PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25795251-6	2015	Both NBDHEX and MC3181 induced marked antiproliferative and apoptotic effects in A375-VR8 cells and, at equitoxic concentrations, caused a strong phosphorylation of JNK, p38, and of the downstream mediators of apoptosis ATF2 and p53.	MC3181	16-22	mitogen-activated protein kinase 8	Homo sapiens	165-168	
25795251-8	2015	Finally, in vivo administration of MC3181 provoked JNK activation at the tumor site and markedly reduced A375-VR8 growth.	MC3181	35-41	mitogen-activated protein kinase 8	Homo sapiens	51-54	
28107182-6	2017	Our data disclosed both a decrease of the phospho-active form of JNK and an increased expression of the transcription factor AP2, events that occur in the very early phase of drug treatment and may be responsible of the antimetastatic effects of MC3181.	MC3181	246-252	mitogen-activated protein kinase 8	Homo sapiens	65-68	
26847645-1	2016	BACKGROUND: Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and ability to sequester TNF-receptor associated factor 2 (TRAF2) and c-Jun N-terminal kinase (JNK).	MC3181	96-102	mitogen-activated protein kinase 8	Homo sapiens	285-308	
26847645-1	2016	BACKGROUND: Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and ability to sequester TNF-receptor associated factor 2 (TRAF2) and c-Jun N-terminal kinase (JNK).	MC3181	96-102	mitogen-activated protein kinase 8	Homo sapiens	310-313	
26847645-9	2016	RESULTS: Similar to NBDHEX, MC3181 reduced viability and activated TRAF2/JNK signaling in U-2OS cells.	MC3181	28-34	mitogen-activated protein kinase 8	Homo sapiens	73-76