PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22659487-2	2012	Leukotriene B4 (LTB4), a potent proinflammatory mediator, is synthesized by 5-lipoxygenase (5-LO), which is activated by the presence of lipid hydroperoxides resulting from oxidative stress on biological membranes.	Lipid Peroxides	137-157	arachidonate 5-lipoxygenase	Homo sapiens	76-90	
19756810-7	2009	In addition, it has anti-inflammatory activity against microglial cells and inhibits the activity of 5-lipoxygenase, thereby reducing the production of lipid peroxides and their pro-inflammatory by-products.	Lipid Peroxides	152-167	arachidonate 5-lipoxygenase	Homo sapiens	101-115	
2502118-0	1989	Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides.	Lipid Peroxides	91-111	arachidonate 5-lipoxygenase	Homo sapiens	47-61	
11371199-4	2001	After oxidation by lipid hydroperoxides, 5LO exhibited axial EPR spectra typified by a signal at g = 6.2.	Lipid Peroxides	19-39	arachidonate 5-lipoxygenase	Homo sapiens	41-44	
1334502-7	1992	Thus a possible mechanism for controlling the influx of neutrophils and their oxidative damage during inflammation may be inhibition of the 5-lipoxygenase by catalase-resistant lipid peroxides released by tissue membranes.	Lipid Peroxides	177-192	arachidonate 5-lipoxygenase	Homo sapiens	140-154	
11325678-3	2001	Upregulation of 5-lipoxygenase (5-Lox) activity and protein content with enhanced production of leukotriene B(4) (LTB(4)) and membrane lipoperoxides was also shown in PBMCs of HD patients.	Lipid Peroxides	135-148	arachidonate 5-lipoxygenase	Homo sapiens	16-30	
11325678-3	2001	Upregulation of 5-lipoxygenase (5-Lox) activity and protein content with enhanced production of leukotriene B(4) (LTB(4)) and membrane lipoperoxides was also shown in PBMCs of HD patients.	Lipid Peroxides	135-148	arachidonate 5-lipoxygenase	Homo sapiens	32-37	
2001245-1	1991	The purified 5-lipoxygenase from porcine leukocytes was found to catalyse the degradation of lipid hydroperoxides in the presence of potent inhibitors of the lipoxygenase reaction.	Lipid Peroxides	93-113	arachidonate 5-lipoxygenase	Homo sapiens	13-27	
34143955-3	2021	Mechanistically, MGST1 binds ALOX5 during ferroptosis induction, inhibiting lipid peroxide production.	Lipid Peroxides	76-90	arachidonate 5-lipoxygenase	Homo sapiens	29-34	
2502118-10	1989	The results indicate that the presence of inhibitors can modify the kinetics of 5-lipoxygenase at the levels of the initiation of the reaction and the rate of enzyme inactivation, with variations depending on the structural class of the inhibitor and the concentration of lipid hydroperoxides.	Lipid Peroxides	272-292	arachidonate 5-lipoxygenase	Homo sapiens	80-94	
2496978-3	1989	Also, since co-incubation of fatty acid hydroperoxides with arachidonate caused activation of 5-lipoxygenase, we propose that Dnp-C1 increases the peroxide level in PMN which is required for the onset of lipoxygenase activity.	Lipid Peroxides	29-54	arachidonate 5-lipoxygenase	Homo sapiens	94-108