PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22107041-5 2012 RESULTS: Our results showed that PGF2alpha and topical prostaglandin analogs down-regulated the expression of PPARgamma and C/EBPalpha, and inhibited accumulation of intra-cytoplasmic lipid droplets and expression of LPL compared with the untreated control. Prostaglandins 55-68 peroxisome proliferator activated receptor gamma Homo sapiens 110-119 22561694-2 2012 These prostanoids are active ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), a master regulator of adipogenesis in adipocytes. Prostaglandins 6-17 peroxisome proliferator activated receptor gamma Homo sapiens 41-89 22561694-2 2012 These prostanoids are active ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), a master regulator of adipogenesis in adipocytes. Prostaglandins 6-17 peroxisome proliferator activated receptor gamma Homo sapiens 91-100 17532302-1 2007 Prostaglandin metabolite 15-Deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) is known to inhibit a number of pro-inflammatory cytokines as well as being a ligand for nuclear receptor PPARgamma. Prostaglandins 0-13 peroxisome proliferator activated receptor gamma Homo sapiens 181-190 18203887-7 2008 Next, we sought to determine whether EPA or a prostaglandin formed from EPA is the functional ligand of PPARgamma. Prostaglandins 46-59 peroxisome proliferator activated receptor gamma Homo sapiens 104-113 18509496-5 2008 While activation of PPARgamma can occur by direct binding of pharmacological ligands to the molecule, emerging data indicate that PPARgamma activation can occur through engagement of other signal transduction pathways, including Wnt signaling and prostaglandin production. Prostaglandins 247-260 peroxisome proliferator activated receptor gamma Homo sapiens 130-139 17673570-1 2007 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a cyclopentenonic prostaglandin endowed with powerful anti-inflammatory activities, as shown in animal models of inflammatory/autoimmune diseases, where pharmacological administration of this prostanoid can ameliorate inflammation and local tissue damage via activation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) and/or covalent modifications of cellular proteins. Prostaglandins 22-35 peroxisome proliferator activated receptor gamma Homo sapiens 401-410 21237281-2 2011 Prostaglandin (PG) D(2) can be produced in adipocytes and dehydrated to J(2) series of PGs including 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and Delta(12)-PGJ(2), which serve as pro-adipogenic prostanoids through the activation of PPARgamma. Prostaglandins 0-13 peroxisome proliferator activated receptor gamma Homo sapiens 233-242 20735405-8 2010 Among PPARgamma ligands, the potency order towards human MGL was troglitazone > ciglitazone > rosiglitazone > 15-deoxy-Delta(12,14) -prostaglandin J(2) CAY 10415 > CAY 10514. Prostaglandins 142-155 peroxisome proliferator activated receptor gamma Homo sapiens 6-15 18615184-3 2008 In particular, PPARgamma ligands including endogenous prostaglandins and the synthetic thiazolidinediones (TZDs) can induce apoptosis of cancer cells with antitumor activity. Prostaglandins 54-68 peroxisome proliferator activated receptor gamma Homo sapiens 15-24 17430113-19 2007 These prostaglandins exert potent anti-inflammatory activities through endogenous signaling mechanisms involving the GPCRs EP2, EP4, and DP1 along with PPARgamma respectively. Prostaglandins 6-20 peroxisome proliferator activated receptor gamma Homo sapiens 152-161 17512458-2 2007 Although cyclopentenone prostaglandins regulate the formation of these prolabor mediators via nuclear factor-kappaB (NF-kappaB) and/or peroxisome proliferator-activated receptor-gamma, recent evidence suggests that they do not exist in vivo. Prostaglandins 24-38 peroxisome proliferator activated receptor gamma Homo sapiens 117-183 16434095-2 2006 We have previously demonstrated that natural and synthetic PPAR-gamma ligands regulate LPS-stimulated pro-inflammatory cytokine release from human gestational tissues, however, the effect of these ligands on the basal and/or LPS-induced expression of prostaglandins and proteases is not known. Prostaglandins 251-265 peroxisome proliferator activated receptor gamma Homo sapiens 59-69 17003477-8 2006 Third, activated, but not naive, human T cells highly express Cox-2 and synthesize prostaglandin D2 and related prostaglandins that are PPAR-gamma ligands. Prostaglandins 112-126 peroxisome proliferator activated receptor gamma Homo sapiens 136-146 16784897-9 2006 Since blood flow regulation is mediated by mechanisms other than NO, such as prostaglandins and endothelial derived hyperpolarizing factor, which, in turn, are compromised by the inflammatory state, we anticipate that activation of both the PPARgamma as well as PPARalpha should ameliorate the disordered blood flow in type 2 diabetes. Prostaglandins 77-91 peroxisome proliferator activated receptor gamma Homo sapiens 241-250 16842938-2 2006 Prostanoids have been proposed as potent adipogenic hormones, e.g. metabolites of prostaglandin J2 (PGJ2) bind and activate PPARgamma. Prostaglandins 0-11 peroxisome proliferator activated receptor gamma Homo sapiens 124-133 16454728-4 2006 The present review summarizes the several lines of evidence supporting that PPAR-gamma natural and synthetic agonists may control brain inflammation by inhibiting several functions associated to microglial activation, such as the expression of surface antigens and the synthesis of nitric oxide, prostaglandins, inflammatory cytokines and chemokines. Prostaglandins 296-310 peroxisome proliferator activated receptor gamma Homo sapiens 76-86 16782410-5 2006 PPARgamma is activated by fatty acid derivatives, such as hydroxyoctadecadienoic acid (HODEs), prostaglandin derivatives, such as 15-deoxy-Delta12,14-prostaglandin J2, and thiazolidinedione (glitazone) drugs, such as pioglitazone and rosiglitazone. Prostaglandins 95-108 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 16386710-0 2006 Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Prostaglandins 123-136 peroxisome proliferator activated receptor gamma Homo sapiens 15-24 15475569-4 2005 In human myeloid leukemia (HL-60) cells, ligand access to PPARgamma is regulated by AKR1C3, which diverts PGD(2) metabolism away from J-series prostanoids (Desmond et al., 2003). Prostaglandins 143-154 peroxisome proliferator activated receptor gamma Homo sapiens 58-67 15821150-1 2005 15-Deoxy delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), an activator of peroxisome proliferator-activated receptor (PPAR)-gamma and -delta, is a prostanoid metabolite with anti-inflammatory actions. Prostaglandins 144-154 peroxisome proliferator activated receptor gamma Homo sapiens 115-137 15879329-1 2005 BACKGROUND AND PURPOSE: The 15-deoxyDelta prostaglandin J2 (15-dPGJ2) is an anti-inflammatory prostaglandin that has been proposed to be the endogenous ligand of peroxisome proliferator-activated receptor-gamma (PPARgamma), a nuclear receptor that can exert potent anti-inflammatory actions by repressing inflammatory genes when activated. Prostaglandins 42-55 peroxisome proliferator activated receptor gamma Homo sapiens 162-210 15879329-1 2005 BACKGROUND AND PURPOSE: The 15-deoxyDelta prostaglandin J2 (15-dPGJ2) is an anti-inflammatory prostaglandin that has been proposed to be the endogenous ligand of peroxisome proliferator-activated receptor-gamma (PPARgamma), a nuclear receptor that can exert potent anti-inflammatory actions by repressing inflammatory genes when activated. Prostaglandins 42-55 peroxisome proliferator activated receptor gamma Homo sapiens 212-221 15695504-6 2005 Screening of lipid metabolites containing the alpha,beta-unsaturated ketone revealed that several other oxidized metabolites of hydroxyeicosatetraenoic acid, hydroxyeicosadecaenoic acid, and prostaglandins can also function as novel covalent ligands for PPARgamma. Prostaglandins 191-205 peroxisome proliferator activated receptor gamma Homo sapiens 254-263 15516334-10 2005 These findings suggested that UVB-generated PPAR gamma activity is necessary for the optimal production of epidermal prostaglandins. Prostaglandins 117-131 peroxisome proliferator activated receptor gamma Homo sapiens 44-54 15287152-0 2004 Thiazolidinediones increase arachidonic acid release and subsequent prostanoid production in a peroxisome proliferator-activated receptor gamma-independent manner. Prostaglandins 68-78 peroxisome proliferator activated receptor gamma Homo sapiens 95-143 15142970-7 2004 Ligands of PPARgamma include naturally occurring FA derivatives, such as hydroxyoctadecadienoic acids (HODEs), prostaglandin derivatives such as 15-deoxyDelta12,14-prostaglandin J2, and glitazones, insulin-sensitizing drugs presently used to treat patients with type 2 diabetes. Prostaglandins 111-124 peroxisome proliferator activated receptor gamma Homo sapiens 11-20 15109566-6 2004 In addition, prostanoids may activate the PPARgamma members of the steroid/thyroid family of nuclear hormone receptors, which act as transcription factors and may thus directly influence gene transcription. Prostaglandins 13-24 peroxisome proliferator activated receptor gamma Homo sapiens 42-51 12731885-1 2003 One of the most potent cyclopentenone prostaglandins, 15-deoxy-Delta(12,14)prostaglandin J(2) (15-d-PGJ(2)), has been shown to be cytotoxic in some tumor cells and, as a ligand of peroxisome proliferator activated receptor gamma (PPARgamma), to influence the transcriptional regulation of several genes. Prostaglandins 38-52 peroxisome proliferator activated receptor gamma Homo sapiens 180-228 15287152-8 2004 In this study, we demonstrated that high concentrations of TZDs increased AA release by the inhibition of AA reuptaking process, leading to subsequent increase in the prostanoid production in a PPARgamma-independent manner. Prostaglandins 167-177 peroxisome proliferator activated receptor gamma Homo sapiens 194-203 12885795-5 2003 When myocytes were transfected with a PPAR response element reporter plasmid (PPRE-TK-luciferase), the PPARgamma activator 15-deoxy-Delta12,14-prostaglandin J2 (15dPGJ2) increased promoter activity, whereas cotransfection of a dominant negative PPARgamma inhibited it. Prostaglandins 143-156 peroxisome proliferator activated receptor gamma Homo sapiens 103-112 12885795-5 2003 When myocytes were transfected with a PPAR response element reporter plasmid (PPRE-TK-luciferase), the PPARgamma activator 15-deoxy-Delta12,14-prostaglandin J2 (15dPGJ2) increased promoter activity, whereas cotransfection of a dominant negative PPARgamma inhibited it. Prostaglandins 143-156 peroxisome proliferator activated receptor gamma Homo sapiens 245-254 12925148-2 2003 We previously reported that prostaglandins (PGs) dramatically increased vascular endothelial growth factor (VEGF), a known angiogenic factor and a vascular permeable factor, by activated macrophages through specific PGE receptor and peroxisome proliferator-activated receptor gamma (PPARgamma, a nuclear receptor of PG) mediated process. Prostaglandins 28-42 peroxisome proliferator activated receptor gamma Homo sapiens 233-281 12925148-2 2003 We previously reported that prostaglandins (PGs) dramatically increased vascular endothelial growth factor (VEGF), a known angiogenic factor and a vascular permeable factor, by activated macrophages through specific PGE receptor and peroxisome proliferator-activated receptor gamma (PPARgamma, a nuclear receptor of PG) mediated process. Prostaglandins 28-42 peroxisome proliferator activated receptor gamma Homo sapiens 283-292 12925148-2 2003 We previously reported that prostaglandins (PGs) dramatically increased vascular endothelial growth factor (VEGF), a known angiogenic factor and a vascular permeable factor, by activated macrophages through specific PGE receptor and peroxisome proliferator-activated receptor gamma (PPARgamma, a nuclear receptor of PG) mediated process. Prostaglandins 44-47 peroxisome proliferator activated receptor gamma Homo sapiens 233-281 12925148-2 2003 We previously reported that prostaglandins (PGs) dramatically increased vascular endothelial growth factor (VEGF), a known angiogenic factor and a vascular permeable factor, by activated macrophages through specific PGE receptor and peroxisome proliferator-activated receptor gamma (PPARgamma, a nuclear receptor of PG) mediated process. Prostaglandins 44-47 peroxisome proliferator activated receptor gamma Homo sapiens 283-292 12731885-1 2003 One of the most potent cyclopentenone prostaglandins, 15-deoxy-Delta(12,14)prostaglandin J(2) (15-d-PGJ(2)), has been shown to be cytotoxic in some tumor cells and, as a ligand of peroxisome proliferator activated receptor gamma (PPARgamma), to influence the transcriptional regulation of several genes. Prostaglandins 38-52 peroxisome proliferator activated receptor gamma Homo sapiens 230-239 12906257-4 2003 Naturally occurring PPAR-gamma ligands include the cyclopentenone prostaglandins of the J series, which are present in bone marrow, thymus, and secondary lymphatic tissues. Prostaglandins 66-80 peroxisome proliferator activated receptor gamma Homo sapiens 20-30 12707336-2 2003 15d-PGJ(2) is a natural ligand of the peroxisome proliferator-activated receptor (PPAR)-gamma nuclear receptor, but relevant PPARgamma-independent actions mediated by this prostanoid have been described. Prostaglandins 172-182 peroxisome proliferator activated receptor gamma Homo sapiens 125-134 12906257-6 2003 Cyclopentenone prostaglandins activate both PPAR-gamma-dependent and PPAR-gamma-independent pathways, possess intrinsic proapoptotic potential and are direct inhibitors of NF-kappaB signaling. Prostaglandins 15-29 peroxisome proliferator activated receptor gamma Homo sapiens 44-54 12906257-6 2003 Cyclopentenone prostaglandins activate both PPAR-gamma-dependent and PPAR-gamma-independent pathways, possess intrinsic proapoptotic potential and are direct inhibitors of NF-kappaB signaling. Prostaglandins 15-29 peroxisome proliferator activated receptor gamma Homo sapiens 69-79 12906257-8 2003 Some of the newly described regulatory pathways might eventually be exploited in the treatment of immune diseases by means of PPAR-gamma ligands, such as thiazolidinediones or prostaglandins. Prostaglandins 176-190 peroxisome proliferator activated receptor gamma Homo sapiens 126-136 11955950-5 2002 In this respect, prostaglandin (PG)-related compounds were identified as good PPARgamma agonists with varying specificity, the most notable PPAR ligand being 15-deoxy-Delta12-14-PGJ2 (15d-PGJ2). Prostaglandins 17-30 peroxisome proliferator activated receptor gamma Homo sapiens 78-87 12239635-1 2002 Cyclopentenone-prostaglandin derivatives, including the peroxisome-proliferator activated receptor gamma (PPARgamma) ligand 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), inhibit tumor cell growth in vitro and in vivo. Prostaglandins 15-28 peroxisome proliferator activated receptor gamma Homo sapiens 56-104 11955950-5 2002 In this respect, prostaglandin (PG)-related compounds were identified as good PPARgamma agonists with varying specificity, the most notable PPAR ligand being 15-deoxy-Delta12-14-PGJ2 (15d-PGJ2). Prostaglandins 32-34 peroxisome proliferator activated receptor gamma Homo sapiens 78-87 11955950-7 2002 In the present review, we discuss the different PPARgamma-dependent and -independent biological effects of the PG PPARgamma ligands and the concern about their low potency in molecular models as compared with thiazolidinediones (TZDs), a family of potent (nanomolar) synthetic PPARgamma ligands. Prostaglandins 111-113 peroxisome proliferator activated receptor gamma Homo sapiens 48-57 11955950-7 2002 In the present review, we discuss the different PPARgamma-dependent and -independent biological effects of the PG PPARgamma ligands and the concern about their low potency in molecular models as compared with thiazolidinediones (TZDs), a family of potent (nanomolar) synthetic PPARgamma ligands. Prostaglandins 111-113 peroxisome proliferator activated receptor gamma Homo sapiens 114-123 11955950-7 2002 In the present review, we discuss the different PPARgamma-dependent and -independent biological effects of the PG PPARgamma ligands and the concern about their low potency in molecular models as compared with thiazolidinediones (TZDs), a family of potent (nanomolar) synthetic PPARgamma ligands. Prostaglandins 111-113 peroxisome proliferator activated receptor gamma Homo sapiens 114-123 12349941-5 2002 The ligands for PPAR-gamma include 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2)--a metabolite from the prostaglandin synthesis pathway, and "glitazones"--drugs utilized in the treatment of patients with diabetes. Prostaglandins 57-70 peroxisome proliferator activated receptor gamma Homo sapiens 16-26 11287611-9 2001 Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1. Prostaglandins 48-62 peroxisome proliferator activated receptor gamma Homo sapiens 81-90 11918736-13 2002 CONCLUSIONS: J-series prostaglandins thus may be involved in the initiation of glomerular hypercellularity through Akt-dependent proliferation, and restoration of normal glomerular architecture through PPARgamma-mediated apoptosis. Prostaglandins 22-36 peroxisome proliferator activated receptor gamma Homo sapiens 202-211 12086407-9 2002 Recently, novel signaling pathways for PG derivatives have been discovered; in particular the PGD2 dehydration product 15-deoxy-delta(12,14)-(15d)-PGJ2 was identified as a ligand for the nuclear receptor/transcription factor, peroxisome proliferator-activated receptor (PPAR)-gamma. Prostaglandins 39-41 peroxisome proliferator activated receptor gamma Homo sapiens 226-281 12160520-4 2002 PPARgamma is activated by a wide variety of ligands such as fatty acids, the anti-diabetic thiazolidinediones (TZDs), and also by certain prostaglandins of which 15-deoxy-Delta(12,14)-PGJ2 (PGJ2). Prostaglandins 138-152 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 12079830-4 2002 PPARalpha has been shown to bind and to be activated by leukotriene B4 and the hypolipidemic drugs of the fibrate class; PPARbeta/delta ligands are polyunsaturated fatty acids and prostaglandins; while prostaglandin J2 derivatives and the antidiabetic glitazones are, respectively, natural and synthetic ligands for PPARgamma. Prostaglandins 180-194 peroxisome proliferator activated receptor gamma Homo sapiens 316-325 11987982-11 2002 PPAR-gamma agonists may serve as a counterbalance to the stimulating effects of other prostaglandins, namely PGE(2), which promotes B cell immunoglobulin class switching. Prostaglandins 86-100 peroxisome proliferator activated receptor gamma Homo sapiens 0-10 12064327-7 2002 Expression of PPAR-gamma in the nucleus is activated by second messengers such as J series prostaglandins and the latter have been shown to cause apoptosis in vivo in explants of human BC cells in immunosuppressed mice. Prostaglandins 91-105 peroxisome proliferator activated receptor gamma Homo sapiens 14-24 11287611-9 2001 Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1. Prostaglandins 64-67 peroxisome proliferator activated receptor gamma Homo sapiens 81-90 11301062-0 2001 Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Prostaglandins 11-25 peroxisome proliferator activated receptor gamma Homo sapiens 35-44 11301062-9 2001 Furthermore, in an attempt to complete the panel of natural PPARgamma ligands, 29 commercially available prostaglandins were screened in the binding assay. Prostaglandins 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 60-69 11301062-12 2001 The fact that these three prostaglandins were equally potent, suggests new pathways of PPARgamma-linked gene activation. Prostaglandins 26-40 peroxisome proliferator activated receptor gamma Homo sapiens 87-96 11697231-4 2001 PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl)tyrosine analogues. Prostaglandins 30-41 peroxisome proliferator activated receptor gamma Homo sapiens 0-10 11078701-1 2000 A cyclopentenone-type prostaglandin, 15-deoxy-Delta(12, 14)-prostaglandin J(2) (15-d-PGJ(2)), has been shown to induce the cellular stress response and to be a ligand for the peroxisome proliferator-activated receptor (PPAR)-gamma. Prostaglandins 22-35 peroxisome proliferator activated receptor gamma Homo sapiens 175-230 10506103-4 1999 Activation of PPARgamma with the known prostanoid agonist 15-deoxy-Delta12,14-prostaglandin J(2) (15dPGJ(2)) or the thiazolidinedione (TZD) agonist troglitazone (TGZ) attenuated cellular proliferation of the estrogen receptor-negative breast cancer cell line MDA-MB-231, as well as the estrogen receptor-positive breast cancer cell line MCF-7. Prostaglandins 39-49 peroxisome proliferator activated receptor gamma Homo sapiens 14-23 10873632-13 2000 These results suggest that PGs dramatically increased VEGF production by activated macrophages through specific PGE receptor and PPARgamma-mediated processes and that PGs may thereby promote tumor growth through VEGF production. Prostaglandins 27-30 peroxisome proliferator activated receptor gamma Homo sapiens 129-138 10613734-2 2000 Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates adipocyte differentiation and controls gene transcription in response to various activators including prostanoids and antidiabetic thiazolidinediones. Prostaglandins 173-184 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 10613734-2 2000 Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates adipocyte differentiation and controls gene transcription in response to various activators including prostanoids and antidiabetic thiazolidinediones. Prostaglandins 173-184 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 10827178-9 2000 Taking these findings together, we propose that expression of COX-2 is regulated by a negative feedback loop mediated through PPARgamma, which makes possible a dynamic production of PG, especially in macrophages, and may be attributed to various expression patterns and physiological functions of COX-2. Prostaglandins 182-184 peroxisome proliferator activated receptor gamma Homo sapiens 126-135 11026084-8 2000 PPAR-gamma, a transcription factor that is activated by fatty acids and prostaglandins, plays a central role in adipose conversion of preadipocytes and appears to participate in controlling the size of mature fat cells as well. Prostaglandins 72-86 peroxisome proliferator activated receptor gamma Homo sapiens 0-10 10536181-3 1999 DNA binding by endogenous PPARgamma in gel shift assays and activation of PPARgamma by prostanoid and thiazolidinedione ligands in reporter gene assays differed between the cell lines. Prostaglandins 87-97 peroxisome proliferator activated receptor gamma Homo sapiens 74-83 9435691-3 1997 8(S)-hydroxyeicosatetraenoic acid (8-S-HETE), leukotriene B4 (LTB4), and hypolipidemic fibrates activate PPAR alpha, whereas PPAR gamma is activated by prostaglandin metabolites. Prostaglandins 152-165 peroxisome proliferator activated receptor gamma Homo sapiens 125-135 10419513-3 1999 It has been well established that peroxisome proliferator-activated receptor (PPAR) gamma, activated by specific prostanoids, plays a central role in the control of adipocyte gene expression and terminal differentiation. Prostaglandins 113-124 peroxisome proliferator activated receptor gamma Homo sapiens 34-89 9442016-0 1998 Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. Prostaglandins 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 74-122 9030579-1 1997 The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) regulates transcription in response to prostanoid and thiazolidinedione ligands and promotes adipocyte differentiation. Prostaglandins 121-131 peroxisome proliferator activated receptor gamma Homo sapiens 21-69 9030579-1 1997 The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) regulates transcription in response to prostanoid and thiazolidinedione ligands and promotes adipocyte differentiation. Prostaglandins 121-131 peroxisome proliferator activated receptor gamma Homo sapiens 71-80 9209705-5 1997 With regards to ligands, we have shown that an unusual prostanoid, 15-deoxy delta 12,14PG J2, can bind to PPAR gamma and activate it. Prostaglandins 55-65 peroxisome proliferator activated receptor gamma Homo sapiens 106-116 33802010-5 2021 This enzyme is involved in prostaglandin synthesis and the latter binds to nuclear receptors like PPARgamma. Prostaglandins 27-40 peroxisome proliferator activated receptor gamma Homo sapiens 98-107 9491639-4 1997 Fortunately, two prostaglandins derived from dietary arachidonic acid bind fat cell PPAR gamma and hepatic PPAR alpha. Prostaglandins 17-31 peroxisome proliferator activated receptor gamma Homo sapiens 84-94 9009672-2 1996 The endogenous ligand is thought to be 15-deoxy-delta 12,14-prostaglandin J2-Thiazolidinedione, an antidiabetic drug, closely mimics the action of the prostaglandin, suggesting a regulatory role by the prostaglandin and PPAR gamma both in adipocyte differentiation and in glucose homeostasis. Prostaglandins 60-73 peroxisome proliferator activated receptor gamma Homo sapiens 220-230 9009672-2 1996 The endogenous ligand is thought to be 15-deoxy-delta 12,14-prostaglandin J2-Thiazolidinedione, an antidiabetic drug, closely mimics the action of the prostaglandin, suggesting a regulatory role by the prostaglandin and PPAR gamma both in adipocyte differentiation and in glucose homeostasis. Prostaglandins 151-164 peroxisome proliferator activated receptor gamma Homo sapiens 220-230 23319937-0 2012 Prostaglandins as PPARgamma Modulators in Adipogenesis. Prostaglandins 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 18-27 22778711-1 2012 Peroxisome proliferator activated receptor (PPAR)-gamma is a nuclear hormone receptor that is activated by multiple agonists including thiazolidinediones, prostaglandins, and synthetic oleanolic acids. Prostaglandins 155-169 peroxisome proliferator activated receptor gamma Homo sapiens 0-55 23319937-4 2012 Prostaglandins (PGs), which are lipid mediators, are associated with the regulation of PPARgamma function in adipocytes. Prostaglandins 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 87-96 23319937-4 2012 Prostaglandins (PGs), which are lipid mediators, are associated with the regulation of PPARgamma function in adipocytes. Prostaglandins 16-19 peroxisome proliferator activated receptor gamma Homo sapiens 87-96 23319937-9 2012 This paper focuses on potential roles of PGs as PPARgamma modulators in adipogenesis and regulators of obesity. Prostaglandins 41-44 peroxisome proliferator activated receptor gamma Homo sapiens 48-57 26429394-5 2016 METHODS: In the current study we investigated the potential for AKR1C3 to regulate the availability of prostaglandin-derived ligands for PPARg mainly, prostaglandin J2 (PGJ2). Prostaglandins 103-116 peroxisome proliferator activated receptor gamma Homo sapiens 137-142 33007445-8 2020 Peroxisome proliferator-activated receptor gamma (PPARgamma) seems to mediate the augmenting activity as the antagonist GW9662 dose-dependently prevented 15(S)-HETE from increasing PG production. Prostaglandins 181-183 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 33007445-8 2020 Peroxisome proliferator-activated receptor gamma (PPARgamma) seems to mediate the augmenting activity as the antagonist GW9662 dose-dependently prevented 15(S)-HETE from increasing PG production. Prostaglandins 181-183 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 29146573-0 2018 Prostanoid EP4 agonist L-902,688 activates PPARgamma and attenuates pulmonary arterial hypertension. Prostaglandins 0-10 peroxisome proliferator activated receptor gamma Homo sapiens 43-52 32766764-2 2020 PPARgamma binds to DNA as a heterodimer with retinoid X receptor and it is activated by polyunsaturated fatty acids and fatty acid derivatives, such as prostaglandins. Prostaglandins 152-166 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 28609844-7 2017 Moreover, CH has been known as the antagonist of NF-kB and the agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) which in down regulation of the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids. Prostaglandins 316-327 peroxisome proliferator activated receptor gamma Homo sapiens 74-122 28609844-7 2017 Moreover, CH has been known as the antagonist of NF-kB and the agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) which in down regulation of the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids. Prostaglandins 316-327 peroxisome proliferator activated receptor gamma Homo sapiens 124-134 23943857-5 2013 Among the COX-2-dependent prostaglandins (PG) induced upon celecoxib treatment, PGD2 and 15-deoxy-Delta12,14-PGJ2 were found to induce a cytosol-to-nucleus translocation of PPARgamma as well as a PPARgamma-dependent apoptosis. Prostaglandins 26-40 peroxisome proliferator activated receptor gamma Homo sapiens 173-182 26244663-8 2015 This suggests that ligand-mediated sumoylation of PPARgamma plays an important role in lung cancer pathogenesis by modulating prostaglandin metabolism. Prostaglandins 126-139 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 24927844-0 2014 Transcriptional regulation in adipogenesis through PPARgamma-dependent and -independent mechanisms by prostaglandins. Prostaglandins 102-116 peroxisome proliferator activated receptor gamma Homo sapiens 51-60 23943857-5 2013 Among the COX-2-dependent prostaglandins (PG) induced upon celecoxib treatment, PGD2 and 15-deoxy-Delta12,14-PGJ2 were found to induce a cytosol-to-nucleus translocation of PPARgamma as well as a PPARgamma-dependent apoptosis. Prostaglandins 26-40 peroxisome proliferator activated receptor gamma Homo sapiens 196-205 23943857-5 2013 Among the COX-2-dependent prostaglandins (PG) induced upon celecoxib treatment, PGD2 and 15-deoxy-Delta12,14-PGJ2 were found to induce a cytosol-to-nucleus translocation of PPARgamma as well as a PPARgamma-dependent apoptosis. Prostaglandins 42-44 peroxisome proliferator activated receptor gamma Homo sapiens 173-182 23943857-5 2013 Among the COX-2-dependent prostaglandins (PG) induced upon celecoxib treatment, PGD2 and 15-deoxy-Delta12,14-PGJ2 were found to induce a cytosol-to-nucleus translocation of PPARgamma as well as a PPARgamma-dependent apoptosis. Prostaglandins 42-44 peroxisome proliferator activated receptor gamma Homo sapiens 196-205