PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18560355-3 2008 Herein, we examined urethane-induced lung tumorigenesis in a new mouse model developed by replacing the Kras gene with an Hras gene in the susceptible A/J-type Pas1 locus and crossing these mice with either C57BL/6J or A/J mice. Urethane 20-28 Harvey rat sarcoma virus oncogene Mus musculus 122-126 10767618-11 2000 In tumors induced by urethane in mice, codon 61 of the Ha-ras gene (liver, skin) and of the Ki-ras gene (lung) seems to be a characteristic target. Urethane 21-29 Harvey rat sarcoma virus oncogene Mus musculus 55-61 10779650-0 2000 Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene. Urethane 74-82 Harvey rat sarcoma virus oncogene Mus musculus 151-159 1352887-5 1992 Activated Ha-ras genes with 61st codon A----T mutations were found in the epidermis of mice 1 week after topical initiation with 7,12-dimethylbenz[a]anthracene or urethane by using this assay. Urethane 163-171 Harvey rat sarcoma virus oncogene Mus musculus 10-16 2000226-1 1991 By selective oligonucleotide hybridization of polymerase chain reaction (PCR) amplified tumor DNAs we have analysed the incidence of mutations at codon 61 of the Ha-ras gene in 42 liver tumors spontaneously developed in Balb/c, C3Hf and B6C3 male mice, and in 79 liver tumors induced by the chemical carcinogens diethylnitrosamine (NDEA) and urethan in B6C3 and B6C male and female mice. Urethane 342-349 Harvey rat sarcoma virus oncogene Mus musculus 162-168 2000226-2 1991 The incidence of Ha-ras gene mutations in both spontaneously developed and urethan-induced liver tumors was 50%-63% in mice genetically susceptible to hepatocarcinogenesis (C3Hf, B6C3) and 7%-9% in mice genetically resistant (Balb/c, B6C). Urethane 75-82 Harvey rat sarcoma virus oncogene Mus musculus 17-23 2000226-6 1991 Our results indicate that liver tumors induced by NDEA or urethan or spontaneously arisen have a different pattern of Ha-ras mutations at codon 61 and that these mutations constitute a rare molecular alteration in the pathogenesis of liver tumors in genetically resistant mice. Urethane 58-65 Harvey rat sarcoma virus oncogene Mus musculus 118-124 2567173-0 1989 Activation of the cellular Harvey ras gene in mouse skin tumors initiated with urethane. Urethane 79-87 Harvey rat sarcoma virus oncogene Mus musculus 27-37 2567173-7 1989 The results demonstrate a highly consistent activation of the Ha-ras oncogene by a specific point mutation, suggesting a functional role for an activated ras gene in the initiation of mouse skin tumors by urethane. Urethane 205-213 Harvey rat sarcoma virus oncogene Mus musculus 62-68