PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17469457-1 2007 BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Prostaglandins 12-26 interleukin 10 Homo sapiens 108-122 20825427-10 2010 Respectively, the production of IL-10 and IFN-gamma was inversely associated with prostaglandin induction before birth. Prostaglandins 82-95 interleukin 10 Homo sapiens 32-37 20825427-12 2010 The production of IL-10 and IFN-gamma was also inversely associated with prostaglandin labour induction before birth. Prostaglandins 73-86 interleukin 10 Homo sapiens 18-23 17894798-4 2008 IL-10 is a key regulator of immune and inflammatory responses, and previous studies have suggested that prostaglandins effect their immunosuppressive functions in part by stimulation of IL-10 production. Prostaglandins 104-118 interleukin 10 Homo sapiens 0-5 17894798-4 2008 IL-10 is a key regulator of immune and inflammatory responses, and previous studies have suggested that prostaglandins effect their immunosuppressive functions in part by stimulation of IL-10 production. Prostaglandins 104-118 interleukin 10 Homo sapiens 186-191 17505022-11 2007 Thus, activated M1, unlike alternatively activated M2, mononuclear phagocytes express mPGES-1, and IL-4, IL-13, and IL-10 tune expression of this key enzyme in prostanoid metabolism. Prostaglandins 160-170 interleukin 10 Homo sapiens 116-121 16364008-0 2006 Evidence for interleukin-10-mediated inhibition of cyclo- oxygenase-2 expression and prostaglandin production in preterm human placenta. Prostaglandins 85-98 interleukin 10 Homo sapiens 13-27 15219461-6 2004 In contrast, anti-IL-10 up-regulates prostanoid production by LPS-stimulated BM-DC. Prostaglandins 37-47 interleukin 10 Homo sapiens 18-23 16164015-5 2005 IL-10 induced the expression of prostaglandin dehydrogenase (PGDH), the major catabolic enzyme involved in prostaglandin degradation. Prostaglandins 32-45 interleukin 10 Homo sapiens 0-5 15219461-7 2004 Taken together, our results show that in response to PGE(2), BM-DC produce IL-10, which in turn down-regulates their own production of IL-6-, TNF-alpha-, and COX-2-derived prostanoids, and plays crucial roles in determining the BM-DC pro-inflammatory phenotype. Prostaglandins 172-183 interleukin 10 Homo sapiens 75-80 14764680-11 2004 Collectively, IL-10 and IL-4 use novel regulatory mechanisms for CD40-induced prostanoid synthesis in monocytes, thus suggesting a potential role for these cytokines in regulating T cell-induced inflammatory responses, including autoimmune diseases. Prostaglandins 78-88 interleukin 10 Homo sapiens 14-19 14984594-8 2004 When DC were activated with LPS in the presence of nimesulide, a COX-2 selective inhibitor, IL-10 synthesis was inhibited, indicating that endogenous prostaglandins regulate DC cytokine production. Prostaglandins 150-164 interleukin 10 Homo sapiens 92-97 14764680-0 2004 Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes. Prostaglandins 44-54 interleukin 10 Homo sapiens 77-82 12096032-10 2002 Taken together, these results suggest that both ERK and p38(MAPK) pathways are involved in LPS-induced COX-2 expression and PGE(2) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down-regulating the activation of p38(MAPK). Prostaglandins 196-206 interleukin 10 Homo sapiens 162-167 12496393-9 2003 Taken together, our results suggest links between DC cyclooxygenase and 5-LO pathways during the inflammatory response, and FLAP is a key target for the PG-induced IL-10-suppressive effects. Prostaglandins 153-155 interleukin 10 Homo sapiens 164-169 12496393-0 2003 Prostaglandins inhibit 5-lipoxygenase-activating protein expression and leukotriene B4 production from dendritic cells via an IL-10-dependent mechanism. Prostaglandins 0-14 interleukin 10 Homo sapiens 126-131 12173196-1 2002 BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin (IL) 6 and IL-10. Prostaglandins 12-26 interleukin 10 Homo sapiens 113-118 12034038-7 2002 Prostaglandin (PGE) and other cAMP agonists had subset-specific effects on IL-10 production opposite to IFN-beta. Prostaglandins 0-13 interleukin 10 Homo sapiens 75-80 7780157-1 1995 Both interleukin-10 (IL-10) and IL-4 inhibited the prostanoid synthesis of lipopolysaccharide (LPS)-stimulated human monocytes, and their inhibition was shown to be based on a common mechanism to suppress the gene expression of inducible cyclooxygenase (COX). Prostaglandins 51-61 interleukin 10 Homo sapiens 5-19 9587398-0 1998 Role of IL-10 in the crossregulation of prostaglandins and cytokines in monocytes. Prostaglandins 40-54 interleukin 10 Homo sapiens 8-13 9587398-1 1998 In the present study we have focused mainly on the role of IL (interleukin)-10 in the crossregulation of prostaglandins and cytokines in human monocytes. Prostaglandins 105-119 interleukin 10 Homo sapiens 59-78 9394829-4 1997 Neutralizing anti-IL-10 antibodies plus indomethacin restored IL-12 secretion in the presence of IC to a high extent, indicating that IL-10 and prostaglandin (PG) partially mediate the IC-induced inhibition of IL-12 secretion. Prostaglandins 144-157 interleukin 10 Homo sapiens 18-23 16764118-7 1996 The majority of these substances (TNFalpha, IL-1, IL-2, IL-3, IL-6) can stimulate the prostaglandin-biosynthesis by intrauterine tissues (amnion, chorion, decidua), some of them have antiinflammatory effects (IL-10, transforming growth factor alpha). Prostaglandins 86-99 interleukin 10 Homo sapiens 209-214 10646483-2 1999 The anti-inflammatory cytokines interleukin 10 (IL-10), which reverses the cartilage degradation induced by antigen-stimulated mononuclear cells, and IL-4, which reduces prostaglandin production by synoviocytes, are currently being tested for their clinical efficacy. Prostaglandins 170-183 interleukin 10 Homo sapiens 32-46 10646483-2 1999 The anti-inflammatory cytokines interleukin 10 (IL-10), which reverses the cartilage degradation induced by antigen-stimulated mononuclear cells, and IL-4, which reduces prostaglandin production by synoviocytes, are currently being tested for their clinical efficacy. Prostaglandins 170-183 interleukin 10 Homo sapiens 48-53 9250693-2 1997 The reason for the presence of these prostaglandins is now becoming apparent with the demonstration of powerful effects of PGE and 19-hydroxy PGE on the balance of cytokines (stimulating IL-10 and inhibiting IL-12) released by antigen presenting cells. Prostaglandins 37-51 interleukin 10 Homo sapiens 187-192 9057644-2 1997 In this study, we investigate the effects of the anti-inflammatory cytokines, interleukin-10 (IL-10) and IL-4, on prostanoid synthesis in human neutrophils. Prostaglandins 114-124 interleukin 10 Homo sapiens 78-92 9057644-2 1997 In this study, we investigate the effects of the anti-inflammatory cytokines, interleukin-10 (IL-10) and IL-4, on prostanoid synthesis in human neutrophils. Prostaglandins 114-124 interleukin 10 Homo sapiens 94-99 7780157-1 1995 Both interleukin-10 (IL-10) and IL-4 inhibited the prostanoid synthesis of lipopolysaccharide (LPS)-stimulated human monocytes, and their inhibition was shown to be based on a common mechanism to suppress the gene expression of inducible cyclooxygenase (COX). Prostaglandins 51-61 interleukin 10 Homo sapiens 21-26 23382072-0 2013 MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop. Prostaglandins 49-62 interleukin 10 Homo sapiens 81-95 8063757-9 1994 Attenuation of PGHS-2 by IL-10 was accompanied by decreased prostaglandin production, including PGE2. Prostaglandins 60-73 interleukin 10 Homo sapiens 25-30 8063757-10 1994 The decrease in prostaglandin production was primarily related to the effect of IL-10 on PGHS-2, since the release of arachidonic acid was unaffected by this cytokine. Prostaglandins 16-29 interleukin 10 Homo sapiens 80-85 32710971-3 2020 Here, we reveal 6-bromoindirubin-3"-glycerol-oxime ether (6BIGOE) as highly potent derivative able to inhibit pro-inflammatory cytokine, chemokine and prostaglandin (PG) release in human primary monocytes while increasing anti-inflammatory interleukin (IL)-10 levels. Prostaglandins 166-168 interleukin 10 Homo sapiens 240-259 22680926-9 2012 Tumor immune escape can be diminished by targeting various immunosuppressive mechanisms used by different tumors, such as tumor production of immunosuppressive cytokines (e.g., interleukin 10, and Transforming Growth Factor-beta, which can promote activity of immunosuppressive regulatory T cells), or by inhibiting production of inflammatory prostanoids with combined cyclooxygenase/lipoxygenase inhibitors. Prostaglandins 343-354 interleukin 10 Homo sapiens 177-191