PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21123035-3 2011 Activities of aconitase (18.4%, p<0.05), KGDHC (26%) and STH (28.2%, p<0.05), enzymes in the first half of the TCA cycle, were lower, but SDH (18.3%, p<0.05) and MDH (34%, p<0.005), enzymes in the second half, were higher than controls. Tricarboxylic Acids 117-120 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 144-147 23380393-1 2013 The Succinate Dehydrogenase (SDH) heterotetrameric complex catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and in the aerobic respiratory chains of eukaryotes and bacteria. Tricarboxylic Acids 115-133 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 4-27 23380393-1 2013 The Succinate Dehydrogenase (SDH) heterotetrameric complex catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and in the aerobic respiratory chains of eukaryotes and bacteria. Tricarboxylic Acids 115-133 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 29-32 23380393-1 2013 The Succinate Dehydrogenase (SDH) heterotetrameric complex catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and in the aerobic respiratory chains of eukaryotes and bacteria. Tricarboxylic Acids 135-138 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 4-27 23380393-1 2013 The Succinate Dehydrogenase (SDH) heterotetrameric complex catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and in the aerobic respiratory chains of eukaryotes and bacteria. Tricarboxylic Acids 135-138 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 29-32 23714463-6 2013 SDH is a mitochondrial enzyme complex involved in the tricarboxylic acid (TCA) cycle, and germline SDHx mutations lead to increased succinate with subsequent paragangliomas, pheochromocytomas, renal cell carcinomas (RCCs), gastrointestinal stromal tumors (GISTs), and other rarer cancers. Tricarboxylic Acids 54-72 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-3 23714463-6 2013 SDH is a mitochondrial enzyme complex involved in the tricarboxylic acid (TCA) cycle, and germline SDHx mutations lead to increased succinate with subsequent paragangliomas, pheochromocytomas, renal cell carcinomas (RCCs), gastrointestinal stromal tumors (GISTs), and other rarer cancers. Tricarboxylic Acids 74-77 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-3 23451094-2 2013 A remarkable puzzle is therefore presented by familial paraganglioma (PGL), a neuroendocrine cancer where the tumor suppressor genes encode subunits of succinate dehydrogenase (SDH), an enzyme of the tricarboxylic acid (TCA) cycle of central metabolism. Tricarboxylic Acids 200-218 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 177-180 23451094-2 2013 A remarkable puzzle is therefore presented by familial paraganglioma (PGL), a neuroendocrine cancer where the tumor suppressor genes encode subunits of succinate dehydrogenase (SDH), an enzyme of the tricarboxylic acid (TCA) cycle of central metabolism. Tricarboxylic Acids 220-223 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 177-180 22889736-1 2012 Succinate dehydrogenase (SDH) or mitochondrial complex II is a multimeric enzyme that is bound to the inner membrane of mitochondria and has a dual role as it serves both as a critical step of the tricarboxylic acid or Krebs cycle and as a member of the respiratory chain that transfers electrons directly to the ubiquinone pool. Tricarboxylic Acids 197-215 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 22889736-1 2012 Succinate dehydrogenase (SDH) or mitochondrial complex II is a multimeric enzyme that is bound to the inner membrane of mitochondria and has a dual role as it serves both as a critical step of the tricarboxylic acid or Krebs cycle and as a member of the respiratory chain that transfers electrons directly to the ubiquinone pool. Tricarboxylic Acids 197-215 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 23453781-1 2013 Succinate dehydrogenase (SDH) oxidises succinate to fumarate as a component of the tricarboxylic acid cycle and ubiquinone to ubiquinol in the mitochondrial electron transport chain. Tricarboxylic Acids 83-101 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 23453781-1 2013 Succinate dehydrogenase (SDH) oxidises succinate to fumarate as a component of the tricarboxylic acid cycle and ubiquinone to ubiquinol in the mitochondrial electron transport chain. Tricarboxylic Acids 83-101 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 20592014-1 2010 PURPOSE: Paragangliomas of the head and neck are neuroendocrine tumors and are associated with germ line mutations of the tricarboxylic acid cycle-related genes SDHB, SDHC, SDHD, and SDHAF2. Tricarboxylic Acids 122-140 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 161-165 20964315-4 2010 Succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the mitochondrial respiratory chain. Tricarboxylic Acids 57-75 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 18519664-8 2008 Microarray analysis showed that >400 genes were influenced (6-fold or more up-regulation or down-regulation) by silencing of SDHB, confirming the importance of the TCA cycle in cellular metabolism. Tricarboxylic Acids 167-170 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 128-132 19628817-4 2009 Both yeast and human Sdh5 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Tricarboxylic Acids 165-183 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 69-92 19628817-4 2009 Both yeast and human Sdh5 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Tricarboxylic Acids 165-183 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 94-97 19778456-1 2009 BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Tricarboxylic Acids 74-92 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 12-35 19778456-1 2009 BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Tricarboxylic Acids 74-92 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 37-40 19778456-1 2009 BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Tricarboxylic Acids 94-97 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 12-35 19778456-1 2009 BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Tricarboxylic Acids 94-97 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 37-40 19368708-2 2009 These three genes encode subunits of succinate dehydrogenase (SDH), the mitochondrial tricarboxylic acid cycle enzyme and complex II component of the electron transport chain. Tricarboxylic Acids 86-104 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 37-60 19368708-2 2009 These three genes encode subunits of succinate dehydrogenase (SDH), the mitochondrial tricarboxylic acid cycle enzyme and complex II component of the electron transport chain. Tricarboxylic Acids 86-104 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 62-65 17520677-2 2007 FH and SDH are operating in the tricarboxylic acid cycle (the TCA cycle, the Krebs cycle). Tricarboxylic Acids 32-50 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 7-10 2384736-6 1990 The findings in our patient suggest a limitation of mitochondrial function, probably related to SDH in the tricarboxylic acid cycle and complex II in the electron transport chain. Tricarboxylic Acids 107-125 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 96-99 17325041-1 2007 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor suppressors. Tricarboxylic Acids 80-98 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 17325041-1 2007 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor suppressors. Tricarboxylic Acids 80-98 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 17325041-1 2007 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor suppressors. Tricarboxylic Acids 100-103 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 17325041-1 2007 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor suppressors. Tricarboxylic Acids 100-103 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 17325041-7 2007 Introduction of alpha-ketoglutarate derivatives restores normal PHD activity and HIF1alpha levels to SDH-suppressed cells, indicating new therapy possibilities for the cancers associated with TCA cycle dysfunction. Tricarboxylic Acids 192-195 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 101-104 15652751-2 2005 These include succinate dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 88-106 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 14-37 15652751-2 2005 These include succinate dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 88-106 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 39-42 15652751-2 2005 These include succinate dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 108-111 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 14-37 15652751-2 2005 These include succinate dehydrogenase (SDH) and fumarate hydratase, both enzymes of the tricarboxylic acid (TCA) cycle. Tricarboxylic Acids 108-111 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 39-42 12612654-2 2003 Two ubiquitously expressed mitochondrial enzymes--succinate dehydrogenase (SDH) and fumarate hydratase (FH, fumarase)--catalyse sequential steps in the Krebs tricarboxylic-acid cycle. Tricarboxylic Acids 158-176 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 41-73 12612654-2 2003 Two ubiquitously expressed mitochondrial enzymes--succinate dehydrogenase (SDH) and fumarate hydratase (FH, fumarase)--catalyse sequential steps in the Krebs tricarboxylic-acid cycle. Tricarboxylic Acids 158-176 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 75-78 34871739-2 2022 3-nitropropionic acid (3-NP) is a naturally occurring plant and fungal neurotoxin that causes neurodegeneration predominantly in the striatum by irreversibly inhibiting the tricarboxylic acid respiratory chain enzyme, succinate dehydrogenase (SDH), the main constituent of the mitochondria respiratory chain complex II. Tricarboxylic Acids 173-191 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 218-241 34871739-2 2022 3-nitropropionic acid (3-NP) is a naturally occurring plant and fungal neurotoxin that causes neurodegeneration predominantly in the striatum by irreversibly inhibiting the tricarboxylic acid respiratory chain enzyme, succinate dehydrogenase (SDH), the main constituent of the mitochondria respiratory chain complex II. Tricarboxylic Acids 173-191 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 243-246 33153035-1 2020 Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. Tricarboxylic Acids 56-74 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 35510387-2 2022 Succinate dehydrogenase (SDH) consists of four nuclear-encoded subunits and it is the only complex involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). Tricarboxylic Acids 120-138 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 35510387-2 2022 Succinate dehydrogenase (SDH) consists of four nuclear-encoded subunits and it is the only complex involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). Tricarboxylic Acids 120-138 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 35510387-2 2022 Succinate dehydrogenase (SDH) consists of four nuclear-encoded subunits and it is the only complex involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). Tricarboxylic Acids 140-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 35510387-2 2022 Succinate dehydrogenase (SDH) consists of four nuclear-encoded subunits and it is the only complex involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). Tricarboxylic Acids 140-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 33112834-3 2020 They encode the four subunits and assembly factor of succinate dehydrogenase (SDH), a mitochondrial enzyme involved both in the tricarboxylic acid cycle and in the electron transport chain. Tricarboxylic Acids 128-146 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 53-76 33112834-3 2020 They encode the four subunits and assembly factor of succinate dehydrogenase (SDH), a mitochondrial enzyme involved both in the tricarboxylic acid cycle and in the electron transport chain. Tricarboxylic Acids 128-146 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 78-81 33153035-1 2020 Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. Tricarboxylic Acids 56-74 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 33153035-1 2020 Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. Tricarboxylic Acids 76-79 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 33153035-1 2020 Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. Tricarboxylic Acids 76-79 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 31408429-1 2020 Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Tricarboxylic Acids 125-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 32887801-1 2020 Mitochondrial complex II, also known as succinate dehydrogenase (SDH), is an integral-membrane heterotetramer (SDHABCD) that links two essential energy-producing processes, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Tricarboxylic Acids 177-195 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 40-63 32887801-1 2020 Mitochondrial complex II, also known as succinate dehydrogenase (SDH), is an integral-membrane heterotetramer (SDHABCD) that links two essential energy-producing processes, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Tricarboxylic Acids 177-195 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 65-68 32887801-1 2020 Mitochondrial complex II, also known as succinate dehydrogenase (SDH), is an integral-membrane heterotetramer (SDHABCD) that links two essential energy-producing processes, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Tricarboxylic Acids 197-200 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 40-63 32887801-1 2020 Mitochondrial complex II, also known as succinate dehydrogenase (SDH), is an integral-membrane heterotetramer (SDHABCD) that links two essential energy-producing processes, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Tricarboxylic Acids 197-200 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 65-68 31408429-1 2020 Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Tricarboxylic Acids 125-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 31408429-1 2020 Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Tricarboxylic Acids 145-148 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 31408429-1 2020 Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), the two primary metabolic pathways for generating ATP. Tricarboxylic Acids 145-148 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 31564436-4 2019 Relatedly, SDH sits at the crossroad of the electron transport chain and tricarboxylic acid (TCA) cycle, two central bioenergetic pathways. Tricarboxylic Acids 73-91 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 11-14 31914648-5 2020 However, due to the block in the TCA cycle at SDH, the high glutamine oxidation activity is only maintained through an efflux of succinate. Tricarboxylic Acids 33-36 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 46-49 31564436-4 2019 Relatedly, SDH sits at the crossroad of the electron transport chain and tricarboxylic acid (TCA) cycle, two central bioenergetic pathways. Tricarboxylic Acids 93-96 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 11-14 27587393-1 2016 Mitochondrial complex II or succinate dehydrogenase (SDH) is at the crossroads of oxidative phosphorylation and the tricarboxylic acid cycle. Tricarboxylic Acids 116-134 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 53-56 28619735-5 2017 Therefore, we hypothesized that accumulation of succinate due to the TCA cycle defect could be the major connecting hub between SDH-mutated tumors and the 18F-FDG uptake profile. Tricarboxylic Acids 69-72 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 128-131 28423651-8 2017 Tracer experiments showed bidirectional metabolic flow in the tricarboxylic acid (TCA) cycle, possibly to maintain the necessary amounts of metabolites in the SDHB knockout cells. Tricarboxylic Acids 62-80 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 159-163 28423651-8 2017 Tracer experiments showed bidirectional metabolic flow in the tricarboxylic acid (TCA) cycle, possibly to maintain the necessary amounts of metabolites in the SDHB knockout cells. Tricarboxylic Acids 82-85 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 159-163 31236625-1 2019 Succinate dehydrogenase (SDH) also known as complex II or succinate:quinone oxidoreductase is an enzyme involved in both oxidative phosphorylation and tricarboxylic acid cycle; the processes that generate energy. Tricarboxylic Acids 151-169 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 31236625-1 2019 Succinate dehydrogenase (SDH) also known as complex II or succinate:quinone oxidoreductase is an enzyme involved in both oxidative phosphorylation and tricarboxylic acid cycle; the processes that generate energy. Tricarboxylic Acids 151-169 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 30604579-1 2019 Complex II [succinate dehydrogenase (succinate-ubiquinone oxidoreductase); EC 1.3.5.1; SDH] is the only enzyme shared by both the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria. Tricarboxylic Acids 163-181 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 87-90 30604579-1 2019 Complex II [succinate dehydrogenase (succinate-ubiquinone oxidoreductase); EC 1.3.5.1; SDH] is the only enzyme shared by both the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria. Tricarboxylic Acids 183-186 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 87-90 26585387-3 2015 By competitive inhibition of the mitochondrial tricarboxylic acid cycle enzyme succinate dehydrogenase (SDH), R-2HG preferentially induced succinyl-CoA accumulation and hypersuccinylation in the mitochondria. Tricarboxylic Acids 47-65 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 79-102 26697888-5 2016 Moreover, our analyses demonstrate a cardiac-specific loss of succinate dehydrogenase (SDH), an enzyme linking the respiratory chain with the tricarboxylic acid cycle. Tricarboxylic Acids 142-160 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 62-85 26697888-5 2016 Moreover, our analyses demonstrate a cardiac-specific loss of succinate dehydrogenase (SDH), an enzyme linking the respiratory chain with the tricarboxylic acid cycle. Tricarboxylic Acids 142-160 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 87-90 27528759-3 2016 In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. Tricarboxylic Acids 120-138 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 152-175 27528759-3 2016 In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. Tricarboxylic Acids 120-138 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 177-180 27528759-3 2016 In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. Tricarboxylic Acids 140-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 152-175 27528759-3 2016 In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations. Tricarboxylic Acids 140-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 177-180 27493882-4 2016 Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle. Tricarboxylic Acids 177-195 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 27493882-4 2016 Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle. Tricarboxylic Acids 177-195 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 27493882-4 2016 Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle. Tricarboxylic Acids 177-195 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 93-97 26472283-1 2015 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Tricarboxylic Acids 62-80 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 26472283-1 2015 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Tricarboxylic Acids 62-80 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 26472283-1 2015 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Tricarboxylic Acids 82-85 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-23 26472283-1 2015 Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Tricarboxylic Acids 82-85 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-28 26585387-3 2015 By competitive inhibition of the mitochondrial tricarboxylic acid cycle enzyme succinate dehydrogenase (SDH), R-2HG preferentially induced succinyl-CoA accumulation and hypersuccinylation in the mitochondria. Tricarboxylic Acids 47-65 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 104-107 25985299-1 2015 Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. Tricarboxylic Acids 156-174 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 123-146 26522426-3 2015 However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Tricarboxylic Acids 69-72 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 95-118 26522426-3 2015 However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Tricarboxylic Acids 69-72 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 120-123 26522426-3 2015 However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Tricarboxylic Acids 243-246 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 95-118 26522426-3 2015 However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Tricarboxylic Acids 243-246 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 120-123 25985299-1 2015 Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. Tricarboxylic Acids 156-174 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 148-151 25985299-1 2015 Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. Tricarboxylic Acids 176-179 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 123-146 25985299-1 2015 Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. Tricarboxylic Acids 176-179 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 148-151 25435987-2 2015 SDH is a tetrameric iron-sulfur flavoprotein of the tricarboxylic acid cycle and respiratory chain. Tricarboxylic Acids 52-70 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 0-3 25328978-1 2015 AIMS: Mitochondrial succinate dehydrogenase (SDH) is an essential complex of the electron transport chain and tricarboxylic acid cycle. Tricarboxylic Acids 110-128 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 45-48 25004247-2 2014 Mutations in genes (SDHB, SDHD, SDHC, and SDHA) encoding a component of the tricarboxylic acid cycle, succinate dehydrogenase (SDH), are a major cause of inherited PCC and PGL. Tricarboxylic Acids 76-94 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 20-24 25004247-2 2014 Mutations in genes (SDHB, SDHD, SDHC, and SDHA) encoding a component of the tricarboxylic acid cycle, succinate dehydrogenase (SDH), are a major cause of inherited PCC and PGL. Tricarboxylic Acids 76-94 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 102-125 25004247-2 2014 Mutations in genes (SDHB, SDHD, SDHC, and SDHA) encoding a component of the tricarboxylic acid cycle, succinate dehydrogenase (SDH), are a major cause of inherited PCC and PGL. Tricarboxylic Acids 76-94 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 20-23 25004247-4 2014 Inactivation of SDH and another tricarboxylic acid cycle component, fumarate hydratase (FH), have both been associated with abnormalities of cellular metabolism, responsible for the activation of hypoxic gene response pathways and epigenetic alterations (eg, DNA methylation). Tricarboxylic Acids 32-50 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 16-19 24678033-1 2014 Succinate-ubiquinone oxidoreductase (SQR, EC 1.3.5.1), also known as mitochondrial respiratory complex II or succinate dehydrogenase (SDH), catalyzes the oxidation of succinate to fumarate as part of the tricarboxylic acid cycle. Tricarboxylic Acids 204-222 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 109-132 24678033-1 2014 Succinate-ubiquinone oxidoreductase (SQR, EC 1.3.5.1), also known as mitochondrial respiratory complex II or succinate dehydrogenase (SDH), catalyzes the oxidation of succinate to fumarate as part of the tricarboxylic acid cycle. Tricarboxylic Acids 204-222 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 134-137 24595825-2 2014 About 30-40 % of these tumours are mutated in one of the different susceptibility genes, including those encoding the different subunits of the succinate dehydrogenase, a complex involved both in the tricarboxylic acid cycle and in the oxygen transport chain. Tricarboxylic Acids 200-218 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 144-167 24086109-7 2013 Extension of these findings identified a functional role for stretch-induced inhibition of succinate dehydrogenase (SDH) in mediating normoxic HIF1A stabilization, concomitant increases in glycolytic capacity, and improved tricarboxylic acid (TCA) cycle function. Tricarboxylic Acids 223-241 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 91-114 24086109-7 2013 Extension of these findings identified a functional role for stretch-induced inhibition of succinate dehydrogenase (SDH) in mediating normoxic HIF1A stabilization, concomitant increases in glycolytic capacity, and improved tricarboxylic acid (TCA) cycle function. Tricarboxylic Acids 223-241 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 116-119 24086109-7 2013 Extension of these findings identified a functional role for stretch-induced inhibition of succinate dehydrogenase (SDH) in mediating normoxic HIF1A stabilization, concomitant increases in glycolytic capacity, and improved tricarboxylic acid (TCA) cycle function. Tricarboxylic Acids 243-246 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 91-114 24086109-7 2013 Extension of these findings identified a functional role for stretch-induced inhibition of succinate dehydrogenase (SDH) in mediating normoxic HIF1A stabilization, concomitant increases in glycolytic capacity, and improved tricarboxylic acid (TCA) cycle function. Tricarboxylic Acids 243-246 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 116-119