PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31123759-9	2019	CONCLUSION: BSV in CYP3A activity was well described by caffeine/TMU ratios pre- and post-induction.	1,3,7-trimethyluric acid	65-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	19-24	
9868741-8	1998	The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine.	1,3,7-trimethyluric acid	65-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	4-10	
9868741-8	1998	The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine.	1,3,7-trimethyluric acid	65-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	195-201	
1306118-9	1992	An anti-CYP3A antibody essentially abolished the 8-hydroxylation of CA to form trimethyluric acid, suggesting formation of this metabolite may potentially serve as a marker of CYP3A isozyme(s) activity.	1,3,7-trimethyluric acid	79-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	8-13	
26967371-0	2016	Role of Enzyme Flexibility in Ligand Access and Egress to Active Site: Bias-Exchange Metadynamics Study of 1,3,7-Trimethyluric Acid in Cytochrome P450 3A4.	1,3,7-trimethyluric acid	107-131	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-154