PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3046823-0 1988 Longitudinal study of renal prostaglandin excretion in cirrhotic rats: relationship with the renin-aldosterone system. Prostaglandins 28-41 renin Rattus norvegicus 93-98 3071584-0 1988 Interaction between the vascular renin-angiotensin system and prostaglandins. Prostaglandins 62-76 renin Rattus norvegicus 33-38 3071584-9 1988 In contrast with their effects on renal renin, prostaglandins suppress the vascular renin-angiotensin system. Prostaglandins 47-61 renin Rattus norvegicus 84-89 3057301-0 1988 Effect of vasodilator prostaglandins on the vascular renin-angiotensin system. Prostaglandins 22-36 renin Rattus norvegicus 53-58 3057301-1 1988 The interaction of prostaglandin (PG) with the vascular renin-angiotensin (R-A) system was examined by studies on the effects of PGI2, PGE2 and the inhibitor of PG synthesis, indomethacin, on the release of angiotensin II (Ang II) from isolated rat mesenteric arteries. Prostaglandins 19-32 renin Rattus norvegicus 56-61 3057301-1 1988 The interaction of prostaglandin (PG) with the vascular renin-angiotensin (R-A) system was examined by studies on the effects of PGI2, PGE2 and the inhibitor of PG synthesis, indomethacin, on the release of angiotensin II (Ang II) from isolated rat mesenteric arteries. Prostaglandins 34-36 renin Rattus norvegicus 56-61 3037621-9 1987 They also provide evidence that during infusion of such peptides, both prostaglandins and beta-adrenergic mechanisms are still involved in the regulation of renin secretion. Prostaglandins 71-85 renin Rattus norvegicus 157-162 3037924-7 1987 However, by maintaining increased vasoconstriction at reduced RPP, prostaglandin-dependent renin release reduces autoregulatory efficiency in the young rat. Prostaglandins 67-80 renin Rattus norvegicus 91-96 3018765-0 1986 Role of volume and prostaglandin synthesis in the suppression of renin by saline in the rat. Prostaglandins 19-32 renin Rattus norvegicus 65-70 6383082-1 1984 This study examines the role of the renal prostaglandin system in stimulus-secretion coupling for renal baroreceptor-dependent renin release in the anesthetized rat. Prostaglandins 42-55 renin Rattus norvegicus 127-132 2420298-1 1985 The present study was done to investigate the role of endogenous prostaglandins and kinins in the mechanism of captopril-induced hypotensive effect and stimulating effect of plasma renin activity (PRA) in pentobarbital-anesthetized rats. Prostaglandins 65-79 renin Rattus norvegicus 181-186 3883811-0 1985 Role of prostaglandins in renin suppression during acute potassium loading. Prostaglandins 8-22 renin Rattus norvegicus 26-31 3895329-0 1985 Participation of prostaglandin and adrenergic nervous system in renin release induced by changes in renal arterial pressure in rats. Prostaglandins 17-30 renin Rattus norvegicus 64-69 6089584-0 1984 Relationship between PG and beta-adrenergic pathways to renin release in rat renal cortical slices. Prostaglandins 21-23 renin Rattus norvegicus 56-61 2840395-9 1988 These results suggest that the renin-angiotensin in the hind legs is modulated by prostaglandins and that a difference exists in the beta-adrenergic receptor-mediated release of Ang II among diverse vascular beds. Prostaglandins 82-96 renin Rattus norvegicus 31-36 3861577-0 1985 Effects of prostaglandin synthesis inhibitors on the renin-angiotensin system and renal function. Prostaglandins 11-24 renin Rattus norvegicus 53-58 3901121-1 1985 The role of prostaglandins in the control of adrenal renin in vivo was evaluated in nephrectomized rats. Prostaglandins 12-26 renin Rattus norvegicus 53-58 3901121-8 1985 These data indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the adrenal renin response to nephrectomy, suggesting that prostaglandins may play a role in the adrenal response to nephrectomy. Prostaglandins 39-52 renin Rattus norvegicus 108-113 3901121-8 1985 These data indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the adrenal renin response to nephrectomy, suggesting that prostaglandins may play a role in the adrenal response to nephrectomy. Prostaglandins 155-169 renin Rattus norvegicus 108-113 3891614-1 1985 Renin-prostaglandin interaction. Prostaglandins 6-19 renin Rattus norvegicus 0-5 6331173-0 1984 Role of prostaglandins in renin secretion in the isolated kidney. Prostaglandins 8-22 renin Rattus norvegicus 26-31 6331173-1 1984 Prostaglandins (PG) stimulate renin secretion through a mechanism that does not require activation of the intrarenal vascular, macula densa (MD), or beta-adrenergic receptors. Prostaglandins 0-14 renin Rattus norvegicus 30-35 6331173-1 1984 Prostaglandins (PG) stimulate renin secretion through a mechanism that does not require activation of the intrarenal vascular, macula densa (MD), or beta-adrenergic receptors. Prostaglandins 16-18 renin Rattus norvegicus 30-35 6331173-2 1984 In the present study the isolated perfused rat kidney was used to study the role of PG as a mediator of renin secretion when extracellular calcium was decreased and after activation of each of the intrarenal receptors. Prostaglandins 84-86 renin Rattus norvegicus 104-109 6089584-1 1984 The precise importance of prostaglandin (PG) in the beta-adrenergic pathway to renin release is unresolved. Prostaglandins 26-39 renin Rattus norvegicus 79-84 6089584-1 1984 The precise importance of prostaglandin (PG) in the beta-adrenergic pathway to renin release is unresolved. Prostaglandins 41-43 renin Rattus norvegicus 79-84 6316059-11 1983 These results demonstrate that vasodilator-induced renin release is only partially mediated via the prostaglandin system, that the degree of this control is related to the intensity of vasodilator stimulus and that renin release following administration of hydralazine can be attributed almost entirely to activation of the beta-adrenergic nervous and prostaglandin systems. Prostaglandins 100-113 renin Rattus norvegicus 51-56 6089584-11 1984 Rather, high concentrations of prostaglandins may increase the renin-releasing action of beta-agonists, thereby modulating the release of renin. Prostaglandins 31-45 renin Rattus norvegicus 63-68 6089584-11 1984 Rather, high concentrations of prostaglandins may increase the renin-releasing action of beta-agonists, thereby modulating the release of renin. Prostaglandins 31-45 renin Rattus norvegicus 138-143 6430607-5 1984 These results suggest that bradykinin does not directly increase plasma renin activity and that prostaglandins may participate in the bradykinin-induced renin release under these experimental conditions. Prostaglandins 96-110 renin Rattus norvegicus 153-158 6375797-1 1984 The effect of inhibiting prostaglandin (PG) synthesis on basal and frusemide-stimulated renin secretion was examined in the rat isolated perfused kidney. Prostaglandins 40-42 renin Rattus norvegicus 88-93 6316059-11 1983 These results demonstrate that vasodilator-induced renin release is only partially mediated via the prostaglandin system, that the degree of this control is related to the intensity of vasodilator stimulus and that renin release following administration of hydralazine can be attributed almost entirely to activation of the beta-adrenergic nervous and prostaglandin systems. Prostaglandins 352-365 renin Rattus norvegicus 215-220 6810710-9 1982 These results suggest that the mechanism of direct interaction between renal PG and renin in isolated glomeruli is selectively due to the action of PGI2. Prostaglandins 77-79 renin Rattus norvegicus 84-89 6139189-1 1983 In the isolated perfused rat kidney renin release is increased by physiological agents which stimulate adenylate cyclase activity, such as beta-adrenoceptor agonists, prostaglandins, histamine (histamine H2-receptor mediated) and adenosine (adenosine RA-receptor mediated). Prostaglandins 167-181 renin Rattus norvegicus 36-41 6756166-0 1982 Prostaglandin in renin release during sodium deprivation. Prostaglandins 0-13 renin Rattus norvegicus 17-22 6756166-1 1982 This study was designed to examine the role of prostaglandins in the macula densa-mediated increase in plasma renin activity (PRA) during dietary sodium deprivation in rats. Prostaglandins 47-61 renin Rattus norvegicus 110-115 15171019-0 1982 Effect of prostaglandins on renin release from rat renal cortical slices. Prostaglandins 10-24 renin Rattus norvegicus 28-33 7043495-0 1982 Evening primrose oil, a dietary prostaglandin precursor, diminishes vascular reactivity to renin and angiotensin II in rats. Prostaglandins 32-45 renin Rattus norvegicus 91-115 7018800-11 1981 These findings suggest that a prostaglandin normally inhibits the renin response of spontaneously hypertensive rats to frusemide-induced volume contraction. Prostaglandins 30-43 renin Rattus norvegicus 66-71 6797255-6 1981 Increased endogenous PG-levels were associated with only a modest (insignificant) increase in renin release under the present conditions. Prostaglandins 21-23 renin Rattus norvegicus 94-99 7016365-9 1981 These data provide evidence that the prostaglandin system is involved in the release of renin and in the pathogenesis of elevated blood pressure in this model of renin-dependent hypertension. Prostaglandins 37-50 renin Rattus norvegicus 88-93 7016365-9 1981 These data provide evidence that the prostaglandin system is involved in the release of renin and in the pathogenesis of elevated blood pressure in this model of renin-dependent hypertension. Prostaglandins 37-50 renin Rattus norvegicus 162-167 7018800-12 1981 Inhibition of prostaglandin synthesis allows volume contraction to stimulate renin release. Prostaglandins 14-27 renin Rattus norvegicus 77-82 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 55-57 renin Rattus norvegicus 69-74 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 55-57 renin Rattus norvegicus 228-233 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 221-224 renin Rattus norvegicus 69-74 6260459-9 1981 In view of the fact that we have previously shown that PG-stimulated renin release is not blocked by propranolol and is enhanced by phosphodiesterase inhibitors, our present experiments suggest that the site of action of PGs on renin release is located between the beta-adrenergic receptor and the generation of cAMP. Prostaglandins 221-224 renin Rattus norvegicus 228-233 7012843-0 1981 Direct action of prostaglandins on renin release from rat renal cortical slices. Prostaglandins 17-31 renin Rattus norvegicus 35-40 7011052-1 1981 The role of prostaglandins in the control of renin release in vivo was evaluated in the conscious rat. Prostaglandins 12-26 renin Rattus norvegicus 45-50 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 42-55 renin Rattus norvegicus 103-108 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 42-55 renin Rattus norvegicus 228-233 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 171-185 renin Rattus norvegicus 103-108 7011052-8 1981 These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release. Prostaglandins 171-185 renin Rattus norvegicus 228-233 7449251-0 1980 Effects of prostaglandins on renin substrate production by the liver. Prostaglandins 11-25 renin Rattus norvegicus 29-34 6252558-0 1980 Role of prostaglandins, beta-adrenoceptors, and the central nervous system in the control of renin release in conscious sodium-depleted rats. Prostaglandins 8-22 renin Rattus norvegicus 93-98 7010370-1 1980 The efficacy of various prostaglandins to stimulate renin release was compared in the isolated perfused rat kidney. Prostaglandins 24-38 renin Rattus norvegicus 52-57 286300-8 1979 These prostaglandins may exert important physiologic effects, because renin secretion and arteriolar resistance are regulated by the glomerulus and the afferent and efferent arterioles. Prostaglandins 6-20 renin Rattus norvegicus 70-75 6260459-0 1981 The role of renal prostaglandins in the renin response to isoproterenol in the rat in vitro. Prostaglandins 18-32 renin Rattus norvegicus 40-45 6260459-1 1981 Renal prostaglandins (PGs) have been considered to be important mediators of renin release. Prostaglandins 6-20 renin Rattus norvegicus 77-82 6260459-1 1981 Renal prostaglandins (PGs) have been considered to be important mediators of renin release. Prostaglandins 22-25 renin Rattus norvegicus 77-82 7002082-1 1980 Renal prostaglandins (PG) appear to mediate the release of renin due to activation of the intrarenal baroreceptor and stimulation of the renal sympathetic nerves. Prostaglandins 6-20 renin Rattus norvegicus 59-64 7002082-1 1980 Renal prostaglandins (PG) appear to mediate the release of renin due to activation of the intrarenal baroreceptor and stimulation of the renal sympathetic nerves. Prostaglandins 22-24 renin Rattus norvegicus 59-64 6244927-0 1980 Prostaglandin stimulation of renin release: independence of beta-adrenergic receptor activity and possible mechanism of action. Prostaglandins 0-13 renin Rattus norvegicus 29-34 6997808-0 1980 [Renin secretion by rat and rabbit kidneys under the influence of prostaglandins]. Prostaglandins 66-80 renin Rattus norvegicus 1-6 500824-11 1979 The present findings suggest that prostaglandins modulate the effects of the renin-angiotensin system by stimulating the release of renin from the kidney and augmenting the steroidogenic effects of AII and AIII in the adrenal cortex. Prostaglandins 34-48 renin Rattus norvegicus 77-82 500824-11 1979 The present findings suggest that prostaglandins modulate the effects of the renin-angiotensin system by stimulating the release of renin from the kidney and augmenting the steroidogenic effects of AII and AIII in the adrenal cortex. Prostaglandins 34-48 renin Rattus norvegicus 132-137 120320-8 1979 These findings suggest 1) that saralasin-induced renin release is mediated by renal prostaglandins, and 2) an interrelationship exists between the receptor controlling AII-mediated inhibition of renin release, which is blocked by saralasin, and the juxtaglomerular beta-adrenergic receptor. Prostaglandins 84-98 renin Rattus norvegicus 49-54 522895-2 1979 Seventy-two hours after adrenalectomy the inhibitors of prostaglandin biosynthesis indomethacin and meclofenamate diminished the plasma renin concentration by about 50%. Prostaglandins 56-69 renin Rattus norvegicus 136-141 522895-5 1979 It is concluded that in adrenalectomized rats renal prostaglandins effect the baro-receptor-mechanism in the afferent arterioles and thus enhance renin release. Prostaglandins 52-66 renin Rattus norvegicus 146-151 37256-0 1979 Role of renal prostaglandins in sympathetically mediated renin relase in the rat. Prostaglandins 14-28 renin Rattus norvegicus 57-62 37256-1 1979 Renal prostaglandins (PG) appear to mediate renin release due to stimulation of the intrarenal baroreceptor, but not that due to activation of the macula densa. Prostaglandins 6-20 renin Rattus norvegicus 44-49 37256-1 1979 Renal prostaglandins (PG) appear to mediate renin release due to stimulation of the intrarenal baroreceptor, but not that due to activation of the macula densa. Prostaglandins 22-24 renin Rattus norvegicus 44-49 439781-3 1979 Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion. Prostaglandins 36-49 renin Rattus norvegicus 129-134 441427-1 1979 Prostaglandins are thought to play an important role in the local regulation of glomerular blood flow and in the release of renin from the juxtaglomerular apparatus. Prostaglandins 0-14 renin Rattus norvegicus 124-129 990450-0 1976 [Renin-angiotensin system in the presence of altered prostaglandin synthesis]. Prostaglandins 53-66 renin Rattus norvegicus 1-6 990450-1 1976 The activity of the renin-angiotensin system was studied in experiments on rats under conditions of the inhibited prostaglandin synthesis. Prostaglandins 114-127 renin Rattus norvegicus 20-25 1022407-7 1976 It is concluded that there exists a notable connection between adrenal cortex regeneration, renal antihypertensive prostaglandins and the kidney and brain renin-angiotensin systems, which pays a correlated role in the mechanism of adrenal regeneration hypertension. Prostaglandins 115-129 renin Rattus norvegicus 155-160 31378306-14 2019 Cox2-derived prostaglandins might play a role in brain-renin angiotensin system associated hypertension, and astrocytes could be significant players. Prostaglandins 13-27 renin Rattus norvegicus 55-60 16467505-2 2006 Both nitric oxide (NO) and prostaglandins have been considered to mediate or modulate the control of renin secretion. Prostaglandins 27-41 renin Rattus norvegicus 101-106 30554341-2 2019 PGE2, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. Prostaglandins 0-2 renin Rattus norvegicus 84-89 12434137-1 2002 COX-2-derived prostaglandins (PG) have been suggested to be important modulators of renin release and expression. Prostaglandins 14-28 renin Rattus norvegicus 84-89 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Prostaglandins 154-165 renin Rattus norvegicus 48-53 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Prostaglandins 154-165 renin Rattus norvegicus 208-213 12434137-1 2002 COX-2-derived prostaglandins (PG) have been suggested to be important modulators of renin release and expression. Prostaglandins 30-32 renin Rattus norvegicus 84-89 12434137-3 2002 In the present studies we explored the role of COX-2-derived PG on basal and angiotensin converting enzyme inhibitor (ACEI)-stimulated plasma and renal renin concentrations (PRC and RRC, RIA), and mRNA expression (RmRNA, RNAse protection assay) in experimental diabetes (DM). Prostaglandins 61-63 renin Rattus norvegicus 152-157 11135058-1 2001 BACKGROUND: During a low salt intake, maintenance of renal blood flow and renin secretion depends on intact formation of prostaglandins. Prostaglandins 121-135 renin Rattus norvegicus 74-79 12184998-0 2002 Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Prostaglandins 0-14 renin Rattus norvegicus 29-34 12110513-0 2002 Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake. Prostaglandins 8-19 renin Rattus norvegicus 41-46 12110513-7 2002 These findings suggest that COX-1-derived, but not COX-2-derived, prostanoids are of relevance for the regulation of the renin system by salt intake. Prostaglandins 66-77 renin Rattus norvegicus 121-126 11680616-10 2001 COX-2-derived prostanoids may play a role in the regulation of renin secretion but not in renin gene expression during the intake of a low-salt diet. Prostaglandins 14-25 renin Rattus norvegicus 63-68 11316844-7 2001 These findings suggest that in states of increased renocortical expression of COX-2, overall renal vascular resistance and the macula densa control of renin secretion become dependent on COX-2-derived prostanoids. Prostaglandins 201-212 renin Rattus norvegicus 151-156 7675628-6 1995 While blood pressure, PRA and renin m-RNA levels of the contralateral kidneys were virtually unchanged by the cyclooxygenase inhibitors indomethacin and meclofenamate, renin gene expression in the clipped kidney was markedly influenced by inhibition of prostaglandin synthesis. Prostaglandins 253-266 renin Rattus norvegicus 168-173 10489401-10 1999 Because macula densa-derived prostaglandins are considered stimulators of renin secretion and renin synthesis, inhibition of macula densa COX-2 by angiotensin II could form a novel indirect negative feedback control of the renin system. Prostaglandins 29-43 renin Rattus norvegicus 74-79 10489401-10 1999 Because macula densa-derived prostaglandins are considered stimulators of renin secretion and renin synthesis, inhibition of macula densa COX-2 by angiotensin II could form a novel indirect negative feedback control of the renin system. Prostaglandins 29-43 renin Rattus norvegicus 94-99 10489401-10 1999 Because macula densa-derived prostaglandins are considered stimulators of renin secretion and renin synthesis, inhibition of macula densa COX-2 by angiotensin II could form a novel indirect negative feedback control of the renin system. Prostaglandins 29-43 renin Rattus norvegicus 94-99 9453303-1 1998 Prostaglandins contribute to the regulation of renin synthesis and secretion. Prostaglandins 0-14 renin Rattus norvegicus 47-52 8594876-0 1995 Nitric oxide and prostaglandins are involved in the macula densa control of the renin system. Prostaglandins 17-31 renin Rattus norvegicus 80-85 8594876-7 1995 These findings suggest that activation of renin gene expression by blockade of the macula densa function is dependent on intact NO and prostaglandin formation, whereas for stimulation of renin secretion mainly intact NO formation appears to be necessary. Prostaglandins 135-148 renin Rattus norvegicus 42-47 10892668-0 2000 Evidence that prostaglandins mediate the antihypertensive actions of angiotensin-(1-7) during chronic blockade of the renin-angiotensin system. Prostaglandins 14-28 renin Rattus norvegicus 118-123 8662293-1 1996 This study aimed to investigate the possible involvement of endothelial autacoids such as nitric oxide or prostaglandins in the well-known stimulatory effect of a low salt intake on renin secretion and renin gene expression in the kidney. Prostaglandins 106-120 renin Rattus norvegicus 182-207 7644529-1 1995 This study was designed to examine the possible involvement of prostaglandins and nitric oxide (NO) in the renin stimulatory effect of angiotensin II (AngII) antagonists. Prostaglandins 63-77 renin Rattus norvegicus 107-112 7675628-0 1995 Prostaglandins are involved in the stimulation of renin gene expression in 2 kidney-1 clip rats. Prostaglandins 0-14 renin Rattus norvegicus 50-55 7675628-1 1995 This study was done to obtain information about a possible involvement of prostaglandins in the renal baroreceptor mechanism regulating renin secretion and renin gene expression. Prostaglandins 74-88 renin Rattus norvegicus 136-141 2035656-0 1991 Protein-induced modulation of renin secretion is mediated by prostaglandins. Prostaglandins 61-75 renin Rattus norvegicus 30-35 7533733-1 1995 Eicosanoids (prostaglandins) can alter renin secretion and angiotensin (ANG) II action. Prostaglandins 13-27 renin Rattus norvegicus 39-44 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Prostaglandins 14-27 renin Rattus norvegicus 124-129 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Prostaglandins 14-27 renin Rattus norvegicus 240-245 7700000-4 1994 Inhibition of prostaglandin (PG) formation by meclofenamate or EDRF synthesis by L-NAME markedly attenuated the increase of renin mRNA levels in response to clipping, and a combination of PG/EDRF inhibition almost abolished the increase of renin mRNA levels. Prostaglandins 29-31 renin Rattus norvegicus 124-129 8238382-6 1993 Our previous studies show that both prostaglandins and lipoxygenase (LO) products of arachidonic acid play an important dual regulatory role in renin secretion; therefore, we have examined the effects of both cyclooxygenase (CO) and LO inhibition in TGF-beta action. Prostaglandins 36-50 renin Rattus norvegicus 144-149 7853791-6 1994 These findings indicate that both the inhibition of prostaglandin synthesis and of the formation of endothelium-derived relaxing factor (EDRF) attenuate the increase of renin gene expression and of renin secretion in response to acute unilateral renal hypoperfusion and that the effects of both maneuvers are additive. Prostaglandins 52-65 renin Rattus norvegicus 169-174 7853791-6 1994 These findings indicate that both the inhibition of prostaglandin synthesis and of the formation of endothelium-derived relaxing factor (EDRF) attenuate the increase of renin gene expression and of renin secretion in response to acute unilateral renal hypoperfusion and that the effects of both maneuvers are additive. Prostaglandins 52-65 renin Rattus norvegicus 198-203 1438875-3 1992 Excessive prostaglandin production, therefore, might contribute to the altered sodium balance and renin release observed in primary adrenal insufficiency. Prostaglandins 10-23 renin Rattus norvegicus 98-103 2035656-9 1991 This impairment in renin release is mediated by PG. Prostaglandins 48-50 renin Rattus norvegicus 19-24 2352361-9 1990 In addition, it has been suggested that prostaglandins are also capable of modulating the response only in the presence of the renin-angiotensin system. Prostaglandins 40-54 renin Rattus norvegicus 127-132 2013478-0 1991 Role of prostanoids in renin-dependent and renin-independent hypertension. Prostaglandins 8-19 renin Rattus norvegicus 23-28 2073934-6 1990 These observations, combined with previous studies of the role of central angiotensin II and central prostanoids in the physiological control of vasopressin release, suggest that there may be important interactions between brain prostanoids and the brain renin-angiotensin system in this control. Prostaglandins 101-112 renin Rattus norvegicus 255-260 2104586-9 1990 Since the effect of TNF and IL-1 on renin can be blocked by a (CO) inhibitor, the studies indicate a role of prostaglandins in their action. Prostaglandins 109-123 renin Rattus norvegicus 36-41