptional control of PAR-1 in human VSMC and that PKA-dependent NFAT2 inhibition represents a mechanism by which vasodilatory prostaglandins regulate the vascular actions of thrombin. Prostaglandins 214-228 coagulation factor II, thrombin Homo sapiens 262-270 32104332-6 2017 Serine protease possesses a higher affinity for cyclooxygenase (COX-I and COX-II), a key enzyme associated with production of different inflammatory mediators including interleukins (IL), prostaglandins (PGs) and thromboxane (TXs) etc. Prostaglandins 188-202 coagulation factor II, thrombin Homo sapiens 0-15 32104332-6 2017 Serine protease possesses a higher affinity for cyclooxygenase (COX-I and COX-II), a key enzyme associated with production of different inflammatory mediators including interleukins (IL), prostaglandins (PGs) and thromboxane (TXs) etc. Prostaglandins 204-207 coagulation factor II, thrombin Homo sapiens 0-15 21059757-6 2011 Pharmacological approaches revealed that phospholipase A2 (PLA2) activity and cyclooxygenase (COX)-mediated synthesis of prostaglandins was required for the thrombin-induced elevation of [cAMP]. Prostaglandins 121-135 coagulation factor II, thrombin Homo sapiens 157-165 27050800-2 2016 Previously, we reported that thrombin increased matrix metalloproteinases and prostaglandin synthesis in human amnion mesenchymal cells. Prostaglandins 78-91 coagulation factor II, thrombin Homo sapiens 29-37 20143010-0 2010 Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins. Prostaglandins 93-107 coagulation factor II, thrombin Homo sapiens 0-8 20143010-5 2010 Thrombin-responsive PARs are transcriptionally down-regulated in human vascular SMC by vasodilatory prostaglandins (PGI2/PGE2). Prostaglandins 100-114 coagulation factor II, thrombin Homo sapiens 0-8 12600906-7 2003 Activation of PAR-2 receptors in vivo dilated human blood vessels in a dose-dependent manner, and the effects were reduced by inhibition of both nitric oxide and prostanoid synthesis CONCLUSIONS: These findings demonstrate that serine protease activity can cause human vasodilation and provide a possible explanation of why serine protease activation in critical illness is associated with vascular dysfunction. Prostaglandins 162-172 coagulation factor II, thrombin Homo sapiens 228-243 17403097-5 2007 Biosynthesis of prostanoids from exogenous or endogenous substrate was analyzed by high-performance liquid chromatography or enzyme-immunoassay after incubation of cells with labeled arachidonic acid or thrombin, respectively. Prostaglandins 16-27 coagulation factor II, thrombin Homo sapiens 203-211 11372689-0 2001 Serotonin 5-HT1 receptors potentiate histamine and thrombin stimulated prostaglandin synthesis in endothelial cells. Prostaglandins 71-84 coagulation factor II, thrombin Homo sapiens 51-59 12009388-9 2002 CONCLUSION: Thrombin-induced relaxation of renal arteries appears to be mediated by nitric oxide and vasodilator prostaglandins liberated from the endothelium, whereas uterine arterial contraction is caused by an endothelium-independent mechanism. Prostaglandins 113-127 coagulation factor II, thrombin Homo sapiens 12-20 11372689-3 2001 However, 5-CT potentiated the histamine and thrombin stimulated increases in prostaglandins released by HAEC. Prostaglandins 77-91 coagulation factor II, thrombin Homo sapiens 44-52 11372689-5 2001 The ability of 5-CT to potentiate prostaglandin production was correlated with its ability to potentiate the histamine and thrombin mediated mobilization of arachidonic acid. Prostaglandins 34-47 coagulation factor II, thrombin Homo sapiens 123-131 11372689-6 2001 These results demonstrate that the ability of 5-HT1 receptors to stimulate prostaglandin production in endothelial cells is activated by histamine and thrombin. Prostaglandins 75-88 coagulation factor II, thrombin Homo sapiens 151-159 9839700-2 1998 Bradykinin (BK) and thrombin are known to cause a significant time- and concentration-dependent burst of prostanoid biosynthesis in cultured human periodontal-ligament (PDL) cells. Prostaglandins 105-115 coagulation factor II, thrombin Homo sapiens 20-28 9765255-8 1998 Finally, PDGF-BB and thrombin raise ETB receptors through the PG pathway. Prostaglandins 62-64 coagulation factor II, thrombin Homo sapiens 21-29 9839700-3 1998 The aim now was to investigate interactive effects between interleukin 1 alpha, -beta (IL-1 alpha, -1 beta), tumour necrosis factor-alpha,-beta (TNF-alpha, -beta) and BK or thrombin on prostaglandin biosynthesis in human PDL cells. Prostaglandins 185-198 coagulation factor II, thrombin Homo sapiens 173-181 9839700-5 1998 Synergistic stimulation of prostanoid biosynthesis was demonstrated when BK or thrombin were added together with IL-1 alpha or -1 beta. Prostaglandins 27-37 coagulation factor II, thrombin Homo sapiens 79-87 9839700-12 1998 These experiments demonstrate synergistic interactions between BK, thrombin, IL-1 and TNF on prostaglandin biosynthesis in cultured human PDL cells. Prostaglandins 93-106 coagulation factor II, thrombin Homo sapiens 67-75 7528372-8 1994 In addition, bradykinin and thrombin act in concert with interleukin-1 to synergistically stimulate bone resorption and prostaglandin biosynthesis. Prostaglandins 120-133 coagulation factor II, thrombin Homo sapiens 28-36 8777276-0 1996 Bradykinin and thrombin synergistically potentiate interleukin 1 and tumour necrosis factor induced prostanoid biosynthesis in human dental pulp fibroblasts. Prostaglandins 100-110 coagulation factor II, thrombin Homo sapiens 15-23 8552614-0 1996 Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury. Prostaglandins 74-87 coagulation factor II, thrombin Homo sapiens 130-138 7605251-11 1995 These data show that human dental-pulp fibroblasts are equipped with receptors for bradykinin and thrombin linked to enhanced prostanoid biosynthesis. Prostaglandins 126-136 coagulation factor II, thrombin Homo sapiens 98-106 7605251-12 1995 Occupancy of the thrombin receptors also leads to a prostaglandin-independent stimulation of cell proliferation and collagen biosynthesis. Prostaglandins 52-65 coagulation factor II, thrombin Homo sapiens 17-25 8954139-7 1996 These results suggest the key role of PKC on the cross-talk between [Ca2+]i and cAMP signalings through prostanoid and thrombin receptors; PKC, which is activated with TXA2 or thrombin, concomitantly suppress further [Ca2+]i elevation and enhances the PGI2 receptor-mediated cAMP formation, which, in turn, suppress [Ca2+]i elevation. Prostaglandins 104-114 coagulation factor II, thrombin Homo sapiens 176-184 8777276-14 1996 These data show that proinflammatory mediators such as BK and thrombin act in concert with IL-1 and TNF in stimulating prostanoid formation in human pulpal fibroblasts and that the action of BK is linked to BK B2-receptors. Prostaglandins 119-129 coagulation factor II, thrombin Homo sapiens 62-70 7605251-1 1995 Bradykinin and thrombin caused a time- and dose-dependent stimulation of prostanoid biosynthesis in human dental-pulp fibroblasts, as assessed by the release of prostaglandin E2 (PGE2) and 6-keto-prostaglandin F1 alpha (the stable breakdown product of prostacyclin). Prostaglandins 73-83 coagulation factor II, thrombin Homo sapiens 15-23 7528372-6 1994 Both kinins and thrombin stimulate prostaglandin biosynthesis in bone parallel with the bone resorptive effect. Prostaglandins 35-48 coagulation factor II, thrombin Homo sapiens 16-24 7528372-7 1994 The stimulatory effect of bradykinin on bone resorption is completely lost when the prostaglandin response is abolished, whereas thrombin can stimulate bone resorption both via prostaglandin-dependent and independent mechanisms. Prostaglandins 177-190 coagulation factor II, thrombin Homo sapiens 129-137 7528372-10 1994 Moreover, haptoglobin synergistically potentiates bradykinin-induced and thrombin-induced prostanoid biosynthesis in osteoblasts. Prostaglandins 90-100 coagulation factor II, thrombin Homo sapiens 73-81 8360259-0 1993 Thrombin receptor activating peptides induce Ca2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. Prostaglandins 85-98 coagulation factor II, thrombin Homo sapiens 0-8 8062861-0 1994 Bradykinin and thrombin stimulate release of arachidonic acid and formation of prostanoids in human periodontal ligament cells. Prostaglandins 79-90 coagulation factor II, thrombin Homo sapiens 15-23 8062861-3 1994 In the present study, the effect of bradykinin (BK) and thrombin, two inflammatory mediators, on prostanoid biosynthesis in human PDL-cells was investigated. Prostaglandins 97-107 coagulation factor II, thrombin Homo sapiens 56-64 8062861-9 1994 BK and BK-B2 receptor agonists as well as thrombin, but not BK-B1 receptor agonists, also significantly increased [3H] release in human PDL-cells prelabelled with [3H]-arachidonic acid, indicating that BK and thrombin stimulate prostanoid biosynthesis, at least partly, due to activation of phospholipase A2. Prostaglandins 228-238 coagulation factor II, thrombin Homo sapiens 42-50 8062861-10 1994 These data show that BK via BK-B2 receptors, as well as thrombin, have the capacity to stimulate arachidonic acid release and subsequent prostanoid biosynthesis in human PDL-cells and thus may be implicated in the tissue reactions involved in orthodontic tooth movement. Prostaglandins 137-147 coagulation factor II, thrombin Homo sapiens 56-64 2105325-8 1990 In contrast, the G-protein inhibitor GDP beta S, (guanosine 5"-0-2-thiodiphosphate), attenuated alpha-thrombin-mediated prostaglandin generation. Prostaglandins 120-133 coagulation factor II, thrombin Homo sapiens 102-110 8365478-7 1993 Proliferation of osteoblastic cells induced by alpha-thrombin or TSP was specifically and totally inhibited by anti-TSP monoclonal antibodies (3-10 micrograms/ml) or by indomethacin (1 microM), an inhibitor of prostaglandin synthesis. Prostaglandins 210-223 coagulation factor II, thrombin Homo sapiens 53-61 8365478-9 1993 Our experiments support the existence of a mechanism whereby TSP bound to the cell surface of thrombin-treated MG-63 cells stimulates secretion of prostaglandins which, in turn, allow cell proliferation to proceed. Prostaglandins 147-161 coagulation factor II, thrombin Homo sapiens 94-102 1331412-5 1992 The thrombin effect 1) produced an increase in the efficacy of the prostaglandins with no change in potency; 2) was long-lived; 3) required the proteolytic activity of thrombin; 4) was insensitive to pertussis toxin; and 5) was at least partially mimicked by trypsin, extracellular ATP and UTP, platelet activating factor and activators of protein kinase C. Down-regulation of protein kinase C or pre-exposure to the protein kinase inhibitor staurosporine blocked the potentiating effect. Prostaglandins 67-81 coagulation factor II, thrombin Homo sapiens 4-12 2290027-3 1990 In addition to short acting stimuli like thrombin and histamine an increased prostanoid release occurs in the presence of endotoxin, interleukin 1 or tumor necrosis factor (TNF). Prostaglandins 77-87 coagulation factor II, thrombin Homo sapiens 41-49 2555202-0 1989 Diacylglycerol in the synergy of bradykinin and thrombin stimulation of prostaglandin synthesis. Prostaglandins 72-85 coagulation factor II, thrombin Homo sapiens 48-56 2550484-5 1989 Pretreatment with tumor necrosis factor synergistically enhanced prostaglandin synthesis in response to bradykinin, bombesin, thrombin, norepinephrine, and platelet-activating factor. Prostaglandins 65-78 coagulation factor II, thrombin Homo sapiens 126-134 3532206-4 1986 In human platelets, SKF 525-A inhibited prostaglandin and thromboxane production induced by A23187, thrombin and ADP. Prostaglandins 40-53 coagulation factor II, thrombin Homo sapiens 100-108 2495258-5 1989 The release of all three prostanoids was significantly increased by the addition of the calcium ionophore (A23187), human thrombin, bradykinin and histamine. Prostaglandins 25-36 coagulation factor II, thrombin Homo sapiens 122-130 3109426-6 1987 In human platelets, SKF 525-A inhibited prostaglandin and thromboxane production induced by A23187, thrombin and ADP. Prostaglandins 40-53 coagulation factor II, thrombin Homo sapiens 100-108 2539730-2 1989 Replacement of extracellular Na+ with choline or N-methylglucamine reduced thrombin-stimulated PG secretion but did not significantly affect either ATP- or A23187-stimulated PG secretion. Prostaglandins 95-97 coagulation factor II, thrombin Homo sapiens 75-83 2539730-6 1989 Since manipulations known to inhibit Na+ -H+ exchange (EIPA, HMA, replacement of Na+ with choline or N-methylglucamine) reduced thrombin-stimulated RCME cell PG release, we conclude that activation of Na+ -H+ exchange is involved in the coupling of thrombin interaction with RCME cells to subsequent phospholipase activation and PG release. Prostaglandins 158-160 coagulation factor II, thrombin Homo sapiens 128-136 2671341-0 1989 Thrombin and bradykinin enhance prostaglandin production in human peripheral blood monocytes. Prostaglandins 32-45 coagulation factor II, thrombin Homo sapiens 0-8 3104353-2 1987 Since thrombin stimulates the release and metabolism of arachidonic acid, the precursor of prostaglandins, we examined the relationship between this release and metabolism and the stimulation of cell division in cultured fibroblasts. Prostaglandins 91-105 coagulation factor II, thrombin Homo sapiens 6-14 3104353-3 1987 We also examined the role of prostaglandin synthesis in thrombin-stimulated phosphatidylinositol synthesis. Prostaglandins 29-42 coagulation factor II, thrombin Homo sapiens 56-64 2433528-2 1986 The formation of cyclic AMP (cAMP) by the adenylate cyclase system--consisting of the catalyst itself, the Ns and Ni proteins, and various hormone receptors--is stimulated by prostaglandins and adenosine, and is inhibited by alpha 2-adrenergic agonists, ADP, vasopressin, platelet-activating factor, and thrombin. Prostaglandins 175-189 coagulation factor II, thrombin Homo sapiens 304-312 3001080-9 1986 Thrombin-induced hydrolysis of arachidonyl esters and synthesis of prostanoids were similar to regulation of adenylate cyclase; they were blocked, with partial correction at high concentrations of thrombin. Prostaglandins 67-78 coagulation factor II, thrombin Homo sapiens 0-8 3001080-9 1986 Thrombin-induced hydrolysis of arachidonyl esters and synthesis of prostanoids were similar to regulation of adenylate cyclase; they were blocked, with partial correction at high concentrations of thrombin. Prostaglandins 67-78 coagulation factor II, thrombin Homo sapiens 197-205 3001080-12 1986 It is concluded that platelets have at least two types of thrombin receptors or coupling mechanisms, one of which is sensitive to chymotrypsin, unresponsive to gamma-thrombin, and coupled to inhibition of adenylate cyclase and activation of prostanoid synthesis. Prostaglandins 241-251 coagulation factor II, thrombin Homo sapiens 58-66 3867194-3 1985 Addition of thrombin, following the incubation of thrombocytes with prostaglandins, removed the activating effect of the prostaglandins on the pentosephosphate pathway reactions, inhibited glutathione reductase and lactate dehydrogenase. Prostaglandins 68-82 coagulation factor II, thrombin Homo sapiens 12-20 2994748-0 1985 The role of thrombin in the regulation of the endothelial prostaglandin production. Prostaglandins 58-71 coagulation factor II, thrombin Homo sapiens 12-20 2994748-1 1985 Prostaglandin synthesis in endothelial cells may be initiated by the addition of exogenous substrate (arachidonic acid) or by addition of thrombin or the CA2+-ionophore A23187, which leads to prostacyclin formation from endogenous substrates. Prostaglandins 0-13 coagulation factor II, thrombin Homo sapiens 138-146 3867194-3 1985 Addition of thrombin, following the incubation of thrombocytes with prostaglandins, removed the activating effect of the prostaglandins on the pentosephosphate pathway reactions, inhibited glutathione reductase and lactate dehydrogenase. Prostaglandins 121-135 coagulation factor II, thrombin Homo sapiens 12-20