PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15034803-3 2004 In response to stimuli, arachidonic acid is mobilized from phospholipid pools and metabolized by cyclooxygenases (COX), lipoxygenases (LOX), and p450 epoxygenases (EOX) to form a variety of eicosanoids. Eicosanoids 190-201 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 145-149 17431031-0 2007 Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Eicosanoids 16-27 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-15 17431031-1 2007 Cytochrome P450 (P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. Eicosanoids 23-34 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-21 17431031-4 2007 We show here that P450 eicosanoids can bind to and activate PPARalpha and result in the modulation of PPARalpha target gene expression. Eicosanoids 23-34 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 18-22 17431031-8 2007 In addition, P450 eicosanoids induced CYP4A1, sEH, and CYP2C11 expression, suggesting that they can regulate their own levels. Eicosanoids 18-29 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 13-17 17431031-9 2007 Given that P450 eicosanoids have multiple cardiovascular effects, pharmacological modulation of their formation and/or degradation may yield therapeutic benefits. Eicosanoids 16-27 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-15 17164128-3 2007 The four regioisomeric eicosanoids, 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs) of AA metabolites derived by P450 epoxygenases have shown to possess potent biological effects in numerous tissues. Eicosanoids 23-34 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 128-132 17073778-1 2006 P450 (cytochrome P450) enzymes have major roles in the biosynthesis of endogenous factors such as steroids and eicosanoids, in the termination of the action of endogenous factors such as retinoic acid, in the metabolism of most drugs and xenobiotics and in the generation of toxic and carcinogenic products. Eicosanoids 111-122 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 17073778-1 2006 P450 (cytochrome P450) enzymes have major roles in the biosynthesis of endogenous factors such as steroids and eicosanoids, in the termination of the action of endogenous factors such as retinoic acid, in the metabolism of most drugs and xenobiotics and in the generation of toxic and carcinogenic products. Eicosanoids 111-122 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 17-21 12088278-2 2002 Studies from several laboratories documenting the powerful biological activities of the P450-derived eicosanoids have suggested important roles for the P450 arachidonic acid monooxygenase in renal and vascular physiology, and in the pathophysiology of experimental hypertension. Eicosanoids 101-112 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 88-92 12088278-2 2002 Studies from several laboratories documenting the powerful biological activities of the P450-derived eicosanoids have suggested important roles for the P450 arachidonic acid monooxygenase in renal and vascular physiology, and in the pathophysiology of experimental hypertension. Eicosanoids 101-112 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 152-156 11469727-1 2001 Cytochrome P450 (P450) enzymes play major roles in the metabolism of drugs, carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as well as chemicals normally endogenous to the body. Eicosanoids 99-110 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-21 9134230-6 1997 The potential significance of P450 inhibition by anaesthetics resides in the contribution of this enzyme family, in conjunction with that of cyclo-oxygenases and lipoxygenases, to the generation from arachidonic acid of lipid second messengers, the eicosanoids. Eicosanoids 249-260 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 30-34 28298143-0 2018 P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection. Eicosanoids 5-16 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 25231529-2 2015 Experimental and human studies implicate the vasoconstrictor P450 eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE) in the pathogenesis of DCI. Eicosanoids 66-76 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 61-65 25231529-4 2015 METHODS: Using mass spectrometry, we measured P450 eicosanoids in cerebrospinal fluid (CSF) from 34 SAH patients from 1 to 14 days after admission. Eicosanoids 51-62 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 46-50 25231529-10 2015 CONCLUSIONS: Our findings suggest that P450 eicosanoids play an important role in the pathogenesis of DCI. Eicosanoids 44-55 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-43 26002738-2 2015 P450 enzymes play an important role in the detoxification of exogenous bioactive compounds and hydrophobic xenobiotics (e.g. carcinogens, drugs, environment pollutants, food supplements, medicines, plant products) and in the biotransformation of endogenous bioactive compounds (e.g. amino acids, cholesterol, eicosanoids, saturated/unsaturated fatty acids, melatonin, steroid hormones). Eicosanoids 309-320 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 23330950-1 2013 INTRODUCTION: Cytochromes P450 (P450) and associated monooxygenases are a family of heme proteins involved in metabolism of endogenous compounds (arachidonic acid, eicosanoids and prostaglandins) as also xenobiotics including drugs and environmental chemicals. Eicosanoids 164-175 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 26-30 23330950-1 2013 INTRODUCTION: Cytochromes P450 (P450) and associated monooxygenases are a family of heme proteins involved in metabolism of endogenous compounds (arachidonic acid, eicosanoids and prostaglandins) as also xenobiotics including drugs and environmental chemicals. Eicosanoids 164-175 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 32-36 23388178-3 2013 Following release from the phospholipid membrane, arachidonic acid can be metabolized into different classes of eicosanoids through cyclooxygenases, lipoxygenases, or p450 epoxygenase pathways. Eicosanoids 112-123 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 167-171 28188297-1 2017 The human genome encodes 57 cytochrome P450 genes, whose enzyme products metabolize hundreds of drugs, thousands of xenobiotics, and unknown numbers of endogenous compounds, including steroids, retinoids, and eicosanoids. Eicosanoids 209-220 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-43