PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2161304-0	1990	Uridine kinase inhibition is involved in the vasodilator effects of minoxidil in the rat.	Minoxidil	68-77	uridine-cytidine kinase 2	Homo sapiens	0-14	
2161304-4	1990	Minoxidil at a low vasodepressor dose of 0.03 mg/kg per min abolished the pressor response to uridine at doses from 2 to 8 mumol/kg per min, but did not reduce the responses to uridine monophosphate or uridine diphosphate in similar pressor doses, suggesting an action on either transport of uridine into cells or on uridine kinase which catalyses phosphorylation of uridine to uridine monophosphate, the mediator of uridine"s vascular actions.	Minoxidil	0-9	uridine-cytidine kinase 2	Homo sapiens	317-331	
2161304-6	1990	The active metabolite of minoxidil was found to inhibit rat liver uridine kinase in vivo using an HPLC technique.	Minoxidil	25-34	uridine-cytidine kinase 2	Homo sapiens	66-80	
2161304-8	1990	Plasma uridine concentration was significantly higher in 11 hypertensive patients on minoxidil compared with pretreatment values, suggesting that uridine kinase inhibition is of a degree sufficient to increase the circulating pool of uridine.	Minoxidil	85-94	uridine-cytidine kinase 2	Homo sapiens	146-160	
2161304-10	1990	The data is consistent with uridine kinase inhibition being a mechanism for the vasodilator actions of minoxidil.	Minoxidil	103-112	uridine-cytidine kinase 2	Homo sapiens	28-42