PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24095834-5 2014 Experiments with double knockdown of Acsl4 and intracellular phospholipase A2 (PLA2) isozymes revealed that cytosolic PLA2alpha, but not calcium-independent PLA2s, is involved in the Acsl4 knockdown-enhanced PG biosynthesis. Prostaglandins 208-210 phospholipase A2 group IB Rattus norvegicus 79-83 24704528-11 2014 The results suggest that CDP-choline may stimulate prostaglandin synthesis through the activation of PLA2, cyclooxygenases (COX-1 and -2) and prostaglandins and at least TXA2, may mediate the drug s cardiovascular effects. Prostaglandins 51-64 phospholipase A2 group IB Rattus norvegicus 101-105 26063975-2 2015 These prostaglandins are produced from arachidonic acid, which is cleaved from membrane phospholipids by the action of phospholipase A2 (PLA2). Prostaglandins 6-20 phospholipase A2 group IB Rattus norvegicus 119-135 26063975-2 2015 These prostaglandins are produced from arachidonic acid, which is cleaved from membrane phospholipids by the action of phospholipase A2 (PLA2). Prostaglandins 6-20 phospholipase A2 group IB Rattus norvegicus 137-141 26063975-3 2015 Which isozyme of PLA2 is responsible for the cleavage of arachidonic acid and the production of prostaglandins essential to inflammation-induced hyperalgesia is not clear. Prostaglandins 96-110 phospholipase A2 group IB Rattus norvegicus 17-21 19293335-9 2009 Second, glucocorticoid-GR signaling promoted gene expression of the enzymes involved in the prostaglandin biosynthesis, including cyclooxygenase-2 and phospholipase A2 in cardiomyocytes. Prostaglandins 92-105 phospholipase A2 group IB Rattus norvegicus 151-167 18539271-1 2008 The phospholipase A(2) (PLA(2))-prostanoid cascade is involved in cannabinoid receptor-mediated neuronal functions. Prostaglandins 32-42 phospholipase A2 group IB Rattus norvegicus 4-22 18539271-1 2008 The phospholipase A(2) (PLA(2))-prostanoid cascade is involved in cannabinoid receptor-mediated neuronal functions. Prostaglandins 32-42 phospholipase A2 group IB Rattus norvegicus 24-30 11953449-2 2002 In the present study, we examined the involvement of two types of phospholipase A2 (PLA2) enzymes, which lie upstream of COX in the prostanoid-generating pathway, in the IL-1beta-induced release of SP from DRG cells. Prostaglandins 132-142 phospholipase A2 group IB Rattus norvegicus 66-82 16120751-9 2005 These results suggest that myometrial cells express multiple PLA2 isoforms that may serve as a target and effector for ortho-substituted PCB-mediated stimulation of uterine function through arachidonic acid and prostaglandin release. Prostaglandins 211-224 phospholipase A2 group IB Rattus norvegicus 61-65 12206852-1 2002 The sequential action of phospholipase A(2) and cyclooxygenase leads to the production of prostaglandins in the brain, an event hypothesised to cause dopaminergic stimulation. Prostaglandins 90-104 phospholipase A2 group IB Rattus norvegicus 25-62 16120751-0 2005 Late-gestation rat myometrial cells express multiple isoforms of phospholipase A2 that mediate PCB 50-induced release of arachidonic acid with coincident prostaglandin production. Prostaglandins 154-167 phospholipase A2 group IB Rattus norvegicus 65-81 14506285-3 2003 Evidence suggests that cAMP generation is due to the prostaglandins produced in response to AVP binding to V1a receptors and subsequent activation of phospholipase A2. Prostaglandins 53-67 phospholipase A2 group IB Rattus norvegicus 150-166 11953449-2 2002 In the present study, we examined the involvement of two types of phospholipase A2 (PLA2) enzymes, which lie upstream of COX in the prostanoid-generating pathway, in the IL-1beta-induced release of SP from DRG cells. Prostaglandins 132-142 phospholipase A2 group IB Rattus norvegicus 84-88 11953449-7 2002 These observations suggested that two types of PLA2, sPLA2 -IIA and cPLA2, were involved in the IL-1beta-induced release of SP from DRG cells, and that the functional cross-talk between the two enzymes might help to control their activity in the prostanoid-generating system in DRG cells. Prostaglandins 246-256 phospholipase A2 group IB Rattus norvegicus 47-51 9681442-3 1998 The synthesis of prostaglandins depends upon the production and conversion of arachidonic acid, steps that are catalyzed by phospholipase A2 (PLA2) and cyclooxygenase (COX), respectively. Prostaglandins 17-31 phospholipase A2 group IB Rattus norvegicus 124-140 11053223-1 2000 The regulatory effects of transforming growth factor (TGF)-alpha on phospholipase A(2) (PLA(2)) isozymes contributing to prostaglandin generation in rat gastric epithelial RGM1 cells were examined. Prostaglandins 121-134 phospholipase A2 group IB Rattus norvegicus 68-86 11053223-1 2000 The regulatory effects of transforming growth factor (TGF)-alpha on phospholipase A(2) (PLA(2)) isozymes contributing to prostaglandin generation in rat gastric epithelial RGM1 cells were examined. Prostaglandins 121-134 phospholipase A2 group IB Rattus norvegicus 88-94 9681442-3 1998 The synthesis of prostaglandins depends upon the production and conversion of arachidonic acid, steps that are catalyzed by phospholipase A2 (PLA2) and cyclooxygenase (COX), respectively. Prostaglandins 17-31 phospholipase A2 group IB Rattus norvegicus 142-146 9605513-13 1998 Our findings further suggest that sPLA2 and cPLA2 are differentially regulated and that they may well differ in their relative contribution to ovarian prostaglandin biosynthesis in general and to PLA2 activity in particular. Prostaglandins 151-164 phospholipase A2 group IB Rattus norvegicus 35-39 9605513-3 1998 To test this hypothesis, we examined the effect of treatment with dexamethasone on the activity of ovarian phospholipase A2 (PLA2), the event-limiting enzyme in prostaglandin biosynthesis, and on the gene expression pattern of secretory and cytosolic PLA2 (sPLA2 and cPLA2, respectively). Prostaglandins 161-174 phospholipase A2 group IB Rattus norvegicus 107-123 9425915-3 1998 The aim of the current study was to determine the activity of phospholipase A2 (PLA2), the key enzyme in the regulation of prostaglandin synthesis, in kidney and vascular tissue obtained from rats with carbon tetrachloride-induced cirrhosis and ascites (n = 9) and control rats (n = 6). Prostaglandins 123-136 phospholipase A2 group IB Rattus norvegicus 62-78 9425915-3 1998 The aim of the current study was to determine the activity of phospholipase A2 (PLA2), the key enzyme in the regulation of prostaglandin synthesis, in kidney and vascular tissue obtained from rats with carbon tetrachloride-induced cirrhosis and ascites (n = 9) and control rats (n = 6). Prostaglandins 123-136 phospholipase A2 group IB Rattus norvegicus 80-84 9249592-8 1997 These data suggest a major role for PLA2 activation in Gent-induced mesangial cell contraction, proliferation and prostanoid secretion. Prostaglandins 114-124 phospholipase A2 group IB Rattus norvegicus 36-40 7988463-13 1994 The stimulation of PGE2 production by CuOOH appears to involve the activation of phospholipase-A2, which is a rate-limiting step in PG synthesis. Prostaglandins 19-21 phospholipase A2 group IB Rattus norvegicus 81-97 9005967-7 1997 These findings provide evidence to suggest a mechanism linking increased polyol pathway activity and an increase in PLA2 activity to increased prostaglandin production, which is observed in diabetes of recent onset and may ultimately lead to changes associated with the development of diabetic nephropathy. Prostaglandins 143-156 phospholipase A2 group IB Rattus norvegicus 116-120 8755646-3 1996 The purpose of the present study was to establish whether the first enzyme of the prostaglandin cascade synthesis, the phospholipase A2(PLA2) is altered in liver cirrhosis induced by bile duct excision. Prostaglandins 82-95 phospholipase A2 group IB Rattus norvegicus 119-135 7700023-2 1994 Phospholipase A2 (PLA2)-mediated release of arachidonic acid from the sn-2 position of membrane phospholipids is thought to be one of the rate-limiting steps in prostaglandin (PG) synthesis. Prostaglandins 161-174 phospholipase A2 group IB Rattus norvegicus 0-16 7700023-2 1994 Phospholipase A2 (PLA2)-mediated release of arachidonic acid from the sn-2 position of membrane phospholipids is thought to be one of the rate-limiting steps in prostaglandin (PG) synthesis. Prostaglandins 161-174 phospholipase A2 group IB Rattus norvegicus 18-22 7700023-2 1994 Phospholipase A2 (PLA2)-mediated release of arachidonic acid from the sn-2 position of membrane phospholipids is thought to be one of the rate-limiting steps in prostaglandin (PG) synthesis. Prostaglandins 176-178 phospholipase A2 group IB Rattus norvegicus 0-16 7700023-2 1994 Phospholipase A2 (PLA2)-mediated release of arachidonic acid from the sn-2 position of membrane phospholipids is thought to be one of the rate-limiting steps in prostaglandin (PG) synthesis. Prostaglandins 176-178 phospholipase A2 group IB Rattus norvegicus 18-22 8039843-7 1994 The synthesis of vasoconstrictor prostaglandins, such as thromboxane A2, may be stimulated during acetylcholine treatment, resulting in the attenuation of acetylcholine relaxation, because the relaxation was abolished by treatment with the phospholipase A2 inhibitor quinacrine, cyclooxygenase inhibitor indomethacin, prostaglandin H2/thromboxane A2 receptor antagonist S1452, and thromboxane A2 synthase inhibitor dazmegrel. Prostaglandins 33-47 phospholipase A2 group IB Rattus norvegicus 240-256 8039843-7 1994 The synthesis of vasoconstrictor prostaglandins, such as thromboxane A2, may be stimulated during acetylcholine treatment, resulting in the attenuation of acetylcholine relaxation, because the relaxation was abolished by treatment with the phospholipase A2 inhibitor quinacrine, cyclooxygenase inhibitor indomethacin, prostaglandin H2/thromboxane A2 receptor antagonist S1452, and thromboxane A2 synthase inhibitor dazmegrel. Prostaglandins 33-46 phospholipase A2 group IB Rattus norvegicus 240-256 8283439-1 1993 The ovulatory effect of LH is mediated by prostaglandins, the synthesis of which involves prostaglandin synthetase and phospholipase A2 (PLA2). Prostaglandins 42-56 phospholipase A2 group IB Rattus norvegicus 119-135 8283439-1 1993 The ovulatory effect of LH is mediated by prostaglandins, the synthesis of which involves prostaglandin synthetase and phospholipase A2 (PLA2). Prostaglandins 42-56 phospholipase A2 group IB Rattus norvegicus 137-141 1417924-0 1992 Stimulation of prostaglandin production in rat thymic epithelial cells by protein kinase C mediated activation of phospholipase A2. Prostaglandins 15-28 phospholipase A2 group IB Rattus norvegicus 114-130 8367382-1 1993 Dexamethasone blocks aromatase and phospholipase A2 enzyme activities that are essentially involved in the formation of oestrogens and prostaglandins, the key chemicals to initiate parturition. Prostaglandins 135-149 phospholipase A2 group IB Rattus norvegicus 35-51 1757333-9 1991 The most likely locus of action is the activation of the enzyme phospholipase A2, which regulates the production of arachidonic acid from cellular phospholipids in the prostanoid cascade. Prostaglandins 168-178 phospholipase A2 group IB Rattus norvegicus 64-80 1636484-6 1992 Pretreatment of the cells with dexamethasone, a known inhibitor of prostaglandin synthesis, dose-dependently inhibits cytokine-induced phospholipase A2 activity. Prostaglandins 67-80 phospholipase A2 group IB Rattus norvegicus 135-151 1815236-0 1991 Effect of exogenous phospholipase A2 and triacylglycerol lipase on the synthesis and release of monoenoic and bisenoic prostaglandins from isolated rat uterus. Prostaglandins 119-133 phospholipase A2 group IB Rattus norvegicus 20-36 1807005-9 1991 Thus, an interaction between phospholipase A2 (prostaglandin synthesis) and phospholipase C (inositol trisphosphate-Ca2+ mobilization) is suggested. Prostaglandins 47-60 phospholipase A2 group IB Rattus norvegicus 29-45 1397475-2 1992 One step in prostaglandin synthesis is the enzymatic hydrolysis of membrane phospholipids by Phospholipase A2 (PLA2). Prostaglandins 12-25 phospholipase A2 group IB Rattus norvegicus 93-109 1397475-2 1992 One step in prostaglandin synthesis is the enzymatic hydrolysis of membrane phospholipids by Phospholipase A2 (PLA2). Prostaglandins 12-25 phospholipase A2 group IB Rattus norvegicus 111-115 1397475-4 1992 An evaluation of PLA2 activity is therefore a useful method for studying prostaglandin synthesis in the peripheral target tissues of insulin activity. Prostaglandins 73-86 phospholipase A2 group IB Rattus norvegicus 17-21 1828830-9 1991 This tonic inhibition of PLA2 is the most likely explanation for unsuccessful attempts to evoke PG release in astrocyte cultures by various physiological stimuli. Prostaglandins 96-98 phospholipase A2 group IB Rattus norvegicus 25-29 3240923-7 1988 In conclusion, these results might suggest that enhanced phospholipase A2 cause by hypertension activate the arachidonic acid cascade and increase prostaglandin synthesis, which might have an homeostatic action to lower the blood pressure in SHRSP. Prostaglandins 147-160 phospholipase A2 group IB Rattus norvegicus 57-73 2090584-10 1990 These studies suggest a direct effect of H2O2 on colonic fragments leading to submicroscopic cellular membrane damage and excess prostanoid production utilizing a PLA2/cyclooxygenase and catalase-sensitive pathway without the formation of toxic hydroxyl ions. Prostaglandins 129-139 phospholipase A2 group IB Rattus norvegicus 163-167 1980544-4 1990 The contraction could be blocked by the cyclooxygenase inhibitor indomethacin and the phospholipase A2 inhibitor quinacrine, suggesting a role for prostaglandins in the response. Prostaglandins 147-161 phospholipase A2 group IB Rattus norvegicus 86-102 2231411-3 1990 Melittin is a polypeptide component of bee venom which stimulates phospholipase A2 activity, thereby increasing arachidonic acid release and prostaglandin (PG) synthesis, and which inhibits protein kinase C activity. Prostaglandins 141-154 phospholipase A2 group IB Rattus norvegicus 66-82 2231411-3 1990 Melittin is a polypeptide component of bee venom which stimulates phospholipase A2 activity, thereby increasing arachidonic acid release and prostaglandin (PG) synthesis, and which inhibits protein kinase C activity. Prostaglandins 156-158 phospholipase A2 group IB Rattus norvegicus 66-82 1645257-5 1991 Within the first hour of prostaglandin treatment, there was also a significant increase in the activity of phospholipase A2 and ATP-dependent calcium uptake in the membrane samples. Prostaglandins 25-38 phospholipase A2 group IB Rattus norvegicus 107-123 2195986-13 1990 Since one important metabolite generated by PLA2 is arachidonic acid, which is converted into prostaglandins and leukotrienes by cyclooxygenase or lipooxygenase, respectively, the levels of prostaglandin E2 (PGE2) in the various cell lines were monitored. Prostaglandins 94-108 phospholipase A2 group IB Rattus norvegicus 44-48 2848583-1 1988 In polymorphonuclear neutrophils, phospholipase A2 activity is the rate-limiting step for platelet-activating factor (PAF) formation and for the biosynthesis of arachidonic acid derivatives, leukotrienes and prostaglandins. Prostaglandins 208-222 phospholipase A2 group IB Rattus norvegicus 34-50 3141409-1 1988 The activity of phospholipase A2 (PLA2), the regulatory enzyme in arachidonic acid release and prostaglandin synthesis, was measured in cell-free extracts of rat renal mesangial cells. Prostaglandins 95-108 phospholipase A2 group IB Rattus norvegicus 16-32 3141409-1 1988 The activity of phospholipase A2 (PLA2), the regulatory enzyme in arachidonic acid release and prostaglandin synthesis, was measured in cell-free extracts of rat renal mesangial cells. Prostaglandins 95-108 phospholipase A2 group IB Rattus norvegicus 34-38 3207972-19 1988 In conclusion, these data show that PLA2 (an enzyme involved in the synthesis of Paf-acether, prostaglandins, thromboxanes, leukotrienes, diacylglycerol, superoxide free radicals and lipid peroxides, etc.) Prostaglandins 94-108 phospholipase A2 group IB Rattus norvegicus 36-40 3164726-3 1988 Phospholipase A2, the enzyme believed to be rate limiting for prostaglandin synthesis, is stimulated by Ca2+; however, the levels of Ca2+ necessary to stimulate phospholipase A2 in cell-free systems are higher than levels achieved in intact cells in response to agonists that stimulate prostaglandin synthesis. Prostaglandins 62-75 phospholipase A2 group IB Rattus norvegicus 0-16 3164726-3 1988 Phospholipase A2, the enzyme believed to be rate limiting for prostaglandin synthesis, is stimulated by Ca2+; however, the levels of Ca2+ necessary to stimulate phospholipase A2 in cell-free systems are higher than levels achieved in intact cells in response to agonists that stimulate prostaglandin synthesis. Prostaglandins 286-299 phospholipase A2 group IB Rattus norvegicus 0-16 3132411-0 1988 Role of enhanced arachidonate availability through phospholipase A2 pathway in mediation of increased prostaglandin synthesis by glomeruli from diabetic rats. Prostaglandins 102-115 phospholipase A2 group IB Rattus norvegicus 51-67 20501115-4 1987 The formation of prostanoids was stimulated in a concentration dependent manner (up to 6-10 fold) by the calcium ionophore A 23187 (0.01-10 ?M) as well as by melittin (0.01-5 ?g/ml), phospholipase A(2) (10-40 U/ml) and phospholipase C (0.01-1 U/ml). Prostaglandins 17-28 phospholipase A2 group IB Rattus norvegicus 183-201 20501115-14 1987 Stimulation of prostanoid biosynthesis involves Ca(2+)-dependent activation of phospholipase A(2), cyclooxygenase reaction and further PG metabolism. Prostaglandins 15-25 phospholipase A2 group IB Rattus norvegicus 79-97 6597497-1 1983 Phospholipase A2 (PLA2), one of the enzymes considered to be rate-limiting in generating free arachidonic acid for prostaglandin (PG) synthesis, endogenous concentrations and in vitro production of PGs in the rat uterus were studied under various experimental conditions. Prostaglandins 115-128 phospholipase A2 group IB Rattus norvegicus 0-16 3119146-6 1987 We conclude that stimulation of protein kinase C by phorbol ester elicits prostanoid synthesis and release by a process that involves calcium influx and the activation of phospholipase A2. Prostaglandins 74-84 phospholipase A2 group IB Rattus norvegicus 171-187 3634729-3 1986 We measured plasma kallikrein and muscular phospholipase A2 activity, respectively the first and the last steps of reactions leading to prostaglandin synthesis. Prostaglandins 136-149 phospholipase A2 group IB Rattus norvegicus 43-59 3634729-6 1986 Our findings demonstrate, under physiological conditions of enhanced muscular glucose uptake, a concomitant significant increase of plasma kallikrein and muscular phospholipase A2 activity, supporting the hypothesis that activation of the kallikrein-kinin-prostaglandin system may play some part in the enhanced muscular glucose uptake during physical activity. Prostaglandins 256-269 phospholipase A2 group IB Rattus norvegicus 163-179 2863829-5 1985 Inasmuch as mepacrine and corticosterone antagonized the response to norepinephrine on PG release the possible involvement of the adrenergic agonist on the activity of phospholipase A2 is suggested. Prostaglandins 87-89 phospholipase A2 group IB Rattus norvegicus 168-184 3956877-3 1986 An enzyme important in the control of prostaglandin production is phospholipase A2. Prostaglandins 38-51 phospholipase A2 group IB Rattus norvegicus 66-82 6231183-5 1984 Phospholipase A2 activity specific for 2-arachidonoyl phosphatide and with a pH optimum of 8.1 was measured in homogenized Kupffer cells; it was stimulated by agents previously shown to enhance prostaglandin synthesis in Kupffer cells, e.g. zymosan particles and lipopolysaccharide isolated from Salmonella minnesota. Prostaglandins 194-207 phospholipase A2 group IB Rattus norvegicus 0-16 6424672-4 1984 This effect was blocked by pretreating the cells with indomethacin or aspirin (inhibitors of cyclo-oxygenase) and bromo-phenacyl bromide (an inhibitor of phospholipase A2), implicating the synthesis of a prostanoid as an intermediary step. Prostaglandins 204-214 phospholipase A2 group IB Rattus norvegicus 154-170 6139416-9 1983 These results suggest that calcium influx induced by synaptosomal depolarization activates endogenous phospholipase A2, with subsequent formation of lysophosphatidylcholine and prostaglandins, both of which may modulate neurosecretion. Prostaglandins 177-191 phospholipase A2 group IB Rattus norvegicus 102-118 6597497-1 1983 Phospholipase A2 (PLA2), one of the enzymes considered to be rate-limiting in generating free arachidonic acid for prostaglandin (PG) synthesis, endogenous concentrations and in vitro production of PGs in the rat uterus were studied under various experimental conditions. Prostaglandins 115-128 phospholipase A2 group IB Rattus norvegicus 18-22 6597497-1 1983 Phospholipase A2 (PLA2), one of the enzymes considered to be rate-limiting in generating free arachidonic acid for prostaglandin (PG) synthesis, endogenous concentrations and in vitro production of PGs in the rat uterus were studied under various experimental conditions. Prostaglandins 130-132 phospholipase A2 group IB Rattus norvegicus 0-16 6597497-1 1983 Phospholipase A2 (PLA2), one of the enzymes considered to be rate-limiting in generating free arachidonic acid for prostaglandin (PG) synthesis, endogenous concentrations and in vitro production of PGs in the rat uterus were studied under various experimental conditions. Prostaglandins 130-132 phospholipase A2 group IB Rattus norvegicus 18-22 6807980-10 1982 Indomethacin and aspirin, which inhibit the cyclooxygenase, and mepacrine, which inhibits the Ca2+-activated phospholipase A2, markedly reduced the increase in prostaglandin production. Prostaglandins 160-173 phospholipase A2 group IB Rattus norvegicus 109-125 6354779-6 1983 These glucose-induced increases in 3H-arachidonic acid-derived radioactivity in both the phospholipid and the prostaglandin fractions were eliminated by the inhibition of phospholipase A2 activity with mepacrine or by the inhibition of cyclooxygenase activity with sodium salicylate. Prostaglandins 110-123 phospholipase A2 group IB Rattus norvegicus 171-187 6403536-7 1983 The results are consistent with the involvement of phospholipase A2, C, or both in the Ca2+ (+A23187)-stimulated release of free arachidonate for prostaglandin synthesis and support a role for calmodulin in Ca2+ activation of phospholipase A2 and particulate phospholipase C. Prostaglandins 146-159 phospholipase A2 group IB Rattus norvegicus 51-67 601247-0 1977 Formation by phospholipase A2 of prostaglandins and thromboxane A2-like activity in the platelets of normal and essential fatty acid deficient rats. Prostaglandins 33-47 phospholipase A2 group IB Rattus norvegicus 13-29 7122911-5 1982 It is postulated that the inhibition of phospholipase A2 activity by Fluosol might interfere with the release of arachidonic acid, a substrate used in biosynthesis of prostaglandins. Prostaglandins 167-181 phospholipase A2 group IB Rattus norvegicus 40-56 7122905-1 1982 Phospholipase A2 (PLA2), an enzyme which provides free arachidonic acid for the synthesis of prostaglandins (PG), has been studied in the rat uterus under various experimental conditions. Prostaglandins 93-107 phospholipase A2 group IB Rattus norvegicus 0-16 7122905-1 1982 Phospholipase A2 (PLA2), an enzyme which provides free arachidonic acid for the synthesis of prostaglandins (PG), has been studied in the rat uterus under various experimental conditions. Prostaglandins 93-107 phospholipase A2 group IB Rattus norvegicus 18-22 7122905-1 1982 Phospholipase A2 (PLA2), an enzyme which provides free arachidonic acid for the synthesis of prostaglandins (PG), has been studied in the rat uterus under various experimental conditions. Prostaglandins 109-111 phospholipase A2 group IB Rattus norvegicus 0-16 7122905-1 1982 Phospholipase A2 (PLA2), an enzyme which provides free arachidonic acid for the synthesis of prostaglandins (PG), has been studied in the rat uterus under various experimental conditions. Prostaglandins 109-111 phospholipase A2 group IB Rattus norvegicus 18-22 7122905-6 1982 The results are consistent with the view that estrogen stimulates uterine prostaglandin production because of its effect upon PLA2; this effect can be greatly reduced by a glucocorticoid. Prostaglandins 74-87 phospholipase A2 group IB Rattus norvegicus 126-130 6955805-1 1982 The activity of phospholipase A2 (PLA2), which provides free arachidonic acid and is widely accepted as the rate-limiting step in the biosynthesis of prostaglandins (PGs), was determined by radioisotopic method in the rat uterus on days 1 through 6 of pregnancy. Prostaglandins 150-164 phospholipase A2 group IB Rattus norvegicus 16-32 6955805-1 1982 The activity of phospholipase A2 (PLA2), which provides free arachidonic acid and is widely accepted as the rate-limiting step in the biosynthesis of prostaglandins (PGs), was determined by radioisotopic method in the rat uterus on days 1 through 6 of pregnancy. Prostaglandins 150-164 phospholipase A2 group IB Rattus norvegicus 34-38 6955805-1 1982 The activity of phospholipase A2 (PLA2), which provides free arachidonic acid and is widely accepted as the rate-limiting step in the biosynthesis of prostaglandins (PGs), was determined by radioisotopic method in the rat uterus on days 1 through 6 of pregnancy. Prostaglandins 166-169 phospholipase A2 group IB Rattus norvegicus 16-32 6955805-1 1982 The activity of phospholipase A2 (PLA2), which provides free arachidonic acid and is widely accepted as the rate-limiting step in the biosynthesis of prostaglandins (PGs), was determined by radioisotopic method in the rat uterus on days 1 through 6 of pregnancy. Prostaglandins 166-169 phospholipase A2 group IB Rattus norvegicus 34-38 6913858-3 1981 Both phospholipase A2, an enzyme involved in prostaglandin synthesis, and arachidonic acid, a precursor of prostaglandins, also increased the Na+ concentration of parotid saliva in a dose-dependent fashion. Prostaglandins 45-58 phospholipase A2 group IB Rattus norvegicus 5-21 6791696-5 1981 The release of this fatty acid by action of phospholipase A2 may lead via intermediates to the generation of potent mediators such as prostaglandins, thromboxane or slow-reacting substance. Prostaglandins 134-148 phospholipase A2 group IB Rattus norvegicus 44-60 655005-0 1978 Formation by phospholipase A2 of prostaglandins and endoperoxides in platelets of normal and essential fatty acid-deficient rats. Prostaglandins 33-47 phospholipase A2 group IB Rattus norvegicus 13-29 601247-2 1977 When rat platelets are incubated with phospholipase A2, thromboxane A2-like activity and prostaglandins are formed. Prostaglandins 89-103 phospholipase A2 group IB Rattus norvegicus 38-54