PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18035502-0 2007 Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Prostaglandins 0-14 interleukin 1 beta Rattus norvegicus 97-115 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Prostaglandins 223-237 interleukin 1 beta Rattus norvegicus 93-110 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Prostaglandins 223-237 interleukin 1 beta Rattus norvegicus 112-120 26827495-6 2015 Because diclofenac is a non-specific antagonist of cyclooxygenases, it had been concluded that the prostaglandins mediate respiratory effects of IL-1beta in point of fact. Prostaglandins 99-113 interleukin 1 beta Rattus norvegicus 145-153 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 182-195 interleukin 1 beta Rattus norvegicus 143-160 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 182-195 interleukin 1 beta Rattus norvegicus 162-170 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 197-199 interleukin 1 beta Rattus norvegicus 143-160 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 197-199 interleukin 1 beta Rattus norvegicus 162-170 24095834-3 2014 Treatment of 3Y1 cells with triacsin C, an ACSL inhibitor, markedly enhanced the IL-1beta-induced prostaglandin (PG) biosynthesis. Prostaglandins 98-111 interleukin 1 beta Rattus norvegicus 81-89 24095834-3 2014 Treatment of 3Y1 cells with triacsin C, an ACSL inhibitor, markedly enhanced the IL-1beta-induced prostaglandin (PG) biosynthesis. Prostaglandins 113-115 interleukin 1 beta Rattus norvegicus 81-89 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 51-64 interleukin 1 beta Rattus norvegicus 83-91 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 51-64 interleukin 1 beta Rattus norvegicus 159-167 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 66-68 interleukin 1 beta Rattus norvegicus 83-91 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 66-68 interleukin 1 beta Rattus norvegicus 159-167 18035502-4 2007 Cyclooxygenase (COX) inhibition blocked the disruption in contextual fear conditioning produced by IL-1beta and COX inhibition alone also disrupted contextual memory, suggesting an inverted U-shaped relationship between PG levels and memory. Prostaglandins 220-222 interleukin 1 beta Rattus norvegicus 99-107 16784727-15 2006 However, IL-1beta can also exert direct effects on IL-1 receptors on cerebral blood vessels, activating cyclooxygenases and hence synthesis of prostaglandins which in turn can affect body temperature, behavior and HPA axis activation. Prostaglandins 143-157 interleukin 1 beta Rattus norvegicus 9-17 17077517-0 2006 2-methoxycinnamaldehyde reduces IL-1beta-induced prostaglandin production in rat cerebral endothelial cells. Prostaglandins 49-62 interleukin 1 beta Rattus norvegicus 32-40 16011486-3 2005 In the present study, using whole-cell patch clamp recordings of rat neurones in a slice preparation of the PVN, we show that the effects of IL-1beta are abolished in the presence of a cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandin (PG) synthesis and activation. Prostaglandins 269-271 interleukin 1 beta Rattus norvegicus 141-149 16011486-3 2005 In the present study, using whole-cell patch clamp recordings of rat neurones in a slice preparation of the PVN, we show that the effects of IL-1beta are abolished in the presence of a cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandin (PG) synthesis and activation. Prostaglandins 254-267 interleukin 1 beta Rattus norvegicus 141-149 15758944-1 2005 Interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression in many of its cellular targets resulting in production and release of prostaglandins. Prostaglandins 144-158 interleukin 1 beta Rattus norvegicus 0-17 15758944-1 2005 Interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression in many of its cellular targets resulting in production and release of prostaglandins. Prostaglandins 144-158 interleukin 1 beta Rattus norvegicus 19-27 15888326-0 2005 Ageing alters the production of nitric oxide and prostanoids after IL-1beta exposure in mesenteric resistance arteries. Prostaglandins 49-60 interleukin 1 beta Rattus norvegicus 67-75 15927699-5 2005 The effects of IL-1beta on MNC neurons were blocked in the presence of a specific cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandins (PG) in mediating these effects. Prostaglandins 151-165 interleukin 1 beta Rattus norvegicus 15-23 15927699-5 2005 The effects of IL-1beta on MNC neurons were blocked in the presence of a specific cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandins (PG) in mediating these effects. Prostaglandins 167-169 interleukin 1 beta Rattus norvegicus 15-23 15927699-8 2005 These data provide evidence that IL-1beta depolarizes MNC neurons in the PVN as a result of prostaglandin-mediated activation of a NSCC. Prostaglandins 92-105 interleukin 1 beta Rattus norvegicus 33-41 15927699-0 2005 Interleukin-1beta depolarizes magnocellular neurons in the paraventricular nucleus of the hypothalamus through prostaglandin-mediated activation of a non selective cationic conductance. Prostaglandins 111-124 interleukin 1 beta Rattus norvegicus 0-17 14684367-1 2004 Interleukin (IL)-1beta is a potent inducer of inflammatory prostaglandins, which are important mediators of vascular response to cerebral injury, whereas estrogen reduces brain injury in models of ischemic stroke. Prostaglandins 59-73 interleukin 1 beta Rattus norvegicus 0-22 15665080-11 2005 As in rats, the final mediators of this cascade were prostaglandins released by IL-1beta and sympathetic amines released by KC. Prostaglandins 53-67 interleukin 1 beta Rattus norvegicus 80-88 12897060-3 2003 Moreover, rosiglitazone both synergized with IL-1beta to further induce prostaglandin release and affected the expression of phospholipase A2 and COX-2. Prostaglandins 72-85 interleukin 1 beta Rattus norvegicus 45-53 15135362-1 2004 We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. Prostaglandins 110-123 interleukin 1 beta Rattus norvegicus 33-50 15135362-1 2004 We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. Prostaglandins 110-123 interleukin 1 beta Rattus norvegicus 52-60 15024756-1 2004 Interleukin-1 beta (IL-1 beta) is thought to act on the brain to induce fever, neuroendocrine activation, and behavioral changes during disease through induction of prostaglandins at the blood-brain barrier (BBB). Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 0-18 15024756-1 2004 Interleukin-1 beta (IL-1 beta) is thought to act on the brain to induce fever, neuroendocrine activation, and behavioral changes during disease through induction of prostaglandins at the blood-brain barrier (BBB). Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 20-29 15024756-2 2004 However, despite the fact that IL-1 beta induces the prostaglandin-synthesizing enzyme cyclooxygenase-2 (COX-2) in brain vascular cells, no study has established the presence of IL-1 receptor type 1 (IL-1R1) protein in these cells. Prostaglandins 53-66 interleukin 1 beta Rattus norvegicus 31-40 11260389-4 2001 METHODS: Synthesis of prostanoid by resting and interleukin-1beta (IL-1beta)-treated (overnight) RGMCs from exogenous or endogenous arachidonic acid (AA) was assessed by high-performance liquid chromtography or enzyme immunoassay, respectively. Prostaglandins 22-32 interleukin 1 beta Rattus norvegicus 48-65 12871832-15 2003 In conclusion, our results suggest that the TNFalpha-, IL-1beta- and CINC-1-driven release of prostaglandins, sympathetic amines and LTB(4) mediates the first 3 h of mechanical hypersensitivity induced by antigen challenge in rats. Prostaglandins 94-108 interleukin 1 beta Rattus norvegicus 55-63 12803978-11 2003 In cultured rat mesangial cells, DHEF (and DHEA) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin (PGE2) production. Prostaglandins 127-140 interleukin 1 beta Rattus norvegicus 68-85 11578770-3 2001 IL-1 beta, which can act as a mitogen for astrocytes, also elicits the expression and secretion of multiple factors and paracrine "second messengers" such as other cytokines, nerve growth factor, prostaglandins and nitric oxide that may in turn modulate neuronal and glial responses to injury. Prostaglandins 196-210 interleukin 1 beta Rattus norvegicus 0-9 11525800-0 2001 Intracerebroventricular interleukin-1beta impairs clearance of tumor cells from the lungs: role of brain prostaglandins. Prostaglandins 105-119 interleukin 1 beta Rattus norvegicus 24-41 11525800-7 2001 Central administration of the prostaglandin antagonist, diclofenac (250 ug), but not ibuprofen, completely blocked the effect of IL-1beta on lung clearance of tumor cells. Prostaglandins 30-43 interleukin 1 beta Rattus norvegicus 129-137 11274144-1 2001 Transforming growth factor (TGF)-alpha and interleukin (IL)-1beta are responsible for the healing of gastric lesions through, in part, prostaglandin (PG) generation. Prostaglandins 135-148 interleukin 1 beta Rattus norvegicus 43-65 11274144-1 2001 Transforming growth factor (TGF)-alpha and interleukin (IL)-1beta are responsible for the healing of gastric lesions through, in part, prostaglandin (PG) generation. Prostaglandins 150-152 interleukin 1 beta Rattus norvegicus 43-65 11247753-1 2001 Central administration of interleukin-1 beta (IL-1 beta) increases cerebral blood flow (CBF) and body temperature, in part, through the production of prostaglandins. Prostaglandins 150-164 interleukin 1 beta Rattus norvegicus 26-44 11247753-1 2001 Central administration of interleukin-1 beta (IL-1 beta) increases cerebral blood flow (CBF) and body temperature, in part, through the production of prostaglandins. Prostaglandins 150-164 interleukin 1 beta Rattus norvegicus 46-55 12761362-0 2003 IL-1 beta depresses respiration and anoxic survival via a prostaglandin-dependent pathway in neonatal rats. Prostaglandins 58-71 interleukin 1 beta Rattus norvegicus 0-9 12761362-2 2003 We hypothesized that IL-1 beta acts in this capacity by depressing brainstem respiratory neurons via a prostaglandin-dependent pathway. Prostaglandins 103-116 interleukin 1 beta Rattus norvegicus 21-30 12761362-12 2003 These findings suggest that IL-1 beta does not inhibit respiratory neurons directly but may depress breathing and hypoxic defense via a prostaglandin-mediated mechanism. Prostaglandins 136-149 interleukin 1 beta Rattus norvegicus 28-37 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Prostaglandins 43-56 interleukin 1 beta Rattus norvegicus 91-99 11953449-2 2002 In the present study, we examined the involvement of two types of phospholipase A2 (PLA2) enzymes, which lie upstream of COX in the prostanoid-generating pathway, in the IL-1beta-induced release of SP from DRG cells. Prostaglandins 132-142 interleukin 1 beta Rattus norvegicus 170-178 11953449-7 2002 These observations suggested that two types of PLA2, sPLA2 -IIA and cPLA2, were involved in the IL-1beta-induced release of SP from DRG cells, and that the functional cross-talk between the two enzymes might help to control their activity in the prostanoid-generating system in DRG cells. Prostaglandins 246-256 interleukin 1 beta Rattus norvegicus 96-104 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 128-145 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 147-155 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 227-230 interleukin 1 beta Rattus norvegicus 128-145 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 227-230 interleukin 1 beta Rattus norvegicus 147-155 11260389-4 2001 METHODS: Synthesis of prostanoid by resting and interleukin-1beta (IL-1beta)-treated (overnight) RGMCs from exogenous or endogenous arachidonic acid (AA) was assessed by high-performance liquid chromtography or enzyme immunoassay, respectively. Prostaglandins 22-32 interleukin 1 beta Rattus norvegicus 67-75 10800959-3 2000 In a first set of experiments, animals were treated with the inhibitor of PG synthesis ketorolac to determine the endogenous contribution of PG in mediating the neuronal activation and EP4 expression in response to circulating interleukin-1beta(IL-1beta). Prostaglandins 141-143 interleukin 1 beta Rattus norvegicus 227-244 11189033-8 2000 The present results suggest that the subdiaphragmatic vagal afferents modulate the parasympathetic efferent outflow in response to IL-1beta partly through prostaglandin dependent mechanisms and that supradiaphragmatic afferents or central sites are more sensitive to the low doses of IL-1beta which becomes evident after elimination of the subdiaphragmatic vagal input. Prostaglandins 155-168 interleukin 1 beta Rattus norvegicus 131-139 11132246-9 2000 These results suggest that the augmenting effect of high glucose on IL-1beta-induced PG production and COX-2 expression is, at least in part, due to increased glucose metabolism via sorbitol pathway following PKC activation. Prostaglandins 85-87 interleukin 1 beta Rattus norvegicus 68-76 11035283-10 2000 Treatment with indomethacin (10 microg/mL), an established inhibitor of prostaglandin biosynthesis, resulted in a significant (P <.05) decrease (79%) in the ability of IL-1 beta to up-regulate IL-6 transcripts. Prostaglandins 72-85 interleukin 1 beta Rattus norvegicus 171-180 11132246-3 2000 In this study, we investigated the effect of high glucose on IL-1beta-induced PG production and the possible underlying mechanism in cultured vascular smooth muscle cell (VSMC). Prostaglandins 78-80 interleukin 1 beta Rattus norvegicus 61-69 11132246-4 2000 High glucose evoked an augmentation of IL-1beta-induced PG synthesis in a dose dependent manner and enhanced cyclooxygenase (COX) activity, which reached to maximum at 8-12 hours after stimulation. Prostaglandins 56-58 interleukin 1 beta Rattus norvegicus 39-47 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 21-38 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 40-48 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 113-121 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 113-121 10800959-9 2000 Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats. Prostaglandins 29-31 interleukin 1 beta Rattus norvegicus 209-217 10678764-10 2000 These findings demonstrate that in the central nervous system, LPS increases IL-1beta production after activation of tyrosine kinase and NO synthase, and IL-1beta promotes prostaglandin production resulting in increased rectal temperature. Prostaglandins 172-185 interleukin 1 beta Rattus norvegicus 154-162 10371676-1 1999 Prostaglandins mediate the suppressive effects of interleukin-1beta. Prostaglandins 0-14 interleukin 1 beta Rattus norvegicus 50-67 10537081-6 1999 These observations indicated that IL-1beta induced the release of SP from the DRG cells via specific IL-1 receptors, the mechanism of which might involve prostanoid systems produced by COX-2. Prostaglandins 154-164 interleukin 1 beta Rattus norvegicus 34-42 9824295-0 1998 Inhibition of Ca2+-independent phospholipase A2 by bromoenol lactone attenuates prostaglandin generation induced by interleukin-1 beta and dibutyryl cAMP in rat mesangial cells. Prostaglandins 80-93 interleukin 1 beta Rattus norvegicus 116-134 9786861-1 1998 The inflammatory cytokine interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression with a concomitant release of prostaglandins from glomerular mesangial cells. Prostaglandins 129-143 interleukin 1 beta Rattus norvegicus 26-43 9786861-1 1998 The inflammatory cytokine interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression with a concomitant release of prostaglandins from glomerular mesangial cells. Prostaglandins 129-143 interleukin 1 beta Rattus norvegicus 45-53 9832392-8 1998 These data suggest that acute administration of interleukin-1beta inhibits the ascending and descending contractile reflex pathway and this effect seems not to be mediated by prostaglandins or histamine receptors. Prostaglandins 175-189 interleukin 1 beta Rattus norvegicus 48-65 9688345-0 1998 Effect of endotoxin and interleukin-1beta on corticotropin-releasing-factor and prostaglandin release by rat brainstem slices. Prostaglandins 80-93 interleukin 1 beta Rattus norvegicus 24-41 9728078-0 1998 IL-1beta increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO, and glutamate. Prostaglandins 78-89 interleukin 1 beta Rattus norvegicus 0-8 9728078-7 1998 These findings suggest that the IL-1beta-induced rise in NE levels in the mPFC is caused by activation of the glutamatergic system and the glutamate-induced increases in prostanoids and NO. Prostaglandins 170-181 interleukin 1 beta Rattus norvegicus 32-40 9730687-5 1998 In contrast, blockade of prostaglandin formation prevents both the stimulatory effect of IL-1beta on ACTH release, and its potentiation by L-NAME. Prostaglandins 25-38 interleukin 1 beta Rattus norvegicus 89-97 9619376-1 1998 A number of previous studies have concluded that prostaglandins (PGs) play a crucial role in mediating the corticotropin-releasing hormone and adrenocorticotropin (ACTH) secretion induced by interleukin (IL) 1 beta in the rat. Prostaglandins 49-63 interleukin 1 beta Rattus norvegicus 191-214 9619376-1 1998 A number of previous studies have concluded that prostaglandins (PGs) play a crucial role in mediating the corticotropin-releasing hormone and adrenocorticotropin (ACTH) secretion induced by interleukin (IL) 1 beta in the rat. Prostaglandins 65-68 interleukin 1 beta Rattus norvegicus 191-214 9430720-1 1998 Activation of rat fibroblastic 3Y1 cells with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) induced delayed prostaglandin (PG) E2 generation over 6-48 h, which occurred in parallel with de novo induction of type IIA secretory phospholipase A2 (sPLA2) and cyclooxygenase (COX)-2, without accompanied by changes in the constitutive expression of type IV cytosolic PLA2 (cPLA2) and COX-1. Prostaglandins 137-150 interleukin 1 beta Rattus norvegicus 46-64 9568691-0 1998 Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Prostaglandins 107-120 interleukin 1 beta Rattus norvegicus 73-81 9568691-3 1998 IL-1beta also induces the coexpression of the inducible isoform of cyclooxygenase (COX-2) that results in the overproduction of proinflammatory prostaglandins. Prostaglandins 144-158 interleukin 1 beta Rattus norvegicus 0-8 9625457-0 1998 Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat. Prostaglandins 145-158 interleukin 1 beta Rattus norvegicus 0-17 9625457-5 1998 These findings suggest that IL-1beta stimulates the release of NA in the PVN via prostaglandin, and that the release of NA in the PVN is not necessarily related to the increase in body temperature. Prostaglandins 81-94 interleukin 1 beta Rattus norvegicus 28-36 9622204-1 1998 In this study, we have compared the time-course effects of lipopolysaccharide (LPS) and interleukin-1beta on prostaglandin (PG) production by primary cultures of rat astrocytes. Prostaglandins 109-122 interleukin 1 beta Rattus norvegicus 88-105 9622204-1 1998 In this study, we have compared the time-course effects of lipopolysaccharide (LPS) and interleukin-1beta on prostaglandin (PG) production by primary cultures of rat astrocytes. Prostaglandins 124-126 interleukin 1 beta Rattus norvegicus 88-105 9430720-8 1998 In contrast, Ca2+ ionophore-stimulated immediate PGE2 generation was regulated predominantly by the constitutive enzymes cPLA2 and COX-1, even when type IIA sPLA2 and COX-2 were maximally induced after IL-1 beta/TNF alpha treatment, revealing functional segregation of the constitutive and inducible PG biosynthetic enzymes. Prostaglandins 49-51 interleukin 1 beta Rattus norvegicus 202-211 9430720-1 1998 Activation of rat fibroblastic 3Y1 cells with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) induced delayed prostaglandin (PG) E2 generation over 6-48 h, which occurred in parallel with de novo induction of type IIA secretory phospholipase A2 (sPLA2) and cyclooxygenase (COX)-2, without accompanied by changes in the constitutive expression of type IV cytosolic PLA2 (cPLA2) and COX-1. Prostaglandins 137-150 interleukin 1 beta Rattus norvegicus 66-75 8977419-1 1997 Interleukin (IL)-1 beta has been shown to stimulate ovarian prostaglandin biosynthesis. Prostaglandins 60-73 interleukin 1 beta Rattus norvegicus 0-23 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 105-119 interleukin 1 beta Rattus norvegicus 0-18 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 105-119 interleukin 1 beta Rattus norvegicus 20-29 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 121-124 interleukin 1 beta Rattus norvegicus 0-18 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 121-124 interleukin 1 beta Rattus norvegicus 20-29 8977419-3 1997 Treatment of cultured whole ovarian dispersates of immature rat origin with IL-1 beta produced significant increases in [3H]arachidonic acid (AA) release and [3H]prostanoid accumulation as well as increases in cellular PLA2 activity and in secretory PLA2 and cytosolic PLA2 transcripts. Prostaglandins 162-172 interleukin 1 beta Rattus norvegicus 76-85 9042373-5 1997 In this study, we studied in the preoptic area (POA) the possible role of PGs and NO in the antidipsogenic action induced by IL-1 beta. Prostaglandins 74-77 interleukin 1 beta Rattus norvegicus 125-134 9042373-14 1997 Our data suggest that the central inhibition of drinking behaviour of IL-1 beta is mediated through the formation of PGs, but not NO, in the POA. Prostaglandins 117-120 interleukin 1 beta Rattus norvegicus 70-79 8741165-11 1996 Furthermore, the hyperalgesic effect of interleukin-1 beta may be mediated by prostaglandins. Prostaglandins 78-92 interleukin 1 beta Rattus norvegicus 40-58 8764661-9 1996 Additionally, the cyclooxygenase inhibitor ketorolac (10 microM) significantly attenuated the facilitatory effects of LPS and IL-1b, indicating involvement of prostanoids. Prostaglandins 159-170 interleukin 1 beta Rattus norvegicus 126-131 8953469-18 1996 Prostaglandins consistently mediate a stimulatory action of interleukin-1 beta on vasopressin release whereas alpha-adrenergic mechanisms mediate a depression of interleukin-1 beta-induced vasopressin release during the early to middle stages of lactation. Prostaglandins 0-14 interleukin 1 beta Rattus norvegicus 60-78 8891309-0 1996 Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever. Prostaglandins 140-153 interleukin 1 beta Rattus norvegicus 101-119 8786002-0 1996 Intravenous interleukin-1-beta-induced inhibition of gastric emptying: involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. Prostaglandins 130-143 interleukin 1 beta Rattus norvegicus 12-30 8924035-8 1996 These findings indicate that IL-1 beta mainly inhibits the vagal motoneurons in the DMV, at least partly through prostaglandin synthesis. Prostaglandins 113-126 interleukin 1 beta Rattus norvegicus 29-38 8624721-9 1995 These findings indicate that IL-1 beta in the MPO and the VMH produces hyperalgesia and analgesia, respectively, while, in addition, both effects are mediated by IL-1 receptors and the synthesis of prostaglandins. Prostaglandins 198-212 interleukin 1 beta Rattus norvegicus 29-38 7695605-6 1995 Indomethacin and NDGA, reported inhibitors of the cyclooxygenase and lipoxygenase pathways, respectively, block these effects, suggesting the involvement of prostaglandins and leukotrienes in IL-1 beta mediated APP processing. Prostaglandins 157-171 interleukin 1 beta Rattus norvegicus 192-201 8580380-0 1995 Role of prostaglandins E1, E2 and F2 alpha in the brain in interleukin 1 beta-induced adrenocorticotropin secretion in the rat. Prostaglandins 8-22 interleukin 1 beta Rattus norvegicus 59-77 7556406-6 1995 These results suggest that centrally administered interleukin-1 beta induces a prostaglandin-mediated central excitation of the sympatho-adrenomedullary system, and the resultant activation of gastric alpha-adrenoceptors inhibits the vagally stimulated gastric acid secretion in rats. Prostaglandins 79-92 interleukin 1 beta Rattus norvegicus 50-68 7768270-1 1995 Interleukin-1 beta stimulates corticotropin-releasing factor (CRF) secretion from the hypothalamus involving the activation of prostaglandins. Prostaglandins 127-141 interleukin 1 beta Rattus norvegicus 0-18 8193934-7 1994 The results suggest that a small amount of IL-1 beta at the site of periodontal disease can induce fos-IR in brain neurons through increased prostaglandin production. Prostaglandins 141-154 interleukin 1 beta Rattus norvegicus 43-52 7817387-10 1994 These results suggest that IL-1 beta affects the release of AVP and ACTH, blood pressure and thermogenesis via prostaglandins (PGs), but ANH release related to IL-1 beta may not be mediated by PGs. Prostaglandins 111-125 interleukin 1 beta Rattus norvegicus 27-36 7817387-10 1994 These results suggest that IL-1 beta affects the release of AVP and ACTH, blood pressure and thermogenesis via prostaglandins (PGs), but ANH release related to IL-1 beta may not be mediated by PGs. Prostaglandins 127-130 interleukin 1 beta Rattus norvegicus 27-36 7922597-5 1994 These results suggest that IL-1 beta in the brain activates splenic sympathetic activity by its receptor-mediated and prostaglandin-dependent action that is sensitive to alpha-MSH, depending on CRF system. Prostaglandins 118-131 interleukin 1 beta Rattus norvegicus 27-36 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 156-169 interleukin 1 beta Rattus norvegicus 26-44 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 156-169 interleukin 1 beta Rattus norvegicus 46-55 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 171-173 interleukin 1 beta Rattus norvegicus 26-44 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 171-173 interleukin 1 beta Rattus norvegicus 46-55 7810664-8 1994 These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Prostaglandins 92-105 interleukin 1 beta Rattus norvegicus 29-38 7810664-8 1994 These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Prostaglandins 120-133 interleukin 1 beta Rattus norvegicus 29-38 7523451-0 1994 The morphogenic/cytotoxic and prostaglandin-stimulating activities of interleukin-1 beta in the rat ovary are nitric oxide independent. Prostaglandins 30-43 interleukin 1 beta Rattus norvegicus 70-88 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. Prostaglandins 158-171 interleukin 1 beta Rattus norvegicus 19-37 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. Prostaglandins 158-171 interleukin 1 beta Rattus norvegicus 39-48 8194703-0 1994 Interleukin 1 beta inhibits gastric emptying in rats: mediation through prostaglandin and corticotropin-releasing factor. Prostaglandins 72-85 interleukin 1 beta Rattus norvegicus 0-18 8194703-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) increases the release of corticotropin-releasing factor (CRF) in the brain through prostaglandin pathways. Prostaglandins 131-144 interleukin 1 beta Rattus norvegicus 17-35 8194703-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) increases the release of corticotropin-releasing factor (CRF) in the brain through prostaglandin pathways. Prostaglandins 131-144 interleukin 1 beta Rattus norvegicus 37-46 8194703-10 1994 CONCLUSIONS: IL-1 beta acts in the brain to induce a long-lasting inhibition of gastric emptying; IL-1 beta action is mediated through central IL-1 receptors and prostaglandin- and CRF-dependent mechanisms. Prostaglandins 162-175 interleukin 1 beta Rattus norvegicus 13-22 8194703-10 1994 CONCLUSIONS: IL-1 beta acts in the brain to induce a long-lasting inhibition of gastric emptying; IL-1 beta action is mediated through central IL-1 receptors and prostaglandin- and CRF-dependent mechanisms. Prostaglandins 162-175 interleukin 1 beta Rattus norvegicus 98-107 8049716-8 1994 These stimulatory effects of IL-1 beta and IL-6 were blocked by cyclo-oxygenase inhibitors, indomethacin (28 microM) and ibuprofen (100 nM), but not by the lipoxygenase inhibitor, BW A4C (10 micrograms/ml), suggesting that prostaglandins are involved in this process. Prostaglandins 223-237 interleukin 1 beta Rattus norvegicus 29-38 8019746-15 1994 These data indicate that IL-1 beta enhances the cutaneous hyperaemic response to afferent nerve stimulation with capsaicin in a prostaglandin-dependent manner. Prostaglandins 128-141 interleukin 1 beta Rattus norvegicus 25-34 8304483-0 1994 Regulation of prostaglandin endoperoxide synthase gene expression in rat mesangial cells by interleukin-1 beta. Prostaglandins 14-27 interleukin 1 beta Rattus norvegicus 92-110 8127005-7 1994 These results demonstrate that in serum-stimulated mesangial cells, both IL-1 beta and IL-6 inhibit mitogenesis and proliferation, and that these effects are mediated, in part, by stimulated endogenous prostaglandin production. Prostaglandins 202-215 interleukin 1 beta Rattus norvegicus 73-82 8138745-2 1994 Certain of the biological effects of LPS may be mediated by cytokines such as interleukin-1 beta (IL-1 beta), while IL-1 beta itself may operate via induction of the prostaglandins and/or nerve growth factor (NGF). Prostaglandins 166-180 interleukin 1 beta Rattus norvegicus 116-125 7691586-0 1993 Interleukin-1 beta (IL-1 beta) modulates prostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Prostaglandins 41-54 interleukin 1 beta Rattus norvegicus 0-18 7691586-0 1993 Interleukin-1 beta (IL-1 beta) modulates prostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Prostaglandins 41-54 interleukin 1 beta Rattus norvegicus 20-29 7691586-14 1993 IL-1 beta modulates PG, but not steroid, production. Prostaglandins 20-22 interleukin 1 beta Rattus norvegicus 0-9 1641429-6 1992 Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins. Prostaglandins 126-140 interleukin 1 beta Rattus norvegicus 71-80 8252417-7 1993 The results suggest that IL-1 beta in the brain produces hyperalgesia by its receptor-mediated and prostaglandin-dependent action which is sensitive to alpha-MSH. Prostaglandins 99-112 interleukin 1 beta Rattus norvegicus 25-34 8317326-1 1993 Using specific antisera for IL-1 beta and IL-8, as well as cyclooxygenase inhibitors and propranolol, we have demonstrated that these cytokines are responsible for the prostaglandin and sympathetic components of carrageenin-induced hyperalgesia in the rat paw test. Prostaglandins 168-181 interleukin 1 beta Rattus norvegicus 28-37 8214107-2 1993 Because the molecular mechanisms that underlie induction of iNOS are still unclear and because tyrosine kinases are implicated in interleukin-1 beta (IL-1 beta)-induced prostaglandin synthesis in mesangial cells and in NO generation by an insulinoma cell line, we investigated the influence of tyrosine kinase inhibitors on iNOS induction in cultured rat aortic smooth muscle cells (RASMC). Prostaglandins 169-182 interleukin 1 beta Rattus norvegicus 130-148 8214107-2 1993 Because the molecular mechanisms that underlie induction of iNOS are still unclear and because tyrosine kinases are implicated in interleukin-1 beta (IL-1 beta)-induced prostaglandin synthesis in mesangial cells and in NO generation by an insulinoma cell line, we investigated the influence of tyrosine kinase inhibitors on iNOS induction in cultured rat aortic smooth muscle cells (RASMC). Prostaglandins 169-182 interleukin 1 beta Rattus norvegicus 150-159 8401568-0 1993 Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats. Prostaglandins 109-123 interleukin 1 beta Rattus norvegicus 19-37 8396869-10 1993 These data suggest that the actions of IL-1 beta on AVP and ACTH release and thermogenesis, but not on blood pressure and the release of ANP, are modulated by the stimulated central production of prostaglandins. Prostaglandins 196-210 interleukin 1 beta Rattus norvegicus 39-48 8419137-10 1993 To elucidate whether the IL-1 beta-stimulated ovarian synthesis of PGF2 alpha was crucial for the ovulatory effect of IL-1 beta, experiments were performed in the presence of indomethacin (5 micrograms/ml), an inhibitor of PG synthesis. Prostaglandins 67-69 interleukin 1 beta Rattus norvegicus 25-34 1319197-6 1992 While the responses to IL-1 beta required the local release of prostaglandins, the responses to IFN alpha were found to be mediated by opioid receptor mechanisms. Prostaglandins 63-77 interleukin 1 beta Rattus norvegicus 23-32 1593469-19 1992 The present results suggest that IL-1 beta stimulates the release of prostaglandins, presumably E series, near regions of the hypothalamus, which act on the hypothalamus to induce activation of the sympathetic nervous system. Prostaglandins 69-83 interleukin 1 beta Rattus norvegicus 33-42 1319228-5 1992 The results suggest that IL-1 beta mainly exerts a direct excitatory effect on SON neurons and further, that prostaglandins may be involved in such an effect. Prostaglandins 109-123 interleukin 1 beta Rattus norvegicus 25-34 1681735-10 1991 These results demonstrate that IL-1 beta is an extremely potent inhibitor of acid secretion stimulated by pentagastrin but not that stimulated by histamine or bethanechol, through a mechanism that is at least in part independent of the vagus nerve and of prostaglandin synthesis. Prostaglandins 255-268 interleukin 1 beta Rattus norvegicus 31-40 1659233-4 1991 ACTH response induced by IL-1 beta (15 micrograms/kg iv) was suppressed by pretreatment with injection of indomethacin (Indo), a potent inhibitor of prostaglandin (PG) synthesis, in a dose-dependent manner (1 and 10 mg/kg iv). Prostaglandins 149-162 interleukin 1 beta Rattus norvegicus 25-34 1659233-4 1991 ACTH response induced by IL-1 beta (15 micrograms/kg iv) was suppressed by pretreatment with injection of indomethacin (Indo), a potent inhibitor of prostaglandin (PG) synthesis, in a dose-dependent manner (1 and 10 mg/kg iv). Prostaglandins 164-166 interleukin 1 beta Rattus norvegicus 25-34 1908387-5 1991 The data obtained suggest that a peripheral prostaglandin synthesizing system may play an important role in the anorexia caused by IL-1 beta. Prostaglandins 44-57 interleukin 1 beta Rattus norvegicus 131-140 1708241-1 1991 The effect of interleukin-1 beta on the production of non-prostanoid vasoactive factors by cultured rat aortic smooth muscle cells was investigated. Prostaglandins 58-68 interleukin 1 beta Rattus norvegicus 14-32 1959024-4 1991 The responses to IL-1 beta, but not to IFN alpha, were blocked by sodium salicylate, suggesting the involvement of synthesis of prostaglandins. Prostaglandins 128-142 interleukin 1 beta Rattus norvegicus 17-26 2289528-1 1990 Interleukin-1 beta (IL-1 beta) has been reported to stimulate prostaglandin synthesis by the rat stomach in vitro and to inhibit gastric acid secretion in vivo. Prostaglandins 62-75 interleukin 1 beta Rattus norvegicus 20-29 2289528-1 1990 Interleukin-1 beta (IL-1 beta) has been reported to stimulate prostaglandin synthesis by the rat stomach in vitro and to inhibit gastric acid secretion in vivo. Prostaglandins 62-75 interleukin 1 beta Rattus norvegicus 0-18 2046458-6 1991 It is concluded from these results that IL-1 acts mainly in the central nervous system to inhibit the occurrence of stress-induced gastric erosion and that the IL-1 beta-induced inhibition of gastric erosion is mediated by prostaglandin in a manner that is independent of brain CRF. Prostaglandins 223-236 interleukin 1 beta Rattus norvegicus 160-169 30528878-1 2019 Synergistic expression of cyclooxygenase-2 (COX-2) by interleukin-1beta (IL-1beta) and bradykinin (BK) in peri-sensory neurons results in the production of prostanoids, which affects sensory neuronal activity and responsiveness and causes hyperalgesia. Prostaglandins 156-167 interleukin 1 beta Rattus norvegicus 54-71 2804553-0 1989 Inhibition by neuropeptides of interleukin-1 beta-induced, prostaglandin-independent hyperalgesia. Prostaglandins 59-72 interleukin 1 beta Rattus norvegicus 31-49 2804553-5 1989 These observations indicate that IL-1 beta sensitized pressure-sensitive but not temperature-sensitive sensory neurones, through a prostaglandin-independent mechanism. Prostaglandins 131-144 interleukin 1 beta Rattus norvegicus 33-42 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Prostaglandins 5-18 interleukin 1 beta Rattus norvegicus 83-93 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Prostaglandins 5-18 interleukin 1 beta Rattus norvegicus 168-178 2228412-6 1990 These data suggest that impaired responses to IL-1 beta in obese mutants may be due to inhibitory actions of glucocorticoids on either prostaglandin synthesis or CRF release within the hypothalamus. Prostaglandins 135-148 interleukin 1 beta Rattus norvegicus 46-55 2847761-2 1988 Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated radiolabel in a time-dependent and dose-dependent manner, with labeled prostaglandins representing 29% of the released radiolabel. Prostaglandins 227-241 interleukin 1 beta Rattus norvegicus 122-132 2847761-7 1988 These data show that rIL-1 beta stimulates phospholipase activities in rat synovial fibroblasts and that at least one of these activities may be regulated by either prostaglandins or cAMP. Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 21-31 2834174-11 1988 It is also suggested that prostaglandins may be involved in this central action of IL-1 beta. Prostaglandins 26-40 interleukin 1 beta Rattus norvegicus 83-92 30528878-1 2019 Synergistic expression of cyclooxygenase-2 (COX-2) by interleukin-1beta (IL-1beta) and bradykinin (BK) in peri-sensory neurons results in the production of prostanoids, which affects sensory neuronal activity and responsiveness and causes hyperalgesia. Prostaglandins 156-167 interleukin 1 beta Rattus norvegicus 73-81 28177673-0 2017 Interleukin-1beta suppresses the ventilatory hypoxic response in rats via prostaglandin-dependent pathways. Prostaglandins 74-87 interleukin 1 beta Rattus norvegicus 0-17 28527691-5 2017 Prostaglandin-mediated mechanisms were shown to have important role in the mode of this action of IL-1beta, since paracetamol pretreatment partially prevented the development of the above mentioned hyperthermia. Prostaglandins 0-13 interleukin 1 beta Rattus norvegicus 98-106 30349936-10 2019 Moreover, it can be hypothesized that CINC-1 is placed upstream TNF-alpha, IL-1beta, and IL-6 among the prostaglandin-dependent fever-mediator cascade and amidst the prostaglandin-independent synthesis pathway of fever. Prostaglandins 104-117 interleukin 1 beta Rattus norvegicus 75-83 28177673-2 2017 The goal was to test the hypothesis that IL-1beta impairs the hypoxic ventilatory response in vivo by indirectly inhibiting respiratory neurons in the brainstem via prostaglandins. Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 41-49 28177673-7 2017 Thus, the data indicate that IL-1beta degrades the ventilatory hypoxic response by stimulating production of prostaglandin. Prostaglandins 109-122 interleukin 1 beta Rattus norvegicus 29-37 27815021-2 2017 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. Prostaglandins 201-212 interleukin 1 beta Rattus norvegicus 142-150 27815021-5 2017 These results indicate that IL-1beta-induced NREM sleep is independent of the PGD2/DP1R system and other COX-2-derived prostaglandins in rats and mice. Prostaglandins 119-133 interleukin 1 beta Rattus norvegicus 28-36