PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19285486-2 2009 One of the prostaglandin-independent pathways is sequentially orchestrated by pre-formed pyrogenic factor derived from LPS-stimulated macrophages (PFPF), corticotrophin releasing factor (CRF), endothelin-1 (ET-1) and interleukin-1 (IL-1). Prostaglandins 11-24 endothelin 1 Rattus norvegicus 193-205 19285486-2 2009 One of the prostaglandin-independent pathways is sequentially orchestrated by pre-formed pyrogenic factor derived from LPS-stimulated macrophages (PFPF), corticotrophin releasing factor (CRF), endothelin-1 (ET-1) and interleukin-1 (IL-1). Prostaglandins 11-24 endothelin 1 Rattus norvegicus 207-211 15086361-3 2004 This study investigated the collateral vascular responses to ET-1, the receptors in mediation and the regulation of ET-1 action by nitric oxide and prostaglandin in cirrhotic rats with a relatively low degree of portal-systemic shunting. Prostaglandins 148-161 endothelin 1 Rattus norvegicus 116-120 16455768-0 2006 Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats. Prostaglandins 54-67 endothelin 1 Rattus norvegicus 23-35 16455768-1 2006 The intracerebroventricular injection of endothelin-1 (ET-1) induces fever and increases PG levels in the cerebrospinal fluid of rats. Prostaglandins 89-91 endothelin 1 Rattus norvegicus 41-53 16455768-1 2006 The intracerebroventricular injection of endothelin-1 (ET-1) induces fever and increases PG levels in the cerebrospinal fluid of rats. Prostaglandins 89-91 endothelin 1 Rattus norvegicus 55-59 16455768-8 2006 In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro. Prostaglandins 166-168 endothelin 1 Rattus norvegicus 37-41 11283844-4 2001 This study investigated the collateral vascular responses to ET-1, the receptors in mediation, and the regulation of ET-1 action by nitric oxide and prostaglandin. Prostaglandins 149-162 endothelin 1 Rattus norvegicus 117-121 12913062-5 2003 These findings indicate that in rats under chronic NOS inhibition, the hypotensive effect of ET-1 is unexpectedly enhanced and appears to be mediated by a non-NO/non-prostanoid mechanism and involves an SR141716A-sensitive mechanism triggered by ETB receptor activation. Prostaglandins 166-176 endothelin 1 Rattus norvegicus 93-97 12051519-1 2002 Endothelin-1 (ET-1), a potent vasoconstrictor peptide and modulator of vasoactive substances such as prostanoids and nitric oxide (NO), plays an important role during embryo and fetal development. Prostaglandins 101-112 endothelin 1 Rattus norvegicus 0-12 12051519-1 2002 Endothelin-1 (ET-1), a potent vasoconstrictor peptide and modulator of vasoactive substances such as prostanoids and nitric oxide (NO), plays an important role during embryo and fetal development. Prostaglandins 101-112 endothelin 1 Rattus norvegicus 14-18 11438307-0 2001 Inhibition of prostanoid-mediated contraction to endothelin-1 after hypoxia in rat aorta. Prostaglandins 14-24 endothelin 1 Rattus norvegicus 49-61 11438307-4 2001 Loss of prostanoid-enhancement of endothelin-1 contraction contributes to impair vascular reactivity after hypoxia. Prostaglandins 8-18 endothelin 1 Rattus norvegicus 34-46 11283844-12 2001 Both nitric oxide and prostaglandin modulate the collateral vascular response to ET-1 and may therefore participate in the development and maintenance of portal hypertension. Prostaglandins 22-35 endothelin 1 Rattus norvegicus 81-85 10637124-7 1999 When pancreatic arachidonic acid (AA) conversion to prostaglandins was explored, ET-1 increased PGF(2alpha), PGE(2), and TXB(2) levels in C but not in D tissues. Prostaglandins 52-66 endothelin 1 Rattus norvegicus 81-85 11080078-10 2000 These results indicate that hemodynamic changes produced by ET-1 are mediated by vasoconstrictor prostanoids and/or prostanoid-like substances, possibly, 20-HETE via activation of ET(A) and ET(B) receptors. Prostaglandins 97-108 endothelin 1 Rattus norvegicus 60-64 11080078-10 2000 These results indicate that hemodynamic changes produced by ET-1 are mediated by vasoconstrictor prostanoids and/or prostanoid-like substances, possibly, 20-HETE via activation of ET(A) and ET(B) receptors. Prostaglandins 97-107 endothelin 1 Rattus norvegicus 60-64 11411740-10 2001 In conclusion, the present data highlight an enhanced ETB receptor mediated hypotensive effect of ET-1 in anesthetized TP as compared to P. The magnitude of the hypotensive effect of ET-1 observed in TP is of the same order as that in virgin rats and neither NO nor vasodilator prostaglandins seem to be involved in TP. Prostaglandins 278-292 endothelin 1 Rattus norvegicus 98-102 11411740-10 2001 In conclusion, the present data highlight an enhanced ETB receptor mediated hypotensive effect of ET-1 in anesthetized TP as compared to P. The magnitude of the hypotensive effect of ET-1 observed in TP is of the same order as that in virgin rats and neither NO nor vasodilator prostaglandins seem to be involved in TP. Prostaglandins 278-292 endothelin 1 Rattus norvegicus 183-187 9806338-22 1998 Therefore, central endothelin(s) participates importantly in the development of LPS-induced fever, via activation of a prostanoid-independent endothelin ET(B) receptor-mediated mechanism possibly not situated downstream from IL-1beta or TNF-alpha in the fever cascade. Prostaglandins 119-129 endothelin 1 Rattus norvegicus 19-29 10100093-10 1999 This mechanism may be linked to the production of prostanoids that add to the direct endothelin-1-evoked vasoconstriction. Prostaglandins 50-61 endothelin 1 Rattus norvegicus 85-97 9324043-3 1997 This inhibition seemed to be mediated by prostaglandins (PGs) released in response to ET-1, since indomethacin (INDO) enhanced ET-1-induced [3H]thymidine incorporation. Prostaglandins 41-55 endothelin 1 Rattus norvegicus 86-90 9458898-11 1998 Thus the capacity of ET-1 to enhance prostaglandin production was primarily expressed in terms of positive effects on renal hemodynamics. Prostaglandins 37-50 endothelin 1 Rattus norvegicus 21-25 9324043-3 1997 This inhibition seemed to be mediated by prostaglandins (PGs) released in response to ET-1, since indomethacin (INDO) enhanced ET-1-induced [3H]thymidine incorporation. Prostaglandins 41-55 endothelin 1 Rattus norvegicus 127-131 9324043-3 1997 This inhibition seemed to be mediated by prostaglandins (PGs) released in response to ET-1, since indomethacin (INDO) enhanced ET-1-induced [3H]thymidine incorporation. Prostaglandins 57-60 endothelin 1 Rattus norvegicus 86-90 9324043-3 1997 This inhibition seemed to be mediated by prostaglandins (PGs) released in response to ET-1, since indomethacin (INDO) enhanced ET-1-induced [3H]thymidine incorporation. Prostaglandins 57-60 endothelin 1 Rattus norvegicus 127-131 9324043-4 1997 In agreement with this hypothesis, exogenous prostaglandins (PGE2, PGF2alpha and TxB2) blocked all basal, ET-1-induced and ET-1 induced-INDO-enhanced [3H]thymidine incorporation and ET-1 stimulated PGE2 release in a time and concentration-dependent manner. Prostaglandins 45-59 endothelin 1 Rattus norvegicus 106-110 9324043-4 1997 In agreement with this hypothesis, exogenous prostaglandins (PGE2, PGF2alpha and TxB2) blocked all basal, ET-1-induced and ET-1 induced-INDO-enhanced [3H]thymidine incorporation and ET-1 stimulated PGE2 release in a time and concentration-dependent manner. Prostaglandins 45-59 endothelin 1 Rattus norvegicus 123-127 9324043-4 1997 In agreement with this hypothesis, exogenous prostaglandins (PGE2, PGF2alpha and TxB2) blocked all basal, ET-1-induced and ET-1 induced-INDO-enhanced [3H]thymidine incorporation and ET-1 stimulated PGE2 release in a time and concentration-dependent manner. Prostaglandins 45-59 endothelin 1 Rattus norvegicus 123-127 9324043-7 1997 Thus, PGs produced in response to ET-1 counteract the ET-1-induced stimulation of [3H]thymidine incorporation into rat AC by increasing cGMP production. Prostaglandins 6-9 endothelin 1 Rattus norvegicus 34-38 9324043-7 1997 Thus, PGs produced in response to ET-1 counteract the ET-1-induced stimulation of [3H]thymidine incorporation into rat AC by increasing cGMP production. Prostaglandins 6-9 endothelin 1 Rattus norvegicus 54-58 8961079-5 1996 These results could be explained if endothelin-1 is releasing vasodilator prostanoids in WKY, whereas in SHR preparations, vasoconstrictor prostanoids predominate. Prostaglandins 74-85 endothelin 1 Rattus norvegicus 36-48 8997390-8 1996 Furthermore, the medullary vasodilation induced by ET-1 is dependent on the NO system and, to a lesser extent, on prostaglandin generation. Prostaglandins 114-127 endothelin 1 Rattus norvegicus 51-55 8961079-5 1996 These results could be explained if endothelin-1 is releasing vasodilator prostanoids in WKY, whereas in SHR preparations, vasoconstrictor prostanoids predominate. Prostaglandins 139-150 endothelin 1 Rattus norvegicus 36-48 7602388-7 1995 Phenotypic responses to endothelin-1 include changes in alkaline phosphatase activity, stimulation of osteocalcin and osteopontin message, stimulation of collagen and noncollagenous protein synthesis, inhibition of osteoclast motility and stimulation of prostaglandin-dependent resorption. Prostaglandins 254-267 endothelin 1 Rattus norvegicus 24-36 8760226-6 1996 To clarify the association between ET and prostaglandins, we showed that the ANP response to 50 nM ET-1 was totally blocked at both high and low pressure by 10 microM indomethacin, but the increased contractility response to ET was unaffected. Prostaglandins 42-56 endothelin 1 Rattus norvegicus 99-103 7589184-4 1995 The blockade is specific for prostanoids since contractions with norepinephrine, phenylephrine, serotonin, endothelin-1 or K+ (120 mM) are not or much less affected. Prostaglandins 29-40 endothelin 1 Rattus norvegicus 107-119 8032649-0 1994 The involvement of endothelial dysfunction, nitric oxide and prostanoids in the rat gastric microcirculatory responses to endothelin-1. Prostaglandins 61-72 endothelin 1 Rattus norvegicus 122-134 7518515-4 1994 Moreover, the effects of ET-1 and ET-3 were completely abolished by the cyclooxygenase inhibitor indomethacin, 2 x 10(-5) M. On the other hand, among prostaglandins, prostaglandin E2 (PGE2) increased cAMP levels in a concentration-dependent manner (10(-7)-10(-5) M), whereas prostaglandin D2 and prostaglandin I2 did not exhibit such effects. Prostaglandins 150-164 endothelin 1 Rattus norvegicus 25-38 7938704-7 1994 were blocked by indomethacin (100 microM), indicating that prostaglandin release by non-parenchymal cells is at least in part involved in the hepatic ET-1 action. Prostaglandins 59-72 endothelin 1 Rattus norvegicus 150-154 8032649-15 1994 These results suggest that locally released NO and prostanoids mediate the gastric vasodilator response to close arterial infusion of ET-1. Prostaglandins 51-62 endothelin 1 Rattus norvegicus 134-138 7509954-9 1993 Our results support the hypothesis that ET-1-induced release of vasodilatory prostanoids from perfused rat lung and rabbit kidney and constriction of rabbit renal vasculature are triggered by activation of ETA receptors. Prostaglandins 77-88 endothelin 1 Rattus norvegicus 40-44 8377844-9 1993 The prostaglandin synthesis inhibitor indomethacin enhanced the endothelin-1-induced vasoconstriction in 2- and 6-mo rats to a similar extent. Prostaglandins 4-17 endothelin 1 Rattus norvegicus 64-76 8064162-3 1994 The concentrations of prostaglandins and thromboxane B2 in the bath solution with the rings contracted by endothelin-1 were measured by radioimmunoassay. Prostaglandins 22-36 endothelin 1 Rattus norvegicus 106-118 8112405-4 1993 The releases of prostanoids induced by endothelin-1 were greatly reduced by infusion of either BQ-123 or PD 145065, whereas PD 145065, but not BQ-123, strongly antagonised the releases induced by sarafotoxin 6c. Prostaglandins 16-27 endothelin 1 Rattus norvegicus 39-51 8112405-5 1993 These results indicate that the vasoconstrictions and the prostanoid releases induced by the endothelin/sarafotoxin peptides are mediated by the activation of both endothelin ETA and endothelin ETB receptors in the isolated perfused kidney of the rat. Prostaglandins 58-68 endothelin 1 Rattus norvegicus 93-103 8477643-10 1993 These results demonstrate that low doses of ET-1 exert an inhibitory and short-acting action on ANP secretion from the heart, although high doses of ET-1 exert stimulating and long-lasting action, and suggest that prostanoids are involved in this inhibitory action. Prostaglandins 214-225 endothelin 1 Rattus norvegicus 44-48 8477643-10 1993 These results demonstrate that low doses of ET-1 exert an inhibitory and short-acting action on ANP secretion from the heart, although high doses of ET-1 exert stimulating and long-lasting action, and suggest that prostanoids are involved in this inhibitory action. Prostaglandins 214-225 endothelin 1 Rattus norvegicus 149-153 1735597-7 1992 Endothelin-1, an endothelium-derived vasoconstrictor, inhibits renin release and stimulates EDRF and prostaglandin synthesis. Prostaglandins 101-114 endothelin 1 Rattus norvegicus 0-12 22326709-8 2012 Incubation of cardiac fibroblasts with ET-1 increased cyclooxygenase 2 (COX-2) and prostaglandin synthase (PGES) mRNAs, while Ang-(1-7) blocked the increase in both enzymes, suggesting that the heptapeptide hormone alters the concentration and the balance between the proliferative and anti-proliferative prostaglandins. Prostaglandins 305-319 endothelin 1 Rattus norvegicus 39-43 1378693-0 1992 Effect of prostaglandins and capsaicin on gastric vascular flow and mucosal injury in endothelin-1-treated rats. Prostaglandins 10-24 endothelin 1 Rattus norvegicus 86-98 1474858-3 1992 In the present study, we determined how the arachidonic acid cascade, mainly thromboxane A2 (TXA2), is related to ET-1 and ET-3 using indomethacin (INDO), which inhibits the biosynthesis of prostaglandin (PG), and OKY-046, a selective inhibitor of TXA2 synthesis. Prostaglandins 190-203 endothelin 1 Rattus norvegicus 114-118 1474858-3 1992 In the present study, we determined how the arachidonic acid cascade, mainly thromboxane A2 (TXA2), is related to ET-1 and ET-3 using indomethacin (INDO), which inhibits the biosynthesis of prostaglandin (PG), and OKY-046, a selective inhibitor of TXA2 synthesis. Prostaglandins 205-207 endothelin 1 Rattus norvegicus 114-118 1474858-4 1992 In the first series of experiments, ET-1 and ET-3 were administered after inhibiting the biosynthesis of PG by s.c. injection of 2 mg/kg of INDO. Prostaglandins 105-107 endothelin 1 Rattus norvegicus 36-49 1725341-0 1991 Effects of endothelin-1 and endothelin-3 on the release of prostanoids from isolated perfused rat kidney. Prostaglandins 59-70 endothelin 1 Rattus norvegicus 11-23 1725341-9 1991 The differential release of prostanoids by ET-1 and ET-3 suggests the existence of separate receptors for ET-1 and ET-3 in the rat kidney. Prostaglandins 28-39 endothelin 1 Rattus norvegicus 43-47 1725341-9 1991 The differential release of prostanoids by ET-1 and ET-3 suggests the existence of separate receptors for ET-1 and ET-3 in the rat kidney. Prostaglandins 28-39 endothelin 1 Rattus norvegicus 43-56 2473337-12 1989 Prostanoids have a role in the pressor response to ET-1 and ET-3 that is more complex than one of simple physiological antagonism or potentiation at the level of the vascular smooth muscle and possibly act as modulators of other regulatory factors such as NPY. Prostaglandins 0-11 endothelin 1 Rattus norvegicus 51-64 28012855-0 2017 Prostanoids counterbalance the synergism between endothelin-1 and angiotensin II in mesenteric veins of trained rats. Prostaglandins 0-11 endothelin 1 Rattus norvegicus 49-61 28012855-14 2017 On the other hand, vasodilator prostanoids are mobilized to act in parallel with NO in order to counterbalance the Ang II responses that have been potentiated by ET-1 in these trained animals. Prostaglandins 31-42 endothelin 1 Rattus norvegicus 162-166 26407475-14 2015 SIGNIFICANCE: The major new findings of our study are that ethanol consumption induces erectile dysfunction (ED) and increases the contraction induced by ET-1 in the rat CC by a mechanism that involves decreased generation of H2O2 and vasodilator prostanoids as well as increased activation of the RhoA/Rho-kinase pathway. Prostaglandins 247-258 endothelin 1 Rattus norvegicus 154-158 1877674-12 1991 Ibuprofen potentiated the endothelin-1 increase in plasma prostanoids. Prostaglandins 58-69 endothelin 1 Rattus norvegicus 26-38 1877674-13 1991 Endothelin-1 plus indomethacin increased vascular resistance and blocked prostaglandin production. Prostaglandins 73-86 endothelin 1 Rattus norvegicus 0-12 22553222-4 2012 Recent experiments demonstrate that the ET-1 axis exerts a potent antiapoptotic effect involving sphingolipid metabolism and prostaglandin-endoperoxide synthase 2/prostaglandin system in the rat Eker leiomyoma tumor-derived ELT3 cell line. Prostaglandins 125-138 endothelin 1 Rattus norvegicus 40-44 21084714-11 2011 This MAPK14 activation was required, in addition to MAPK3/1 in ET-1-mediated survival through the COX2/prostaglandin axis, and may explain the absence of ET-1 antiapoptotic effect in normal myometrial cells. Prostaglandins 103-116 endothelin 1 Rattus norvegicus 63-67