PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35480532-0 2022 Rasagiline Pharmacokinetics in CYP1A2 Variant Healthy Smokers & Non-smokers in Different Doses. rasagiline 0-10 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 31-37 26951202-1 2016 BACKGROUND AND OBJECTIVE: Although there is evidence indicating cytochome P450 (CYP) 1A2 is responsible for the metabolism of rasagiline, the role of other CYP isoforms is unclear. rasagiline 126-136 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 74-88 18488080-6 2007 Rasagiline undergoes extensive hepatic metabolism primarily by cytochrome P450 type 1A2 (CYP1A2). rasagiline 0-10 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 63-87 18488080-6 2007 Rasagiline undergoes extensive hepatic metabolism primarily by cytochrome P450 type 1A2 (CYP1A2). rasagiline 0-10 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 89-95 17296539-12 2006 CYP1A2 inhibitors slow the elimination of rasagiline and mandate dosage reduction. rasagiline 42-52 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 35480532-1 2022 Objectives: Rasagiline, a drug for Parkinson"s disease is metabolized by CYP1A2 enzyme. rasagiline 12-22 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 73-79 35480532-2 2022 The objective of the study was to investigate the influence of cytochrome P450 1A2 variants and smoking status of healthy individuals on the pharmacokinetics of rasagiline. rasagiline 161-171 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 63-82 35480532-13 2022 Conclusion: The study concludes that the systemic metabolism of rasagiline is significantly increased in CYP1A2*AA variants while smoking status did not show consistent difference in PK parameters. rasagiline 64-74 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 105-111