PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25450364-9 2014 Next, to investigate the mechanism by which ALA is transported into erythroid cells, quantitative RT-PCR analysis was performed on previously identified ALA transporters, including solute carrier family 15 (oligopeptide transporter), member (SLC15A) 1, SLC15A2, solute carrier family 36 (proton/amino acid symporter), member (SLC36A1), and solute carrier family 6 (neurotransmitter transporter), member 13 (SLC6A13). 5-amino levulinic acid 44-47 solute carrier family 15 member 1 Homo sapiens 242-251 23993855-0 2013 Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer. 5-amino levulinic acid 55-76 solute carrier family 15 member 1 Homo sapiens 21-26 23993855-0 2013 Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer. 5-amino levulinic acid 78-81 solute carrier family 15 member 1 Homo sapiens 21-26 23993855-8 2013 CONCLUSION: The induction of PEPT1 gene and the suppression of ABCG2 gene expression are among the key molecular mechanisms underlying tumor-specific PpIX accumulation after the administration of ALA in bladder cancer. 5-amino levulinic acid 196-199 solute carrier family 15 member 1 Homo sapiens 29-34 33059124-8 2021 Studies with qPCR showed upregulation of ALA influx transporter PEPT1 in CFPAC-1, whereas PANC-1 upregulated the efflux transporter ABCG2. 5-amino levulinic acid 41-44 solute carrier family 15 member 1 Homo sapiens 64-69 19789362-7 2010 The inhibitory effects of 5-hydroxytryptophan and 4-aminomethylbenzoic acid were additive, demonstrating that both PAT1 and PepT1 contribute to intestinal transport of ALA. 5-amino levulinic acid 168-171 solute carrier family 15 member 1 Homo sapiens 124-129 32884434-7 2020 Results: The expression of oligopeptide transporter-1 (PEPT-1), through which ALA is absorbed, was significantly higher in AsPC-1 cells and lower in MIA PaCa-2 cells than in hPDECs. 5-amino levulinic acid 78-81 solute carrier family 15 member 1 Homo sapiens 55-61 32884434-8 2020 AsPC-1 cells showed rapid and intense fluorescence after ALA administration, and that was attenuated by PEPT-1 inhibition. 5-amino levulinic acid 57-60 solute carrier family 15 member 1 Homo sapiens 104-110 32884434-10 2020 Conclusion: We revealed the association of PEPT-1 with ALA-induced fluorescence. 5-amino levulinic acid 55-58 solute carrier family 15 member 1 Homo sapiens 43-49 22959800-9 2012 CONCLUSION: PEPT1 and ABCG2 are key players in regulating intracellular PpIX levels and determining the efficacy of ALA-based photocytotoxicity against gastric cancer cells in vitro. 5-amino levulinic acid 116-119 solute carrier family 15 member 1 Homo sapiens 12-17 22959800-10 2012 Evaluation of the expression levels of PEPT1 and ABCG2 genes could be useful to predict the efficacy of ALA-PDT. 5-amino levulinic acid 104-107 solute carrier family 15 member 1 Homo sapiens 39-44 15901802-5 2005 A pH-dependent effect was observed in the hPepT1-expressing clones and Caco-2 cells, with an increase of 1.96-, 1.84-, and 2.05-fold for VACV, 5-ALA, and BENZ uptake, respectively, at pH 6 versus 7.4 in the high-expressing hPepT1 cells. 5-amino levulinic acid 143-148 solute carrier family 15 member 1 Homo sapiens 42-48 15901802-8 2005 The apical-to-basal apparent permeability coefficient (P(app)) values of VACV, 5-ALA, and BENZ in mock-corrected hPepT1-MDCK cells showed solely hPepT1-mediated transport in contrast to Caco-2 cells. 5-amino levulinic acid 79-84 solute carrier family 15 member 1 Homo sapiens 145-151 34679666-9 2021 Since SLC15A1 is an accumulating transporter for ALA, while ABCG2 is a porphyrin efflux transporter, porphyrin accumulation was enhanced. 5-amino levulinic acid 49-52 solute carrier family 15 member 1 Homo sapiens 6-13 33059124-9 2021 We conclude that PEPT1 and ABCG2 expression may be key contributory factors for variability in ALA-induced fluorescence in PDAC. 5-amino levulinic acid 95-98 solute carrier family 15 member 1 Homo sapiens 17-22 30639584-0 2019 Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer. 5-amino levulinic acid 108-129 solute carrier family 15 member 1 Homo sapiens 14-35 31426474-8 2019 In this study, we investigated whether cisplatin-increased mitROS production in gastric cancer cell lines (RGK36 and RGK45) enhanced the cytotoxicity of ALA-PDT by regulation the expression of both PEPT1 and ABCG2. 5-amino levulinic acid 153-156 solute carrier family 15 member 1 Homo sapiens 198-203 31426474-3 2019 ALA is imported into cells via peptide transporter 1 (PEPT1), and porphyrin is exported via ATP-binding cassette member 2 of subfamily G (ABCG2). 5-amino levulinic acid 0-3 solute carrier family 15 member 1 Homo sapiens 31-52 31426474-3 2019 ALA is imported into cells via peptide transporter 1 (PEPT1), and porphyrin is exported via ATP-binding cassette member 2 of subfamily G (ABCG2). 5-amino levulinic acid 0-3 solute carrier family 15 member 1 Homo sapiens 54-59 30639584-10 2019 CONCLUSION: Expression of PEPT1 was found to be positively correlated with 5-ALA-induced protoporphyrin IX accumulation detected by photodynamic reaction in metastatic brain tumors originating from NSCLC. 5-amino levulinic acid 75-80 solute carrier family 15 member 1 Homo sapiens 26-31 29196245-14 2018 The cell lines sensitive to ALA-PDT expressed PEPT1 (an ALA uptake transporter). 5-amino levulinic acid 28-31 solute carrier family 15 member 1 Homo sapiens 46-51