PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11208767-1 2001 -It has been reported that bradykinin (BK) can induce or activate both cyclooxygenase (COX) isoforms and that the renal effects of BK seem to be mediated by prostaglandins and NO. Prostaglandins 157-171 kininogen 1 Canis lupus familiaris 27-37 11208767-1 2001 -It has been reported that bradykinin (BK) can induce or activate both cyclooxygenase (COX) isoforms and that the renal effects of BK seem to be mediated by prostaglandins and NO. Prostaglandins 157-171 kininogen 1 Canis lupus familiaris 39-41 11208767-1 2001 -It has been reported that bradykinin (BK) can induce or activate both cyclooxygenase (COX) isoforms and that the renal effects of BK seem to be mediated by prostaglandins and NO. Prostaglandins 157-171 kininogen 1 Canis lupus familiaris 131-133 11208767-18 2001 The results of this study suggest that (1) NO and prostanoids dependent on COX-2 seem to be involved in the renal vasodilatation induced by BK, and (2) there is an interaction between NO and COX-1-derived metabolites in mediating the natriuretic and diuretic response to BK. Prostaglandins 50-61 kininogen 1 Canis lupus familiaris 140-142 10474781-13 1999 Renal vasodilative and natriuretic responses are mainly linked to NO generation, while both NO and prostaglandin biosynthesis are involved in the BK-induced water diuresis. Prostaglandins 99-112 kininogen 1 Canis lupus familiaris 146-148 8141360-6 1994 These results suggest that endothelium-dependent relaxations by M-1 and captopril in canine femoral arteries are mediated through the release of both prostanoids and endothelium-derived nitric oxide via endogenous bradykinin. Prostaglandins 150-161 kininogen 1 Canis lupus familiaris 214-224 9724280-8 1998 These data suggest that the RSNA response to BK is mediated by nitric oxide to a large degree in the normal state but is primarily mediated by prostaglandins in the HF state. Prostaglandins 143-157 kininogen 1 Canis lupus familiaris 45-47 10386238-19 1999 Both receptor subtypes mediate either vasodilation or vasoconstriction and BK-induced vasodilation is mostly endothelium dependent, although it may also be partially prostaglandin dependent. Prostaglandins 166-179 kininogen 1 Canis lupus familiaris 75-77 8853400-14 1996 These data suggest that the enhanced cardiac sympathetic afferent reflex to epicardial BK in HF appears to be mediated by altered levels of prostaglandin synthesis. Prostaglandins 140-153 kininogen 1 Canis lupus familiaris 87-89 7646841-2 1995 Bradykinin elicits the production of vasodilator prostanoids and nitric oxide by endothelial cells. Prostaglandins 49-60 kininogen 1 Canis lupus familiaris 0-10 8087948-12 1994 Since bradykinin stimulates the formation of both prostaglandins and nitric oxide, we tested in a second protocol which of these mediators was further involved in the beneficial effects of ramiprilat. Prostaglandins 50-64 kininogen 1 Canis lupus familiaris 6-16 1334347-9 1992 Both endothelial nitric oxide and prostaglandin(s) are participated in the BK"s effect. Prostaglandins 34-47 kininogen 1 Canis lupus familiaris 75-77 8105700-10 1993 In conclusion, in vivo BK induces a direct negative chronotropic effect, which is potentiated by converting-enzyme inhibition and is mediated by the B2-receptors independently of the prostaglandins. Prostaglandins 183-197 kininogen 1 Canis lupus familiaris 23-25 8177499-1 1994 In clarifying the possible involvement of cyclic AMP (cAMP) in prostaglandin (PG) E2-induced sensitization of the bradykinin response of canine testicular polymodal receptors, the effects of forskolin, an activator of adenylyl cyclase, were studied in the presence and absence of acetylsalicylic acid (ASA, 550 microM) which blocks PG production. Prostaglandins 78-80 kininogen 1 Canis lupus familiaris 114-124 1550682-0 1992 Topographic distribution of prostaglandin secretion caused by bradykinin in canine tracheal epithelial cells. Prostaglandins 28-41 kininogen 1 Canis lupus familiaris 62-72 1351697-4 1992 These results suggest that 5-HT plays a modulatory role on BK action; the latter depends on the release of prostaglandins and nitric oxide or a related compound and includes the activation of guanylate cyclase which appears to be involved in primary afferent excitation. Prostaglandins 107-121 kininogen 1 Canis lupus familiaris 59-61 3224899-7 1988 These results suggest that acetylcholine, histamine, bradykinin, substance P and norepinephrine, if present, influence the local vasomotor regulation in the dental pulp, and that bradykinin may exert the effect via prostaglandin synthesis. Prostaglandins 215-228 kininogen 1 Canis lupus familiaris 179-189 1694407-7 1990 1) Bradykinin added to either surface stimulates prostaglandin synthesis and release at the basolateral surface. Prostaglandins 49-62 kininogen 1 Canis lupus familiaris 3-13 2404862-7 1990 The present results support the hypothesis that immediate hypotension induced by captopril involves a prostaglandin-dependent component possibly resulting from increased bradykinin levels generated in the vicinity of captopril action. Prostaglandins 102-115 kininogen 1 Canis lupus familiaris 170-180 2545457-9 1989 Indomethacin blocks the effects of both bradykinin and des-Arg9-bradykinin on the dog renal artery without endothelium, suggesting that muscular B1 and B2 receptors act by promoting the release of prostaglandins. Prostaglandins 197-211 kininogen 1 Canis lupus familiaris 40-50 2545457-9 1989 Indomethacin blocks the effects of both bradykinin and des-Arg9-bradykinin on the dog renal artery without endothelium, suggesting that muscular B1 and B2 receptors act by promoting the release of prostaglandins. Prostaglandins 197-211 kininogen 1 Canis lupus familiaris 64-74 3147804-0 1988 Prostaglandins involved in contractions by angiotensin II and bradykinin of isolated dog sphincter pupillae. Prostaglandins 0-14 kininogen 1 Canis lupus familiaris 62-72 2263534-3 1990 The reflex responses induced by bradykinin are enhanced by concomitant application of prostaglandins of the E type or prostacyclin, and reduced by indomethacin. Prostaglandins 86-100 kininogen 1 Canis lupus familiaris 32-42 2512675-0 1989 Prostanoid release from ex vivo perfused canine arteries and veins: effects of prolonged perfusion, intermittent perfusion, as well as exposure to exogenous arachidonic acid, thrombin and bradykinin. Prostaglandins 0-10 kininogen 1 Canis lupus familiaris 188-198 3925124-0 1985 Permissive role of prostaglandins in the action of bradykinin on the pancreas of anesthetized dogs. Prostaglandins 19-33 kininogen 1 Canis lupus familiaris 51-61 3812104-0 1986 Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation. Prostaglandins 50-64 kininogen 1 Canis lupus familiaris 34-44 3812104-3 1986 The response to the threshold dose of bradykinin (0.3 nmol), which was suppressed during the indomethacin infusion, was potentiated by simultaneous injection of exogenous PGs. Prostaglandins 171-174 kininogen 1 Canis lupus familiaris 38-48 3812104-5 1986 Thus, it is clear that bradykinin induced pain through the generation of one of prostaglandins. Prostaglandins 80-94 kininogen 1 Canis lupus familiaris 23-33 3925124-1 1985 We have investigated the contribution of prostaglandins (PGs) to the effect of bradykinin on pancreatic blood flow and pancreatic exocrine secretion by examining its actions in the isolated blood-perfused pancreas of pentobarbital-anesthetized dogs. Prostaglandins 57-60 kininogen 1 Canis lupus familiaris 79-89 3925124-11 1985 These data indicate that PGs, presumably PGI2 and PGE2, play a permissive role in the vasodilator effect of bradykinin in the pancreas of anesthetized dogs. Prostaglandins 25-28 kininogen 1 Canis lupus familiaris 108-118 3924453-7 1985 The results indicate that locally formed prostanoids, specifically prostacyclin and PGE2, can facilitate activation of the pericardial pressor reflex by bradykinin. Prostaglandins 41-52 kininogen 1 Canis lupus familiaris 153-163 6346852-3 1983 The reflex pressor effects evoked by bradykinin are reduced after inhibition of prostaglandins biosynthesis with indomethacin and potentiated by concomitant topical application of low doses (0.1 to 0.3 microgram/min) of PGE1 or PGE2 and prostacyclin (PGI2). Prostaglandins 80-94 kininogen 1 Canis lupus familiaris 37-47 6196567-1 1983 Angiotensin II and bradykinin are potent releasers of prostanoids, and it has been suggested that these prostanoids may modulate vascular tone in a number of organs. Prostaglandins 54-65 kininogen 1 Canis lupus familiaris 19-29 6196567-1 1983 Angiotensin II and bradykinin are potent releasers of prostanoids, and it has been suggested that these prostanoids may modulate vascular tone in a number of organs. Prostaglandins 104-115 kininogen 1 Canis lupus familiaris 19-29 6309869-4 1983 On the other hand, three dissimilar stimulators of prostaglandin synthesis: bradykinin, Ca2+-ionophore A23187 and arachidonate, increased cellular cyclic AMP levels, and stimulated prostaglandin E2 synthesis. Prostaglandins 51-64 kininogen 1 Canis lupus familiaris 76-86 6346852-4 1983 The pressor and tachycardic responses to bradykinin are also enhanced after temporary (10-minute) coronary occlusion; this potentiation is abolished by indomethacin treatment and can be restored by superfusing the ventricle with prostaglandins. Prostaglandins 229-243 kininogen 1 Canis lupus familiaris 41-51 6952258-9 1982 We conclude that bradykinin relaxes canine and human arteries via a similar mechanism but that it relaxes cat and rabbit arteries by stimulating release of prostaglandins from as yet undefined cell types. Prostaglandins 156-170 kininogen 1 Canis lupus familiaris 17-27 6806549-0 1982 Difference in prostaglandin modulation of arterial and venous smooth muscle responses to bradykinin and norepinephrine. Prostaglandins 14-27 kininogen 1 Canis lupus familiaris 89-99 6806549-1 1982 The role of endogenously synthesized prostaglandins as modulators of canine vascular smooth muscle responses to bradykinin (BK) and norepinephrine (NE) was evaluated in vitro with the use of helical strips of canine arteries and veins and measurement of prostaglandins with bioassay and thin layer chromatography. Prostaglandins 37-51 kininogen 1 Canis lupus familiaris 112-122 6806549-1 1982 The role of endogenously synthesized prostaglandins as modulators of canine vascular smooth muscle responses to bradykinin (BK) and norepinephrine (NE) was evaluated in vitro with the use of helical strips of canine arteries and veins and measurement of prostaglandins with bioassay and thin layer chromatography. Prostaglandins 37-51 kininogen 1 Canis lupus familiaris 124-126 7282958-0 1981 Bradykinin effects on adrenergic transmission in the canine kidney: relation to prostaglandins. Prostaglandins 80-94 kininogen 1 Canis lupus familiaris 0-10 7282958-10 1981 These data suggest that bradykinin acts on postjunctional sites to reduce adrenergically induced vasoconstriction in the canine kidney by a mechanism dependent on prostaglandin synthesis. Prostaglandins 163-176 kininogen 1 Canis lupus familiaris 24-34 1138295-5 1975 These results suggest that BK does not normally cause venoconstriction by stimulating synthesis of a venoconstrictor PG and that the increase in response to BK after prolonged periods in the bath may be related to changes in PG synthesis. Prostaglandins 117-119 kininogen 1 Canis lupus familiaris 27-29 474758-0 1979 Contribution of renal prostaglandins to the natriuretic action of bradykinin in the dog. Prostaglandins 22-36 kininogen 1 Canis lupus familiaris 66-76 474758-1 1979 To study the effects of stimulation of renal prostaglandin biosynthesis by bradykinin, we assessed the changes in renal functions induced by intrarenal infusion of bradykinin (10 ng . Prostaglandins 45-58 kininogen 1 Canis lupus familiaris 75-85 495338-4 1979 This autoreversal of bradykinin response tentatively was explained on the basis of known effects of bradykinin on prostaglandin synthesis with specific reference to PGF2 alpha. Prostaglandins 114-127 kininogen 1 Canis lupus familiaris 21-31 495338-4 1979 This autoreversal of bradykinin response tentatively was explained on the basis of known effects of bradykinin on prostaglandin synthesis with specific reference to PGF2 alpha. Prostaglandins 114-127 kininogen 1 Canis lupus familiaris 100-110 517243-0 1979 Relationship between kinins and prostaglandins: contribution of renal prostaglandins to the natriuretic action of bradykinin in the dog. Prostaglandins 70-84 kininogen 1 Canis lupus familiaris 114-124 679427-0 1978 Inhibition of prostaglandin synthesis by indomethacin augments the renal vasodilator response to bradykinin in the anesthetized dog. Prostaglandins 14-27 kininogen 1 Canis lupus familiaris 97-107 679427-1 1978 It has been proposed that the increase in renal blood flow (RBF) produced by bradykinin (BK) is mediated or amplified by the intrarenal generation of prostaglandins. Prostaglandins 150-164 kininogen 1 Canis lupus familiaris 77-87 679427-1 1978 It has been proposed that the increase in renal blood flow (RBF) produced by bradykinin (BK) is mediated or amplified by the intrarenal generation of prostaglandins. Prostaglandins 150-164 kininogen 1 Canis lupus familiaris 89-91 626093-0 1978 Kidney volume expansion and prostaglandin release by bradykinin. Prostaglandins 28-41 kininogen 1 Canis lupus familiaris 53-63 626093-5 1978 When renal blood flow was maintained constant during the infusion of bradykinin, urine PG-excretion increased (330%), the glomerular filtration decreased (60%) and this was accompanied by decreased kidney volume, diuresis/natriuresis with unchanged urine osmolarity. Prostaglandins 87-89 kininogen 1 Canis lupus familiaris 69-79 948031-0 1976 Influence of inhibitors of prostaglandin synthesis on venoconstrictor responses to bradykinin. Prostaglandins 27-40 kininogen 1 Canis lupus familiaris 83-93 948031-2 1976 The hypothesis that PGs mediate the venoconstrictor effect of bradykinin was evaluated by determining the influence of low concentrations of indomethacin (Indo) (1 muM) or eicosa-5,8,11,14-tetraynoic acid (ETA) (3 muM), two inhibitors of PG synthesis, on cumulative concentration-response curves for BK or norepinephrine (NE). Prostaglandins 20-23 kininogen 1 Canis lupus familiaris 62-72 948031-2 1976 The hypothesis that PGs mediate the venoconstrictor effect of bradykinin was evaluated by determining the influence of low concentrations of indomethacin (Indo) (1 muM) or eicosa-5,8,11,14-tetraynoic acid (ETA) (3 muM), two inhibitors of PG synthesis, on cumulative concentration-response curves for BK or norepinephrine (NE). Prostaglandins 20-22 kininogen 1 Canis lupus familiaris 62-72 1149403-0 1975 The actions of bradykinin and eledoisin in the canine isolated kidney: relationships to prostaglandins. Prostaglandins 88-102 kininogen 1 Canis lupus familiaris 15-25 1149403-10 1975 The release of prostaglandins from the kidney by bradykinin amplifies the renal vasodilator action of the kinin and possibly mediates its effect on excretion of solute-free water. Prostaglandins 15-29 kininogen 1 Canis lupus familiaris 49-59 6165819-5 1981 Pretreatment of dogs with an inhibitor of PG synthesis, sodium meclofenamate (5 mg/kg), abolished the inhibitory effect of bradykinin on angiotensin II-induced renal vasoconstriction. Prostaglandins 42-44 kininogen 1 Canis lupus familiaris 123-133 6165819-7 1981 These results suggest that bradykinin reduces the reactivity of the renal vasculature to angiotensin II by a mechanism dependent upon PG synthesis. Prostaglandins 134-136 kininogen 1 Canis lupus familiaris 27-37 7449252-0 1980 Inhibition of bradykinin of the vascular effects of pressor hormones in the canine kidney: relationship to prostaglandins. Prostaglandins 107-121 kininogen 1 Canis lupus familiaris 14-24 7449252-6 1980 Pretreatment of the dogs with an inhibitor of prostaglandin synthesis, sodium meclofenamate (5 mg/kg), blunted the inhibitory action of bradykinin, but not that of prostaglandin E2, on renal vascular reactivity to angiotensin II and noradrenaline. Prostaglandins 46-59 kininogen 1 Canis lupus familiaris 136-146 7449252-8 1980 These results indicate that bradykinin reduces the renal vasoconstriction induced by angiotensin II and noradrenaline in the dog by a mechanism dependent upon synthesis of prostaglandins. Prostaglandins 172-186 kininogen 1 Canis lupus familiaris 28-38 7381766-12 1980 Involvement of prostaglandins in the response of the polymodal units to bradykinin is suggested. Prostaglandins 15-29 kininogen 1 Canis lupus familiaris 72-82 118033-0 1979 On the contribution of prostaglandin-like substances to the action of bradykinin on intestinal motility and blood flow in canine jejunal loop in situ. Prostaglandins 23-36 kininogen 1 Canis lupus familiaris 70-80 417634-0 1978 Prostaglandins: renal vascular responses to bradykinin, histamine, and nitroglycerine. Prostaglandins 0-14 kininogen 1 Canis lupus familiaris 44-54 406936-2 1977 Bradykinin stimulated microsomal prostaglandin synthesis in both artery and vein; this stimulation was more pronounced when [14C] hosphatidylcholine rather than [14C] arachidonate was used as the substrate for prostaglandin synthetase. Prostaglandins 33-46 kininogen 1 Canis lupus familiaris 0-10 842682-9 1977 Contractile responses of canine cerebral arteries to BK do not appear to derive from prostaglandins released, but rather from a direct action on vascular smooth muscle cells. Prostaglandins 85-99 kininogen 1 Canis lupus familiaris 53-55 948031-8 1976 These data suggest that endogenous PGs act to attenuate, rather than mediate, the venoconstrictor response to BK. Prostaglandins 35-38 kininogen 1 Canis lupus familiaris 110-112 948031-12 1976 However, these data do suggest that PGs are a determinant of venous responsiveness to BK. Prostaglandins 36-39 kininogen 1 Canis lupus familiaris 86-88 4853840-0 1974 Proceedings: Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint. Prostaglandins 29-43 kininogen 1 Canis lupus familiaris 75-85 4207046-2 1973 Resting splenic venous outflow from anaesthetized dogs contains prostaglandin-like material: the concentration increases after intra-arterial injections of bradykinin into the spleen, and is abolished by treatment with indomethacin.2. Prostaglandins 64-77 kininogen 1 Canis lupus familiaris 156-166 1138295-5 1975 These results suggest that BK does not normally cause venoconstriction by stimulating synthesis of a venoconstrictor PG and that the increase in response to BK after prolonged periods in the bath may be related to changes in PG synthesis. Prostaglandins 225-227 kininogen 1 Canis lupus familiaris 157-159