PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26218892-7	2015	Strikingly, 3-N demethylation is more favorable than 7-N demethylation due to its lower free energy barrier and 7-methylxanthine therefore is the optimum product reported for the demethylation of theobromine catalyzed by CYP1A2, which are in good agreement with the experimental observation.	Theobromine	196-207	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	221-227	
26218892-2	2015	The main N-demethylation metabolic mechanism of theobromine catalyzed by P450 isoenzyme 1A2 (CYP1A2) has been explored in this work using the unrestricted hybrid density functional method UB3LYP in conjunction with the LACVP(Fe)/6-31G (H, C, N, O, S, Cl) basis set.	Theobromine	48-59	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	93-99	
10215755-7	1999	Consistent with the microsomal studies, recombinant CYP1A2 and CYP2E1 exhibited similar apparent Km values for 7-MX formation and CYP2E1 was further shown to have the capacity to convert TB to both 3-MX and 3,7-DMU.	Theobromine	187-189	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	52-58	
1302044-0	1992	Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1.	Theobromine	45-56	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104	
1302044-3	1992	The metabolic profile of caffeine biotransformation by CYP1A2 averaged 81.5% for paraxanthine, 10.8% for theobromine and 5.4% for theophylline formation.	Theobromine	105-116	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61	
9868741-7	1998	The formation of 1,7-dimethylxanthine was virtually abolished by 10 microM of fluvoxamine, indicating that the N3-demethylation of caffeine is almost exclusively catalysed by CYP1A2.	Theobromine	19-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	175-181