PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34537856-14 2021 Importantly, inhibition of GPX4 interferes with both intracellular iron homeostasis and lipid peroxide reducibility, inducing ferroptosis and exerting anti-cancer effect, which can be a potential effective strategy for ovarian cancer therapy. Lipid Peroxides 88-102 glutathione peroxidase 4 Mus musculus 27-31 1394132-3 1992 This study focuses on the cytoprotective effects of the glutathione-dependent selenoperoxidases GPX and PHGPX, which can detoxify a wide variety of hydroperoxides, including lipid-derived species (LOOHs). Lipid Peroxides 197-202 glutathione peroxidase 4 Mus musculus 104-109 34469757-4 2022 Ferroptosis is a new type of programmed cell death caused by iron-dependent accumulation of lipid peroxides, in which glutathione peroxidase 4 (GPX4) is a key protein affecting ferroptosis. Lipid Peroxides 92-107 glutathione peroxidase 4 Mus musculus 118-142 34469757-4 2022 Ferroptosis is a new type of programmed cell death caused by iron-dependent accumulation of lipid peroxides, in which glutathione peroxidase 4 (GPX4) is a key protein affecting ferroptosis. Lipid Peroxides 92-107 glutathione peroxidase 4 Mus musculus 144-148 34879292-7 2022 shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH of the cancer cells. Lipid Peroxides 56-71 glutathione peroxidase 4 Mus musculus 91-95 34879292-13 2022 The shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH. Lipid Peroxides 60-75 glutathione peroxidase 4 Mus musculus 95-99 33590347-5 2021 DA promoted the expression downstream of Nrf2 such as heme oxygenase-1 (HO-1), glutathione (GSH) and its peroxidase 4 (GPX4), so as to eliminate the accumulation of reactive oxygen species (ROS) and reduce lipid peroxides malondialdehyde (MDA) in the liver. Lipid Peroxides 206-221 glutathione peroxidase 4 Mus musculus 119-123 35384401-1 2022 Ferroptosis is iron-dependent, lipid peroxidation-driven, regulated cell death that is triggered when cellular glutathione peroxidase 4 (GPX4)-mediated cellular defense is insufficient to prevent pathologic accumulation of toxic lipid peroxides. Lipid Peroxides 229-244 glutathione peroxidase 4 Mus musculus 137-141 35318305-7 2022 In addition, we found that ferroptosis is the major cell death form in Hemin-induced OPC death by using RNA-seq analysis, and the mechanism was glutathione peroxidase 4 activity reduction-resulted lipid peroxide accumulation. Lipid Peroxides 197-211 glutathione peroxidase 4 Mus musculus 144-168 33951302-11 2021 CONCLUSION: Zinc promoted the degradation of oxidative stress products and lipid peroxides through the NRF2/HO-1 and GPX4 signaling pathways to inhibit ferroptosis in neurons. Lipid Peroxides 75-90 glutathione peroxidase 4 Mus musculus 117-121 34999258-5 2022 Glutathione peroxidase GPx4, which can catalyze lipid hydroperoxide detoxification, was detected in mitochondria of MA-10 cells. Lipid Peroxides 48-67 glutathione peroxidase 4 Mus musculus 23-27 35186185-7 2022 Results: In the present study, the accumulation of lipid peroxide, a defect in the glutathione peroxidase 4 (GPx4)/glutathione (GSH) antioxidant system, highly expressed ALOX15 in microglia and endothelium, and ferroptotic changes in microglial mitochondria confirmed the occurrence of ferroptosis after SAH in vivo. Lipid Peroxides 51-65 glutathione peroxidase 4 Mus musculus 83-107 35186185-7 2022 Results: In the present study, the accumulation of lipid peroxide, a defect in the glutathione peroxidase 4 (GPx4)/glutathione (GSH) antioxidant system, highly expressed ALOX15 in microglia and endothelium, and ferroptotic changes in microglial mitochondria confirmed the occurrence of ferroptosis after SAH in vivo. Lipid Peroxides 51-65 glutathione peroxidase 4 Mus musculus 109-113 35224150-2 2022 While metabolic dysfunctions can lead to excessive lipid peroxidation culminating in ferroptotic cell death, glutathione peroxidase 4 (GPX4) resides in the center of a network that functions to prevent lipid hydroperoxides from accumulation, thereby suppressing ferroptosis. Lipid Peroxides 202-222 glutathione peroxidase 4 Mus musculus 109-133 35224150-2 2022 While metabolic dysfunctions can lead to excessive lipid peroxidation culminating in ferroptotic cell death, glutathione peroxidase 4 (GPX4) resides in the center of a network that functions to prevent lipid hydroperoxides from accumulation, thereby suppressing ferroptosis. Lipid Peroxides 202-222 glutathione peroxidase 4 Mus musculus 135-139 33854057-2 2021 Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. Lipid Peroxides 0-20 glutathione peroxidase 4 Mus musculus 36-60 33854057-2 2021 Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. Lipid Peroxides 0-20 glutathione peroxidase 4 Mus musculus 62-66 33854057-2 2021 Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. Lipid Peroxides 0-20 glutathione peroxidase 4 Mus musculus 72-76 31248967-1 2020 Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids. Lipid Peroxides 135-150 glutathione peroxidase 4 Mus musculus 0-24 33156626-2 2020 Both are cofactors of glutathione peroxide 4 (GPX4) that act against oxidative stress via catalyzing the reduction of lipid peroxides. Lipid Peroxides 118-133 glutathione peroxidase 4 Mus musculus 46-50 32531676-10 2020 The glutathione-dependent lipid hydroperoxidase GPX4 prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols. Lipid Peroxides 88-108 glutathione peroxidase 4 Mus musculus 48-52 32376803-6 2020 Additionally, GPx4, an endogenous regulator of ferroptosis, was downregulated, accompanied by the accumulation of lipid peroxides, especially in mitochondria. Lipid Peroxides 114-129 glutathione peroxidase 4 Mus musculus 14-18 31248967-1 2020 Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids. Lipid Peroxides 135-150 glutathione peroxidase 4 Mus musculus 26-30 30984534-1 2019 Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Lipid Peroxides 87-102 glutathione peroxidase 4 Mus musculus 122-146 31341276-2 2019 The enzyme glutathione peroxidase 4 (GPX4) is a central regulator of ferroptosis, and protects cells by neutralizing lipid peroxides, which are by-products of cellular metabolism. Lipid Peroxides 117-132 glutathione peroxidase 4 Mus musculus 11-35 31341276-2 2019 The enzyme glutathione peroxidase 4 (GPX4) is a central regulator of ferroptosis, and protects cells by neutralizing lipid peroxides, which are by-products of cellular metabolism. Lipid Peroxides 117-132 glutathione peroxidase 4 Mus musculus 37-41 30984534-1 2019 Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Lipid Peroxides 87-102 glutathione peroxidase 4 Mus musculus 148-152 29971532-1 2018 PURPOSE: Ferroptosis is a programmed form of iron-dependent cell death caused by lipid hydroperoxide accumulation, which can be prevented by glutathione peroxidase 4 (GPx4) activity. Lipid Peroxides 81-100 glutathione peroxidase 4 Mus musculus 141-165 29971532-1 2018 PURPOSE: Ferroptosis is a programmed form of iron-dependent cell death caused by lipid hydroperoxide accumulation, which can be prevented by glutathione peroxidase 4 (GPx4) activity. Lipid Peroxides 81-100 glutathione peroxidase 4 Mus musculus 167-171 19001413-7 2009 In support of this, muscle atrophy and the Amplex Red signal are inhibited in caloric restricted mice and in transgenic mice that overexpress the lipid hydroperoxide-detoxifying enzyme glutathione peroxidase 4. Lipid Peroxides 146-165 glutathione peroxidase 4 Mus musculus 185-209 28552631-3 2017 As ferroptosis is induced by inhibition of cysteine uptake or inactivation of the lipid repair enzyme glutathione peroxidase 4 (GPX4), the process is favored by chemical or mutational inhibition of the cystine/glutamate antiporter and culminates in the accumulation of reactive oxygen species (ROS) in the form of lipid hydroperoxides. Lipid Peroxides 314-334 glutathione peroxidase 4 Mus musculus 102-126 28552631-3 2017 As ferroptosis is induced by inhibition of cysteine uptake or inactivation of the lipid repair enzyme glutathione peroxidase 4 (GPX4), the process is favored by chemical or mutational inhibition of the cystine/glutamate antiporter and culminates in the accumulation of reactive oxygen species (ROS) in the form of lipid hydroperoxides. Lipid Peroxides 314-334 glutathione peroxidase 4 Mus musculus 128-132 25824823-7 2015 Ex vivo, Gpx4-deficient T cells rapidly accumulated membrane lipid peroxides and concomitantly underwent cell death driven by ferroptosis but not necroptosis. Lipid Peroxides 61-76 glutathione peroxidase 4 Mus musculus 9-13 23695217-3 2013 Therefore, we hypothesized that mice overexpressing glutathione peroxidase-4 (GPx4), an enzyme that specifically reduces lipid peroxides, are protected from fat-induced beta-cell dysfunction. Lipid Peroxides 121-136 glutathione peroxidase 4 Mus musculus 52-76 23695217-3 2013 Therefore, we hypothesized that mice overexpressing glutathione peroxidase-4 (GPx4), an enzyme that specifically reduces lipid peroxides, are protected from fat-induced beta-cell dysfunction. Lipid Peroxides 121-136 glutathione peroxidase 4 Mus musculus 78-82 23408027-3 2013 The goal of this study was to determine whether overexpression of mitochondria phospholipid hydroperoxide glutathione peroxidase 4 (mPHGPx), an antioxidant enzyme capable of scavenging membrane-associated lipid peroxides in the IMM, could reverse proteomic alterations, dysfunctional protein import, and ultimately, mitochondrial dysfunction associated with the diabetic heart. Lipid Peroxides 205-220 glutathione peroxidase 4 Mus musculus 132-138 16413410-2 2006 By lowering cellular lipid hydroperoxide levels, GP x 4 inhibits cyclooxygenase (COX) and lipoxygenase (LOX) activities. Lipid Peroxides 21-40 glutathione peroxidase 4 Mus musculus 49-55 16673405-2 2006 Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme that can directly detoxify lipid hydroperoxides generated by ROS. Lipid Peroxides 92-112 glutathione peroxidase 4 Mus musculus 0-24 16673405-2 2006 Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme that can directly detoxify lipid hydroperoxides generated by ROS. Lipid Peroxides 92-112 glutathione peroxidase 4 Mus musculus 26-30 17395155-2 2007 Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme found in mitochondria as well as other subcellular organelles that directly detoxifies membrane lipid hydroperoxides. Lipid Peroxides 161-181 glutathione peroxidase 4 Mus musculus 0-24 17395155-2 2007 Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme found in mitochondria as well as other subcellular organelles that directly detoxifies membrane lipid hydroperoxides. Lipid Peroxides 161-181 glutathione peroxidase 4 Mus musculus 26-30 12745070-1 2003 Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is the only known intracellular antioxidant enzyme that can directly reduce lipid hydroperoxide in membrane. Lipid Peroxides 7-26 glutathione peroxidase 4 Mus musculus 51-56 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 161-175 glutathione peroxidase 4 Mus musculus 0-49 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 161-175 glutathione peroxidase 4 Mus musculus 51-56 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 161-175 glutathione peroxidase 4 Mus musculus 73-97 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 161-175 glutathione peroxidase 4 Mus musculus 99-103 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 223-238 glutathione peroxidase 4 Mus musculus 0-49 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 223-238 glutathione peroxidase 4 Mus musculus 51-56 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 223-238 glutathione peroxidase 4 Mus musculus 73-97 10341094-1 1999 Phospholipid hydroperoxide glutathione peroxidase (PHGPx), also known as glutathione peroxidase 4 (GPX4), is a 19-kDa, monomeric enzyme that protects cells from lipid peroxide-mediated damage by catalyzing the reduction of lipid peroxides. Lipid Peroxides 223-238 glutathione peroxidase 4 Mus musculus 99-103 10341094-10 1999 This information may be valuable in characterizing the role of PHGPx in modulating susceptibility to lipid peroxide-mediated injury in inbred murine strains and for targeted disruption of the gene. Lipid Peroxides 101-115 glutathione peroxidase 4 Mus musculus 63-68