PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25450232-2 2015 Current dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by 15-hydroxyprostaglandin dehydrogenase (15PGDH). Prostaglandins 51-65 carbonyl reductase 1 Homo sapiens 99-136 25450232-2 2015 Current dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by 15-hydroxyprostaglandin dehydrogenase (15PGDH). Prostaglandins 51-65 carbonyl reductase 1 Homo sapiens 138-144 23247010-1 2013 Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Prostaglandins 184-198 carbonyl reductase 1 Homo sapiens 10-30 25773924-12 2014 Taken together, these findings suggest that 15 d-PGJ2 induces the expression of 15-PGDH through ROS-mediated activation of ERK1/2 and subsequently Elk-1 in the MDA-MB-231 cells, which may contribute to tumor suppressive activity of this cyclopentenone prostaglandin. Prostaglandins 252-265 carbonyl reductase 1 Homo sapiens 80-87 23717544-1 2013 BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids. Prostaglandins 182-193 carbonyl reductase 1 Homo sapiens 12-49 23717544-1 2013 BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids. Prostaglandins 182-193 carbonyl reductase 1 Homo sapiens 51-58 24838973-1 2014 HPGDand SLCO2A1 genes encode components of the prostaglandin catabolic pathway, with HPGD encoding the degradative enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and SLCO2A1 encoding the prostaglandin transporter PGT that brings substrate to 15-PGDH. Prostaglandins 47-60 carbonyl reductase 1 Homo sapiens 251-258 23247010-1 2013 Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Prostaglandins 184-198 carbonyl reductase 1 Homo sapiens 32-36 23247010-1 2013 Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Prostaglandins 184-198 carbonyl reductase 1 Homo sapiens 38-45 22553128-2 2012 We previously described deficiency of the prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) as a cause of this condition, implicating elevated circulating prostaglandin E(2) (PGE(2)) as causative of PHO, and perhaps also as the principal mediator of secondary HO. Prostaglandins 42-55 carbonyl reductase 1 Homo sapiens 73-110 22553128-2 2012 We previously described deficiency of the prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) as a cause of this condition, implicating elevated circulating prostaglandin E(2) (PGE(2)) as causative of PHO, and perhaps also as the principal mediator of secondary HO. Prostaglandins 42-55 carbonyl reductase 1 Homo sapiens 112-116 22213326-5 2012 The current study aimed to evaluate the expression of prostaglandin-metabolising enzymes COX-2 and 15-hydroxyprostaglandin-dehydrogenase (15-PGDH) along with the vitamin D receptor (VDR) in benign and malignant breast and ovarian tissues. Prostaglandins 54-67 carbonyl reductase 1 Homo sapiens 99-136 22213326-5 2012 The current study aimed to evaluate the expression of prostaglandin-metabolising enzymes COX-2 and 15-hydroxyprostaglandin-dehydrogenase (15-PGDH) along with the vitamin D receptor (VDR) in benign and malignant breast and ovarian tissues. Prostaglandins 54-67 carbonyl reductase 1 Homo sapiens 138-145 21763448-4 2011 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), a key prostaglandin catabolic enzyme, was recently shown to be a tumor suppressor. Prostaglandins 10-23 carbonyl reductase 1 Homo sapiens 39-46 22020925-1 2011 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a key prostaglandin catabolic enzyme catalyzing the oxidation and inactivation of prostaglandin E(2) (PGE(2)) synthesized from the cyclooxygenase (COX) pathway. Prostaglandins 10-23 carbonyl reductase 1 Homo sapiens 39-46 21426412-2 2011 Homozygous and compound heterozygous germline mutations in the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene encoding the major prostaglandin PGE2 catabolizing enzyme have been recently described in familial PHO cases. Prostaglandins 73-86 carbonyl reductase 1 Homo sapiens 102-106 20304053-3 2010 In order to gain further insight into the prostaglandin (PG)- and vitamin D-metabolism in ovarian carcinomas, the study aimed to evaluate the expression of the PG metabolising enzymes COX-2 and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) compared to the vitamin D receptor (VDR) in benign and malignant ovarian tissues. Prostaglandins 160-162 carbonyl reductase 1 Homo sapiens 233-240 21735612-0 2010 Potent and selective inhibitors of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. Prostaglandins 193-207 carbonyl reductase 1 Homo sapiens 52-89 21735612-0 2010 Potent and selective inhibitors of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. Prostaglandins 193-207 carbonyl reductase 1 Homo sapiens 97-134 21735612-0 2010 Potent and selective inhibitors of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. Prostaglandins 193-207 carbonyl reductase 1 Homo sapiens 136-143 21178489-4 2011 This study suggests that ERG activation plays a role in prostaglandin signaling because knockdown of ERG expression in TMPRSS2-ERG fusion containing CaP cells leads to altered levels of the 15-hydroxy-prostaglandin dehydrogenase (HPGD), a tumor suppressor and prostaglandin catabolizing enzyme, and prostaglandin E2 (PGE2) . Prostaglandins 56-69 carbonyl reductase 1 Homo sapiens 190-228 21178489-4 2011 This study suggests that ERG activation plays a role in prostaglandin signaling because knockdown of ERG expression in TMPRSS2-ERG fusion containing CaP cells leads to altered levels of the 15-hydroxy-prostaglandin dehydrogenase (HPGD), a tumor suppressor and prostaglandin catabolizing enzyme, and prostaglandin E2 (PGE2) . Prostaglandins 56-69 carbonyl reductase 1 Homo sapiens 230-234 21072165-1 2010 BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. Prostaglandins 116-130 carbonyl reductase 1 Homo sapiens 12-49 21072165-1 2010 BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. Prostaglandins 116-130 carbonyl reductase 1 Homo sapiens 51-58 20615530-5 2010 Among several enzymes involved in the prostaglandin synthesis pathway tested in the present study PGF(2alpha) synthase (PTGFS) and prostaglandin 9-ketoreductase (CBR1), which convert PGE(2) to PGF(2alpha), expression were significantly down-regulated in the oviducts on Day 1 after seminal plasma infusion into the uterine horns. Prostaglandins 38-51 carbonyl reductase 1 Homo sapiens 131-160 20615530-5 2010 Among several enzymes involved in the prostaglandin synthesis pathway tested in the present study PGF(2alpha) synthase (PTGFS) and prostaglandin 9-ketoreductase (CBR1), which convert PGE(2) to PGF(2alpha), expression were significantly down-regulated in the oviducts on Day 1 after seminal plasma infusion into the uterine horns. Prostaglandins 38-51 carbonyl reductase 1 Homo sapiens 162-166 20304053-7 2010 We detected significantly higher expressions of the PG metabolising enzymes 15-PGDH and COX-2 in malignant tissue and PGE2 serum levels were 2-fold higher in tumour patients. Prostaglandins 52-54 carbonyl reductase 1 Homo sapiens 76-83 19034772-2 2008 NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme involved in prostaglandin (including PGE(2)) bio-inactivation, is down-expressed in several epithelial malignancies including CRC. Prostaglandins 27-40 carbonyl reductase 1 Homo sapiens 56-63 19501039-2 2009 15-Hydroxyprostaglandin dehyrogenase (15-PGDH), a key prostaglandin catabolic enzyme, was recently shown to be a tumor suppressor. Prostaglandins 10-23 carbonyl reductase 1 Homo sapiens 38-45 19108014-2 2008 However, little is known about the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the biological inactivation of PG, in gastric carcinomas. Prostaglandins 91-93 carbonyl reductase 1 Homo sapiens 49-86 18639206-2 2008 Prostaglandin output is regulated by the synthetic and metabolic enzymes, prostaglandin synthase type 2 (PTGS2) and 15-hydroxyprostaglandin dehydrogenase (PGDH). Prostaglandins 0-13 carbonyl reductase 1 Homo sapiens 116-153 18757412-3 2008 Here, we report that NSAIDs may inhibit the growth of glioblastoma multiforme (GBM) cells through COX-2-independent mechanisms, including up-regulation of both 15-hydroxyprostaglandin dehydrogenase (15-PGDH, the key prostaglandin catabolic enzyme) and the cell cycle inhibitor p21. Prostaglandins 170-183 carbonyl reductase 1 Homo sapiens 199-206 19667157-4 2009 First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 on the expression of COX-2 and 15-PGDH. Prostaglandins 61-74 carbonyl reductase 1 Homo sapiens 151-158 18826943-1 2008 Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics. Prostaglandins 198-212 carbonyl reductase 1 Homo sapiens 6-26 18826943-1 2008 Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics. Prostaglandins 198-212 carbonyl reductase 1 Homo sapiens 28-33 18493841-3 2008 Human CBR1 (hCBR1) is known as prostaglandin 9-keto reductase and 15-hydroxy dehydrogenase, and regulates the metastasis of cancer cells through the regulation of prostaglandin metabolism. Prostaglandins 31-44 carbonyl reductase 1 Homo sapiens 6-10 18493841-3 2008 Human CBR1 (hCBR1) is known as prostaglandin 9-keto reductase and 15-hydroxy dehydrogenase, and regulates the metastasis of cancer cells through the regulation of prostaglandin metabolism. Prostaglandins 31-44 carbonyl reductase 1 Homo sapiens 12-17 17636240-2 2007 15-Hydroxyprostaglandin dehydrogenase (PGDH), localized primarily to chorion trophoblasts, is the key enzyme responsible for the metabolism of prostaglandins. Prostaglandins 143-157 carbonyl reductase 1 Homo sapiens 0-37 18325997-5 2008 Both CRH and UCNI antibodies significantly decreased mRNA and protein expression of synthetic enzymes cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX)-2 and increased mRNA and protein expression of 15-hydroxyprostaglandin dehydrogenase (PGDH), the key enzyme of PG metabolism. Prostaglandins 248-250 carbonyl reductase 1 Homo sapiens 209-246 17546626-3 2007 On the other hand, 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which is involved in the degradation pathway of PG including PGE(2,) thus counteracting the activities of COX-2 and PGES, was found to be downregulated in human epithelial tumors, indicating a tumor suppressor activity of this enzyme. Prostaglandins 62-64 carbonyl reductase 1 Homo sapiens 19-57 18212353-2 2008 The enzymes responsible for PG synthesis and metabolism are prostaglandin-endoperoxide synthase 2 (PTGS2) and 15-hydroxyprostaglandin dehydrogenase (PGDH). Prostaglandins 28-30 carbonyl reductase 1 Homo sapiens 110-147 17481556-1 2007 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-linked oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and is the key enzyme responsible for the biological inactivation of these eicosanoids. Prostaglandins 110-124 carbonyl reductase 1 Homo sapiens 0-37 17481556-1 2007 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-linked oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and is the key enzyme responsible for the biological inactivation of these eicosanoids. Prostaglandins 110-124 carbonyl reductase 1 Homo sapiens 39-46 16533162-1 2006 NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15(S)-hydroxyl group of prostaglandins and lipoxins resulting in the formation of 15-keto metabolites which exhibit greatly reduced biological activities. Prostaglandins 113-127 carbonyl reductase 1 Homo sapiens 14-51 17182827-2 2007 Calcitriol inhibits the PG pathway in PCa cells in 3 separate ways: by decreasing cyclooxygenase-2 (COX-2) expression, stimulating 15-hydroxyprostaglandin dehydrogenase (15-PGDH) expression, and decreasing EP (PGE2) and FP (PGF(2alpha)) receptors. Prostaglandins 24-26 carbonyl reductase 1 Homo sapiens 170-177 16880406-1 2006 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Prostaglandins 10-23 carbonyl reductase 1 Homo sapiens 39-46 16880406-2 2006 Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and acts in the colon as a required physiologic antagonist of the prostaglandin-synthesizing activity of the cyclooxygenase 2 (COX-2) oncogene. Prostaglandins 181-194 carbonyl reductase 1 Homo sapiens 28-35 16885386-2 2006 Little is known about the role of the key prostaglandin catabolic enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in breast cancer pathogenesis. Prostaglandins 42-55 carbonyl reductase 1 Homo sapiens 73-110 16885386-2 2006 Little is known about the role of the key prostaglandin catabolic enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in breast cancer pathogenesis. Prostaglandins 42-55 carbonyl reductase 1 Homo sapiens 112-119 16631754-6 2006 These studies have also presented compelling evidence for a direct link, through the expression of the prostaglandin degrading enzyme 15-PGDH, between early apocrine lesions and pure apocrine carcinomas. Prostaglandins 103-116 carbonyl reductase 1 Homo sapiens 134-141 16828555-1 2006 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic pathways of prostaglandins and lipoxins. Prostaglandins 184-198 carbonyl reductase 1 Homo sapiens 54-61 16997128-3 2006 We reported that in tumoral TT cell, indomethacin, in vivo and in vitro, decreases proliferation and increases activity of 15-hydroxyprostaglandin-dehydrogenase (15-PGDH), the PG catabolism key enzyme. Prostaglandins 165-167 carbonyl reductase 1 Homo sapiens 123-160 16533162-1 2006 NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15(S)-hydroxyl group of prostaglandins and lipoxins resulting in the formation of 15-keto metabolites which exhibit greatly reduced biological activities. Prostaglandins 113-127 carbonyl reductase 1 Homo sapiens 53-60 16533162-8 2006 Apparently, 15-PGDH works with cyclooxygenase-2 to control the cellular levels of prostaglandins. Prostaglandins 82-96 carbonyl reductase 1 Homo sapiens 12-19 14718596-2 2004 Ureteral obstruction is associated with increased prostanoid synthesis via cyclooxygenase induction; however, prostaglandin degradation mediated by 15-hydroxyprostaglandin dehydrogenase (PGDH) has not been evaluated in the ureter. Prostaglandins 110-123 carbonyl reductase 1 Homo sapiens 148-185 15581601-1 2005 NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic pathways of prostaglandins and lipoxins, and is believed to be the key enzyme responsible for the biological inactivation of these biologically potent eicosanoids. Prostaglandins 186-200 carbonyl reductase 1 Homo sapiens 56-63 15531523-1 2004 The prostaglandin (PG)-inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH) is highly expressed in the chorion leave. Prostaglandins 4-17 carbonyl reductase 1 Homo sapiens 43-80 15531523-1 2004 The prostaglandin (PG)-inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH) is highly expressed in the chorion leave. Prostaglandins 19-21 carbonyl reductase 1 Homo sapiens 43-80 16140963-5 2005 Calcitriol also up-regulated the expression of 15-hydroxyprostaglandin dehydrogenase, the enzyme initiating PG catabolism. Prostaglandins 108-110 carbonyl reductase 1 Homo sapiens 47-84 16103446-1 2005 Carbonyl reductase (CBR) is a cytosolic NADPH-dependent oxidoreductase metabolizing prostaglandins, steroids, quinines, and anthracycline antibiotics. Prostaglandins 84-98 carbonyl reductase 1 Homo sapiens 0-18 16103446-1 2005 Carbonyl reductase (CBR) is a cytosolic NADPH-dependent oxidoreductase metabolizing prostaglandins, steroids, quinines, and anthracycline antibiotics. Prostaglandins 84-98 carbonyl reductase 1 Homo sapiens 20-23 15574495-2 2004 We report that, in addition to inducing expression of COX-2, colon cancers further target the prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2. Prostaglandins 94-107 carbonyl reductase 1 Homo sapiens 168-205 15574495-2 2004 We report that, in addition to inducing expression of COX-2, colon cancers further target the prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2. Prostaglandins 94-107 carbonyl reductase 1 Homo sapiens 207-214 15574495-2 2004 We report that, in addition to inducing expression of COX-2, colon cancers further target the prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2. Prostaglandins 178-191 carbonyl reductase 1 Homo sapiens 207-214 14749354-1 2004 The nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and participates along with cyclooxygenases and lipoxygenases in controlling the cellular levels of prostaglandins and lipoxins. Prostaglandins 148-162 carbonyl reductase 1 Homo sapiens 48-85 14749354-1 2004 The nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and participates along with cyclooxygenases and lipoxygenases in controlling the cellular levels of prostaglandins and lipoxins. Prostaglandins 148-162 carbonyl reductase 1 Homo sapiens 87-94 14749354-1 2004 The nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and participates along with cyclooxygenases and lipoxygenases in controlling the cellular levels of prostaglandins and lipoxins. Prostaglandins 276-290 carbonyl reductase 1 Homo sapiens 48-85 14749354-1 2004 The nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and participates along with cyclooxygenases and lipoxygenases in controlling the cellular levels of prostaglandins and lipoxins. Prostaglandins 276-290 carbonyl reductase 1 Homo sapiens 87-94 12468268-1 2002 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-dependent oxidation of 15(S)-hydroxyl group of prostaglandins and has been considered a key enzyme involved in biological inactivation of prostaglandins. Prostaglandins 112-126 carbonyl reductase 1 Homo sapiens 0-37 12468268-1 2002 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-dependent oxidation of 15(S)-hydroxyl group of prostaglandins and has been considered a key enzyme involved in biological inactivation of prostaglandins. Prostaglandins 112-126 carbonyl reductase 1 Homo sapiens 39-46 12468268-1 2002 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-dependent oxidation of 15(S)-hydroxyl group of prostaglandins and has been considered a key enzyme involved in biological inactivation of prostaglandins. Prostaglandins 203-217 carbonyl reductase 1 Homo sapiens 0-37 12468268-1 2002 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-dependent oxidation of 15(S)-hydroxyl group of prostaglandins and has been considered a key enzyme involved in biological inactivation of prostaglandins. Prostaglandins 203-217 carbonyl reductase 1 Homo sapiens 39-46 11447235-9 2001 Human 15-hydroxyprostaglandin dehydrogenase, the enzyme responsible for the initial step in PG inactivation in vivo, oxidized both PGE(2)-G and PGE(2)-EA less efficiently than the free acid. Prostaglandins 92-94 carbonyl reductase 1 Homo sapiens 6-43 11688989-2 2001 These autacoids are rapidly inactivated by specific enzymes such as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and 15-oxoprostaglandin 13-reductase/leukotriene B(4) 12-hydroxydehydrogenase (PGR/LTB(4)DH) that act on main series of eicosanoids (i.e., leukotrienes, prostaglandins), and recently found to act in lipoxin inactivation. Prostaglandins 269-283 carbonyl reductase 1 Homo sapiens 68-105 11688989-2 2001 These autacoids are rapidly inactivated by specific enzymes such as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and 15-oxoprostaglandin 13-reductase/leukotriene B(4) 12-hydroxydehydrogenase (PGR/LTB(4)DH) that act on main series of eicosanoids (i.e., leukotrienes, prostaglandins), and recently found to act in lipoxin inactivation. Prostaglandins 269-283 carbonyl reductase 1 Homo sapiens 107-114 10837478-2 2000 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) and 15-oxoprostaglandin 13-reductase, also termed leukotriene B(4) 12-hydroxydehydrogenase (PGR/LTB(4)DH), are two enzymatic activities appreciated for their roles in the metabolism of prostaglandins and LTB(4). Prostaglandins 233-247 carbonyl reductase 1 Homo sapiens 0-37 11702189-3 2001 Prostaglandins play a key role during in vitro human fetal lung development and are synthesised by prostaglandin H synthase-1 (PGHS-1) and inactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH) with formation of inactive 13,14-dihydro-15-keto-prostaglandins. Prostaglandins 0-14 carbonyl reductase 1 Homo sapiens 154-191 11352223-3 2001 It was recently suggested that the decreased activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme catabolysing PGs, may be responsible too for experimentally induced colon tumor enhancement. Prostaglandins 134-137 carbonyl reductase 1 Homo sapiens 57-94 11352223-3 2001 It was recently suggested that the decreased activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme catabolysing PGs, may be responsible too for experimentally induced colon tumor enhancement. Prostaglandins 134-137 carbonyl reductase 1 Homo sapiens 96-103 34876851-2 2021 Previous studies have shown that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of prostaglandins to reduce their biological activities and behaves as a tumor suppressor in various cancers. Prostaglandins 108-122 carbonyl reductase 1 Homo sapiens 33-70 9859867-5 1998 Levels of prostaglandin metabolites were generally decreased following incubation with IL-1beta or LPS, which is consistent with a decrease in the activity of 15-hydroxyprostaglandin dehydrogenase (PGDH). Prostaglandins 10-23 carbonyl reductase 1 Homo sapiens 159-196 10765972-0 2000 Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase. Prostaglandins 53-66 carbonyl reductase 1 Homo sapiens 96-133 1773286-2 1991 In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. Prostaglandins 18-31 carbonyl reductase 1 Homo sapiens 46-83 1773286-2 1991 In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. Prostaglandins 248-262 carbonyl reductase 1 Homo sapiens 46-83 34655851-0 2021 Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins. Prostaglandins 77-91 carbonyl reductase 1 Homo sapiens 30-37 34655851-1 2021 15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2alpha) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2). Prostaglandins 145-159 carbonyl reductase 1 Homo sapiens 0-37 34655851-1 2021 15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2alpha) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2). Prostaglandins 145-159 carbonyl reductase 1 Homo sapiens 39-46 34655851-1 2021 15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2alpha) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2). Prostaglandins 161-164 carbonyl reductase 1 Homo sapiens 0-37 34655851-1 2021 15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2alpha) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2). Prostaglandins 161-164 carbonyl reductase 1 Homo sapiens 39-46 34876851-2 2021 Previous studies have shown that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of prostaglandins to reduce their biological activities and behaves as a tumor suppressor in various cancers. Prostaglandins 108-122 carbonyl reductase 1 Homo sapiens 72-79 1032817-1 1976 Inactivation of prostaglandins in the placenta was studied using an assay for 15-hydroxy-prostaglandin dehydrogenase (PGDH). Prostaglandins 16-30 carbonyl reductase 1 Homo sapiens 78-116 3459214-2 1986 It is well established that prostaglandin catabolism involves sequential actions of a 15-hydroxyprostaglandin dehydrogenase, a 15-keto-prostaglandin delta 13-reductase and a 15-ketoprostaglandin reductase. Prostaglandins 28-41 carbonyl reductase 1 Homo sapiens 86-123 7378925-4 1980 These results prove that spinal nerve roots, unlike the spinal cord, contain 15-hydroxyprostaglandin dehydrogenase (15-PGDH) which is the major and rate-limiting enzyme in the inactivation of prostaglandins. Prostaglandins 192-206 carbonyl reductase 1 Homo sapiens 77-114 177012-0 1976 Regulation of prostaglandin metabolism: activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imipramine related drugs. Prostaglandins 14-27 carbonyl reductase 1 Homo sapiens 54-91 6396732-5 1983 Although it has carbonyl reductase activity, a comparison of the Km and kcat/Km for prostaglandin and non-prostaglandin substrates of this enzyme suggests that its most likely function is as a 15-hydroxyprostaglandin dehydrogenase. Prostaglandins 84-97 carbonyl reductase 1 Homo sapiens 193-230 6396732-5 1983 Although it has carbonyl reductase activity, a comparison of the Km and kcat/Km for prostaglandin and non-prostaglandin substrates of this enzyme suggests that its most likely function is as a 15-hydroxyprostaglandin dehydrogenase. Prostaglandins 106-119 carbonyl reductase 1 Homo sapiens 193-230 6252782-1 1980 The activities of the enzymes catalyzing in the early steps in prostaglandin metabolism (the nicotinamide adenine dinucleotide [NAD]-linked 15-hydroxyprostaglandin dehydrogenase, the nicotinamide adenine dinucleotide phosphate [NADP]-linked 15-hydroxyprostaglandin dehydrogenase, and the 15-ketoprostaglandin delta 13 reductase) were measured in homogenates of term placenta. Prostaglandins 63-76 carbonyl reductase 1 Homo sapiens 140-177 7378925-4 1980 These results prove that spinal nerve roots, unlike the spinal cord, contain 15-hydroxyprostaglandin dehydrogenase (15-PGDH) which is the major and rate-limiting enzyme in the inactivation of prostaglandins. Prostaglandins 192-206 carbonyl reductase 1 Homo sapiens 116-123 1032817-1 1976 Inactivation of prostaglandins in the placenta was studied using an assay for 15-hydroxy-prostaglandin dehydrogenase (PGDH). Prostaglandins 16-30 carbonyl reductase 1 Homo sapiens 118-122 30248390-4 2018 RESULTS: Prostaglandin synthases and two enzymes involved in prostaglandin degradation, hydroxyprostaglandin dehydrogenase (HPGD) and CBR1, were detected by the mass spectrometer. Prostaglandins 61-74 carbonyl reductase 1 Homo sapiens 134-138 187034-1 1976 The enzyme system 15-hydroxyprostaglandin dehydrogenase, which catalyzes the oxidation of the 15-hydroxy group of all naturally occurring prostaglandins, has been purified 1,270-fold by isoelectric focusing. Prostaglandins 138-152 carbonyl reductase 1 Homo sapiens 18-55 4364240-0 1974 Regulation of prostaglandin metabolism: inhibition of 15-hydroxyprostaglandin dehydrogenase by thyroid hormones. Prostaglandins 14-27 carbonyl reductase 1 Homo sapiens 54-91 32917645-1 2021 Increased cyclooxygenase-2 (COX-2) and decreased 15-hydroxyprostaglandin dehydrogenase (15-HPGD) expression promote prostaglandin-mediated inflammation and colorectal carcinogenesis. Prostaglandins 59-72 carbonyl reductase 1 Homo sapiens 88-95 30931980-2 2019 Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH, HPGD), in colonic tumors contributes to increased prostaglandin levels and poor patient survival. Prostaglandins 152-165 carbonyl reductase 1 Homo sapiens 181-188 29224225-3 2018 The enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) degrades prostaglandin and is frequently decreased in several types of cancer; however, the molecular mechanisms of 15-PGDH suppression are unclear. Prostaglandins 21-34 carbonyl reductase 1 Homo sapiens 50-57 29796776-10 2018 Importantly, DHA significantly reduced PGE2 levels in line with the upregulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH, a key enzyme for prostaglandin degradation). Prostaglandins 94-107 carbonyl reductase 1 Homo sapiens 123-130 29414038-1 2018 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin metabolizing enzyme that oxidizes the hydroxyl group at carbon 15 (C15). Prostaglandins 10-23 carbonyl reductase 1 Homo sapiens 39-46 29224225-3 2018 The enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) degrades prostaglandin and is frequently decreased in several types of cancer; however, the molecular mechanisms of 15-PGDH suppression are unclear. Prostaglandins 21-34 carbonyl reductase 1 Homo sapiens 175-182 29249255-1 2018 Chorionic NAD-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus and has been implicated in the process of labor. Prostaglandins 119-133 carbonyl reductase 1 Homo sapiens 24-61