PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17017568-5 2006 Rasagiline and propargylamine both regulated amyloid precursor protein (APP) processing towards the non-amyloidogenic pathway. rasagiline 0-10 amyloid beta precursor protein Homo sapiens 45-70 19110207-5 2009 This review discusses the multimodal effects of two rasagiline-containing hybrid molecules, namely ladostigil and M-30, concerning their neuroprotective molecular mechanisms in vivo and in vitro, including regulation of amyloid precursor protein processing, activation of protein kinase C, and mitogen-activated protein kinase signaling pathways, inhibition of cell death markers and upregulation of neurotrophic factors. rasagiline 52-62 amyloid beta precursor protein Homo sapiens 220-245 15147504-1 2004 We have recently shown that the anti-Parkinson-propargyl-containing monoamine oxidase B (MAO-B) inhibitor drug, rasagiline [N-propargyl-(1R)-aminoindan], and its cholinesterase inhibitor derivatives TV3326 and TV3279, regulate amyloid precursor protein (APP) processing by a protein kinase C (PKC)-dependent mechanism in SH-SY5Y neuroblastoma and PC12 cells. rasagiline 112-122 amyloid beta precursor protein Homo sapiens 227-252 12206996-0 2002 Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline. rasagiline 132-142 amyloid beta precursor protein Homo sapiens 47-72 14525944-3 2003 In addition, rasagiline significantly increased (approximately threefold) the secretion of the nonamyloidogenic soluble form of the amyloid precursor protein (sAPPalpha) from SH-SY5Y neuroblastoma and PC12 cells. rasagiline 13-23 amyloid beta precursor protein Homo sapiens 132-157