PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31123759-9 2019 CONCLUSION: BSV in CYP3A activity was well described by caffeine/TMU ratios pre- and post-induction. 1,3,7-trimethyluric acid 65-68 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 19-24 9868741-8 1998 The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine. 1,3,7-trimethyluric acid 65-89 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 4-10 9868741-8 1998 The CYP3A4 inhibitors, ketoconazole and bromocriptine, inhibited 1,3,7-trimethyluric acid formation with Kis of 0.75 microM and 5 microM, respectively, thus further supporting the involvement of CYP3A4 in the 8-hydroxylation of caffeine. 1,3,7-trimethyluric acid 65-89 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 195-201 1306118-9 1992 An anti-CYP3A antibody essentially abolished the 8-hydroxylation of CA to form trimethyluric acid, suggesting formation of this metabolite may potentially serve as a marker of CYP3A isozyme(s) activity. 1,3,7-trimethyluric acid 79-97 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 8-13 26967371-0 2016 Role of Enzyme Flexibility in Ligand Access and Egress to Active Site: Bias-Exchange Metadynamics Study of 1,3,7-Trimethyluric Acid in Cytochrome P450 3A4. 1,3,7-trimethyluric acid 107-131 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 135-154