PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23778262-8 2013 Specifically, FOXO1 knockdown significantly decreased IL-1beta-induced IL-6 and IL-8 expression; production and COX-2 expression and subsequent prostaglandin (PGE2 and PGF2alpha) release; and MMP-9 mRNA expression and activity. Prostaglandins 144-157 interleukin 1 beta Homo sapiens 54-62 25224887-9 2013 For example, peripheral infection increases circulating IL-1beta that induces production of prostaglandins and IL-1beta by CNS immune cells that initiate fever and the behavioral symptoms of sickness. Prostaglandins 92-106 interleukin 1 beta Homo sapiens 56-64 23633206-8 2013 RESULTS: Orbital fibroblasts treated with IL-1beta exhibit greater inductions of IL-1alpha, IL-1beta, and prostaglandin endoperoxide H synthase-2 transcripts than do fibrocytes. Prostaglandins 106-119 interleukin 1 beta Homo sapiens 42-50 23488692-9 2013 Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis. Prostaglandins 152-162 interleukin 1 beta Homo sapiens 82-90 23136298-7 2013 Transfection of primary amnion cells with SIRT6 siRNA was associated with an increase in IL-1beta-induced proinflammatory cytokine gene expression and release (IL6, IL8, TNF [TNF-alpha]), cyclooxygenase ([COX]-2; official symbol PTGS2) expression and subsequent prostaglandin (PGE(2) and PGF(2alpha)) release, and MMP9 gene expression and release of pro-MMP9. Prostaglandins 262-275 interleukin 1 beta Homo sapiens 89-97 22638761-10 2012 BK can potentiate the COX-2 gene expression and consequent prostanoid production induced by IL-1beta. Prostaglandins 59-69 interleukin 1 beta Homo sapiens 92-100 22306363-6 2012 These results confirmed that PGE(2) mediates the effects of ATRA on HIF-1alpha expression; iii) Prostaglandin uptake transporter inhibitor bromocresol green blocked the increase in HIF-1alpha expression induced by PGE(2) or by PGE(2)-increasing cytokine interleukin-1beta, but not by ATRA. Prostaglandins 96-109 interleukin 1 beta Homo sapiens 254-271 22616846-6 2012 Prostaglandins derived from the cyclooxygenase (COX) pathway were determined by liquid-chromatography mass spectrometry in supernatants from interleukin (IL) 1beta-activated fibroblast-like synoviocytes (FLS) treated with methotrexate. Prostaglandins 0-14 interleukin 1 beta Homo sapiens 141-163 21898357-2 2012 Although this prostanoid and the enzymes responsible for its synthesis are up-regulated by interleukin-1beta (IL-1beta) in human chondrocytes in vitro, the role of PGD2 in arthritis remains unclear. Prostaglandins 14-24 interleukin 1 beta Homo sapiens 91-108 21898357-2 2012 Although this prostanoid and the enzymes responsible for its synthesis are up-regulated by interleukin-1beta (IL-1beta) in human chondrocytes in vitro, the role of PGD2 in arthritis remains unclear. Prostaglandins 14-24 interleukin 1 beta Homo sapiens 110-118 20069553-1 2010 Cytosolic phospholipase A(2) (cPLA(2)) plays a pivotal role in mediating agonist-induced arachidonic acid (AA) release for prostaglandin (PG) synthesis during inflammation triggered by IL-1beta. Prostaglandins 123-136 interleukin 1 beta Homo sapiens 185-193 22067128-7 2012 There were increased levels of IL-1beta, IL-6, MMP-1, MMP-3, and MMP-9 and decreased levels of TIMP-1 and TIMP-2 in the tears of PG-treated patients. Prostaglandins 129-131 interleukin 1 beta Homo sapiens 31-39 20470889-2 2010 According to a widely accepted hypothesis interleukin-1beta induces the synthesis of cyclooxygenase-2 at the blood-brain interface, which produces prostaglandins that diffuse into brain parenchyma to activate neurons. Prostaglandins 147-161 interleukin 1 beta Homo sapiens 42-59 20470889-6 2010 These findings moderate the prevailing view and indicate that brain cyclooxygenase-2-dependent prostaglandin production is important to activation of the median preoptic and arcuate hypothalamus, but not necessarily involved in fever, rises in plasma corticosterone and anorexia after peripheral interleukin-1beta administration. Prostaglandins 95-108 interleukin 1 beta Homo sapiens 296-313 21567074-10 2011 Prostaglandin (PG) and NO synthesis pathways were both affected by trauma and/or IL-1beta. Prostaglandins 0-13 interleukin 1 beta Homo sapiens 81-89 21567074-10 2011 Prostaglandin (PG) and NO synthesis pathways were both affected by trauma and/or IL-1beta. Prostaglandins 15-17 interleukin 1 beta Homo sapiens 81-89 20188355-0 2010 Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1beta. Prostaglandins 75-88 interleukin 1 beta Homo sapiens 102-119 20581349-4 2010 The expression of cytokines (notably interleukin 1beta [IL-1beta], IL-6, IL-8, and tumor necrosis factor alpha [TNF-alpha]) by either the fetal or maternal tissues has been demonstrated to upregulate the activity of a number of uterine and cervical factors (eg, prostaglandin hormones and their receptors, matrix metalloproteinases, vascular endothelial growth factor [VEGF]), leading to premature initiation of the parturition process. Prostaglandins 262-275 interleukin 1 beta Homo sapiens 37-54 19955102-10 2010 This mechanism may allow IL-1beta, possibly from the developing embryo, to modulate the function of the endometrial epithelium to promote successful implantation, for example by regulating prostaglandin production. Prostaglandins 189-202 interleukin 1 beta Homo sapiens 25-33 19751497-0 2009 Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. Prostaglandins 21-34 interleukin 1 beta Homo sapiens 48-56 19109223-2 2009 Although the mechanism of FM weakening leading to rupture is not completely understood, proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 beta (IL1B), have been shown to weaken FMs concomitant with the induction of reactive oxygen species, collagen remodeling, and prostaglandin release. Prostaglandins 298-311 interleukin 1 beta Homo sapiens 157-175 19109223-2 2009 Although the mechanism of FM weakening leading to rupture is not completely understood, proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukin 1 beta (IL1B), have been shown to weaken FMs concomitant with the induction of reactive oxygen species, collagen remodeling, and prostaglandin release. Prostaglandins 298-311 interleukin 1 beta Homo sapiens 177-181 17993511-2 2008 The inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) have been shown previously to inhibit mitogen-stimulated smooth muscle growth through a mechanism presumed to be dependent on the induction of cyclooxygenase-2, prostaglandins, and activation of the cAMP-dependent protein kinase (PKA). Prostaglandins 255-269 interleukin 1 beta Homo sapiens 27-49 18576346-8 2008 IL-4 expressed in the presence of IL-1beta and TNFalpha down-regulated a series of inflammation mediators, prostaglandins, and matrix metalloproteinases. Prostaglandins 107-121 interleukin 1 beta Homo sapiens 34-42 18467203-14 2008 The enhanced kinin receptor expression induced by the pro-inflammatory cytokines IL-1beta and TNF-alpha might be one important mechanism involved in the synergistic enhancement of prostaglandin formation caused by co-treatment with kinins and one of the two cytokines. Prostaglandins 180-193 interleukin 1 beta Homo sapiens 81-89 19135800-6 2009 We also show that IL-1beta induces COX-2 expression and prostaglandin release in DRG neurons in vitro in a MAP kinase-dependent fashion. Prostaglandins 56-69 interleukin 1 beta Homo sapiens 18-26 19135800-8 2009 We conclude that periganglionic inflammation increases cytokine levels, including IL-1beta, leading to the transcription of COX-2 and prostaglandin production in the affected DRG, and thereby to the development of a dermatomally distributed pain hypersensitivity. Prostaglandins 134-147 interleukin 1 beta Homo sapiens 82-90 18571585-13 2008 CONCLUSIONS: Mononuclear cells protect pancreatic cancer cells from drug-induced apoptosis in vitro by interleukin-1beta-mediated expression of cyclooxygenase-2 and production of prostaglandins. Prostaglandins 179-193 interleukin 1 beta Homo sapiens 103-120 18240548-4 2007 The onset of premature labor in the context of infection is mediated by pro-inflammatory cytokines, such as interleukin (IL)-1beta and tumor necrosis factor alpha (TNF-alpha), as these cytokines are produced by intrauterine tissues in response to microbial products, can stimulate prostaglandin production, and induce labor in animals. Prostaglandins 281-294 interleukin 1 beta Homo sapiens 108-130 18205904-8 2008 Addition of IL-1beta (5 ng/ml) to a COGA-13 culture raised IL-6 production approximately thousandfold via a prostaglandin-independent mechanism. Prostaglandins 108-121 interleukin 1 beta Homo sapiens 12-20 17428554-10 2007 CONCLUSION: Our data suggest, that IL-1beta indirectly increases OT secretion in primary cultures of human decidua in a time dependent fashion through the production of prostaglandins through COX-2 and that this increase in OT peptide may secondarily down-regulate the OTR and its signalling cascade. Prostaglandins 169-183 interleukin 1 beta Homo sapiens 35-43 17428554-3 2007 The present study evaluates the time-dependent effect [0-24 h] of the inflammatory cytokine Interleukin-1beta (IL-1beta) treatment on OT signalling and OT stimulated prostaglandin release in primary cultures of human decidua. Prostaglandins 166-179 interleukin 1 beta Homo sapiens 111-119 16904269-10 2007 Such data indicate that the effect of IL-1beta on HAS1 is mediated by prostaglandins. Prostaglandins 70-84 interleukin 1 beta Homo sapiens 38-46 16481008-5 2006 Cell proliferation and inhibition of interleukin 1beta (IL-1beta) induced prostaglandin (PG) production were examined. Prostaglandins 74-92 interleukin 1 beta Homo sapiens 37-54 17014957-1 2006 Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). Prostaglandins 135-149 interleukin 1 beta Homo sapiens 0-17 17014957-1 2006 Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). Prostaglandins 135-149 interleukin 1 beta Homo sapiens 19-27 16792994-0 2006 Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta. Prostaglandins 38-51 interleukin 1 beta Homo sapiens 104-112 16481008-5 2006 Cell proliferation and inhibition of interleukin 1beta (IL-1beta) induced prostaglandin (PG) production were examined. Prostaglandins 74-92 interleukin 1 beta Homo sapiens 56-64 16567019-3 2006 Within cartilage and synovium, pro-inflammatory cytokines, particularly IL-1b and TNF-a, auto-catalytically stimulate their own production and induce chondrocytes to produce additional catabolic mediators, including proteases, chemokines, nitric oxide, and prostaglandins. Prostaglandins 257-271 interleukin 1 beta Homo sapiens 72-77 16159661-4 2006 Moreover we found that: (i) this cell line releases prostaglandin E2 and the output is enhanced by interleukin-1beta; (ii) the prostanoid consistently inhibits serum- or epidermal growth factor-induced cell proliferation and also migration. Prostaglandins 127-137 interleukin 1 beta Homo sapiens 99-116 16469798-10 2006 We conclude that cortisol up-regulates 11beta-HSD1 expression through induction of promoter activity, and the effect was enhanced by IL-1beta, suggesting that more biologically active glucocorticoids could be generated in the fetal membranes in the presence of infection, which may consequently feed forward in up-regulation of prostaglandin synthesis. Prostaglandins 328-341 interleukin 1 beta Homo sapiens 133-141 16556676-8 2006 The selective COX-2 inhibitor NS-398 completely inhibits the increased production of PGs induced by IL-1beta in both cell types, whereas dexamethasone (DEX) exerts a stronger inhibition in HIESC than in HIEEC. Prostaglandins 85-88 interleukin 1 beta Homo sapiens 100-108 15801029-0 2005 Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. Prostaglandins 16-29 interleukin 1 beta Homo sapiens 110-127 16423868-2 2006 Cyclohexamide pretreatment inhibiting protein synthesis prevents IL-1beta increases in PG levels, indicating that induction requires de novo protein synthesis. Prostaglandins 87-89 interleukin 1 beta Homo sapiens 65-73 16423868-5 2006 PGE(2) and PGF(2alpha) reverse COX-2-mediated inhibition of IL-1beta induction of cytokine expression and PG production. Prostaglandins 0-2 interleukin 1 beta Homo sapiens 60-68 16338461-8 2006 The interaction between dexamethasone and IL-1beta on prostaglandin synthesis and cPLA(2) expression is neither synergistic nor conventionally antagonistic. Prostaglandins 54-67 interleukin 1 beta Homo sapiens 42-50 16338461-1 2006 OBJECTIVE: To investigate the interaction of dexamethasone and interleukin-1beta (IL-1beta) on the expression of cytosolic phospholipase A(2) (cPLA(2)), the enzyme catalyzing the first reaction in the formation of prostaglandins, in cultured primary human amnion fibroblasts. Prostaglandins 214-228 interleukin 1 beta Homo sapiens 63-80 16338461-1 2006 OBJECTIVE: To investigate the interaction of dexamethasone and interleukin-1beta (IL-1beta) on the expression of cytosolic phospholipase A(2) (cPLA(2)), the enzyme catalyzing the first reaction in the formation of prostaglandins, in cultured primary human amnion fibroblasts. Prostaglandins 214-228 interleukin 1 beta Homo sapiens 82-90 15755849-2 2005 The expression of the prostaglandin synthetic enzyme cyclooxygenase (COX)-2 and cytokines IL-1beta and IL-8 increases within the uterus at the time of labor, and each is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB). Prostaglandins 22-35 interleukin 1 beta Homo sapiens 90-98 15295712-0 2004 Modification of prostanoid secretion in endothelial cells by amphotericin B acting synergistically with interleukin-1beta: possible explanation of proinflammatory effects. Prostaglandins 16-26 interleukin 1 beta Homo sapiens 104-121 15298980-0 2004 Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1beta and hCG in human endometrial cells. Prostaglandins 26-40 interleukin 1 beta Homo sapiens 83-100 15363968-6 2004 We conclude that brief ischemia of remote preconditioning such as heart or liver protects gastric mucosa against severe ischemia-reperfusion-induced gastric lesions as effectively as local preconditioning of the stomach itself via the mechanism involving prostaglandin derived from cyclooxygenase-1 and cyclooxygenase-2 and the activation of sensory nerves releasing calcitonin gene-related peptide (CGRP) combined with the suppression of interleukin-1beta and TNF-alpha expression and release. Prostaglandins 255-268 interleukin 1 beta Homo sapiens 439-456 15621371-10 2005 These results indicate that TNFalpha and IL-1beta induce the functional expression of COX-2 but not EP receptors in DRG cells in culture and suggest that cytokine-induced sensitization of sensory neurons is secondary to prostaglandin production and not alterations in EP receptors. Prostaglandins 220-233 interleukin 1 beta Homo sapiens 41-49 15298980-10 2004 hCG inhibits IL-1beta-induced PG level. Prostaglandins 30-32 interleukin 1 beta Homo sapiens 13-21 15295712-3 2004 Measurement of the resulting prostanoids indicated that amphotericin B and IL-1 beta acted synergistically to increase the ability of endothelial cells to synthesize prostanoids from endogenous and exogenous substrate and to increase expression of cyclooxygenase-2. Prostaglandins 29-40 interleukin 1 beta Homo sapiens 75-84 15295712-3 2004 Measurement of the resulting prostanoids indicated that amphotericin B and IL-1 beta acted synergistically to increase the ability of endothelial cells to synthesize prostanoids from endogenous and exogenous substrate and to increase expression of cyclooxygenase-2. Prostaglandins 166-177 interleukin 1 beta Homo sapiens 75-84 15067222-1 2004 Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways. Prostaglandins 91-104 interleukin 1 beta Homo sapiens 0-17 15067222-1 2004 Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways. Prostaglandins 91-104 interleukin 1 beta Homo sapiens 19-27 15067222-1 2004 Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways. Prostaglandins 106-108 interleukin 1 beta Homo sapiens 0-17 15067222-1 2004 Interleukin-1beta (IL-1beta) has been recognized as a potent stimulus for the synthesis of prostaglandin (PG), which has been implicated in inflammatory responses of the airways. Prostaglandins 106-108 interleukin 1 beta Homo sapiens 19-27 12788874-0 2003 Interleukin-1 beta stimulates progesterone production by in vitro human luteal cells: evidence of a mediatory role of prostaglandins. Prostaglandins 118-132 interleukin 1 beta Homo sapiens 0-18 14670842-9 2004 These results show that BK, IL-1beta, and TGF-beta1 downregulate adenylyl cyclase in human pulmonary artery smooth muscle cells via COX-2 induction and prostanoid release. Prostaglandins 152-162 interleukin 1 beta Homo sapiens 28-36 12855693-3 2003 This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release. Prostaglandins 84-94 interleukin 1 beta Homo sapiens 120-137 12855693-3 2003 This study also demonstrates that two well established activators of AA release and prostanoid synthesis, the cytokine, interleukin-1beta (IL-1beta), and the calcium ionophore, A23187, induce an increase in C-1-P levels within the relevant time-frame of AA release. Prostaglandins 84-94 interleukin 1 beta Homo sapiens 139-147 12967678-3 2003 Both untreated and IL-1beta-treated HUVEC were exposed to various NOS inhibitors and NO donors in short-term (1 or 3 hours) experiments, and the effects on prostanoid production were evaluated through the measurement of prostaglandins (PG) I2, E2 and F2alpha released in the incubation medium. Prostaglandins 156-166 interleukin 1 beta Homo sapiens 19-27 12967678-6 2003 Pharmacological levels of NO, obtained with various NO donors, inhibit basal and IL-1beta-stimulated PG release. Prostaglandins 101-103 interleukin 1 beta Homo sapiens 81-89 12788874-5 2003 Treatment with the human IL-1 receptor antagonist was associated with a decrease in both basal and IL-1 beta-stimulated PG production. Prostaglandins 120-122 interleukin 1 beta Homo sapiens 99-108 12788874-3 2003 We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release. Prostaglandins 38-51 interleukin 1 beta Homo sapiens 70-79 12788874-3 2003 We observed a significant increase in prostaglandin (PG)release after IL-1 beta treatment; the cytokine was more effective on PGE(2) than PGF(2 alpha) release. Prostaglandins 53-55 interleukin 1 beta Homo sapiens 70-79 12141945-1 2002 Initial experiments in the present study investigated the effects of epidermal growth factor (EGF), interleukin 1beta (IL-1beta) and sodium nitroprusside (a nitric oxide donor) on the output of prostaglandins from guinea-pig uterus on day 7 of the oestrous cycle. Prostaglandins 194-208 interleukin 1 beta Homo sapiens 100-117 12639911-1 2003 Prostaglandins (PG) mediate IL-1beta regulation of several interleukin mRNAs in progenitor Leydig cells. Prostaglandins 0-14 interleukin 1 beta Homo sapiens 28-36 12193665-0 2002 COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells. Prostaglandins 64-74 interleukin 1 beta Homo sapiens 43-52 12193665-5 2002 Basal and IL-1 beta-stimulated COX activities were inhibited by NS-398, indicating substantial COX-2 contribution to endothelial prostanoid synthesis in neonatal human brain cortex and cerebellum at rest and when mimicking the inflammatory conditions. Prostaglandins 129-139 interleukin 1 beta Homo sapiens 10-19 12193665-9 2002 Altogether, these data indicate that both COX-1 and COX-2 contribute to endothelial prostanoid synthesis in the neonatal human brain under basal conditions and in response to proinflammatory cytokine IL-1 beta. Prostaglandins 84-94 interleukin 1 beta Homo sapiens 200-209 12141945-1 2002 Initial experiments in the present study investigated the effects of epidermal growth factor (EGF), interleukin 1beta (IL-1beta) and sodium nitroprusside (a nitric oxide donor) on the output of prostaglandins from guinea-pig uterus on day 7 of the oestrous cycle. Prostaglandins 194-208 interleukin 1 beta Homo sapiens 119-127 11732737-1 2001 Interleukin-1 beta (IL-1beta) is a potent bone-resorptive cytokine that also mediates soft-tissue destruction by stimulating prostaglandin production and inducing collagenase and other protease activity. Prostaglandins 125-138 interleukin 1 beta Homo sapiens 0-18 12021045-1 2002 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis. Prostaglandins 91-93 interleukin 1 beta Homo sapiens 19-27 12021045-1 2002 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis. Prostaglandins 189-191 interleukin 1 beta Homo sapiens 0-17 12021045-1 2002 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis. Prostaglandins 189-191 interleukin 1 beta Homo sapiens 19-27 11717138-5 2001 In contrast, inhibition of prostaglandin biosynthesis with a series of distinct inhibitors suggests that the ability of IL-1beta to upregulate ovarian PGS-2 transcripts is due, if only in part, to the generation of endogenous prostaglandin estradiol-17beta (E(2)). Prostaglandins 27-40 interleukin 1 beta Homo sapiens 120-128 11527948-12 2001 Pretreatment of RPE cells with a NF-kappa B inhibitor, PDTC, resulted in dose-dependent decrease in IL-1 beta-induced COX-2 gene expression and PG production. Prostaglandins 144-146 interleukin 1 beta Homo sapiens 100-109 12021045-1 2002 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis. Prostaglandins 76-89 interleukin 1 beta Homo sapiens 0-17 12021045-1 2002 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis. Prostaglandins 76-89 interleukin 1 beta Homo sapiens 19-27 12021045-1 2002 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin (PG) output by up-regulating the expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in PG synthesis. Prostaglandins 91-93 interleukin 1 beta Homo sapiens 0-17 11732737-1 2001 Interleukin-1 beta (IL-1beta) is a potent bone-resorptive cytokine that also mediates soft-tissue destruction by stimulating prostaglandin production and inducing collagenase and other protease activity. Prostaglandins 125-138 interleukin 1 beta Homo sapiens 20-28 11525777-11 2001 Plasma obtained from the blood was tested for its ability to inhibit prostanoid formation in interleukin-1beta-treated A549 cells (cyclooxygenase-2 system) and human washed platelets (cyclooxygenase-1 system). Prostaglandins 69-79 interleukin 1 beta Homo sapiens 93-110 10976994-10 2000 Comparison of the signaling pathways required for 0.33 Hz PIS and IL-1beta-induced membrane hyperpolarization shows that both involve the phospholipase C/inositol triphosphate pathway, protein kinase C (PKC), and prostaglandin synthesis. Prostaglandins 213-226 interleukin 1 beta Homo sapiens 66-74 11000287-7 2000 Analysis of DC supernatants after treatment with PG demonstrated significantly higher amounts of the proinflammatory cytokines IL-1 beta, IL-6, TNF-alpha, and IL-12. Prostaglandins 49-51 interleukin 1 beta Homo sapiens 127-136 11453112-6 2001 Control and lipid-treated cultures were exposed to human recombinant interleukin-1beta for 48 h and prostaglandin secretion from interleukin-1beta-treated fibroblasts was compared with control and lipid-treated fibroblasts without interleukin-1beta treatment. Prostaglandins 100-113 interleukin 1 beta Homo sapiens 129-146 11453112-6 2001 Control and lipid-treated cultures were exposed to human recombinant interleukin-1beta for 48 h and prostaglandin secretion from interleukin-1beta-treated fibroblasts was compared with control and lipid-treated fibroblasts without interleukin-1beta treatment. Prostaglandins 100-113 interleukin 1 beta Homo sapiens 129-146 11453112-7 2001 These experiments demonstrated that P. gingivalis lipids or calculus-tooth lipids potentiate interleukin-1beta-mediated prostaglandin secretory responses from gingival fibroblasts. Prostaglandins 120-133 interleukin 1 beta Homo sapiens 93-110 11260714-4 2001 The major inducer of central Cox-2 upregulation is interleukin-1beta in the CNS, and as basal phospholipase A2 activity in the CNS does not change with peripheral inflammation, Cox-2 levels must regulate central prostanoid production. Prostaglandins 212-222 interleukin 1 beta Homo sapiens 51-68 11260714-6 2001 Thus, preventing central prostanoid production by inhibiting the interleukin-1beta-mediated induction of Cox-2 in neurons or by inhibiting central Cox-2 activity reduces centrally generated inflammatory pain hypersensitivity. Prostaglandins 25-35 interleukin 1 beta Homo sapiens 65-82 10896792-1 2000 We investigated the molecular mechanisms by which treatment of the human osteoblast-like cell line MG-63 with interleukin 1beta (IL-1) and/or fibroblast growth factor 1 (FGF-1) elicited prostaglandin biosynthesis. Prostaglandins 186-199 interleukin 1 beta Homo sapiens 110-127 10999850-6 2000 Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398. Prostaglandins 393-404 interleukin 1 beta Homo sapiens 92-109 10999850-6 2000 Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398. Prostaglandins 393-404 interleukin 1 beta Homo sapiens 111-119 10999850-6 2000 Cultured myometrial cells expressed low levels of Cox-2 mRNA under baseline conditions, but interleukin-1beta (IL-1beta) caused a 17-fold induction of expression of the Cox-2 transcript after incubation for 6 h. IL-1beta also induced expression of biologically active Cox-2 protein, as detected by immunofluorescence, Western blot analysis, and measuring the conversion of arachidonic acid to prostanoids in the presence and absence of a Cox-2-selective inhibitor, NS-398. Prostaglandins 393-404 interleukin 1 beta Homo sapiens 212-220 10896792-1 2000 We investigated the molecular mechanisms by which treatment of the human osteoblast-like cell line MG-63 with interleukin 1beta (IL-1) and/or fibroblast growth factor 1 (FGF-1) elicited prostaglandin biosynthesis. Prostaglandins 186-199 interleukin 1 beta Homo sapiens 129-133 10731036-2 2000 We reported previously that IL-1beta induced a prostanoid-dependent increase in the density of bradykinin B2 receptors in cultured human bronchial smooth muscle cells. Prostaglandins 47-57 interleukin 1 beta Homo sapiens 28-36 10825375-2 2000 Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour. Prostaglandins 121-134 interleukin 1 beta Homo sapiens 16-34 10825375-2 2000 Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour. Prostaglandins 121-134 interleukin 1 beta Homo sapiens 36-44 10825375-2 2000 Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour. Prostaglandins 203-216 interleukin 1 beta Homo sapiens 16-34 10825375-2 2000 Cytokines, e.g. interleukin 1 beta (IL-1beta), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour. Prostaglandins 203-216 interleukin 1 beta Homo sapiens 36-44 11219391-5 2000 Tumour necrosis factor (TNF) reportedly plays a pivotal role in the pathogenesis o RA, especially its ability to regulate interleukin (IL)-1beta expression, this being important for the induction of prostanoid and matrix metalloproteinase production by synovial fibroblasts and chondrocytes. Prostaglandins 199-209 interleukin 1 beta Homo sapiens 122-144 10681439-0 2000 IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma. Prostaglandins 61-74 interleukin 1 beta Homo sapiens 0-4 10765972-2 2000 Treatment of trophoblast cells in primary culture with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) resulted in decreased prostaglandin metabolizing activity. Prostaglandins 150-163 interleukin 1 beta Homo sapiens 55-72 10724331-1 2000 Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature. Prostaglandins 77-90 interleukin 1 beta Homo sapiens 0-17 10724331-1 2000 Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature. Prostaglandins 77-90 interleukin 1 beta Homo sapiens 19-23 10724331-1 2000 Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature. Prostaglandins 204-214 interleukin 1 beta Homo sapiens 0-17 10724331-1 2000 Interleukin-1beta (IL-1) is a potent inducer of cyclooxygenase-2 (COX-2) and prostaglandin biosynthesis in many types of cells, yet little is known about the molecular mechanisms regulating IL-1 mediated prostanoid biosynthesis in the endothelium of the microvasculature. Prostaglandins 204-214 interleukin 1 beta Homo sapiens 19-23 10651950-7 2000 Combinations of TGF-beta1 with IL-1beta also increased PGE2 output and caused appropriate changes in prostaglandin pathway enzymes, whereas TGF-beta1 and IL-1alpha had more limited effects. Prostaglandins 101-114 interleukin 1 beta Homo sapiens 31-39 10765972-2 2000 Treatment of trophoblast cells in primary culture with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) resulted in decreased prostaglandin metabolizing activity. Prostaglandins 150-163 interleukin 1 beta Homo sapiens 74-82 10765973-1 2000 We have determined that prostaglandin H synthase-2 localises strongly to the nuclear membrane as well as being found in the endoplasmic reticulum in human amnion-derived WISH cells which have been stimulated with interleukin 1beta and phorbol ester. Prostaglandins 24-37 interleukin 1 beta Homo sapiens 213-230 10564178-8 1999 We have previously reported that the IL-1beta effect on beta-adrenergic responsiveness is mediated through cyclooxygenase-2 expression and prostanoid formation. Prostaglandins 139-149 interleukin 1 beta Homo sapiens 37-45 10564179-1 1999 We have previously reported that interleukin (IL)-1beta causes beta-adrenergic hyporesponsiveness in cultured human airway smooth muscle cells by increasing cyclooxygenase-2 (COX-2) expression and prostanoid formation. Prostaglandins 197-207 interleukin 1 beta Homo sapiens 33-55 10523409-17 1999 Induction of COX-2 by IL-1beta in HMSMCs provides support for the hypothesis that autocrine prostaglandin signalling in the myometrium, initiated by elevated intrauterine cytokine concentrations, plays a role in regulating myometrial contractility during labour. Prostaglandins 92-105 interleukin 1 beta Homo sapiens 22-30 10499376-6 1999 In conclusion, our results show that interleukin-1beta pre-treatment is able to potentiate the contractions of isolated human small bronchi provoked by [Sar9,Met(O2)11]substance P both by increasing prostanoid synthesis and by inducing a cyclooxygenase-2 pathway. Prostaglandins 199-209 interleukin 1 beta Homo sapiens 37-54 10209072-3 1999 In this study, the authors compared the effect of CRF on IL-1alpha- and IL-1beta-induced PG synthesis. Prostaglandins 89-91 interleukin 1 beta Homo sapiens 72-80 9952427-10 1999 However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response. Prostaglandins 180-194 interleukin 1 beta Homo sapiens 38-42 9863663-3 1998 We have reported that IL-1beta induces cyclo-oxygenase-2 (COX-2) in human ASM cells and results in a marked increase in prostanoid generation with PGE2 and PGI2 as the major products. Prostaglandins 120-130 interleukin 1 beta Homo sapiens 22-30 10065757-0 1999 Interleukin-4 and interferon-gamma inhibit prostaglandin production by interleukin-1beta-stimulated human periodontal ligament fibroblasts. Prostaglandins 43-56 interleukin 1 beta Homo sapiens 71-88 10065947-0 1999 Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts. Prostaglandins 72-85 interleukin 1 beta Homo sapiens 100-149 10065947-2 1999 In this study, the effects and interactions between IL-1beta and TNFalpha on prostaglandin production and its regulation were investigated. Prostaglandins 77-90 interleukin 1 beta Homo sapiens 52-60 9834469-9 1998 These results suggest that IL-1ra has partial agonist properties when used together with IL-1alpha and IL-1beta in fetal membranes by increasing cPLA2 protein levels, which leads to an increase in the production of prostaglandins. Prostaglandins 215-229 interleukin 1 beta Homo sapiens 103-111 10065947-11 1999 The study indicates that the synergistic stimulation of prostaglandin production by IL-1beta, and TNFalpha is mediated partly at the level of COX-2 and partly at the level of PLA2 and that PKC is involved in the signal transduction of the synergy between the two cytokines. Prostaglandins 56-69 interleukin 1 beta Homo sapiens 84-92 9863663-10 1998 Our study demonstrates that COX-2 induction and the consequent release of prostanoids plays a crucial role in IL-1beta induced attenuation of human ASM cell cyclic AMP response to ISO. Prostaglandins 74-85 interleukin 1 beta Homo sapiens 110-118 9863663-4 1998 We investigated the role of COX-2 induction and prostanoid release (measured as PGE2) in IL-1beta induced attenuation of cyclic AMP generation in response to the beta-adrenoceptor agonist isoprenaline (ISO). Prostaglandins 48-58 interleukin 1 beta Homo sapiens 89-97 9763540-4 1998 After stimulation with interleukin-1beta, tumor necrosis factor-alpha, interferon-gamma, and bacterial lipopolysaccharide, both venous and arterial SMC expressed COX-2 protein and released increased amounts of prostaglandins. Prostaglandins 210-224 interleukin 1 beta Homo sapiens 23-69 9859867-5 1998 Levels of prostaglandin metabolites were generally decreased following incubation with IL-1beta or LPS, which is consistent with a decrease in the activity of 15-hydroxyprostaglandin dehydrogenase (PGDH). Prostaglandins 10-23 interleukin 1 beta Homo sapiens 87-95 9859867-6 1998 It is concluded that IL-1beta and LPS moderately decrease the metabolism of prostaglandins, which may contribute to increasing the local levels of active prostaglandins induced by these stimuli. Prostaglandins 76-90 interleukin 1 beta Homo sapiens 21-29 9859867-6 1998 It is concluded that IL-1beta and LPS moderately decrease the metabolism of prostaglandins, which may contribute to increasing the local levels of active prostaglandins induced by these stimuli. Prostaglandins 154-168 interleukin 1 beta Homo sapiens 21-29 9780320-1 1998 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin output by cultures of human amnion cells. Prostaglandins 76-89 interleukin 1 beta Homo sapiens 0-17 9780320-1 1998 Interleukin-1beta (IL-1beta) has been shown in numerous studies to increase prostaglandin output by cultures of human amnion cells. Prostaglandins 76-89 interleukin 1 beta Homo sapiens 19-27 9797107-11 1998 CONCLUSION(S): Induction of COX-2 by IL-1beta and PMA suggests that COX-2 and prostaglandin have important roles in the growth and differentiation of endometrial stromal cells. Prostaglandins 78-91 interleukin 1 beta Homo sapiens 37-45 9721692-6 1998 PGF2alpha was the main prostanoid released into the medium during exposure to IL-1beta, whereas when HUVECs treated with IL-1beta were stimulated with histamine or exogenous AA, PGE2 was released in a higher quantity than PGF2alpha. Prostaglandins 23-33 interleukin 1 beta Homo sapiens 78-86 9743373-0 1998 Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms. Prostaglandins 147-160 interleukin 1 beta Homo sapiens 129-138 9728043-0 1998 Prostanoids mediate IL-1beta-induced beta-adrenergic hyporesponsiveness in human airway smooth muscle cells. Prostaglandins 0-11 interleukin 1 beta Homo sapiens 20-28 9728043-2 1998 The purpose of this study was to determine whether prostanoids released as a result of cyclooxygenase-2 (COX-2) induction by IL-1beta contribute to this effect of the cytokine. Prostaglandins 51-62 interleukin 1 beta Homo sapiens 125-133 9728043-13 1998 In summary, our results indicate that IL-1beta significantly increases prostanoid release by HASM cells as a result of increased COX-2 expression. Prostaglandins 71-81 interleukin 1 beta Homo sapiens 38-46 9562240-0 1998 An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis. Prostaglandins 60-73 interleukin 1 beta Homo sapiens 34-51 9614202-5 1998 These effects of IL-1beta were largely inhibited by indomethacin, suggesting the involvement of a prostanoid pathway in IL-1beta transduction process. Prostaglandins 98-108 interleukin 1 beta Homo sapiens 17-25 9614202-5 1998 These effects of IL-1beta were largely inhibited by indomethacin, suggesting the involvement of a prostanoid pathway in IL-1beta transduction process. Prostaglandins 98-108 interleukin 1 beta Homo sapiens 120-128 9575890-0 1998 IGF-I and insulin amplify IL-1 beta-induced nitric oxide and prostaglandin biosynthesis. Prostaglandins 61-74 interleukin 1 beta Homo sapiens 26-35 9645680-0 1998 The intracerebroventricular injection of interleukin-1beta blunts the testosterone response to human chorionic gonadotropin: role of prostaglandin- and adrenergic-dependent pathways. Prostaglandins 133-146 interleukin 1 beta Homo sapiens 41-58 9758210-1 1998 Interleukin-1beta (IL-1beta) and tumor necrosis factor (TNF alpha) induce prostanoid biosynthesis in vascular smooth muscle cells by promoting cyclooxygenase (COX) expression, but little is known about the biosynthesis of lipoxygenase (LPO) metabolites. Prostaglandins 74-84 interleukin 1 beta Homo sapiens 0-17 9758210-1 1998 Interleukin-1beta (IL-1beta) and tumor necrosis factor (TNF alpha) induce prostanoid biosynthesis in vascular smooth muscle cells by promoting cyclooxygenase (COX) expression, but little is known about the biosynthesis of lipoxygenase (LPO) metabolites. Prostaglandins 74-84 interleukin 1 beta Homo sapiens 19-27 9839700-8 1998 These data suggest that the synergistic effect of BK and IL-1 beta on prostanoid biosynthesis is not due to interactions at the receptor level nor to enhanced release of arachidonic acid, but may be due to increased activity of cyclo-oxygenase. Prostaglandins 70-80 interleukin 1 beta Homo sapiens 57-66 9836494-8 1998 Interleukin-1beta and lipopolysaccharide stimulated the formation of all prostanoids compared with untreated cells, but failed to stimulate leukotriene B4. Prostaglandins 73-84 interleukin 1 beta Homo sapiens 0-17 9548183-1 1998 Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues. Prostaglandins 164-177 interleukin 1 beta Homo sapiens 35-52 9548183-1 1998 Elevated uterine concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour-necrosis factor-alpha (TNF-alpha) are suspected to cause increased prostaglandin release from gestational tissues, but little information is available about the expression pattern of cytokine receptors in these tissues. Prostaglandins 164-177 interleukin 1 beta Homo sapiens 54-62 9327757-7 1997 Inclusion of interleukin-1 beta in the culture medium increased the release of prostanoids by the saphenous vein but not by the internal mammary artery. Prostaglandins 79-90 interleukin 1 beta Homo sapiens 13-31 9927229-3 1998 The purpose of this study was to determine the relative contributions of COX-1 and COX-2 in the production of prostanoids by human intestinal smooth muscle (HISM) cells when stimulated by interleukin-1beta (IL-1beta) and lipopolysaccharide (LPS). Prostaglandins 110-121 interleukin 1 beta Homo sapiens 188-205 9927229-3 1998 The purpose of this study was to determine the relative contributions of COX-1 and COX-2 in the production of prostanoids by human intestinal smooth muscle (HISM) cells when stimulated by interleukin-1beta (IL-1beta) and lipopolysaccharide (LPS). Prostaglandins 110-121 interleukin 1 beta Homo sapiens 207-215 9322624-6 1997 Interleukin-1 receptor antagonist inhibited interleukin-1 alpha- and interleukin-1 beta-induced prostaglandin formation, with 50% inhibitory concentration values of 30 ng/ml for prostaglandin E2 and 90 ng/ml for prostaglandin F2 alpha. Prostaglandins 96-109 interleukin 1 beta Homo sapiens 0-87 9266823-7 1997 We conclude that IL-1beta stimulates PG production via transcriptional activation of COX-2 and provide evidence that this may involve NF-kappaB. Prostaglandins 37-39 interleukin 1 beta Homo sapiens 17-25 9275047-9 1997 Further, IL-1beta-induced synthesis of prostanoids was blocked by a Cox-2-specific inhibitor, NS-398. Prostaglandins 39-50 interleukin 1 beta Homo sapiens 9-17 9179403-3 1997 IL-1 beta, TNF alpha and interferon-gamma (IFN gamma) are known to stimulate a number of cells to produce inflammatory mediators such as prostaglandins. Prostaglandins 137-151 interleukin 1 beta Homo sapiens 0-9 9179403-8 1997 IL-1 beta, but not TNF alpha or IFN gamma, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1 alpha, PGF2 alpha, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1 alpha as the principal products. Prostaglandins 116-126 interleukin 1 beta Homo sapiens 0-9 9179403-17 1997 This study demonstrates that human cultured ASM cells release prostanoids in response to IL-1 beta stimulation and that the response is mostly mediated by the induction of COX-2 rather than COX-1 isoenzyme, implying that airway smooth muscle may be an important source of prostaglandins in human airways and that COX-2 may play an important role in the regulation of the inflammatory process in asthma. Prostaglandins 62-73 interleukin 1 beta Homo sapiens 89-98 9093911-8 1997 However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production. Prostaglandins 37-39 interleukin 1 beta Homo sapiens 107-125 9093911-8 1997 However, the increased production of PGE2 resulting from TNF stimulation was blocked by the addition of an interleukin-1 beta (IL-1 beta) neutralizing antibody, suggesting that TNF regulation of hOB cell PG synthesis was secondary to its capacity to increase hOB cell IL-1 beta production. Prostaglandins 37-39 interleukin 1 beta Homo sapiens 127-136 9117018-1 1997 The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in cultured human bronchial smooth-muscle cells challenged with interleukin-1 beta (IL-1 beta). Prostaglandins 69-82 interleukin 1 beta Homo sapiens 157-175 9117018-1 1997 The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in cultured human bronchial smooth-muscle cells challenged with interleukin-1 beta (IL-1 beta). Prostaglandins 69-82 interleukin 1 beta Homo sapiens 177-186 9047011-0 1997 Interleukin-1 beta modulates prostaglandin and progesterone production by primate luteal cells in vitro. Prostaglandins 29-42 interleukin 1 beta Homo sapiens 0-18 9065483-9 1997 The activation of p38 MAPK may provide a crucial signaling mechanism, which mediates the up-regulation of PG synthesis and the down-regulation of NO biosynthesis induced by IL-1beta. Prostaglandins 106-108 interleukin 1 beta Homo sapiens 173-181 9065483-1 1997 The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells. Prostaglandins 173-187 interleukin 1 beta Homo sapiens 26-43 9065483-1 1997 The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells. Prostaglandins 173-187 interleukin 1 beta Homo sapiens 45-53 9065483-1 1997 The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells. Prostaglandins 189-192 interleukin 1 beta Homo sapiens 26-43 9065483-1 1997 The inflammatory cytokine interleukin 1beta (IL-1beta) induces both cyclooxygenase-2 (Cox-2) and the inducible nitric-oxide synthase (iNOS) with increases in the release of prostaglandins (PGs) and nitric oxide (NO) from glomerular mesangial cells. Prostaglandins 189-192 interleukin 1 beta Homo sapiens 45-53 9089670-8 1997 The inhibitory effect of hIL-1 beta was blocked by human recombinant IL-1 receptor antagonist (50 ng/ml), and by the cyclooxygenase inhibitor, diclofenac (1 mumol/l), suggesting that hIL-1 beta inhibited NA release through the formation of prostaglandins. Prostaglandins 240-254 interleukin 1 beta Homo sapiens 25-35 9047011-11 1997 In summary, these date suggest that IL-1 beta is a potentially important modulator of prostaglandin production by the primate corpus luteum. Prostaglandins 86-99 interleukin 1 beta Homo sapiens 36-45 8796776-6 1996 The results revealed that cultured myometrial cells produced prostaglandins in response to IL-1 beta, TNF-alpha, EGF, PMA, and ionomycin at all gestational ages tested at a significantly increased rate (P < 0.05 vs controls at and above 10 ng/ml of IL-1 beta, TNF alpha, and EGF; 1 microM for PMA, and 5 microM for ionomycin). Prostaglandins 61-75 interleukin 1 beta Homo sapiens 91-100 9124475-6 1997 These results suggest that the AV3V neurons alter their activity in response to the blood-borne IL-1beta, at least in part, through a local synthesis of prostanoids and then send the information to the mPOA and PVN. Prostaglandins 153-164 interleukin 1 beta Homo sapiens 96-104 9561147-0 1997 Differential effect of corticotropin releasing factor on interleukin-1 alpha and interleukin-1 beta-induced prostaglandin synthesis in endothelial cells and fibroblasts. Prostaglandins 108-121 interleukin 1 beta Homo sapiens 81-99 8982097-0 1996 Recombinant human interleukin 1 beta induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures. Prostaglandins 59-73 interleukin 1 beta Homo sapiens 18-36 8875957-0 1996 Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta. Prostaglandins 0-13 interleukin 1 beta Homo sapiens 155-172 8875957-5 1996 IL-1beta increased the formation of both 13-HODE and 9-HODE in a concentration-dependent manner with similar EC50 values as for prostanoid formation. Prostaglandins 128-138 interleukin 1 beta Homo sapiens 0-8 8875957-12 1996 These results indicate that prostaglandin H-synthase-2 is the enzyme responsible for the increase in the ability to form HODEs of dermal fibroblasts stimulated with IL-1beta. Prostaglandins 28-41 interleukin 1 beta Homo sapiens 165-173 8915021-7 1996 The study indicates that the stimulatory effect of IL-1beta on prostanoid formation (PGE2, PGI2) in human gingival fibroblasts was diminished in the presence of triclosan partly at the level of phospholipase A2 and partly at the level of cyclooxygenase. Prostaglandins 63-73 interleukin 1 beta Homo sapiens 51-59 8641202-0 1996 Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. Prostaglandins 147-160 interleukin 1 beta Homo sapiens 0-18 8891757-7 1996 In these cells, indomethacin and flurbiprofen abolished the effects of IL-1 beta and TNF-alpha on prostaglandin formation without affecting the inhibitory effects of the cytokines on osteocalcin biosynthesis. Prostaglandins 98-111 interleukin 1 beta Homo sapiens 71-80 7559890-8 1995 The ability of IL-1 to suppress PA activity and to produce PAI-1 persisted in the presence of indomethacin, a potent inhibitor of PG synthesis. Prostaglandins 130-132 interleukin 1 beta Homo sapiens 15-19 8623807-6 1996 RESULTS: Cultured human myometrial cells from patients with and without prior intrauterine infection produced prostaglandins in response to interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor at a significantly increased rate (p<0.05 vs controls at and above 10 ng/ml of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor). Prostaglandins 110-124 interleukin 1 beta Homo sapiens 140-187 8623807-6 1996 RESULTS: Cultured human myometrial cells from patients with and without prior intrauterine infection produced prostaglandins in response to interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor at a significantly increased rate (p<0.05 vs controls at and above 10 ng/ml of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor). Prostaglandins 110-124 interleukin 1 beta Homo sapiens 299-346 8543370-7 1995 The study indicates that the IL-1 beta induced PGE2 formation is mediated by an enhanced gene expression of COX-2 in gingival fibroblasts suggesting that the enzyme COX-2 may play an important role in the regulation of prostanoid formation at inflammatory lesions in gingival tissue. Prostaglandins 219-229 interleukin 1 beta Homo sapiens 29-38 8671241-6 1996 These cells are viable for at least 48 h in culture after the enrichment procedure, and produce prostaglandins after stimulation with interleukin-1 beta. Prostaglandins 96-110 interleukin 1 beta Homo sapiens 134-152 7559890-10 1995 The present findings suggest a pluripotent response of GLCs to IL-1, characterized by the induction of PAI-1 and the suppression of PA occurring concurrent with, but independent of, PG production. Prostaglandins 182-184 interleukin 1 beta Homo sapiens 63-67 7792388-5 1995 Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells. Prostaglandins 117-130 interleukin 1 beta Homo sapiens 87-105 7628398-6 1995 Finally, as expected, blockade of PG synthesis with ibuprofen totally abolished IL-1 beta-induced ACTH secretion; in addition, it prevented the interaction between L-NAME and the pituitary response. Prostaglandins 34-36 interleukin 1 beta Homo sapiens 80-89 7480804-9 1995 These data suggest that in WISH cells, IL-1 beta induces both translocation to the membrane and de novo synthesis of cPLA2 protein to sustain prostaglandin (PG) synthesis. Prostaglandins 142-155 interleukin 1 beta Homo sapiens 39-48 7480804-9 1995 These data suggest that in WISH cells, IL-1 beta induces both translocation to the membrane and de novo synthesis of cPLA2 protein to sustain prostaglandin (PG) synthesis. Prostaglandins 157-159 interleukin 1 beta Homo sapiens 39-48 7480804-11 1995 Our results provide a mechanism for the effect of IL-1 beta on prostaglandin synthesis in human amnion cells and provide support for a role of cPLA2 in the mechanism initiating human parturition. Prostaglandins 63-76 interleukin 1 beta Homo sapiens 50-59 8589264-10 1995 These results indicate that a prostaglandin-dependent increase in cAMP is important to in the lipolytic effects of IL-1 beta but that the anti-lipogenic effects of the cytokine are, at least in part, independent of PG synthesis. Prostaglandins 30-43 interleukin 1 beta Homo sapiens 115-124 7480798-0 1995 Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis. Prostaglandins 30-43 interleukin 1 beta Homo sapiens 0-18 7769093-5 1995 Studies on ET-1-induced intracellular signaling events in IL-1 beta-treated cells revealed that the failure of ET-1 to induce mitogenic responses was due to an increase in cAMP formation secondary to ET-1-induced activation of prostanoid metabolism. Prostaglandins 227-237 interleukin 1 beta Homo sapiens 58-67 7824084-10 1994 Indomethacin, an inhibitor of prostaglandin (PG) synthesis, has been shown to block both the induction of CRH secretion by IL-1 beta from hypothalamic explants, as well as the ACTH response to intravenous IL-1 beta. Prostaglandins 45-47 interleukin 1 beta Homo sapiens 123-132 7502507-4 1995 Liberation of cytokines (IL-1, IL-6, IL-8) stimulates prostanoid synthesis in the decidua and amnion, as well as migration of granulocytes into the cervix. Prostaglandins 54-64 interleukin 1 beta Homo sapiens 25-29 7892511-1 1994 The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in amnion-derived WISH cell cultures when stimulated by interleukin-1 beta (IL-1 beta). Prostaglandins 69-82 interleukin 1 beta Homo sapiens 149-167 7892511-1 1994 The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in amnion-derived WISH cell cultures when stimulated by interleukin-1 beta (IL-1 beta). Prostaglandins 69-82 interleukin 1 beta Homo sapiens 169-178 7824084-0 1994 Prostaglandins mediate the ACTH response to interleukin-1-beta instilled into the hypothalamic median eminence. Prostaglandins 0-14 interleukin 1 beta Homo sapiens 44-62 8077670-9 1994 However, this effect is not enough, in and of itself, to induce prostanoid synthesis; the concomitant induction by IL-1 of a PG-generating enzyme is also required. Prostaglandins 125-127 interleukin 1 beta Homo sapiens 115-119 8131416-9 1994 Our data suggest a role for immunoregulatory cytokines and prostanoids such as IL-1 beta and PGE2 in these interactions. Prostaglandins 59-70 interleukin 1 beta Homo sapiens 79-88 7996812-7 1994 Co-incubation of HPMC with PMo-S.epiCM in the presence of anti-IL-1 beta and/or anti-TNF-alpha antibody, interleukin-1 receptor antagonist or soluble TNF receptor (TNF p75) significantly reduced the capacity of these supernatants to stimulate prostaglandin synthesis. Prostaglandins 243-256 interleukin 1 beta Homo sapiens 63-72 8078306-3 1994 The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG). Prostaglandins 268-282 interleukin 1 beta Homo sapiens 69-87 8078306-3 1994 The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG). Prostaglandins 268-282 interleukin 1 beta Homo sapiens 89-98 8078306-3 1994 The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG). Prostaglandins 284-286 interleukin 1 beta Homo sapiens 69-87 8078306-3 1994 The aim of this study was to investigate the mode of action by which interleukin-1 beta (IL-1 beta) induced collagenase and stromelysin mRNA expression and synthesis in normal human synoviocytes and to explore mechanisms of suppression of these proteolytic enzymes by prostaglandins (PG). Prostaglandins 284-286 interleukin 1 beta Homo sapiens 89-98 8176221-10 1994 Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway. Prostaglandins 223-233 interleukin 1 beta Homo sapiens 34-38 8176221-10 1994 Finally, we demonstrated that the IL-1-mediated amplification of PGE2 release in response to BK was reduced by the presence of ethanol in the culture medium, suggesting that part of the synergistic action of IL-1 and BK on prostanoid production was dependent on the activation of the PC-specific PLD pathway. Prostaglandins 223-233 interleukin 1 beta Homo sapiens 208-219 8208752-0 1994 Regulation of intrauterine prostaglandin biosynthesis: interactions between protein kinase C and interleukin 1 beta. Prostaglandins 27-40 interleukin 1 beta Homo sapiens 97-115 8208752-2 1994 Interleukin-1 beta (IL-1 beta) can stimulate PG production by intrauterine tissues and may play a significant part in the mechanisms of preterm labor associated with intrauterine infection. Prostaglandins 45-47 interleukin 1 beta Homo sapiens 0-18 8208752-2 1994 Interleukin-1 beta (IL-1 beta) can stimulate PG production by intrauterine tissues and may play a significant part in the mechanisms of preterm labor associated with intrauterine infection. Prostaglandins 45-47 interleukin 1 beta Homo sapiens 20-29 7996812-2 1994 The present study examines the regulation of prostaglandin production by human peritoneal mesothelial cells (HPMC) following stimulation with peritoneal macrophage-conditioned medium and the cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). Prostaglandins 45-58 interleukin 1 beta Homo sapiens 221-230 7996812-3 1994 IL-1 beta and TNF-alpha stimulated significant release of prostaglandin above background levels in a time and dose dependent manner. Prostaglandins 58-71 interleukin 1 beta Homo sapiens 0-9 8195358-5 1994 Follicular fluid IL-1 beta might contribute to prostaglandin-induced oocyte maturation and ovulation. Prostaglandins 47-60 interleukin 1 beta Homo sapiens 17-26 9419743-1 1994 OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua. Prostaglandins 192-205 interleukin 1 beta Homo sapiens 139-157 9419743-1 1994 OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua. Prostaglandins 192-205 interleukin 1 beta Homo sapiens 159-168 9419743-1 1994 OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua. Prostaglandins 207-209 interleukin 1 beta Homo sapiens 139-157 9419743-1 1994 OBJECTIVE: The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua. Prostaglandins 207-209 interleukin 1 beta Homo sapiens 159-168 9419743-8 1994 CONCLUSIONS: Interleukin-1 beta and TNF alpha both act on decidual PG biosynthesis in a manner requiring new protein synthesis. Prostaglandins 67-69 interleukin 1 beta Homo sapiens 13-31 8311923-0 1993 Evidence for a common mechanism of action of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor on prostaglandin production in human chorion cells. Prostaglandins 125-138 interleukin 1 beta Homo sapiens 45-92 8190840-6 1994 In addition, IL-1 may activate brain endothelial cells to produce IL-1, IL-6, prostaglandins, etc., and secrete these substances into the brain. Prostaglandins 78-92 interleukin 1 beta Homo sapiens 13-17 8140125-7 1993 During a 10 day incubation period, stimulatory effects of IL-1 beta on PG synthesis were observed only on the first 2 days incubations. Prostaglandins 71-73 interleukin 1 beta Homo sapiens 58-67 8140125-9 1993 This study demonstrated that IL-1 beta stimulates PG synthesis in human ovarian granulosa cells in vitro. Prostaglandins 50-52 interleukin 1 beta Homo sapiens 29-38 8153084-0 1993 Mechanism of interleukin-1 beta stimulation of human amnion prostaglandin biosynthesis: mediation via a novel inducible cyclooxygenase. Prostaglandins 60-73 interleukin 1 beta Homo sapiens 13-31 7691182-1 1993 Interleukin 1 (IL-1) induces prostanoid biosynthesis in endothelial cells by promoting cyclooxygenase expression, but little is known about its activity on the biosynthesis of hydroxyeicosatetraenoic acids (HETEs). Prostaglandins 29-39 interleukin 1 beta Homo sapiens 15-19 7760523-7 1994 These results suggest that IL-1 acts via prostaglandins on the peripheral tissues to release catecholamines into the circulation. Prostaglandins 41-55 interleukin 1 beta Homo sapiens 27-31 8295979-2 1993 We considered that it might block interleukin-1 beta-stimulated prostaglandin production from human decidual cells. Prostaglandins 64-77 interleukin 1 beta Homo sapiens 34-52 8311923-1 1993 PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. Prostaglandins 35-49 interleukin 1 beta Homo sapiens 65-83 8311923-1 1993 PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. Prostaglandins 35-49 interleukin 1 beta Homo sapiens 85-94 8311923-1 1993 PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. Prostaglandins 35-48 interleukin 1 beta Homo sapiens 65-83 8311923-1 1993 PROBLEM: Although chorion produces prostaglandins in response to interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and epidermal growth factor (EGF), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. Prostaglandins 35-48 interleukin 1 beta Homo sapiens 85-94 1504741-14 1992 The results indicate that treatment with PHT results in upregulation of prostaglandin biosynthesis in gingival fibroblasts challenged with IL-1 or TNF alpha, at least partly due to enhanced level of phospholipase A2 activity. Prostaglandins 72-85 interleukin 1 beta Homo sapiens 139-143 8304239-4 1993 Regarding the synthesis of these prostaglandins, IL-1 beta was again more potent than IL-1 alpha. Prostaglandins 33-47 interleukin 1 beta Homo sapiens 49-58 8378543-6 1993 Taken together, these results indicate that IL-1 beta was a potent stimulator of the synthesis of prostaglandins by decidua and by amnion, whereas IL-1 alpha only stimulated the amnion. Prostaglandins 98-112 interleukin 1 beta Homo sapiens 44-53 8341137-8 1993 The results indicate that treatment with p-HPPH results in upregulation of prostaglandin synthesis in gingival fibroblasts challenged to IL-1 or TNF alpha at the level of phospholipase A2. Prostaglandins 75-88 interleukin 1 beta Homo sapiens 137-141 1438464-8 1992 In view of the interregulatory effects between prostanoids and macrophage cytokines in their production, these findings may indicate that the impaired release of PGI2 during peritonitis has allowed the macrophages to secrete more IL-1 beta after in vitro stimulation with LPS. Prostaglandins 47-58 interleukin 1 beta Homo sapiens 230-239 8218931-8 1993 The results demonstrate that EGF and IL-1 as well as EGF and TNF-alpha act in concert to enhance prostanoid formation in gingival fibroblasts. Prostaglandins 97-107 interleukin 1 beta Homo sapiens 37-41 1309558-0 1992 The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production. Prostaglandins 75-88 interleukin 1 beta Homo sapiens 48-52 1348040-2 1992 The present study examined the possibility that the mechanism underlying the protective effects of IL-1 in experimental nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy is related to effects on gastric acid secretion, on prostaglandin synthesis, and/or on neutrophil function. Prostaglandins 236-249 interleukin 1 beta Homo sapiens 99-103 1409001-6 1992 These results show that systemic hIL-1 beta-induced inhibition of gastric acid secretion is mediated through IL-1 receptors and prostaglandin pathways, and does not involves CRF receptors, afferent fibers, or changes in circulating gastrin or somatostatin levels. Prostaglandins 128-141 interleukin 1 beta Homo sapiens 33-43 1561233-2 1992 The aim of the present study is to investigate a potential interaction between interleukin-1 beta (IL-1) and bradykinin (BK) in the regulation of decidual PGF2 alpha production and PG precursor release. Prostaglandins 155-157 interleukin 1 beta Homo sapiens 79-97 1561233-2 1992 The aim of the present study is to investigate a potential interaction between interleukin-1 beta (IL-1) and bradykinin (BK) in the regulation of decidual PGF2 alpha production and PG precursor release. Prostaglandins 155-157 interleukin 1 beta Homo sapiens 99-103 1641502-0 1992 Interleukin-1 beta stimulates decidual stromal cell cyclo-oxygenase enzyme and prostaglandin production. Prostaglandins 79-92 interleukin 1 beta Homo sapiens 0-18 1641502-1 1992 The cytokine interleukin-1 (IL-1 beta) increased prostaglandin production by decidual stromal cells in culture in a time and dose dependent manner. Prostaglandins 49-62 interleukin 1 beta Homo sapiens 28-37 1641502-5 1992 A pre-incubation period of 72 hours was found to be necessary to observe the stimulatory effect of IL-1 beta on prostaglandin production, but this did not seem to be due to any change in the sensitivity of the cells to IL-1 beta; the increase in the number of cyclo-oxygenase positive cells was the same if IL-1 beta was added on day 1, day 2 or day 3 of culture, even though prostaglandin production was not stimulated on day 1 or day 2. Prostaglandins 112-125 interleukin 1 beta Homo sapiens 99-108 1641502-5 1992 A pre-incubation period of 72 hours was found to be necessary to observe the stimulatory effect of IL-1 beta on prostaglandin production, but this did not seem to be due to any change in the sensitivity of the cells to IL-1 beta; the increase in the number of cyclo-oxygenase positive cells was the same if IL-1 beta was added on day 1, day 2 or day 3 of culture, even though prostaglandin production was not stimulated on day 1 or day 2. Prostaglandins 376-389 interleukin 1 beta Homo sapiens 99-108 1946245-3 1991 In the present study we examined the effect of interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF), and endotoxin on prostaglandin production by chorion laeve cells. Prostaglandins 125-138 interleukin 1 beta Homo sapiens 47-65 1717702-4 1991 Depolarizing agents, interferon-gamma, glucocorticoid hormones, and prostaglandin synthesis inhibitors all diminish the induction of SP and PPT mRNA by IL-1. Prostaglandins 68-81 interleukin 1 beta Homo sapiens 152-156 1894750-1 1991 Interleukin 1 beta is a potent bone resorptive cytokine which also mediates soft tissue destruction through the stimulation of prostaglandin production, and the induction of collagenase and other proteases. Prostaglandins 127-140 interleukin 1 beta Homo sapiens 0-18 1946245-3 1991 In the present study we examined the effect of interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF), and endotoxin on prostaglandin production by chorion laeve cells. Prostaglandins 125-138 interleukin 1 beta Homo sapiens 67-76 1903934-6 1991 To determine whether IL-1-induced prostaglandin release influences proline uptake, indomethacin (14 microM) was added as a cyclo-oxygenase inhibitor. Prostaglandins 34-47 interleukin 1 beta Homo sapiens 21-25 1903934-9 1991 This suggests that the inhibitory effect of IL-1 on proline uptake by skin fibroblast does not only involve the prostaglandins that accumulate in the medium, but no firm conclusion can be drawn, due to the fact that the inhibition by the two agents was not statistically independent. Prostaglandins 112-126 interleukin 1 beta Homo sapiens 44-48 1857723-5 1991 In all experiments interleukin 1 beta consistently induced a stimulation of prostaglandin production that greatly exceeded that caused by any bacterial product. Prostaglandins 76-89 interleukin 1 beta Homo sapiens 19-37 1888884-3 1991 However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta. Prostaglandins 245-259 interleukin 1 beta Homo sapiens 9-18 1888884-3 1991 However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta. Prostaglandins 245-259 interleukin 1 beta Homo sapiens 173-182 1888884-3 1991 However, IL-1 beta-induced 45Ca release was only partially inhibited by blocking the PGE2 response with indomethacin, suggesting that enhanced PGE2 formation in response to IL-1 beta is not necessary to obtain a bone resorptive effect, but that prostaglandins potentiate the action of IL-1 beta. Prostaglandins 245-259 interleukin 1 beta Homo sapiens 173-182 1888884-7 1991 These data indicate that (1) IL-1 beta-induced stimulation of bone resorption is dissociable from IL-1 beta-induced increase of prostanoid biosynthesis and (2) the epitope of the IL-1 beta molecule involved in the immunostimulatory effects may be different from that involved in the stimulatory effects on bone resorption. Prostaglandins 128-138 interleukin 1 beta Homo sapiens 98-107 1888884-7 1991 These data indicate that (1) IL-1 beta-induced stimulation of bone resorption is dissociable from IL-1 beta-induced increase of prostanoid biosynthesis and (2) the epitope of the IL-1 beta molecule involved in the immunostimulatory effects may be different from that involved in the stimulatory effects on bone resorption. Prostaglandins 128-138 interleukin 1 beta Homo sapiens 98-107 1900463-5 1991 The results make a role for endogenous prostaglandins and leukotrienes in the regulation of monocyte IL-1 beta and TNF-alpha production unlikely. Prostaglandins 39-53 interleukin 1 beta Homo sapiens 101-110 3109443-5 1987 The elevation in plasminogen activator activity was inhibited by indomethacin, and this suggests that endogenous prostanoids are important in the IL-1-mediated stimulation of proteinase activity. Prostaglandins 113-124 interleukin 1 beta Homo sapiens 146-150 2125218-6 1990 These data suggest that IL-1 may suppress in vivo insulin release at least in part through the mediation of prostaglandin synthesis in the absence of adrenal glands. Prostaglandins 108-121 interleukin 1 beta Homo sapiens 24-28 2121579-10 1990 These results show that IC interleukin-1 beta acts centrally to induce a long-lasting inhibition of gastric acid secretion, and this effect requires the integrity of prostaglandin pathways. Prostaglandins 166-179 interleukin 1 beta Homo sapiens 27-45 2171341-4 1990 The addition of indomethacin, a prostaglandin synthesis inhibitor, partially reversed the effect of interleukin-1 beta. Prostaglandins 32-45 interleukin 1 beta Homo sapiens 100-118 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Prostaglandins 66-76 interleukin 1 beta Homo sapiens 47-56 2107353-7 1990 However, when PDGF-BB or -AB was combined with IL-1 beta or IL-6, prostanoid generation by HMC was synergistically increased up to 222-fold (IL-1 beta) or 12-fold (IL-6) above the control values, with the induction of PGE2 greater than 6-keto-PGF1 alpha greater than PGF2 alpha much greater than TXB2. Prostaglandins 66-76 interleukin 1 beta Homo sapiens 141-150 2847761-2 1988 Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated radiolabel in a time-dependent and dose-dependent manner, with labeled prostaglandins representing 29% of the released radiolabel. Prostaglandins 227-241 interleukin 1 beta Homo sapiens 102-120 3119705-15 1987 Enhanced prostaglandin synthesis may play a role in the IL-1- and TNF-induced suppression of accessory cell function, but other factors are likely to be involved. Prostaglandins 9-22 interleukin 1 beta Homo sapiens 56-60 3495574-3 1987 We characterized the effects on PG production by confluent normal lung fibroblasts of recombinant interleukin 1 alpha (IL 1 alpha), interleukin 1 beta (IL 1 beta) and tumor necrosis factor (TNF), alone and in combination. Prostaglandins 32-34 interleukin 1 beta Homo sapiens 132-150 2390678-16 1990 The different potencies of IL-l alpha and IL-1 beta may be related to their relative ability to stimulate prostanoid biosynthesis. Prostaglandins 106-116 interleukin 1 beta Homo sapiens 42-51 2107353-4 1990 Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (IL-1 beta) or up to fourfold (TNF alpha) increases of prostanoid release. Prostaglandins 168-178 interleukin 1 beta Homo sapiens 17-35 2107353-4 1990 Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (IL-1 beta) or up to fourfold (TNF alpha) increases of prostanoid release. Prostaglandins 168-178 interleukin 1 beta Homo sapiens 37-46 2107353-4 1990 Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold (IL-1 beta) or up to fourfold (TNF alpha) increases of prostanoid release. Prostaglandins 168-178 interleukin 1 beta Homo sapiens 114-123 2298922-10 1990 These data demonstrate that pretreatment with IL-1 beta 24 h before the induction of colitis reduces inflammation by a mechanism that requires prostaglandin synthesis. Prostaglandins 143-156 interleukin 1 beta Homo sapiens 46-55 2075374-2 1990 With relevance to rheumatoid arthritis (RA) IL-1 augments release of prostanoids, proteinases and oxygen metabolites and is a potent inducer of bone and cartilage resorption. Prostaglandins 69-80 interleukin 1 beta Homo sapiens 44-48 2503605-1 1989 The induction of prostaglandin (PG) biosynthesis by human recombinant interleukin-1 beta (hrIL-1 beta) has been investigated using rat-isolated stomach strip preparations. Prostaglandins 17-30 interleukin 1 beta Homo sapiens 70-88 2503605-1 1989 The induction of prostaglandin (PG) biosynthesis by human recombinant interleukin-1 beta (hrIL-1 beta) has been investigated using rat-isolated stomach strip preparations. Prostaglandins 32-34 interleukin 1 beta Homo sapiens 70-88 3263855-3 1988 Blockage of the prostaglandin synthesis by indomethacin reduced the basal level of IL-1 beta mRNA in control cultures and decreased also the stimulatory effect exerted by both IL-1s on IL-1 beta gene expression. Prostaglandins 16-29 interleukin 1 beta Homo sapiens 83-92 3263855-3 1988 Blockage of the prostaglandin synthesis by indomethacin reduced the basal level of IL-1 beta mRNA in control cultures and decreased also the stimulatory effect exerted by both IL-1s on IL-1 beta gene expression. Prostaglandins 16-29 interleukin 1 beta Homo sapiens 185-194 3263855-4 1988 These data suggest that IL-1 and prostaglandin (mainly PGE2) may act synergistically to stimulate IL-1 gene expression in dermal fibroblasts, contributing as a local amplifier system to the alterations of connective tissue in inflammatory processes. Prostaglandins 33-46 interleukin 1 beta Homo sapiens 98-102 3034257-3 1987 Interleukin 1 beta or phorbol ester increased the levels of procollagenase (assayed after trypsin activation) and the labeling of several medium proteins by cells incubated with [35S]methionine, independent of prostaglandin synthesis. Prostaglandins 210-223 interleukin 1 beta Homo sapiens 0-18 30661603-1 2019 IL-1beta stimulates expression of prostaglandin (PG)-synthesizing enzymes cyclooxygenase (COX)-2 and aldo-keto reductase (AKR)1B1 in human preadipocytes. Prostaglandins 34-52 interleukin 1 beta Homo sapiens 0-8 3021848-1 1986 The effect of prostaglandins and cyclic 3",5"-adenosine monophosphate (cAMP) on expression of human interleukin 1 (IL 1) activity was investigated in the promonocytic tumor cell line U937 and peripheral blood monocytes. Prostaglandins 14-28 interleukin 1 beta Homo sapiens 100-119 3485152-6 1986 Recombinant IL 1 is capable of stimulating T cell and fibroblast proliferation and inducing fibroblast collagenase and prostaglandin production, thus proving that a single molecule has many of the activities previously ascribed to only partially purified IL 1 preparations. Prostaglandins 119-132 interleukin 1 beta Homo sapiens 12-16 30340925-12 2018 Moreover, TNF-alpha, IL-1 and IL-6 can induce the production of other cytokines, matrix metalloproteinases (MMPs) and prostaglandins and inhibit the synthesis of proteoglycans and type II collagen; thus, they play a pivotal role in cartilage matrix degradation and bone resorption in OA. Prostaglandins 118-132 interleukin 1 beta Homo sapiens 21-25 27612965-3 2016 We detected cyclooxygenase-2 (COX-2)-dependent production of both proinflammatory and proresolving prostaglandins (PGs) in conditioned culture medium from HLFs treated with a proinflammatory stimulus, IL-1beta. Prostaglandins 115-118 interleukin 1 beta Homo sapiens 201-209 28651331-1 2017 The proinflammatory cytokine interleukin-1beta (IL-1beta) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis in granulosa cells. Prostaglandins 142-155 interleukin 1 beta Homo sapiens 29-46 28651331-1 2017 The proinflammatory cytokine interleukin-1beta (IL-1beta) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis in granulosa cells. Prostaglandins 142-155 interleukin 1 beta Homo sapiens 48-56 28820025-4 2018 We examined interleukin (IL)-1beta regulation of the expression of PR-A, PR-B, and genes governing prostaglandin synthesis in human cervical fibroblasts (HCFs). Prostaglandins 99-112 interleukin 1 beta Homo sapiens 12-34 28820025-11 2018 Blockade of prostaglandin synthesis (indomethacin) prevented both the IL-1beta-induced increase in PR mRNA and the acute decrease in PR-A and PR-B protein, implicating a role for prostaglandins in regulating PR expression in HCFs. Prostaglandins 12-25 interleukin 1 beta Homo sapiens 70-78 28820025-11 2018 Blockade of prostaglandin synthesis (indomethacin) prevented both the IL-1beta-induced increase in PR mRNA and the acute decrease in PR-A and PR-B protein, implicating a role for prostaglandins in regulating PR expression in HCFs. Prostaglandins 179-193 interleukin 1 beta Homo sapiens 70-78 29358306-6 2018 In human primary myometrial cells transfected with PARK7 siRNA (siPARK7), there was a significant decrease in IL1B, TNF, fsl-1 and poly(I:C)-induced expression of pro-inflammatory cytokine IL6, chemokines (CXCL8, CCL2), adhesion molecule ICAM1, prostaglandin PGF2alpha and its receptor PTGFR. Prostaglandins 245-258 interleukin 1 beta Homo sapiens 110-114 28887458-3 2017 Interleukin(IL)-1beta treatment markedly induced prostaglandin biosynthesis in diseased compared to healthy tendon cells, and up regulated the formation of several pro-resolving mediators including 15-epi-LXA4 and MaR1. Prostaglandins 49-62 interleukin 1 beta Homo sapiens 0-21 27780541-7 2016 Silencing ATF3 significantly increased IL-1beta- or fsl-1-induced expression of pro-inflammatory cytokines (TNF-alpha, IL-1alpha, IL-1beta, IL-6) and chemokines (IL-8 and monocyte chemoattractant protein-1 (MCP-1)); cyclooxygenase-2 (COX-2) mRNA expression and prostaglandin PGF2alpha release; and MMP-9 expression. Prostaglandins 261-274 interleukin 1 beta Homo sapiens 39-47 27650753-5 2016 Here we found that zofenoprilat, in a CSE/H2S-mediated manner, abolished all the inflammatory features induced by interlukin-1beta (IL-1beta) in human umbilical vein endothelial cells (HUVEC), especially the NF-kappaB/cyclooxygenase-2 (COX-2)/prostanoid biochemical pathway. Prostaglandins 243-253 interleukin 1 beta Homo sapiens 132-140 26674566-9 2016 IL1B-, fsl-1-, and poly (I:C)-induced PTGS2 mRNA expression and IL1B-induced prostaglandin release was also decreased by IRF1 silencing. Prostaglandins 77-90 interleukin 1 beta Homo sapiens 64-68 27344616-8 2016 The stimulating and inhibitory effects of TGF-beta were reproduced in IL-1beta-stimulated PG production. Prostaglandins 90-92 interleukin 1 beta Homo sapiens 70-78 27372869-4 2016 IL-1beta was found to stimulate the secretion of antidiuretic hormone (ADH) from the posterior pituitary gland either by action of prostaglandins or indirectly by causing the release of IL-6. Prostaglandins 131-145 interleukin 1 beta Homo sapiens 0-8 26811545-7 2016 Knockdown of RAF1 by siRNA in primary myometrial cells significantly decreased IL1B- and TNF-induced IL1A, IL1B, IL6, (C-X-C motif) ligand 8 (CXCL8)and chemokine (C-C motif) ligand 2 (CCL2) mRNA abundance and IL6, IL8 and CCL2; prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA levels and prostaglandin PGF2 alpha release; and NF-kappaB activation. Prostaglandins 228-241 interleukin 1 beta Homo sapiens 79-83 26140661-4 2015 KEY RESULTS: In dHUVEC treated with IL-1beta, the expression of COX-2 mRNA and protein was enhanced and generation of prostanoids increased (the most abundant was the promitogenic PGF2alpha ). Prostaglandins 118-129 interleukin 1 beta Homo sapiens 36-44 26492523-2 2016 IL-1beta stimulates cyclooxygenase-2 (COX-2) and prostaglandins production of pulp cells and affects the pulpal inflammation and repair. Prostaglandins 49-63 interleukin 1 beta Homo sapiens 0-8 26407807-7 2015 Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle. Prostaglandins 260-273 interleukin 1 beta Homo sapiens 122-130 25687411-7 2015 KLF5 silencing in myometrial cells significantly decreased IL1beta-induced cytokine expression (IL6 and IL8 mRNA expression and release), COX2 mRNA expression, and subsequent release of prostaglandins PGE2 and PGF2 alpha. Prostaglandins 186-200 interleukin 1 beta Homo sapiens 59-66 25656973-9 2015 IL-1beta also induced COX-2 mRNA expression and prostaglandin release. Prostaglandins 48-61 interleukin 1 beta Homo sapiens 0-8 24647791-2 2015 IL-1beta stimulates cyclooxygenase-2 (COX-2) expression and prostanoid production of pulp cells and affects the inflammatory and healing processes of the dental pulp. Prostaglandins 60-70 interleukin 1 beta Homo sapiens 0-8 24501112-5 2014 METHODS: Prostanoids produced by human oral keratinocytes (HOK) stimulated with IL-1beta were measured by enzyme immunoassay. Prostaglandins 9-20 interleukin 1 beta Homo sapiens 80-88 24248185-11 2014 IL-1beta, IL-6, and TNF-alpha stimulated the expression of UAPs and output of PGs in USMCs. Prostaglandins 78-81 interleukin 1 beta Homo sapiens 0-8 29123689-1 2015 Background: We have reported that administration of recombinant human interleukin (IL)-1beta induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VO2) on oxygen delivery (DO2). Prostaglandins 172-185 interleukin 1 beta Homo sapiens 70-92 24726893-2 2014 We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and prostaglandin responses to the inflammatory cytokine interleukin-1beta (IL-1beta). Prostaglandins 154-167 interleukin 1 beta Homo sapiens 226-234