PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34425095-6	2021	IRG1 catalyzes the production of a TCA derivative, itaconate, an inhibitor of succinate dehydrogenase (SDH).	Tricarboxylic Acids	35-38	aminoadipate-semialdehyde synthase	Mus musculus	78-101	
34425095-6	2021	IRG1 catalyzes the production of a TCA derivative, itaconate, an inhibitor of succinate dehydrogenase (SDH).	Tricarboxylic Acids	35-38	aminoadipate-semialdehyde synthase	Mus musculus	103-106	
31894617-3	2020	The transition from immune resistance to tolerance also diverts the TCA cycle from citrate-derived cis-aconitate to itaconate, a recently discovered catabolic mediator that separates the TCA cycle at isocitrate and succinate dehydrogenase (SDH).	Tricarboxylic Acids	68-71	aminoadipate-semialdehyde synthase	Mus musculus	215-238	
31894617-3	2020	The transition from immune resistance to tolerance also diverts the TCA cycle from citrate-derived cis-aconitate to itaconate, a recently discovered catabolic mediator that separates the TCA cycle at isocitrate and succinate dehydrogenase (SDH).	Tricarboxylic Acids	68-71	aminoadipate-semialdehyde synthase	Mus musculus	240-243	
31894617-3	2020	The transition from immune resistance to tolerance also diverts the TCA cycle from citrate-derived cis-aconitate to itaconate, a recently discovered catabolic mediator that separates the TCA cycle at isocitrate and succinate dehydrogenase (SDH).	Tricarboxylic Acids	187-190	aminoadipate-semialdehyde synthase	Mus musculus	215-238	
31894617-3	2020	The transition from immune resistance to tolerance also diverts the TCA cycle from citrate-derived cis-aconitate to itaconate, a recently discovered catabolic mediator that separates the TCA cycle at isocitrate and succinate dehydrogenase (SDH).	Tricarboxylic Acids	187-190	aminoadipate-semialdehyde synthase	Mus musculus	240-243	
32029222-7	2020	RESULTS: We demonstrate that the "immunometabolite" itaconate slowed tricarboxylic acid (TCA) cycle metabolism and buffered redox imbalance via succinate dehydrogenase (SDH) inhibition and induction of anti-oxidative stress response in primary cultures of astrocytes and neurons.	Tricarboxylic Acids	69-87	aminoadipate-semialdehyde synthase	Mus musculus	169-172	
32029222-7	2020	RESULTS: We demonstrate that the "immunometabolite" itaconate slowed tricarboxylic acid (TCA) cycle metabolism and buffered redox imbalance via succinate dehydrogenase (SDH) inhibition and induction of anti-oxidative stress response in primary cultures of astrocytes and neurons.	Tricarboxylic Acids	89-92	aminoadipate-semialdehyde synthase	Mus musculus	169-172	
26302408-1	2015	Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle.	Tricarboxylic Acids	138-156	aminoadipate-semialdehyde synthase	Mus musculus	25-28	
19956719-1	2009	BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the electron transport chain.	Tricarboxylic Acids	83-101	aminoadipate-semialdehyde synthase	Mus musculus	26-49	
19956719-1	2009	BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the electron transport chain.	Tricarboxylic Acids	83-101	aminoadipate-semialdehyde synthase	Mus musculus	51-54	
18951770-3	2009	The activity of TCA cycle enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) have been studied.	Tricarboxylic Acids	16-19	aminoadipate-semialdehyde synthase	Mus musculus	100-103	
33247500-1	2021	Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound enzyme complex that is involved in both the tricarboxylic acid cycle and the electron transport chain, can lead to a variety of disorders.	Tricarboxylic Acids	166-184	aminoadipate-semialdehyde synthase	Mus musculus	60-83	
33247500-1	2021	Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound enzyme complex that is involved in both the tricarboxylic acid cycle and the electron transport chain, can lead to a variety of disorders.	Tricarboxylic Acids	166-184	aminoadipate-semialdehyde synthase	Mus musculus	85-88	
26302408-1	2015	Succinate dehydrogenase (SDH) is a heterotetrameric nuclear-encoded complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle.	Tricarboxylic Acids	138-156	aminoadipate-semialdehyde synthase	Mus musculus	0-23	
18951770-3	2009	The activity of TCA cycle enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) have been studied.	Tricarboxylic Acids	16-19	aminoadipate-semialdehyde synthase	Mus musculus	75-98	
18569708-3	2008	Decreased activities of electron transport chain complexes and TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), in lung cancer bearing animals were observed.	Tricarboxylic Acids	63-66	aminoadipate-semialdehyde synthase	Mus musculus	126-149	
18569708-3	2008	Decreased activities of electron transport chain complexes and TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), in lung cancer bearing animals were observed.	Tricarboxylic Acids	63-66	aminoadipate-semialdehyde synthase	Mus musculus	151-154