PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22177675-11 2012 Some patients with acute viral infection cannot destroy the aggressive clone and they suppress autoimmune reaction to insulin by prostaglandin synthesizing cells (PGSC) or sells with histamine receptors (CHR). Prostaglandins 129-142 insulin Homo sapiens 118-125 17495844-4 2007 Concealed indirect reaction of lymphocytes to insulin was revealed at inhibition of cells with receptors to histamine or prostaglandin synthesizing cells in 13 and 19 of 71 patients, respectively (p<0.01 and p<0.05 compared with control group). Prostaglandins 121-134 insulin Homo sapiens 46-53 22629828-4 2012 The lymphocyte sensibilization with insulin suppressed by prostaglandin-synthesizing cells or cells with histamine receptor expression (DM predictor) is more common in BC patients than in control group (29 of 56 vs 5 of 37, p < 0.001). Prostaglandins 58-71 insulin Homo sapiens 36-43 20964072-3 2010 Some of the mechanisms involved include: reduction of c-HDL concentration, increase of low density lipoprotein, Lp (a), triglycerides; disturbance in prostaglandin balance and they may also promote insulin resistance. Prostaglandins 150-163 insulin Homo sapiens 198-205 15628590-5 2004 Indirect LS to insulin, defectable after inhibition of the cells with histamine receptors (CHR) or prostaglandin synthetizing cells (PGSC), was found in 26 patients with stroke (10-with diabetes type 2, 8-with pre-diabetes, 8 non-diabetic) and in 5 patients with CVD. Prostaglandins 99-112 insulin Homo sapiens 15-22 16784183-5 2006 Using cimetidine to inhibit cells with histamine receptors and indometacin to inhibit prostaglandin-synthesising cells, a higher incidence of stroke was found in patients with indirect cell-mediated immunity to insulin. Prostaglandins 86-99 insulin Homo sapiens 211-218 12920574-2 2003 PTGS2 generates prostaglandins, which negatively modulate glucose-stimulated insulin secretion, and functions as a mediator of the inflammatory response, which is associated with decreased insulin sensitivity. Prostaglandins 16-30 insulin Homo sapiens 77-84 9575890-5 1998 These findings implicate the possible role of the MAPK pathway in mediating the effects of insulin and IGF-I on the upregulation of cytokine-stimulated NO and PG biosynthesis. Prostaglandins 159-161 insulin Homo sapiens 91-98 12848074-6 2003 Vasodilation is the most remarkable peripheral effect of insulin that seems to be due to a direct activity on vascular smooth muscle cells and, more remarkably, on an increased release of endothelium-derived relaxing factors, such as nitric oxide and vasodilator prostaglandins. Prostaglandins 263-277 insulin Homo sapiens 57-64 10647203-4 1999 Latent sensitization of lymphocytes to insulin detectable in inhibition of functional activity of prostaglandin-synthesizing cells is encountered in classic course of DM type II, while detectable in inhibition of functional activity of the cells carrying receptors to histamine is observed in patients with symptoms of either DM type I or DM type II. Prostaglandins 98-111 insulin Homo sapiens 39-46 9575890-0 1998 IGF-I and insulin amplify IL-1 beta-induced nitric oxide and prostaglandin biosynthesis. Prostaglandins 61-74 insulin Homo sapiens 10-17 9217894-0 1997 Prostaglandins and nitric oxide mediate insulin-induced vasodilation in the human forearm. Prostaglandins 0-14 insulin Homo sapiens 40-47 9633025-4 1998 We report the case of a 52 year-old diabetic patient treated with insulin injections with intestinal malabsorption leading to chronic hyperkalemia and hypocalcemia in whom a low renin syndrome and low levels of urinary prostaglandins were observed. Prostaglandins 219-233 insulin Homo sapiens 66-73 9217894-8 1997 CONCLUSIONS: Insulin has vasodilating properties in skeletal muscle vasculature that is mediated by increases in nitric oxide, that subsequently stimulates prostaglandin release. Prostaglandins 156-169 insulin Homo sapiens 13-20 8580869-3 1995 We present evidence that prostaglandins may act as one of these signals by a direct action on cells of the immune system, or by inhibition of insulin secretion which in turn suppresses immune function, or both. Prostaglandins 25-39 insulin Homo sapiens 142-149 8291502-4 1994 The decrease of insulin binding sites in the acute phase and their subsequent increase during recovery were directly related to the hormone-induced increase in sensitivity to prostaglandin E1 through the stimulation of adenosine 3",5"-cyclic monophosphate formation in platelets by the prostanoid. Prostaglandins 286-296 insulin Homo sapiens 16-23 7905262-1 1994 Recent reports of a pertussis-toxin (Ptx)-sensitive inhibition of glucose-induced insulin release by prostaglandin E2 (PGE2) in transformed beta-cells prompted us to look for the presence of prostaglandin-regulatable GTP-binding proteins (G-proteins) on the secretory granules of normal pancreatic islets. Prostaglandins 101-114 insulin Homo sapiens 82-89 1654491-3 1991 Insulin increases the PGE1 binding to platelets and thereby enhances the platelet antiaggregatory action of prostaglandin by increasing cyclic AMP levels. Prostaglandins 108-121 insulin Homo sapiens 0-7 1730458-5 1992 The following discussion attempts to review our knowledge of the effects of insulin on renal sodium reabsorption and describes new data suggesting that insulin"s antinatriuretic response is dependent on antidiuretic hormone but independent of the angiotensin and prostaglandin systems. Prostaglandins 263-276 insulin Homo sapiens 152-159 1845854-0 1991 Restoration by insulin of impaired prostaglandin E1/I2 receptor activity of platelets in acute ischemic heart disease. Prostaglandins 35-48 insulin Homo sapiens 15-22 1845854-4 1991 The increased binding of the prostanoid to the insulin-treated platelets also resulted in increased cyclic AMP levels both in normal subjects (44.14 +/- 3.1 pmol/10(8) [insulin-treated] platelets versus 16.35 +/- 2.91 pmol/10(8) [control] platelets) and in patients with acute ischemic heart disease (23.87 +/- 4.1 pmol/10(8) [insulin-treated] platelets versus 7.70 +/- 2.0 pmol/10(8) [control] platelets) by the prostanoid (1.0 microM). Prostaglandins 29-39 insulin Homo sapiens 47-54 1845854-4 1991 The increased binding of the prostanoid to the insulin-treated platelets also resulted in increased cyclic AMP levels both in normal subjects (44.14 +/- 3.1 pmol/10(8) [insulin-treated] platelets versus 16.35 +/- 2.91 pmol/10(8) [control] platelets) and in patients with acute ischemic heart disease (23.87 +/- 4.1 pmol/10(8) [insulin-treated] platelets versus 7.70 +/- 2.0 pmol/10(8) [control] platelets) by the prostanoid (1.0 microM). Prostaglandins 29-39 insulin Homo sapiens 169-176 1845854-4 1991 The increased binding of the prostanoid to the insulin-treated platelets also resulted in increased cyclic AMP levels both in normal subjects (44.14 +/- 3.1 pmol/10(8) [insulin-treated] platelets versus 16.35 +/- 2.91 pmol/10(8) [control] platelets) and in patients with acute ischemic heart disease (23.87 +/- 4.1 pmol/10(8) [insulin-treated] platelets versus 7.70 +/- 2.0 pmol/10(8) [control] platelets) by the prostanoid (1.0 microM). Prostaglandins 29-39 insulin Homo sapiens 169-176 1845854-4 1991 The increased binding of the prostanoid to the insulin-treated platelets also resulted in increased cyclic AMP levels both in normal subjects (44.14 +/- 3.1 pmol/10(8) [insulin-treated] platelets versus 16.35 +/- 2.91 pmol/10(8) [control] platelets) and in patients with acute ischemic heart disease (23.87 +/- 4.1 pmol/10(8) [insulin-treated] platelets versus 7.70 +/- 2.0 pmol/10(8) [control] platelets) by the prostanoid (1.0 microM). Prostaglandins 413-423 insulin Homo sapiens 47-54 1510005-5 1992 Administration of aspirin inhibited the insulin-induced increase of plasma prostanoid level. Prostaglandins 75-85 insulin Homo sapiens 40-47 1510005-8 1992 These results indicated the feasibility of using physiologic quantities of insulin for controlling of platelet aggregation through resensitization of platelet response to prostaglandin and increased synthesis of PGI2 in vivo in acute coronary artery disease. Prostaglandins 171-184 insulin Homo sapiens 75-82 1799258-8 1991 These data suggest: (1) that a small number of fetal pancreases procured from prostaglandin-induced abortuses do yield islets which remain viable in culture over 30 days, and (2) the functional status of islets can be monitored in vivo by measuring insulin secretion, thereby providing a means of identifying tissue suitable for transplantation. Prostaglandins 78-91 insulin Homo sapiens 249-256 2125218-6 1990 These data suggest that IL-1 may suppress in vivo insulin release at least in part through the mediation of prostaglandin synthesis in the absence of adrenal glands. Prostaglandins 108-121 insulin Homo sapiens 50-57 2203383-1 1990 Local hormones such as adenosine or prostaglandins can dramatically change the sensitivity of glucose transport in muscle to insulin. Prostaglandins 36-50 insulin Homo sapiens 125-132 1969414-3 1990 The membranes prepared from the insulin-treated platelets also showed similar enhanced binding of the prostaglandin. Prostaglandins 102-115 insulin Homo sapiens 32-39 1969414-5 1990 This increased binding of the prostanoid to the membranes prepared from the insulin-treated platelets resulted in the stimulation of adenylate cyclase by more than 2-fold when compared with the control of membrane preparation by the prostaglandin alone. Prostaglandins 30-40 insulin Homo sapiens 76-83 1969414-5 1990 This increased binding of the prostanoid to the membranes prepared from the insulin-treated platelets resulted in the stimulation of adenylate cyclase by more than 2-fold when compared with the control of membrane preparation by the prostaglandin alone. Prostaglandins 233-246 insulin Homo sapiens 76-83 2481442-7 1989 The ability of inhibitors of arachidonic acid metabolism to prevent insulin-induced increases in RNA metabolism suggests that a prostaglandin or other eicosanoid is involved in the signal mechanism whereby insulin stimulates RNA synthesis. Prostaglandins 128-141 insulin Homo sapiens 68-75 2481442-7 1989 The ability of inhibitors of arachidonic acid metabolism to prevent insulin-induced increases in RNA metabolism suggests that a prostaglandin or other eicosanoid is involved in the signal mechanism whereby insulin stimulates RNA synthesis. Prostaglandins 128-141 insulin Homo sapiens 206-213 3043468-6 1988 1) From animal studies in vitro it appears that prostaglandins can directly augment insulin release. Prostaglandins 48-62 insulin Homo sapiens 84-91 2679144-7 1989 Inhibition of prostaglandin (PG) synthesis with indomethacin prevented the vasodilatory effects of insulin. Prostaglandins 14-27 insulin Homo sapiens 99-106 2679144-7 1989 Inhibition of prostaglandin (PG) synthesis with indomethacin prevented the vasodilatory effects of insulin. Prostaglandins 29-31 insulin Homo sapiens 99-106 2679144-8 1989 These data support the hypothesis that insulin causes renal vasodilation by a PG-dependent process. Prostaglandins 78-80 insulin Homo sapiens 39-46 3073092-3 1988 So, for instance, drugs that increase prostaglandins synthesis as colchicine or furosemide inhibit insulin secretion while non steroid anti-inflammator drugs, mainly salicylates, which inhibit cyclo-oxygenase, enhance the insulin response to various stimuli. Prostaglandins 38-52 insulin Homo sapiens 99-106 3073092-4 1988 In type-2 (non insulin-dependent) diabetes, an increased sensitivity to endogenous prostaglandins has been proposed as a possible cause for the insulin secretion defect which characterizes this disease. Prostaglandins 83-97 insulin Homo sapiens 15-22 2894205-9 1988 The infusion of the prostaglandin antagonists diclofenac or dipyridamole resulted in increases in the plasma insulin level, and as a result glucose turnover decreased in both groups. Prostaglandins 20-33 insulin Homo sapiens 109-116 3043468-7 1988 2) Results from animal experiments in vivo, however, suggest that systemic prostaglandin administration diminishes insulin release. Prostaglandins 75-88 insulin Homo sapiens 115-122 3043468-8 1988 3) No human studies have been performed in vitro which examine the insulin secretory response of pancreatic tissue to prostaglandins. Prostaglandins 118-132 insulin Homo sapiens 67-74 3043468-9 1988 4) Prostaglandins reduce stimulated insulin levels in normal human subjects and in those with diabetes mellitus. Prostaglandins 3-17 insulin Homo sapiens 36-43 3297726-11 1987 The increases in muscle blood flow and insulin sensitivity may be associated with activation of the kinin-prostaglandin system of the muscle. Prostaglandins 106-119 insulin Homo sapiens 39-46 2873626-0 1986 Combinations of palytoxin or 12-O-tetradecanoylphorbol-13-acetate and recombinant human insulin growth factor-I or insulin synergistically stimulate prostaglandin production in cultured rat liver cells and squirrel monkey aorta smooth muscle cells. Prostaglandins 149-162 insulin Homo sapiens 88-95 2880743-3 1986 Aim of this study is to determine the inhibitory effect of SRIF on insulin secretion induced by arginine after the administration of lysine acetylsalicylate (LAS) in a dose which inhibits the endogenous synthesis of prostaglandins. Prostaglandins 216-230 insulin Homo sapiens 67-74 2873626-3 1986 With both types of stimulations, prostaglandin production or deesterification, the synergistic response of the IGF-I and insulin is greater with palytoxin than with TPA. Prostaglandins 33-46 insulin Homo sapiens 121-128 3920854-4 1985 Explants cultured within 2 h of expulsion following prostaglandin induced termination secreted 3.0 times more insulin after 20 days of culture than those cultured within 2-4 h and 8.1 times more than those cultured more than 4 h post-termination. Prostaglandins 52-65 insulin Homo sapiens 110-117 3533052-0 1986 [Postreceptor defect in the effectiveness of insulin: significance of the kallikrein-kinin-prostaglandin system]. Prostaglandins 91-104 insulin Homo sapiens 45-52 6798594-4 1981 At lease one arachidonate derivative (prostaglandin E) inhibits insulin secretion, and several inhibitors of prostaglandin synthesis augment glucose-induced insulin release in normal subjects and type II diabetics. Prostaglandins 38-51 insulin Homo sapiens 64-71 6814899-3 1982 In the current study, we examined the effects of two known lipoxygenase inhibitors, BW755c and nordihydroguaiaretic acid, on the augmentation of insulin release evoked by three pharmacologically distinct classes of insulin secretagogues--one which augments cyclic AMP accumulation (exemplified by theophylline), one which inhibits prostaglandin synthesis (sodium salicylate), and one which is independent of changes in cyclic AMP or prostaglandin availability (tolbutamide). Prostaglandins 331-344 insulin Homo sapiens 145-152 6814899-3 1982 In the current study, we examined the effects of two known lipoxygenase inhibitors, BW755c and nordihydroguaiaretic acid, on the augmentation of insulin release evoked by three pharmacologically distinct classes of insulin secretagogues--one which augments cyclic AMP accumulation (exemplified by theophylline), one which inhibits prostaglandin synthesis (sodium salicylate), and one which is independent of changes in cyclic AMP or prostaglandin availability (tolbutamide). Prostaglandins 433-446 insulin Homo sapiens 145-152 6757082-1 1982 The prostaglandin synthesis inhibitor acetylsalicylic acid (ASA) increases acute insulin response to glucose and improves glucose tolerance in man. Prostaglandins 4-17 insulin Homo sapiens 81-88 3892914-5 1985 The absent acute insulin response to intravenously administered glucose can be restored by alpha-adrenergic blockade, prostaglandin synthesis inhibition, dopaminergic blockade and euglycemia. Prostaglandins 118-131 insulin Homo sapiens 17-24 6352377-4 1983 In contrast, most specimens from prostaglandin-induced abortions showed high levels of insulin in the medium early in the culture period but little thereafter, indicating rapid release of insulin from damaged tissue. Prostaglandins 33-46 insulin Homo sapiens 87-94 6352377-4 1983 In contrast, most specimens from prostaglandin-induced abortions showed high levels of insulin in the medium early in the culture period but little thereafter, indicating rapid release of insulin from damaged tissue. Prostaglandins 33-46 insulin Homo sapiens 188-195 6344749-1 1983 Prostaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glucagon. Prostaglandins 0-14 insulin Homo sapiens 147-154 6759079-1 1982 We examined the role of endogenous opiates and/or prostaglandins on the abnormal insulin secretion characteristic of some non-insulin-dependent diabetic subjects. Prostaglandins 50-64 insulin Homo sapiens 81-88 7026140-0 1981 [Correlations between prostaglandins and secretion of insulin, glucagon and somatotropic hormone. Prostaglandins 22-36 insulin Homo sapiens 54-61 399925-7 1979 These results seen to indicate that an intraislet synthesis of prostaglandins is involved in the beta-cell regulation of insulin release. Prostaglandins 63-77 insulin Homo sapiens 121-128 7035254-0 1982 Modulation of the action of insulin in relation to the energy state in skeletal muscle tissue: possible involvement of kinins and prostaglandins. Prostaglandins 130-144 insulin Homo sapiens 28-35 6246779-0 1980 A role for prostaglandins as mediators of alpha-adrenergic inhibition of the acute insulin response to glucose. Prostaglandins 11-25 insulin Homo sapiens 83-90 6255805-0 1980 Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose. Prostaglandins 0-13 insulin Homo sapiens 80-87 6989847-1 1980 To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation, we have studied the effects of two inhibitors of PG synthesis, indomethacin (INDO) and acetylsalicylic acid (ASA), on plasma insulin during a 72-h fast. Prostaglandins 23-37 insulin Homo sapiens 77-84 6989847-1 1980 To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation, we have studied the effects of two inhibitors of PG synthesis, indomethacin (INDO) and acetylsalicylic acid (ASA), on plasma insulin during a 72-h fast. Prostaglandins 39-42 insulin Homo sapiens 77-84 359352-0 1978 Insulin action on glucose uptake into skeletal muscle: inhibition of endogenous biosynthesis of prostaglandins. Prostaglandins 96-110 insulin Homo sapiens 0-7 315159-0 1979 Possible involvement of kinins and prostaglandins in the translation of insulin action on glucose uptake into skeletal muscle. Prostaglandins 35-49 insulin Homo sapiens 72-79 4353850-0 1973 Enhanced release of insulin by prostaglandins in isolated pancreatic islets. Prostaglandins 31-45 insulin Homo sapiens 20-27 680407-0 1978 Stimulatory effects of prostaglandins E-1, E-2, and F-2-alpha on glucagon and insulin release in vitro. Prostaglandins 23-37 insulin Homo sapiens 78-85 4355984-0 1973 Insulin reversal of growth inhibition of plasma cell tumor by prostaglandin or adenosine 3",5"-monophosphate. Prostaglandins 62-75 insulin Homo sapiens 0-7 669099-6 1978 A possible role of prostaglandins upon the insulin responses to glucose and arginine is discussed. Prostaglandins 19-33 insulin Homo sapiens 43-50 674691-1 1978 Previous studies of the effect of E series prostaglandins /PGs/ on insulin secretion gave conflicting results in animals and little information in man. Prostaglandins 43-57 insulin Homo sapiens 67-74 196957-0 1977 Role of prostaglandins and adenosine 3":5"-cyclic monophosphate in the control by insulin of growth-hormone synthesis in vitro. Prostaglandins 8-22 insulin Homo sapiens 82-89 4837701-0 1974 In vivo insulin secretion: prostaglandin and adrenergic interrelationships. Prostaglandins 27-40 insulin Homo sapiens 8-15 33694300-0 2021 Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion. Prostaglandins 4-17 insulin Homo sapiens 156-163 29537934-4 2018 Also, n-3 Polyunsaturated Fatty acids led to decreased production of prostaglandin, which in turn contributed to the elevation of insulin secretion. Prostaglandins 69-82 insulin Homo sapiens 130-137 22527884-1 2012 Prostaglandins are potent modulators of insulin sensitivity. Prostaglandins 0-14 insulin Homo sapiens 40-47