PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20955746-6 2011 In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT(1) but not AT(2) to induce venoconstriction, which is blunted by vasodilator prostanoids and NO. Prostaglandins 160-171 angiotensinogen Rattus norvegicus 54-68 20172009-9 2010 This increased response to angiotensin II requires an enhancement of the vasocontractile influence of endothelin beyond the influence of nitric oxide and vasodilator prostanoids. Prostaglandins 166-177 angiotensinogen Rattus norvegicus 27-41 20626388-5 2010 4 In conclusion, the basal amount of COX-2 found in aortic smooth muscle cells is sufficient to explain the production of the prostanoids related to the contractile effect of Ang II. Prostaglandins 126-137 angiotensinogen Rattus norvegicus 175-181 18076476-10 2007 4 In conclusion, in fructose rats Ang II in vitro stimulates a vasoconstrictor prostanoid not stimulated in controls. Prostaglandins 79-89 angiotensinogen Rattus norvegicus 34-40 18076476-12 2007 In fructose-fed animals, NA and Ang II also augment vasodilator prostanoids, suggesting a compensatory mechanism because of long-term hypertension. Prostaglandins 64-75 angiotensinogen Rattus norvegicus 32-38 16221213-1 2005 BACKGROUND: Prostaglandins such as prostaglandin E(2) (PGE(2)) and prostaglandin I(2) (PGI(2)) counteract the angiotensin II (Ang II)-induced vasoconstriction in the glomerular microcirculation. Prostaglandins 12-26 angiotensinogen Rattus norvegicus 110-132 17244722-11 2007 In conclusion, AT1 receptor activation by Ang II could be involved in the increased participation of COX-2-derived contractile prostanoids in vasoconstriction to phenylephrine with hypertension, probably through COX-2 expression regulation. Prostaglandins 127-138 angiotensinogen Rattus norvegicus 42-48 17627114-6 2007 Angiotensin II, norepinephrine and other vasoconstrictor agents have been reported to release prostaglandins. Prostaglandins 94-108 angiotensinogen Rattus norvegicus 0-14 16467128-9 2006 Conclusively, the ANG II-induced Cai2+ response was reduced by COX-1-derived prostaglandins in 2K1C, in contrast to control animals, where the COX-1 inhibition had no effect. Prostaglandins 77-91 angiotensinogen Rattus norvegicus 18-24 18076476-0 2007 Noradrenaline and angiotensin II modify vascular prostanoid release in fructose-fed hypertensive rats. Prostaglandins 49-59 angiotensinogen Rattus norvegicus 18-32 18076476-3 2007 2 This study analysed the effects of incubation with noradrenaline (NA) and angiotensin II (Ang II) on prostanoid release in mesenteric vascular beds from control and fructose-fed rats. Prostaglandins 103-113 angiotensinogen Rattus norvegicus 76-90 18076476-3 2007 2 This study analysed the effects of incubation with noradrenaline (NA) and angiotensin II (Ang II) on prostanoid release in mesenteric vascular beds from control and fructose-fed rats. Prostaglandins 103-113 angiotensinogen Rattus norvegicus 92-98 17244722-1 2007 This study analyzes the role of angiotensin II (Ang II), via AT1) receptors, in the involvement of cyclooxygenase (COX)-2-derived prostanoids in phenylephrine responses in normotensive rats (Wistar Kyoto; WKY) and spontaneously hypertensive rats (SHR). Prostaglandins 130-141 angiotensinogen Rattus norvegicus 32-46 17244722-1 2007 This study analyzes the role of angiotensin II (Ang II), via AT1) receptors, in the involvement of cyclooxygenase (COX)-2-derived prostanoids in phenylephrine responses in normotensive rats (Wistar Kyoto; WKY) and spontaneously hypertensive rats (SHR). Prostaglandins 130-141 angiotensinogen Rattus norvegicus 48-54 16221213-9 2005 Strikingly, COX-2 inhibition as well as blockade of the type 1 PGE(2) receptor (EP1) prevented Ang II-induced mesangial cell hypertrophy suggesting that COX-2-derived prostaglandins, and specifically PGE(2), importantly contribute to the growth promoting effects of Ang II. Prostaglandins 167-181 angiotensinogen Rattus norvegicus 266-272 11880319-9 2002 We suggest that in kidney failure, the increase in angiotensin II concentration regulates COX-2 expression, thereby increasing prostaglandin synthesis, which contributes to the development of kidney failure. Prostaglandins 127-140 angiotensinogen Rattus norvegicus 51-65 15963602-4 2005 When injected at 0.1, 10, or 1000 microg/kg i.p., LPS-induced a dose-related increase in AII-like immunoreactivity in renal tubules that was unaffected by treatment with the prostaglandin-synthesis blocker indomethacin. Prostaglandins 174-187 angiotensinogen Rattus norvegicus 89-92 15963602-6 2005 These results suggest that systemically administered LPS induces AII peptide expression in renal tubules by a prostaglandin-independent mechanism. Prostaglandins 110-123 angiotensinogen Rattus norvegicus 65-68 14685012-9 2004 The present findings show that chronic methionine treatment enhances homocysteine plasmatic concentration leading to an enhanced Ang-II-induced contraction, which appears to be related to the release of vasoconstrictor prostanoid(s). Prostaglandins 219-229 angiotensinogen Rattus norvegicus 129-135 12640010-0 2003 Prostaglandins but not nitric oxide protect renal medullary perfusion in anaesthetised rats receiving angiotensin II. Prostaglandins 0-14 angiotensinogen Rattus norvegicus 102-116 12640010-1 2003 Angiotensin II (Ang II) fails to constrict renal medullary vasculature, possibly due to the counteraction of local vasodilators, such as prostaglandins or nitric oxide (NO). Prostaglandins 137-151 angiotensinogen Rattus norvegicus 0-14 12640010-13 2003 We conclude that within the inner medulla, but not the outer medulla or cortex, prostaglandins effectively counteract the vasopressor effect of circulating Ang II. Prostaglandins 80-94 angiotensinogen Rattus norvegicus 156-162 15961422-11 2005 Together with the earlier evidence on the dependence of post-furosemide medullary hypoperfusion on angiotensin II, the study exposes its interaction with PG in the control of medullary circulation. Prostaglandins 154-156 angiotensinogen Rattus norvegicus 99-113 15529593-6 2004 Biphasic, dose-dependent effects were observed for angiotensin (1-7), induced both through nitric oxide, kinins and prostaglandin release for counteracting the vasoconstricting effects of angiotensin II and the modulation of its own vasodilator action. Prostaglandins 116-129 angiotensinogen Rattus norvegicus 188-202 12827020-0 2003 Endogenous prostaglandins limit angiotensin-II induced regional vasoconstriction in conscious rats. Prostaglandins 11-25 angiotensinogen Rattus norvegicus 32-46 12827020-1 2003 In conscious rats, we tested the hypothesis that prostaglandins attenuate regional vasoconstriction caused by acute infusion of angiotensin II. Prostaglandins 49-63 angiotensinogen Rattus norvegicus 128-142 12827020-9 2003 These results suggest that prostaglandins attenuate vasoconstriction caused by Ang II in a manner that is organ-specific and dependent on the dose of Ang II. Prostaglandins 27-41 angiotensinogen Rattus norvegicus 79-85 12586211-1 2003 The present study examined the role of cyclooxygenase-synthetized prostanoids in the pathogenesis of angiotensin-II-induced inflammatory response and vascular injury in transgenic rats harboring mouse renin-2 gene (mREN2 rats). Prostaglandins 66-77 angiotensinogen Rattus norvegicus 101-115 12200113-2 2002 Angiotensin II (Ang II) may activate the cAMP-protein kinase A (PKA) pathway in renal mesangial cells through synthesis of prostaglandins (PGs) and the possibility arises that inhibition of Ang II-induced cAMP formation might result in the overproduction of TNF-alpha in the cell and this hypothesis was tested in the present study. Prostaglandins 123-137 angiotensinogen Rattus norvegicus 0-14 12200113-2 2002 Angiotensin II (Ang II) may activate the cAMP-protein kinase A (PKA) pathway in renal mesangial cells through synthesis of prostaglandins (PGs) and the possibility arises that inhibition of Ang II-induced cAMP formation might result in the overproduction of TNF-alpha in the cell and this hypothesis was tested in the present study. Prostaglandins 123-137 angiotensinogen Rattus norvegicus 16-22 12200113-2 2002 Angiotensin II (Ang II) may activate the cAMP-protein kinase A (PKA) pathway in renal mesangial cells through synthesis of prostaglandins (PGs) and the possibility arises that inhibition of Ang II-induced cAMP formation might result in the overproduction of TNF-alpha in the cell and this hypothesis was tested in the present study. Prostaglandins 123-137 angiotensinogen Rattus norvegicus 190-196 12200113-2 2002 Angiotensin II (Ang II) may activate the cAMP-protein kinase A (PKA) pathway in renal mesangial cells through synthesis of prostaglandins (PGs) and the possibility arises that inhibition of Ang II-induced cAMP formation might result in the overproduction of TNF-alpha in the cell and this hypothesis was tested in the present study. Prostaglandins 139-142 angiotensinogen Rattus norvegicus 0-14 12200113-2 2002 Angiotensin II (Ang II) may activate the cAMP-protein kinase A (PKA) pathway in renal mesangial cells through synthesis of prostaglandins (PGs) and the possibility arises that inhibition of Ang II-induced cAMP formation might result in the overproduction of TNF-alpha in the cell and this hypothesis was tested in the present study. Prostaglandins 139-142 angiotensinogen Rattus norvegicus 16-22 12200113-2 2002 Angiotensin II (Ang II) may activate the cAMP-protein kinase A (PKA) pathway in renal mesangial cells through synthesis of prostaglandins (PGs) and the possibility arises that inhibition of Ang II-induced cAMP formation might result in the overproduction of TNF-alpha in the cell and this hypothesis was tested in the present study. Prostaglandins 139-142 angiotensinogen Rattus norvegicus 190-196 12200113-6 2002 These data suggested that in mesangial cells after blockade of cAMP-PKA by PG inhibition, Ang II was capable of stimulating TNF-alpha transcription which subsequently increased TNF-alpha mRNA accumulation and protein release. Prostaglandins 75-77 angiotensinogen Rattus norvegicus 90-96 11166690-8 2001 These results indicate that a prostaglandin is required for the stimulated release of vasopressin during dehydration and that the elevation of oxytocin secretion in response to ANG II depends largely on activation of cyclo-oxygenase and production of prostaglandins. Prostaglandins 251-265 angiotensinogen Rattus norvegicus 177-183 11689191-0 2001 Prostanoids, but not nitric oxide, counterregulate angiotensin II mediated vasoconstriction in vivo. Prostaglandins 0-11 angiotensinogen Rattus norvegicus 51-65 11689191-7 2001 In conclusion, vasodilator prostanoids, but not nitric oxide, counterregulate angiotensin II-mediated vasoconstriction in vivo. Prostaglandins 27-38 angiotensinogen Rattus norvegicus 78-92 10642344-1 2000 The present study was performed to determine whether physiologically relevant doses of angiotensin II (Ang II), which do not affect renal hemodynamics but do cause slow response hypertension, result in oxidative stress as measured by production of vasoconstrictor F(2)-isoprostane, a prostaglandin-like non-cyclooxygenase-produced arachidonic acid metabolite that is the end product of lipid peroxidation. Prostaglandins 284-297 angiotensinogen Rattus norvegicus 87-101 10642277-1 2000 Angiotensin II (Ang II) stimulates the release of prostaglandins (PGs) in various cells and tissues. Prostaglandins 50-64 angiotensinogen Rattus norvegicus 0-14 10642277-1 2000 Angiotensin II (Ang II) stimulates the release of prostaglandins (PGs) in various cells and tissues. Prostaglandins 50-64 angiotensinogen Rattus norvegicus 16-22 10642277-1 2000 Angiotensin II (Ang II) stimulates the release of prostaglandins (PGs) in various cells and tissues. Prostaglandins 66-69 angiotensinogen Rattus norvegicus 0-14 10642277-1 2000 Angiotensin II (Ang II) stimulates the release of prostaglandins (PGs) in various cells and tissues. Prostaglandins 66-69 angiotensinogen Rattus norvegicus 16-22 10642344-1 2000 The present study was performed to determine whether physiologically relevant doses of angiotensin II (Ang II), which do not affect renal hemodynamics but do cause slow response hypertension, result in oxidative stress as measured by production of vasoconstrictor F(2)-isoprostane, a prostaglandin-like non-cyclooxygenase-produced arachidonic acid metabolite that is the end product of lipid peroxidation. Prostaglandins 284-297 angiotensinogen Rattus norvegicus 103-109 10600931-0 1999 Prostaglandins buffer ANG II-mediated increases in cytosolic calcium in preglomerular VSMC. Prostaglandins 0-14 angiotensinogen Rattus norvegicus 22-28 10600931-1 1999 In order to exert an appropriate biological effect, the action of the vasoconstrictive hormone angiotensin II (ANG II) is modulated by vasoactive factors such as prostaglandins PGE2 and PGI2. Prostaglandins 162-176 angiotensinogen Rattus norvegicus 95-109 10600931-1 1999 In order to exert an appropriate biological effect, the action of the vasoconstrictive hormone angiotensin II (ANG II) is modulated by vasoactive factors such as prostaglandins PGE2 and PGI2. Prostaglandins 162-176 angiotensinogen Rattus norvegicus 111-117 10600931-2 1999 The present study investigates whether prostaglandins alter ANG II-mediated increases in cytosolic calcium concentration ([Ca2+]i) in vascular smooth muscle cells (VSMC) isolated from rat renal preglomerular arterioles. Prostaglandins 39-53 angiotensinogen Rattus norvegicus 60-66 10600931-7 1999 Increasing cAMP levels in cultured VSMC, by using either a cell-permeable analog or inhibiting phosphodiesterase activity, mirrored the antagonistic effects of prostaglandins on ANG II-stimulated increases in [Ca2+]i. Radioimmunoassays demonstrate that ANG II (10(-7) M) stimulates production of PGI2 and PGE2; the stable prostacyclin metabolite 6-keto-PGF(1alpha) was released in 10-fold greater concentrations than PGE(2.) Prostaglandins 160-174 angiotensinogen Rattus norvegicus 178-184 10600931-7 1999 Increasing cAMP levels in cultured VSMC, by using either a cell-permeable analog or inhibiting phosphodiesterase activity, mirrored the antagonistic effects of prostaglandins on ANG II-stimulated increases in [Ca2+]i. Radioimmunoassays demonstrate that ANG II (10(-7) M) stimulates production of PGI2 and PGE2; the stable prostacyclin metabolite 6-keto-PGF(1alpha) was released in 10-fold greater concentrations than PGE(2.) Prostaglandins 160-174 angiotensinogen Rattus norvegicus 253-259 10600931-8 1999 Indomethacin blockade of prostaglandin production potentiated both the peak (264 to 337 +/- 26 nM) and sustained [Ca2+]i responses (95 to 181 +/- 22 nM) to ANG II. Prostaglandins 25-38 angiotensinogen Rattus norvegicus 156-162 10600931-9 1999 When prostaglandin analogs were added during indomethacin treatment, the ANG II response was restored to the typical pattern. Prostaglandins 5-18 angiotensinogen Rattus norvegicus 73-79 10600931-10 1999 In conclusion, we demonstrate that modulation of intracellular calcium levels is one mechanism by which prostaglandins can buffer ANG II-mediated constriction in renal preglomerular VSMC. Prostaglandins 104-118 angiotensinogen Rattus norvegicus 130-136 9059851-13 1997 With aging or development, and depending on the type of blood vessel, NO and prostanoids appear to modify the angiotensin II response differently. Prostaglandins 77-88 angiotensinogen Rattus norvegicus 110-124 10413062-9 1999 Ang II stimulated AA and prostaglandin release from isolated perfused kidneys. Prostaglandins 25-38 angiotensinogen Rattus norvegicus 0-6 9892139-3 1999 They belong to the AT1 subtype as shown by the inhibitory effect of AT1 antagonists on [125I]-Sar1, Ala8 AngII binding and on all of the biologic effects mediated by AngII, such as cytosolic calcium stimulation, inositol phosphate formation, prostaglandin production, and cell contraction. Prostaglandins 242-255 angiotensinogen Rattus norvegicus 166-171 9723960-23 1998 In conclusion, the renal haemodynamic effects of Ang II in the rat kidney appear to be modulated by cyclooxygenase-derived prostaglandins and NO. Prostaglandins 123-137 angiotensinogen Rattus norvegicus 49-55 9704762-7 1998 CONCLUSION: Angiotensin II plays an important role in ovulation in the rat and is associated with ovarian prostaglandin synthesis. Prostaglandins 106-119 angiotensinogen Rattus norvegicus 12-26 9640259-11 1998 They also suggest that PE-induced vasoconstriction is attenuated by the release of NO but not cyclooxygenase products and that constrictor responses evoked by AII are attenuated by both NO and dilator prostaglandin release. Prostaglandins 201-214 angiotensinogen Rattus norvegicus 159-162 10645262-4 1998 More recent study has indicated that the effects of angiotensin II and other vasoactive peptides on anion secretion are mediated through an increase in prostaglandin formation. Prostaglandins 152-165 angiotensinogen Rattus norvegicus 52-66 9401758-16 1997 These results demonstrate that the effect of AII to increase systemic blood pressure and the resulting rise of perfusion pressure in the femoral artery stimulates the formation of NO and prostaglandins and thereby dilates the femoral arterial bed. Prostaglandins 187-201 angiotensinogen Rattus norvegicus 45-48 9369254-6 1997 The major prostanoid formed by cardiac fibroblasts was prostaglandin I2 (PGI2), with more prostacyclin production by WKY cells than SHR cells both under nonstimulated conditions and in response to angiotensin II or bradykinin. Prostaglandins 10-20 angiotensinogen Rattus norvegicus 197-211 9059851-0 1997 Age-related differences and roles of endothelial nitric oxide and prostanoids in angiotensin II responses of isolated, perfused mesenteric arteries and veins of rats. Prostaglandins 66-77 angiotensinogen Rattus norvegicus 81-95 9059851-12 1997 Moreover, in the arteries of rats aged 32 weeks, vasoconstricting prostanoids, such as prostaglandin H2 and thromboxane A2, seem to play a role in angiotensin II-induced vasoconstriction. Prostaglandins 66-77 angiotensinogen Rattus norvegicus 147-161 10642277-11 2000 These results suggest that Ang II regulates COX-2 expression and PG production and modulates cell proliferation through MAPK-mediated signaling pathways in rat VSMCs. Prostaglandins 65-67 angiotensinogen Rattus norvegicus 27-33 9736302-3 1998 In this study, we examine whether constrictory prostanoids are involved in Ang II subtype receptor (AT2)-sensitive potentiation of the Ang II effect during NO blockade. Prostaglandins 47-58 angiotensinogen Rattus norvegicus 75-81 9736302-3 1998 In this study, we examine whether constrictory prostanoids are involved in Ang II subtype receptor (AT2)-sensitive potentiation of the Ang II effect during NO blockade. Prostaglandins 47-58 angiotensinogen Rattus norvegicus 135-141 9662316-5 1998 The increased vascular tone and the enhanced thromboxane production noted in preeclampsia may be mediated by the increased sensitivity to angiotensin II because angiotensin II coupled to an AT1 receptor is a potent vasoconstrictor and stimulates the accumulation of free arachidonic acid, the precursor of thromboxane and the prostaglandins. Prostaglandins 326-340 angiotensinogen Rattus norvegicus 138-152 9662316-5 1998 The increased vascular tone and the enhanced thromboxane production noted in preeclampsia may be mediated by the increased sensitivity to angiotensin II because angiotensin II coupled to an AT1 receptor is a potent vasoconstrictor and stimulates the accumulation of free arachidonic acid, the precursor of thromboxane and the prostaglandins. Prostaglandins 326-340 angiotensinogen Rattus norvegicus 161-175 9519801-8 1998 In each series, the previously attenuated contractile response to phenylephrine and to angiotensin II was fully restored with prostaglandin synthesis inhibition. Prostaglandins 126-139 angiotensinogen Rattus norvegicus 87-101 9401758-0 1997 Dilatation by angiotensin II of the rat femoral arterial bed in vivo via pressure/flow-induced release of nitric oxide and prostaglandins. Prostaglandins 123-137 angiotensinogen Rattus norvegicus 14-28 9038972-0 1997 Endothelial vasoconstrictor prostanoids modulate contractions to acetylcholine and ANG II in Ren-2 rats. Prostaglandins 28-39 angiotensinogen Rattus norvegicus 83-89 7904421-6 1993 32): F573-F580, 1992], we reported that vasodilator prostaglandins (PGs) are defective in buffering the angiotensin II (ANG II)-induced vasoconstriction in the renal vasculature of spontaneously hypertensive rats (SHR). Prostaglandins 52-66 angiotensinogen Rattus norvegicus 104-118 8908622-7 1996 Angiotensin II induced a slight but statistically insignificant increase in the ratio of the two prostanoids released. Prostaglandins 97-108 angiotensinogen Rattus norvegicus 0-14 8797151-9 1996 Activation of the BK and prostaglandin systems may play an important role in regulating renal function during chronic ACE inhibition, primarily by enhancing the renal vasodilatory effects of angiotensin II (AII) blockade. Prostaglandins 25-38 angiotensinogen Rattus norvegicus 191-205 8797151-9 1996 Activation of the BK and prostaglandin systems may play an important role in regulating renal function during chronic ACE inhibition, primarily by enhancing the renal vasodilatory effects of angiotensin II (AII) blockade. Prostaglandins 25-38 angiotensinogen Rattus norvegicus 207-210 8806891-4 1996 Because the contraction induced by ANG II is modulated by the simultaneous release of prostaglandins, we tested the hypothesis that IL-1 interferes with this modulation. Prostaglandins 86-100 angiotensinogen Rattus norvegicus 35-41 8806891-9 1996 This increase might result from an IL-1-induced shift in favor of constrictor prostanoids in the balance of the dilator/constrictor prostanoids, the release of which is associated with stimulation by ANG II. Prostaglandins 78-89 angiotensinogen Rattus norvegicus 200-206 8806891-9 1996 This increase might result from an IL-1-induced shift in favor of constrictor prostanoids in the balance of the dilator/constrictor prostanoids, the release of which is associated with stimulation by ANG II. Prostaglandins 132-143 angiotensinogen Rattus norvegicus 200-206 7998990-1 1994 We previously showed that angiotensin II (Ang II) and angiotensin-(2-8)-peptide [Ang-(2-8)] activate a phosphoinositide-specific phospholipase C (PLC) and cause calcium mobilization in rat aortic vascular smooth-muscle cells (VSMC), while Ang II and Ang-(1-7) produce prostaglandins. Prostaglandins 268-282 angiotensinogen Rattus norvegicus 26-40 7998990-1 1994 We previously showed that angiotensin II (Ang II) and angiotensin-(2-8)-peptide [Ang-(2-8)] activate a phosphoinositide-specific phospholipase C (PLC) and cause calcium mobilization in rat aortic vascular smooth-muscle cells (VSMC), while Ang II and Ang-(1-7) produce prostaglandins. Prostaglandins 268-282 angiotensinogen Rattus norvegicus 42-48 8689646-9 1996 CONCLUSION: The perivascular and interstitial fibrosis of the rat right and left ventricles seen in association with the exogenous administration of AngII is mediated by the release of bradykinin and prostaglandins, and therefore is an indirect response to elevated circulating AngII. Prostaglandins 200-214 angiotensinogen Rattus norvegicus 149-154 8851506-0 1996 Modulation by nitric oxide and prostaglandin of the renal vascular response to angiotensin II (3-8). Prostaglandins 31-44 angiotensinogen Rattus norvegicus 79-93 8720417-0 1996 Role of calcium in angiotensin II-induced prostaglandin release and DNA synthesis in rat vascular smooth muscle cells. Prostaglandins 42-55 angiotensinogen Rattus norvegicus 19-33 8720417-3 1996 We investigated the role of calcium in angiotensin II (AII)-induced prostaglandin release and DNA synthesis in VSMC. Prostaglandins 68-81 angiotensinogen Rattus norvegicus 39-53 8720417-3 1996 We investigated the role of calcium in angiotensin II (AII)-induced prostaglandin release and DNA synthesis in VSMC. Prostaglandins 68-81 angiotensinogen Rattus norvegicus 55-58 8847278-4 1995 Because the contraction induced by ANG II is modulated by the simultaneous release of prostaglandins, we tested the hypothesis that LPS interferes with this modulation. Prostaglandins 86-100 angiotensinogen Rattus norvegicus 35-41 8847278-9 1995 This effect could be a LPS-induced shift in favor of constrictor prostanoids in the balance of dilator/constrictor prostanoids, the release of which is associated with stimulation by ANG II. Prostaglandins 65-76 angiotensinogen Rattus norvegicus 183-189 8847278-9 1995 This effect could be a LPS-induced shift in favor of constrictor prostanoids in the balance of dilator/constrictor prostanoids, the release of which is associated with stimulation by ANG II. Prostaglandins 115-126 angiotensinogen Rattus norvegicus 183-189 7644529-1 1995 This study was designed to examine the possible involvement of prostaglandins and nitric oxide (NO) in the renin stimulatory effect of angiotensin II (AngII) antagonists. Prostaglandins 63-77 angiotensinogen Rattus norvegicus 135-149 7894515-0 1994 In situ microdialysis of prostaglandins in adipose tissue: stimulation of prostacyclin release by angiotensin II. Prostaglandins 25-39 angiotensinogen Rattus norvegicus 98-112 8135755-0 1994 Protein kinase C-dependent prostaglandin production mediates angiotensin II-induced atrial-natriuretic peptide release. Prostaglandins 27-40 angiotensinogen Rattus norvegicus 61-75 7904421-6 1993 32): F573-F580, 1992], we reported that vasodilator prostaglandins (PGs) are defective in buffering the angiotensin II (ANG II)-induced vasoconstriction in the renal vasculature of spontaneously hypertensive rats (SHR). Prostaglandins 52-66 angiotensinogen Rattus norvegicus 120-126 7904421-6 1993 32): F573-F580, 1992], we reported that vasodilator prostaglandins (PGs) are defective in buffering the angiotensin II (ANG II)-induced vasoconstriction in the renal vasculature of spontaneously hypertensive rats (SHR). Prostaglandins 68-71 angiotensinogen Rattus norvegicus 104-118 7904421-6 1993 32): F573-F580, 1992], we reported that vasodilator prostaglandins (PGs) are defective in buffering the angiotensin II (ANG II)-induced vasoconstriction in the renal vasculature of spontaneously hypertensive rats (SHR). Prostaglandins 68-71 angiotensinogen Rattus norvegicus 120-126 8095076-5 1993 Incubation with pertussis toxin (PT, 0.5 micrograms/ml) inhibited the effect of ST on the Ang II-dependent changes in PCSA, but this effect was not inhibited by the blockade of the vasodilatory prostaglandins (indomethacin, 10 microM) or nitric oxide (L-N-methyl-arginine, 0.2 mM) synthesis. Prostaglandins 194-208 angiotensinogen Rattus norvegicus 90-96 8386972-13 1993 These results suggest that PGs generated in the periventricular region, despite their probable stimulatory roles in the ANG II-evoked AVP secretion, may not participate in the AVP-releasing mechanisms activated by dopaminergic and alpha-adrenergic receptors, supporting the view that PGs and the catecholamines may facilitate AVP release via separate pathways. Prostaglandins 27-30 angiotensinogen Rattus norvegicus 120-126 2035693-3 1991 All three ANG peptides stimulated PG release in a dose-dependent manner with the order of potency ANG-(1-7) greater than ANG I greater than ANG II. Prostaglandins 34-36 angiotensinogen Rattus norvegicus 140-146 1280721-2 1992 Angiotensin II (AII) constricts renal vasculature but also increases renal vasodilator PG synthesis. Prostaglandins 87-89 angiotensinogen Rattus norvegicus 0-14 1280721-2 1992 Angiotensin II (AII) constricts renal vasculature but also increases renal vasodilator PG synthesis. Prostaglandins 87-89 angiotensinogen Rattus norvegicus 16-19 1941608-4 1991 Isolated rat kidneys perfused at constant flow with albumin-containing buffer were stimulated to produce prostaglandin by an infusion of angiotensin II or bradykinin. Prostaglandins 105-118 angiotensinogen Rattus norvegicus 137-151 1885223-1 1991 To test the hypothesis that prostanoids contribute to angiotensin II-induced vascular contraction, we compared the effect of angiotensin II on isometric tension development by rings of descending thoracic aorta bathed in Krebs" bicarbonate buffer with and without indomethacin (10 microM) to inhibit cyclooxygenase, CGS13080 (10 microM) to inhibit thromboxane A2 synthesis, or SQ29548 (1 microM) to block thromboxane A2/prostaglandin endoperoxide receptors. Prostaglandins 28-39 angiotensinogen Rattus norvegicus 54-68 1885223-7 1991 These data suggest that a prostanoid-mediated and endothelium-dependent mechanism of vasoconstriction contributes to the constrictor effect of angiotensin II in aortic rings of rats in the early phase of aortic coarctation-induced hypertension. Prostaglandins 26-36 angiotensinogen Rattus norvegicus 143-157 1653798-11 1991 The basal and stimulated (serotonin, norepinephrine and angiotensin II) release of prostaglandins were measured by radioimmunoassay. Prostaglandins 83-97 angiotensinogen Rattus norvegicus 56-70 8474539-3 1993 The enhancement of phasic contraction amplitude caused by angiotensin II was not significantly altered by pretreatment of the rat portal vein with indomethacin 10(-5) mol/l or nitro-L-arginine 10(-4) mol/l, indicating that neither prostaglandins nor the endothelium derived-relaxing factor (NO) are involved. Prostaglandins 231-245 angiotensinogen Rattus norvegicus 58-72 1831598-11 1991 These findings indicate that the exaggerated renal vascular reactivity of SHR to ANG II and TxA2 may be mediated by a shift in the balance between endogenous vasoactive prostanoids and increased density of renal TxA2 receptors. Prostaglandins 169-180 angiotensinogen Rattus norvegicus 81-87 2352361-5 1990 Blockade of prostaglandin synthesis with indomethacin also reduced the pressure-natriuresis response in the presence of low-dose (2 ng/kg/min) of angiotensin II, but indomethacin alone did not affect significantly. Prostaglandins 12-25 angiotensinogen Rattus norvegicus 146-160 2386211-5 1990 This strain difference was abolished by inhibition of prostaglandin synthesis, suggesting that a deficiency in the action of endogenous vasodilator prostaglandins is responsible for the enhanced response to angiotensin II in SHR. Prostaglandins 54-67 angiotensinogen Rattus norvegicus 207-221 2386211-5 1990 This strain difference was abolished by inhibition of prostaglandin synthesis, suggesting that a deficiency in the action of endogenous vasodilator prostaglandins is responsible for the enhanced response to angiotensin II in SHR. Prostaglandins 148-162 angiotensinogen Rattus norvegicus 207-221 2198116-12 1990 In contrast, in the HP rat, the renovascular response to angiotensin II is blunted apparently because of enhanced renal prostaglandin production. Prostaglandins 120-133 angiotensinogen Rattus norvegicus 57-71 2124458-2 1990 Indeed, PG can act in the regulation of the blood pressure (BP) at different levels: vasodilatation, diuretic, natriuretic, antagonism of angiotensin II and vasopressin (VP), action on adrenergic system. Prostaglandins 8-10 angiotensinogen Rattus norvegicus 138-152 2328452-2 1990 The present study assessed the functional significance of this "redirection" of prostaglandin formation using a more physiologic stimulus, angiotensin II. Prostaglandins 80-93 angiotensinogen Rattus norvegicus 139-153 2328452-13 1990 We conclude that furegrelate attenuates the renal vasoconstriction of angiotensin II, presumably by enhancing the formation of vasodilator prostaglandins. Prostaglandins 139-153 angiotensinogen Rattus norvegicus 70-84 2259077-7 1990 We assume that the differences in NE and Ang II responsiveness between C and JM vessels under control conditions are caused by a high prostaglandin content or sensitivity, particularly of JM vessels in the hydronephrotic kidney. Prostaglandins 134-147 angiotensinogen Rattus norvegicus 41-47 2259085-10 1990 The strain differences in renal reactivity to angiotensin II can be abolished by cyclooxygenase inhibition with indomethacin, indicating that endogenous prostanoids counteract some of the constrictor action of angiotensin II, with more pronounced buffering activity in WKY. Prostaglandins 153-164 angiotensinogen Rattus norvegicus 46-60 2259085-10 1990 The strain differences in renal reactivity to angiotensin II can be abolished by cyclooxygenase inhibition with indomethacin, indicating that endogenous prostanoids counteract some of the constrictor action of angiotensin II, with more pronounced buffering activity in WKY. Prostaglandins 153-164 angiotensinogen Rattus norvegicus 210-224 2163467-5 1990 The increase in prostanoid production in response to angiotensin II added in vitro was less in glomeruli from rats with unilateral obstruction than in glomeruli from sham-operated rats. Prostaglandins 16-26 angiotensinogen Rattus norvegicus 53-67 2322437-2 1990 Intravenous AII (500 ng/kg/min) increased mean arterial pressure (MAP) by 35 +/- 3 mm Hg and increased the excretion of prostaglandin PGE2, the metabolites of prostacyclin (6kPGF1 alpha) and Tx (TxB2) (P less than .05). Prostaglandins 120-133 angiotensinogen Rattus norvegicus 12-15 2322437-4 1990 The increases in MAP and prostaglandin excretion produced by AII were reversed by the AII-receptor antagonist saralasin (10 micrograms/kg/min) while those produced by PE were reversed by the alpha-adrenoreceptor antagonist phenoxybenzamine (250 micrograms/kg). Prostaglandins 25-38 angiotensinogen Rattus norvegicus 61-64 2322437-4 1990 The increases in MAP and prostaglandin excretion produced by AII were reversed by the AII-receptor antagonist saralasin (10 micrograms/kg/min) while those produced by PE were reversed by the alpha-adrenoreceptor antagonist phenoxybenzamine (250 micrograms/kg). Prostaglandins 25-38 angiotensinogen Rattus norvegicus 86-89 2154128-5 1990 The prostanoid production in response to addition of ANG II or AVP in vitro was blunted in glomeruli from BUO rats, but the response was restored to "normal" after blockade of ANG II synthesis in vivo in BUO rats. Prostaglandins 4-14 angiotensinogen Rattus norvegicus 53-59 2154128-7 1990 The prostanoid generation in response to addition of both ANG II and arachidonic acid in vitro compared with ANG II addition alone was not significantly stimulated in glomeruli from BUO rats. Prostaglandins 4-14 angiotensinogen Rattus norvegicus 58-64 2154128-9 1990 The results indicate that endogenous ANG II has an important role in the increased synthesis of prostanoids found in isolated glomeruli of rats with BUO and that the in vitro prostanoid production in response to ANG II and AVP can be restored to normal when the synthesis of ANG II is inhibited in vivo. Prostaglandins 96-107 angiotensinogen Rattus norvegicus 37-43 2154128-9 1990 The results indicate that endogenous ANG II has an important role in the increased synthesis of prostanoids found in isolated glomeruli of rats with BUO and that the in vitro prostanoid production in response to ANG II and AVP can be restored to normal when the synthesis of ANG II is inhibited in vivo. Prostaglandins 96-106 angiotensinogen Rattus norvegicus 37-43 2105392-5 1990 In contrast, the release of prostanoids from the kidney stimulated by angiotensin II was increased after repeated administrations of arachidonic acid. Prostaglandins 28-39 angiotensinogen Rattus norvegicus 70-84 2073934-6 1990 These observations, combined with previous studies of the role of central angiotensin II and central prostanoids in the physiological control of vasopressin release, suggest that there may be important interactions between brain prostanoids and the brain renin-angiotensin system in this control. Prostaglandins 229-240 angiotensinogen Rattus norvegicus 74-88 2507288-1 1989 Angiotensin II (AII) action is coupled to the hydrolysis of phospholipids resulting in the formation of arachidonic acid, the precursor of both prostaglandins, and hydroxyeicosatetraenoic acids (HETEs). Prostaglandins 144-158 angiotensinogen Rattus norvegicus 0-14 34845157-8 2022 RESULTS: Chronic low-dose ANG II supplementation in high salt fed rats restored FID of MCAs, which was nitric oxide, prostanoid and epoxyeicosatrienoic acid dependent. Prostaglandins 117-127 angiotensinogen Rattus norvegicus 26-32 2531549-3 1989 However, AVP- and ANG II-stimulated release of prostaglandins into the renal venous effluent was depressed at all times tested. Prostaglandins 47-61 angiotensinogen Rattus norvegicus 18-24 2802003-8 1989 When the PG synthesis inhibitor meclofenamate was given there was no change in the pressor response to ANG II in nonpregnant animals, but in pseudopregnant animals meclofenamate produced a significant increase in the pressor response to ANG II. Prostaglandins 9-11 angiotensinogen Rattus norvegicus 237-243 2802003-12 1989 Increased PG production may, therefore, be partly responsible for the decrease in pressor responsiveness to ANG II. Prostaglandins 10-12 angiotensinogen Rattus norvegicus 108-114 2507288-1 1989 Angiotensin II (AII) action is coupled to the hydrolysis of phospholipids resulting in the formation of arachidonic acid, the precursor of both prostaglandins, and hydroxyeicosatetraenoic acids (HETEs). Prostaglandins 144-158 angiotensinogen Rattus norvegicus 16-19 3164706-8 1988 If so, pressor prostanoids may be contributory factors in the pathogenesis of severe Ang II-salt hypertension in rats. Prostaglandins 15-26 angiotensinogen Rattus norvegicus 85-91 2623198-11 1989 This study demonstrated that CSA significantly inhibits AII-stimulated prostaglandin release. Prostaglandins 71-84 angiotensinogen Rattus norvegicus 56-59 2840395-0 1988 Suppression of angiotensin II release by prostaglandin synthesis inhibitors in hind legs. Prostaglandins 41-54 angiotensinogen Rattus norvegicus 15-29 3146400-16 1988 The demonstration of this is complicated by an excessive release of vasodilator prostaglandins possibly due to the infused AII. Prostaglandins 80-94 angiotensinogen Rattus norvegicus 123-126 3164706-0 1988 Role of pressor prostanoids in rats with angiotensin II-salt-induced hypertension. Prostaglandins 16-27 angiotensinogen Rattus norvegicus 41-55 3279819-1 1988 Angiotensin II has been implicated in the regulation of medullary blood flow and is known to interact with prostaglandins at sites within the kidney. Prostaglandins 107-121 angiotensinogen Rattus norvegicus 0-14 3425755-0 1987 Endogenous prostaglandins selectively mask large arteriole constriction to angiotensin II. Prostaglandins 11-25 angiotensinogen Rattus norvegicus 75-89 3348429-1 1988 Angiotensin II, a vasoconstrictor, has been previously demonstrated to produce a secondary vasodilatation due to release of prostaglandins. Prostaglandins 124-138 angiotensinogen Rattus norvegicus 0-14 3348429-6 1988 The protective effect of angiotensin II was lost when indomethacin was given to block prostaglandin synthesis. Prostaglandins 86-99 angiotensinogen Rattus norvegicus 25-39 3348429-8 1988 Thus exogenous angiotensin II infusion prevents chronic hypoxic pulmonary hypertension, associated right ventricular hypertrophy, and vascular changes and blocks acute hypoxic pulmonary hypertension, and this is likely related to its ability to release vasodilator prostaglandins. Prostaglandins 265-279 angiotensinogen Rattus norvegicus 15-29 3125747-6 1988 Thus vasodilatory prostaglandins act as local modulators of both renal nerve and angiotensin II constrictive actions on glomeruli and renal microcirculation. Prostaglandins 18-32 angiotensinogen Rattus norvegicus 81-95 3425755-3 1987 However, after the inhibition of local prostaglandin synthesis with either mefenamic acid or indomethacin, both A1 and A2, but not the venules, gave a significant constrictor response to angiotensin II (10(-6) M). Prostaglandins 39-52 angiotensinogen Rattus norvegicus 187-201 3425755-5 1987 These observations indicate that endogenous prostaglandins exert a significant dilator influence on the larger arterioles, that this dilator influence appears to oppose the constrictor effect of angiotensin II, and that angiotensin II acts on specific receptors to induce synthesis and/or release of dilator prostaglandins in large arterioles. Prostaglandins 44-58 angiotensinogen Rattus norvegicus 220-234 3425755-5 1987 These observations indicate that endogenous prostaglandins exert a significant dilator influence on the larger arterioles, that this dilator influence appears to oppose the constrictor effect of angiotensin II, and that angiotensin II acts on specific receptors to induce synthesis and/or release of dilator prostaglandins in large arterioles. Prostaglandins 308-322 angiotensinogen Rattus norvegicus 220-234 6742217-6 1984 Treatment of the cremaster muscle with mefenamic acid or indomethacin, inhibitors of prostaglandin synthesis, produced a significant reduction in the diameter of the arterioles and abolished the dilator phase of the arteriolar response to ANG II without preventing the ANG II-induced constriction. Prostaglandins 85-98 angiotensinogen Rattus norvegicus 239-245 3109763-1 1987 Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode"s solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. Prostaglandins 97-110 angiotensinogen Rattus norvegicus 28-42 3109763-1 1987 Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode"s solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. Prostaglandins 97-110 angiotensinogen Rattus norvegicus 44-47 3109763-1 1987 Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode"s solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. Prostaglandins 112-114 angiotensinogen Rattus norvegicus 28-42 3109763-1 1987 Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode"s solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. Prostaglandins 112-114 angiotensinogen Rattus norvegicus 44-47 3109763-1 1987 Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode"s solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. Prostaglandins 238-240 angiotensinogen Rattus norvegicus 28-42 3109763-1 1987 Arginine-vasopressin (AVP), angiotensin II (AII), and norepinephrine (NE) are known to stimulate prostaglandin (PG) synthesis in the intact rat kidney perfused with Tyrode"s solution by a mechanism that requires intracellular Ca2+, while PG synthesis elicited by bradykinin (BK) is independent of Ca2+. Prostaglandins 238-240 angiotensinogen Rattus norvegicus 44-47 3109763-3 1987 Infusion of 1 mM caffeine inhibited PG output elicited by AVP, AII, and NE but not that caused by BK in the absence of extracellular Ca2+. Prostaglandins 36-38 angiotensinogen Rattus norvegicus 63-66 3036706-9 1987 In conclusion, continuous infusion of subpressor concentrations of ANG II in rats enhances the contractile response of the glomerular mesangial cell through effects on the cell"s surface receptor for ANG II and on prostaglandin and cAMP production. Prostaglandins 214-227 angiotensinogen Rattus norvegicus 67-73 3447251-1 1987 In the present study the possible role of endogenous prostaglandins in modulating the renal effects of angiotensin II was investigated in the isolated perfused rat kidney. Prostaglandins 53-67 angiotensinogen Rattus norvegicus 103-117 3466889-1 1986 We studied the influence of vasoactive substances (angiotensin II, epinephrine, norepinephrine and acetylcholine) on the synthesis of prostanoids in isolated rat glomeruli. Prostaglandins 134-145 angiotensinogen Rattus norvegicus 51-65 3466889-4 1986 The stimulation of vasoactive prostaglandins by angiotensin II, may modify the hemodynamic status of the glomerulus. Prostaglandins 30-44 angiotensinogen Rattus norvegicus 48-62 3531461-8 1986 In conclusion the early reduction in GFR which follows daily administration of CyA in rats might be the result of a synergic action of angiotensin II and TxA2 on vascular tone and mesangial contraction which is not modulated by an increase in glomerular vasodilatory prostaglandins. Prostaglandins 267-281 angiotensinogen Rattus norvegicus 135-149 3464936-0 1986 Prostaglandins mediate some central effects of angiotensin II. Prostaglandins 0-14 angiotensinogen Rattus norvegicus 47-61 3464936-4 1986 A specific radioimmunoassay of E-type prostaglandins (PGE1 + PGE2) revealed an increase by 136% in the level of PGE in the striata of rats pretreated with angiotensin II. Prostaglandins 38-52 angiotensinogen Rattus norvegicus 155-169 3464936-5 1986 These results suggest that stimulatory effects of angiotensin II in the central nigrostriatal system are, at least in part, mediated by the release of the E type of prostaglandins. Prostaglandins 165-179 angiotensinogen Rattus norvegicus 50-64 3889500-0 1985 Diminished pressor response to exogenous norepinephrine and angiotensin II in septic, unanesthetized rats: evidence for a prostaglandin-mediated effect. Prostaglandins 122-135 angiotensinogen Rattus norvegicus 60-74 3524265-12 1986 Acute inhibition of prostaglandin synthesis with meclofenamate restored the pressor response to ANG II in HP to that in LP. Prostaglandins 20-33 angiotensinogen Rattus norvegicus 96-102 3524265-14 1986 Resistance to ANG II was not reversed by chronic converting enzyme inhibition but was abolished by inhibition of prostaglandin synthesis. Prostaglandins 113-126 angiotensinogen Rattus norvegicus 14-20 3024620-0 1986 Pertussis toxin abolishes angiotensin II-induced phosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Prostaglandins 81-94 angiotensinogen Rattus norvegicus 26-40 3706534-0 1986 Synergistic action of angiotensin II on norepinephrine-induced prostaglandin release from rat glomeruli. Prostaglandins 63-76 angiotensinogen Rattus norvegicus 22-36 3457671-0 1986 Effect of angiotensin II on prostanoid synthesis in isolated rat glomeruli. Prostaglandins 28-38 angiotensinogen Rattus norvegicus 10-24 3457671-1 1986 The influence of angiotensin II (ANG II) on the synthesis of glomerular prostanoids is controversial, possibly because of the different methodologies employed. Prostaglandins 72-83 angiotensinogen Rattus norvegicus 17-31 3457671-1 1986 The influence of angiotensin II (ANG II) on the synthesis of glomerular prostanoids is controversial, possibly because of the different methodologies employed. Prostaglandins 72-83 angiotensinogen Rattus norvegicus 33-39 4030047-7 1985 In contrast, the output of basal as well as norepinephrine, arginine vasopressin, angiotensin II, bradykinin, or A23187-induced prostaglandin output was significantly reduced in mesenteric vessels from rats treated with dexamethasone for 1 or 14 days. Prostaglandins 128-141 angiotensinogen Rattus norvegicus 82-96 4070024-10 1985 To determine whether vasodilation of the tail of the rat was mediated by AII-induced prostaglandin release, indomethacin (4 and 6 mg/kg) was administered. Prostaglandins 85-98 angiotensinogen Rattus norvegicus 73-76 3917874-7 1985 Calmodulin inhibitors, trifluoperazine (2 microM), napthalene sulfonamide hydrochloride (2 microM), or calmidazolium (2 microM), diminished prostaglandin output elicited by angiotensin II, but not that caused by bradykinin. Prostaglandins 140-153 angiotensinogen Rattus norvegicus 173-187 3917874-9 1985 Prostaglandin output induced by angiotensin II and bradykinin were inhibited by mepacrine and indomethacin, whereas, the prostaglandin output caused by exogenous arachidonic acid (33 nmol) was abolished by indomethacin but was unaltered by mepacrine, calcium antagonists, and calmodulin inhibitors. Prostaglandins 0-13 angiotensinogen Rattus norvegicus 32-46 3917874-10 1985 From these data, we conclude that angiotensin II produces renal vasoconstriction by a mechanism dependent on extracellular calcium but not calmodulin, whereas angiotensin II-induced prostaglandin output depends on intracellular calcium and calmodulin. Prostaglandins 182-195 angiotensinogen Rattus norvegicus 159-173 6507631-6 1984 In ANG II-prostaglandin-blocked rats, PGC and stop-flow pressure responses were completely eliminated, yet SNGFR response persisted (36.2 to 28.0 nl/min) but to a somewhat lesser extent. Prostaglandins 10-23 angiotensinogen Rattus norvegicus 3-9 6507631-8 1984 Studies in ANG II-prostaglandin-blocked rats suggest that tubuloglomerular feedback SNGFR responses can occur without changes in PGC, possibly via parallel changes in afferent and efferent arteriolar resistances. Prostaglandins 18-31 angiotensinogen Rattus norvegicus 11-17 6396653-10 1984 The foregoing results document that an inhibitor of tissue PGs synthesis, namely indomethacin, is able to modify the dose-response curve for AII, rather than that for AI, in the uterus from ovariectomized rats, but not in preparations from spayed animals treated with estradiol. Prostaglandins 59-62 angiotensinogen Rattus norvegicus 141-144 6377924-5 1984 Inhibition of prostaglandin synthesis with meclofenamate increased the pressor response to angiotensin II toward normal in pregnant animals. Prostaglandins 14-27 angiotensinogen Rattus norvegicus 91-105 6742217-8 1984 The ANG II-induced dilation of the arterioles appears to be caused by increased prostaglandin synthesis and release. Prostaglandins 80-93 angiotensinogen Rattus norvegicus 4-10 6589024-1 1984 The relationship between the effects of glucocorticoids on renal vascular reactivity and prostaglandin synthesis elicited by noradrenaline (NA), angiotensin II (AII), arginine vasopressin (AVP) and bradykinin (Bk) was investigated in the isolated kidney of the rat perfused with Tyrode solution. Prostaglandins 89-102 angiotensinogen Rattus norvegicus 145-159 6589024-4 1984 In the presence of dexamethasone (2.6 X 10(-5)M) or corticosterone (2.9 X 10(-5) M), the effects of NA and AII, in enhancing prostaglandin synthesis and producing renal vasoconstriction, were reduced. Prostaglandins 125-138 angiotensinogen Rattus norvegicus 107-110 6383842-2 1984 As a result, the effect of prostaglandin synthesis inhibition on the pressor responsiveness to AII was evaluated. Prostaglandins 27-40 angiotensinogen Rattus norvegicus 95-98 6383842-3 1984 Prostaglandin synthesis inhibition with meclofenamate (5 mg/kg) or indomethacin (5 mg/kg) significantly enhanced the pressor response for AII at infusion rates of 0.10, 0.30 and 1.0 microgram/kg per min (P less than 0.05) in rats previously on a low sodium intake but had no effect in rats previously on a high sodium intake. Prostaglandins 0-13 angiotensinogen Rattus norvegicus 138-141 6595999-4 1984 Vasodilatory renal prostaglandins are relatively unimportant under normal circumstances but play a modulatory role after ischemia or in the presence of increased concentrations of vasoconstrictor substances such as angiotensin II (ANG II), vasopressin or norepinephrine. Prostaglandins 19-33 angiotensinogen Rattus norvegicus 215-229 6375609-9 1984 The data indicate that in intact rats prostaglandins may act as breaking mechanism against hypertensive influences such as a sudden increase in blood pressure by angiotensin II. Prostaglandins 38-52 angiotensinogen Rattus norvegicus 162-176 6595999-6 1984 These stimulatory actions of constrictor peptides are dependent upon calcium entry into the cells since removal of extracellular calcium or co-incubation with verapamil or nifedipine block the prostaglandin stimulatory capacity of ANG II or vasopressin. Prostaglandins 193-206 angiotensinogen Rattus norvegicus 231-237 3917874-0 1985 Mechanism of action of angiotensin II and bradykinin on prostaglandin synthesis and vascular tone in the isolated rat kidney. Prostaglandins 56-69 angiotensinogen Rattus norvegicus 23-37 6595999-4 1984 Vasodilatory renal prostaglandins are relatively unimportant under normal circumstances but play a modulatory role after ischemia or in the presence of increased concentrations of vasoconstrictor substances such as angiotensin II (ANG II), vasopressin or norepinephrine. Prostaglandins 19-33 angiotensinogen Rattus norvegicus 231-237 6141260-5 1984 Since circulating angiotensin II (AII) is a stimulus for PG synthesis during Na+ restriction, it is suggested that captopril may impair the renal responses to frusemide through hormonal and haemodynamic changes resulting from inhibition of A II formation. Prostaglandins 57-59 angiotensinogen Rattus norvegicus 18-32 6393967-1 1984 Experiments were performed to investigate the influence of prostaglandins (PG) on local angiotensin II (ANG II) generation in the brain and on the blood pressure (BP) effects of brain ANG II. Prostaglandins 75-77 angiotensinogen Rattus norvegicus 88-102 6393967-1 1984 Experiments were performed to investigate the influence of prostaglandins (PG) on local angiotensin II (ANG II) generation in the brain and on the blood pressure (BP) effects of brain ANG II. Prostaglandins 75-77 angiotensinogen Rattus norvegicus 104-110 6393967-10 1984 These studies indicate that PG attenuate whereas inhibition of their biosynthesis enhances the BP effects of endogenous brain ANG II in rats. Prostaglandins 28-30 angiotensinogen Rattus norvegicus 126-132 6393967-11 1984 It is suggested that PG may act as inhibitory modulators of the central actions of ANG II and they may participate in feedback mechanisms of the renin angiotensin system (RAS). Prostaglandins 21-23 angiotensinogen Rattus norvegicus 83-89 6141260-5 1984 Since circulating angiotensin II (AII) is a stimulus for PG synthesis during Na+ restriction, it is suggested that captopril may impair the renal responses to frusemide through hormonal and haemodynamic changes resulting from inhibition of A II formation. Prostaglandins 57-59 angiotensinogen Rattus norvegicus 34-37 6614160-1 1983 We investigated the hypothesis that vasopressin, angiotensin II, and norepinephrine stimulate the synthesis of vasodilatory prostaglandins in cultured vascular smooth muscle cells from rat mesenteric arteries. Prostaglandins 124-138 angiotensinogen Rattus norvegicus 49-63 6414846-2 1983 The mesangium contracts in response to angiotensin II (AII) and arginine vasopressin (AVP), both of which are potent stimuli of vasodilatory prostaglandin (PG) production. Prostaglandins 141-154 angiotensinogen Rattus norvegicus 39-53 6414846-2 1983 The mesangium contracts in response to angiotensin II (AII) and arginine vasopressin (AVP), both of which are potent stimuli of vasodilatory prostaglandin (PG) production. Prostaglandins 141-154 angiotensinogen Rattus norvegicus 55-58 6414846-2 1983 The mesangium contracts in response to angiotensin II (AII) and arginine vasopressin (AVP), both of which are potent stimuli of vasodilatory prostaglandin (PG) production. Prostaglandins 156-158 angiotensinogen Rattus norvegicus 39-53 6414846-2 1983 The mesangium contracts in response to angiotensin II (AII) and arginine vasopressin (AVP), both of which are potent stimuli of vasodilatory prostaglandin (PG) production. Prostaglandins 156-158 angiotensinogen Rattus norvegicus 55-58 6414846-7 1983 In these glomerular contraction studies, preincubation with either arachidonate or PGE2 decreased the contractile response to AII, whereas PG inhibition enhanced the glomerular contractile response. Prostaglandins 83-85 angiotensinogen Rattus norvegicus 126-129 6614160-3 1983 Vasopressin and angiotensin II dose dependently increased prostaglandin synthesis with a half-maximal stimulatory concentration of the order of 1 X 10(-8) M for both peptides. Prostaglandins 58-71 angiotensinogen Rattus norvegicus 16-30 6689628-0 1983 Angiotensin II induced release of prostaglandins from rat uterus. Prostaglandins 34-48 angiotensinogen Rattus norvegicus 0-14 6689628-7 1983 Our results suggests that the effect of A-II on prostaglandin synthesis by the rat uterus appears to be dependent of the hormonal milieu of the experimental animal. Prostaglandins 48-61 angiotensinogen Rattus norvegicus 40-44 6689628-8 1983 Estrogen stimulated A-II induced PG synthesis. Prostaglandins 33-35 angiotensinogen Rattus norvegicus 20-24 6689628-9 1983 Progesterone inhibited the synthesis of PGs caused by A-II in non-decidualized uterus but stimulated the release of PG in the decidualized uterus. Prostaglandins 40-42 angiotensinogen Rattus norvegicus 54-58 6689628-10 1983 The apparent differential effect of A-II in stimulating prostaglandin synthesis in the whole uterus indicates that there are different pathways for prostaglandin production in both the endometrium and myometrium. Prostaglandins 56-69 angiotensinogen Rattus norvegicus 36-40 6689628-10 1983 The apparent differential effect of A-II in stimulating prostaglandin synthesis in the whole uterus indicates that there are different pathways for prostaglandin production in both the endometrium and myometrium. Prostaglandins 148-161 angiotensinogen Rattus norvegicus 36-40 6792930-5 1981 Incubation of the prelabeled glomeruli with either angiotensin II or bradykinin significantly increased release of labeled prostaglandins and turnover of [14C]arachidonate on the ligated side. Prostaglandins 123-137 angiotensinogen Rattus norvegicus 51-65 6345587-11 1983 On the other hand, comparison of the RBF and GFR in the AII-inhibited hypercalcemic rats in the presence of PG (7.35 and 0.74 ml/min per gkw, respectively) and absence of PG (5.99 and 0.53 ml/min per gkw, P < 0.01 and P < 0.05, respectively) reveals the vasodilatory role for PG in hypercalcemia. Prostaglandins 108-110 angiotensinogen Rattus norvegicus 56-59 6282841-10 1982 The data suggest that PI may be a major source of arachidonic acid in the Ca2+-dependent release of PG, that angiotensin II stimulates a smaller or different pool of AA release than the divalent ionophore, and the angiotensin II stimulation of PG is a Ca2+-mediated process associated with increased "phosphatidylinositol-polyphosphoinositide" turnover in the rat inner medulla. Prostaglandins 244-246 angiotensinogen Rattus norvegicus 109-123 6871537-0 1983 Prostaglandin synthesis inhibitors: effect on angiotensin II- and oxytocin-induced contractions in rat uterine smooth muscle. Prostaglandins 0-13 angiotensinogen Rattus norvegicus 46-60 6958394-0 1982 Attenuation by prostaglandins of the facilitatory effect of angiotensin II at adrenergic prejunctional sites in the isolated Krebs-perfused rat heart. Prostaglandins 15-29 angiotensinogen Rattus norvegicus 60-74 7457608-4 1981 The AII-induced inhibition of water absorption can be abolished, and a net stimulation ensues after pretreatment of the animals with meclofenamate or indomethacin, suggesting that at high doses AII stimulates intestinal prostaglandin biosynthesis. Prostaglandins 220-233 angiotensinogen Rattus norvegicus 4-7 7457608-4 1981 The AII-induced inhibition of water absorption can be abolished, and a net stimulation ensues after pretreatment of the animals with meclofenamate or indomethacin, suggesting that at high doses AII stimulates intestinal prostaglandin biosynthesis. Prostaglandins 220-233 angiotensinogen Rattus norvegicus 194-197 6259059-0 1981 A possible antihypertensive mechanism of propranolol: antagonism of angiotensin II enhancement of sympathetic nerve transmission through prostaglandins. Prostaglandins 137-151 angiotensinogen Rattus norvegicus 68-82 6282841-2 1982 Prostaglandin (PG) release from rat inner medullary tissue has been shown to be stimulated by angiotensin II, bradykinin, and arginine vasopressin. Prostaglandins 0-13 angiotensinogen Rattus norvegicus 94-108 6282841-2 1982 Prostaglandin (PG) release from rat inner medullary tissue has been shown to be stimulated by angiotensin II, bradykinin, and arginine vasopressin. Prostaglandins 15-17 angiotensinogen Rattus norvegicus 94-108 6259059-10 1981 We conclude that propranolol antagonizes AII enhancement of NS by increasing prostaglandin levels in vascular tissue. Prostaglandins 77-90 angiotensinogen Rattus norvegicus 41-44 7428693-0 1980 Angiotensin II and [Sar1, Ile5, Ala8]angiotensin II effect on contractile activity and prostaglandin production of in vitro pregnant rat uteri. Prostaglandins 87-100 angiotensinogen Rattus norvegicus 0-14 7428693-0 1980 Angiotensin II and [Sar1, Ile5, Ala8]angiotensin II effect on contractile activity and prostaglandin production of in vitro pregnant rat uteri. Prostaglandins 87-100 angiotensinogen Rattus norvegicus 37-51 7428693-5 1980 Angiotensin II (1 microgram) resulted in increased prostaglandin (PG) production, but there was no clear dose-related effect. Prostaglandins 51-64 angiotensinogen Rattus norvegicus 0-14 7428693-5 1980 Angiotensin II (1 microgram) resulted in increased prostaglandin (PG) production, but there was no clear dose-related effect. Prostaglandins 66-68 angiotensinogen Rattus norvegicus 0-14 7428693-8 1980 [Sar1,Ile5,Ala8]Angiotensin II (2.5 microgram) did inhibit (P < 0.05) uterine contractions induced by angiotensin II (0.5 microgram), but PG production was not affected. Prostaglandins 141-143 angiotensinogen Rattus norvegicus 16-30 420294-7 1979 In particular, an indomethacin- and meclofenamate-sensitive vasodilator (presumably prostaglandin) plays a role in antagonizing the effects of a simultaneously acting vasoconstrictor which, although not identified, displayed the functional properties of angiotensin II. Prostaglandins 84-97 angiotensinogen Rattus norvegicus 254-268 500824-0 1979 Attenuation of angiotensin II- and III-induced aldosterone release by prostaglandin synthesis inhibitors. Prostaglandins 70-83 angiotensinogen Rattus norvegicus 15-38 7435623-0 1980 Prostaglandin synthesis by isolated rat glomeruli: effect of angiotensin II. Prostaglandins 0-13 angiotensinogen Rattus norvegicus 61-75 7435623-7 1980 In prelabeled glomeruli angiotensin II causes a small but significant increase in 14C-labeled prostaglandins. Prostaglandins 94-108 angiotensinogen Rattus norvegicus 24-38 6103950-0 1980 Partial inhibition of prostaglandin-induced contraction of the rat colon by analogues of angiotensin II. Prostaglandins 22-35 angiotensinogen Rattus norvegicus 89-103 7369060-0 1980 Release of dilator prostaglandins from rat lung during angiotensin II-induced vasoconstriction. Prostaglandins 19-33 angiotensinogen Rattus norvegicus 55-69 602881-0 1977 A comparison between the prostaglandin releasing effects of angiotensin II and angiotensin III. Prostaglandins 25-38 angiotensinogen Rattus norvegicus 60-74 709751-0 1978 Modulation by prostaglandin synthesis inhibitors of the action of exogenous angiotensin II on glomerular ultrafiltration in the rat. Prostaglandins 14-27 angiotensinogen Rattus norvegicus 76-90 709751-6 1978 When A II infusion was accompanied by inhibition of PG synthesis, however, profound declines in SNGFR and total GFR were seen, due to further reductions in QA and 2-fold greater increases in RA and RE than occurred with the same dose of A II alone. Prostaglandins 52-54 angiotensinogen Rattus norvegicus 5-9 709751-9 1978 It is likely that an interaction between A II and PG may be important in pathophysiological conditions in which endogenous A II levels are elevated. Prostaglandins 50-52 angiotensinogen Rattus norvegicus 123-127 602881-4 1977 These results were taken as evidence that some component of the contractile effects of angiotensin II and angiotensin III on the isolated rat stomach fundus involves the release of prostaglandins by the peptides and in this respect angiotensin III has higher potency than angiotensin II. Prostaglandins 181-195 angiotensinogen Rattus norvegicus 87-101 602881-4 1977 These results were taken as evidence that some component of the contractile effects of angiotensin II and angiotensin III on the isolated rat stomach fundus involves the release of prostaglandins by the peptides and in this respect angiotensin III has higher potency than angiotensin II. Prostaglandins 181-195 angiotensinogen Rattus norvegicus 106-120 913046-12 1977 These results suggest that some actions of angiotensin II and cortisol in vivo are mediated by the regulation of prostaglandin synthesis or release. Prostaglandins 113-126 angiotensinogen Rattus norvegicus 43-57 1169797-6 1975 This result, together with those of previous investigations performed using other prostaglandin inhibitors, suggest that the contractor effect of angiotensin II on the uterus is partially mediated by endogenous prostaglandins. Prostaglandins 82-95 angiotensinogen Rattus norvegicus 146-160 897209-0 1977 Role of prostaglandins in the mediation of systemic tachyphylaxis to angiotensin II. Prostaglandins 8-22 angiotensinogen Rattus norvegicus 69-83 826177-6 1976 These results support the hypothesis that, in th rat, autoregulation of RBF occurs independently of prostaglandin activity, but that a relationship does exist between the renal vascular actions of angiotensin II and prostaglandins. Prostaglandins 216-230 angiotensinogen Rattus norvegicus 197-211 1125304-9 1975 Angiotensin II (10--100 ng/ml) stimulated the biosynthesis of both prostaglandin E2 and prostaglandin F2alpha, thus increasing prostaglandin levels in both the incubation medium and the tissues. Prostaglandins 67-80 angiotensinogen Rattus norvegicus 0-14 1125304-11 1975 The mechanism whereby angiotensin II stimulates prostaglandin biosynthesis was investigated using the isotope dilution technique. Prostaglandins 48-61 angiotensinogen Rattus norvegicus 22-36 1125304-12 1975 In the presence of [14-C]-arachidonic acid, angiotensin II stimulated the output of more prostaglandin that had a significantly lower specific activity than the controls. Prostaglandins 89-102 angiotensinogen Rattus norvegicus 44-58 1125304-13 1975 Angiotensin II therefore increased the availability of endogenous, non-labelled substrate for prostaglandin biosynthesis. Prostaglandins 94-107 angiotensinogen Rattus norvegicus 0-14 1125304-17 1975 It is concluded that angiotensin II controls prostaglandin biosynthesis in the renal papilla by regulating the availability of free precursor. Prostaglandins 45-58 angiotensinogen Rattus norvegicus 21-35 1169797-6 1975 This result, together with those of previous investigations performed using other prostaglandin inhibitors, suggest that the contractor effect of angiotensin II on the uterus is partially mediated by endogenous prostaglandins. Prostaglandins 211-225 angiotensinogen Rattus norvegicus 146-160 23184385-1 2013 During renin-angiotensin system activation, cyclooxygenase-2 (COX-2)-derived prostaglandins attenuate the pressor and antinatriuretic effects of angiotensin II (AngII) in the renal medulla. Prostaglandins 77-91 angiotensinogen Rattus norvegicus 145-159 4376438-3 1974 Maximal contractile effects of angiotensin II, oxytocin and prostaglandin F(2alpha) were thus observed when the ratio oestrogen/progesterone levels was high.2 The oestrogen-dependent sensitivity of the rat uterus is partially mediated by endogenous prostaglandins. Prostaglandins 249-263 angiotensinogen Rattus norvegicus 31-45 33897446-9 2021 However, vasodilator prostanoids as well as other relaxing mechanisms, activated by ETB stimulation, are mobilized by exercise to cooperate with NO in order to maintain controlled Ang II responses in femoral veins. Prostaglandins 21-32 angiotensinogen Rattus norvegicus 180-186 31680980-3 2019 However concurrently, the ACE2-Ang-(1-7) axis and the expression of kallikrein and medullary prostaglandins counteract the effects of Ang II, promoting natriuresis and vasodilation. Prostaglandins 93-107 angiotensinogen Rattus norvegicus 134-140 31378306-3 2019 Further, cyclooxygenase (Cox)-derived prostanoids were implicated in Ang II-dependent hypertension. Prostaglandins 38-49 angiotensinogen Rattus norvegicus 69-75 27225954-0 2016 Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats. Prostaglandins 24-34 angiotensinogen Rattus norvegicus 66-80 27225954-5 2016 This suggests that prostanoid generation caused by administration of ANG II and salt leads to an increase in neurogenic pressor activity and blood pressure (BP) via a mechanism that persists without the need for continuing prostanoid input. Prostaglandins 19-29 angiotensinogen Rattus norvegicus 69-75 27225954-5 2016 This suggests that prostanoid generation caused by administration of ANG II and salt leads to an increase in neurogenic pressor activity and blood pressure (BP) via a mechanism that persists without the need for continuing prostanoid input. Prostaglandins 223-233 angiotensinogen Rattus norvegicus 69-75 24014677-1 2013 Cyclooxygenase (COX)-derived prostanoids contribute to angiotensin II (ANG II) hypertension (HTN). Prostaglandins 29-40 angiotensinogen Rattus norvegicus 55-69 24014677-1 2013 Cyclooxygenase (COX)-derived prostanoids contribute to angiotensin II (ANG II) hypertension (HTN). Prostaglandins 29-40 angiotensinogen Rattus norvegicus 71-77 24014677-4 2013 This study tested the hypothesis that COX-derived prostanoids cause ANG II-salt sympathoexcitation and HTN. Prostaglandins 50-61 angiotensinogen Rattus norvegicus 68-74 28012855-0 2017 Prostanoids counterbalance the synergism between endothelin-1 and angiotensin II in mesenteric veins of trained rats. Prostaglandins 0-11 angiotensinogen Rattus norvegicus 66-80 28012855-2 2017 In femoral veins, exercise mobilizes vasodilator prostanoids to cooperate with NO in order to maintain reduced Ang II responses. Prostaglandins 49-60 angiotensinogen Rattus norvegicus 111-117 28012855-14 2017 On the other hand, vasodilator prostanoids are mobilized to act in parallel with NO in order to counterbalance the Ang II responses that have been potentiated by ET-1 in these trained animals. Prostaglandins 31-42 angiotensinogen Rattus norvegicus 115-121 27575704-10 2016 Further, endothelin receptors and vasoconstrictor prostanoids contribute to the CSA-evoked exaggeration of Ang II vascular responsiveness and hypertension. Prostaglandins 50-61 angiotensinogen Rattus norvegicus 107-113 26611113-8 2016 In contrast, the fall in PBF induced by Ang II (12 %) was enhanced (P < 0.05) by the simultaneous PGs (30 %) or PGs and NO (31 %) synthesis inhibition but not in L-NAME-treated rats (20 %). Prostaglandins 101-104 angiotensinogen Rattus norvegicus 40-46 26611113-8 2016 In contrast, the fall in PBF induced by Ang II (12 %) was enhanced (P < 0.05) by the simultaneous PGs (30 %) or PGs and NO (31 %) synthesis inhibition but not in L-NAME-treated rats (20 %). Prostaglandins 115-118 angiotensinogen Rattus norvegicus 40-46 23184385-1 2013 During renin-angiotensin system activation, cyclooxygenase-2 (COX-2)-derived prostaglandins attenuate the pressor and antinatriuretic effects of angiotensin II (AngII) in the renal medulla. Prostaglandins 77-91 angiotensinogen Rattus norvegicus 161-166 21169864-1 2011 AIMS: To assess whether angiotensin II (Ang II) modulates key enzymes of the cyclooxygenase (COX)-2/prostanoid pathway, including prostaglandin E synthase-1 (mPGES-1) and prostacyclin synthase (PGIS) in rat aortic adventitial fibroblasts in the presence or absence of an inflammatory stimulus [interleukin (IL)-1beta]. Prostaglandins 100-110 angiotensinogen Rattus norvegicus 24-38 21169864-1 2011 AIMS: To assess whether angiotensin II (Ang II) modulates key enzymes of the cyclooxygenase (COX)-2/prostanoid pathway, including prostaglandin E synthase-1 (mPGES-1) and prostacyclin synthase (PGIS) in rat aortic adventitial fibroblasts in the presence or absence of an inflammatory stimulus [interleukin (IL)-1beta]. Prostaglandins 100-110 angiotensinogen Rattus norvegicus 40-46 21169864-4 2011 Ang II did modify neither COX-2 and mPGES-1 expression nor prostanoid levels, but it induced PGIS expression. Prostaglandins 59-69 angiotensinogen Rattus norvegicus 0-6 21169864-10 2011 CONCLUSION: Ang II differentially modulates key enzymes involved in prostanoid biosynthesis thereby altering the balance between PGI2/PGE2 in vascular cells exposed to inflammatory stimuli. Prostaglandins 68-78 angiotensinogen Rattus norvegicus 12-18