PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30293571-6 2018 Elevated ROS evoked by exposing cells to suPAR or H2O2 caused a marked increase in the abundance of tyrosine-phosphorylated proteins including Src, and suPAR-evoked Src activation was blocked by TEMPOL. Hydrogen Peroxide 50-54 Rous sarcoma oncogene Mus musculus 143-146 30293571-6 2018 Elevated ROS evoked by exposing cells to suPAR or H2O2 caused a marked increase in the abundance of tyrosine-phosphorylated proteins including Src, and suPAR-evoked Src activation was blocked by TEMPOL. Hydrogen Peroxide 50-54 Rous sarcoma oncogene Mus musculus 165-168 24036910-0 2013 Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Hydrogen Peroxide 127-131 Rous sarcoma oncogene Mus musculus 15-18 30293571-7 2018 Moreover, mobilization and increased activation of TRPC6 by suPAR or H2O2 was blocked by concurrent exposure to PP2, an inhibitor of Src family tyrosine kinases. Hydrogen Peroxide 69-73 Rous sarcoma oncogene Mus musculus 133-136 25944793-6 2015 Using hydrogen peroxide in vitro and hemorrhagic shock/resuscitation in vivo, oxidant-induced TLR4 translocation in macrophages occurred in an Src-dependent manner. Hydrogen Peroxide 6-23 Rous sarcoma oncogene Mus musculus 143-146 21087961-9 2011 CONCLUSIONS: These findings suggest that H(2)O(2) at low levels promotes cell adhesion, migration, and wound healing in cornea cells or tissue, and the interaction of H(2)O(2) with Src plays a major role. Hydrogen Peroxide 41-49 Rous sarcoma oncogene Mus musculus 181-184 21536676-6 2011 15(S)-HETE induced the production of H(2)O(2) via an NADPH oxidase-dependent manner and its scavengers, N-acetyl cysteine (NAC) and catalase suppressed 15(S)-HETE-stimulated EGFR, Src, Jak2, and STAT3 phosphorylation and MCP-1 expression. Hydrogen Peroxide 37-45 Rous sarcoma oncogene Mus musculus 180-183 21087961-9 2011 CONCLUSIONS: These findings suggest that H(2)O(2) at low levels promotes cell adhesion, migration, and wound healing in cornea cells or tissue, and the interaction of H(2)O(2) with Src plays a major role. Hydrogen Peroxide 167-175 Rous sarcoma oncogene Mus musculus 181-184 18544631-7 2008 Hydrogen peroxide, a reactive oxygen species (ROS), increased Src activity and enhanced Ca(2+) influx, but only in C2 myoblasts co-expressing TRPC1 and caveolin-3. Hydrogen Peroxide 0-17 Rous sarcoma oncogene Mus musculus 62-65 18387943-3 2008 H(2)O(2) activates Src and related Src-family kinases (SFKs), which function as dual PKCdelta-Tyr(311) and -Tyr(332) kinases in vitro and contribute to H(2)O(2)-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation in cardiomyocytes and in mouse embryo fibroblasts. Hydrogen Peroxide 0-8 Rous sarcoma oncogene Mus musculus 19-22 18387943-3 2008 H(2)O(2) activates Src and related Src-family kinases (SFKs), which function as dual PKCdelta-Tyr(311) and -Tyr(332) kinases in vitro and contribute to H(2)O(2)-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation in cardiomyocytes and in mouse embryo fibroblasts. Hydrogen Peroxide 0-8 Rous sarcoma oncogene Mus musculus 35-38 18387943-3 2008 H(2)O(2) activates Src and related Src-family kinases (SFKs), which function as dual PKCdelta-Tyr(311) and -Tyr(332) kinases in vitro and contribute to H(2)O(2)-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation in cardiomyocytes and in mouse embryo fibroblasts. Hydrogen Peroxide 152-160 Rous sarcoma oncogene Mus musculus 19-22 18387943-3 2008 H(2)O(2) activates Src and related Src-family kinases (SFKs), which function as dual PKCdelta-Tyr(311) and -Tyr(332) kinases in vitro and contribute to H(2)O(2)-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation in cardiomyocytes and in mouse embryo fibroblasts. Hydrogen Peroxide 152-160 Rous sarcoma oncogene Mus musculus 35-38 17606629-3 2007 Working with catalytically inactive fer and src/yes/fyn-deficient murine embryonic fibroblasts (ferDR/DR and syf MEF, respectively), we observed that H2O2-induced Ctn tyrosine phosphorylation is primarily dependent on Fer but not Src family kinase (SFK) activity. Hydrogen Peroxide 150-154 Rous sarcoma oncogene Mus musculus 44-47 17606629-3 2007 Working with catalytically inactive fer and src/yes/fyn-deficient murine embryonic fibroblasts (ferDR/DR and syf MEF, respectively), we observed that H2O2-induced Ctn tyrosine phosphorylation is primarily dependent on Fer but not Src family kinase (SFK) activity. Hydrogen Peroxide 150-154 Rous sarcoma oncogene Mus musculus 230-233 9252345-3 1997 Previous investigations indicate that the tyrosine kinase c-Src mediates signal transduction by reactive oxygen species, including H2O2. Hydrogen Peroxide 131-135 Rous sarcoma oncogene Mus musculus 60-63 16914136-8 2006 The phosphorylation of extracellular signal-regulated kinase 1/2 induced by PMA/A23187 and H(2)O(2)/A23187 was significantly decreased by inhibitors of PKC and Src. Hydrogen Peroxide 91-99 Rous sarcoma oncogene Mus musculus 160-163 16914136-9 2006 These findings suggest that H(2)O(2) with Ca(2+) stimulates arachidonic acid release via cPLA(2)alpha in a Src- and PKC-dependent manner in L929 cells. Hydrogen Peroxide 28-36 Rous sarcoma oncogene Mus musculus 107-110 15591224-9 2005 CONCLUSIONS: Our results suggest that TGF-beta1 activates c-Src and generates hydrogen peroxide through NAD(P)H oxidase, and these signaling pathways lead to the activation of specific sets of genes, including SM22alpha and PAI-1. Hydrogen Peroxide 78-95 Rous sarcoma oncogene Mus musculus 60-63 14597424-5 2003 H2O2-mediated ERK1/2 activation was not only Ras-Raf dependent, but also both tyrosine kinase (PDGFbeta receptor and Src) and PKCdelta dependent. Hydrogen Peroxide 0-4 Rous sarcoma oncogene Mus musculus 117-120 10766791-5 2000 First, the specific Src family tyrosine kinase inhibitor, PP2, inhibited JNK activation by H(2)O(2) in a concentration-dependent manner but had no effect on extracellular signal-regulated kinases 1 and 2 and p38 activation. Hydrogen Peroxide 91-99 Rous sarcoma oncogene Mus musculus 20-23 10766791-6 2000 Second, JNK activation in response to H(2)O(2) was completely inhibited in cells derived from transgenic mice deficient in Src but not Fyn. Hydrogen Peroxide 38-46 Rous sarcoma oncogene Mus musculus 123-126 10766791-8 2000 Finally, the importance of Src was further supported by the inhibition of both H(2)O(2)-mediated Cas tyrosine phosphorylation and Cas.Crk complex formation in Src-/- but not Fyn-/- cells. Hydrogen Peroxide 79-87 Rous sarcoma oncogene Mus musculus 27-30 10766791-9 2000 These results demonstrate an essential role for Src and Cas in H(2)O(2)-mediated activation of JNK and suggest a new redox-sensitive pathway for JNK activation mediated by Src. Hydrogen Peroxide 63-71 Rous sarcoma oncogene Mus musculus 48-51 10766791-9 2000 These results demonstrate an essential role for Src and Cas in H(2)O(2)-mediated activation of JNK and suggest a new redox-sensitive pathway for JNK activation mediated by Src. Hydrogen Peroxide 63-71 Rous sarcoma oncogene Mus musculus 172-175 10636870-7 2000 1) The tyrosine kinase inhibitor, herbimycin A, and the specific Src kinase family inhibitor, PP1, blocked p90RSK activation by H(2)O(2) in a concentration-dependent manner. Hydrogen Peroxide 128-136 Rous sarcoma oncogene Mus musculus 65-68 9252345-7 1997 Second, specific Src family tyrosine kinase inhibitors (herbimycin A and CP-118,556) blocked BMK1 activation by H2O2 in a concentration-dependent manner. Hydrogen Peroxide 112-116 Rous sarcoma oncogene Mus musculus 17-20 9252345-8 1997 Third, BMK1 activation in the response to H2O2 was completely inhibited in cells derived from mice deficient in c-Src, but not Fyn. Hydrogen Peroxide 42-46 Rous sarcoma oncogene Mus musculus 114-117 9252345-10 1997 These results demonstrate an essential role for c-Src in H2O2-mediated activation of BMK1 and suggest that redox-sensitive regulation of BMK1 is a new function for c-Src. Hydrogen Peroxide 57-61 Rous sarcoma oncogene Mus musculus 50-53 9252345-10 1997 These results demonstrate an essential role for c-Src in H2O2-mediated activation of BMK1 and suggest that redox-sensitive regulation of BMK1 is a new function for c-Src. Hydrogen Peroxide 57-61 Rous sarcoma oncogene Mus musculus 166-169 16914136-0 2006 Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha. Hydrogen Peroxide 0-17 Rous sarcoma oncogene Mus musculus 75-78 16914136-7 2006 The release induced by PMA/A23187 and by H(2)O(2)/A23187 was significantly inhibited by a PKC inhibitor (10 microM GF109203X) and in PKC-depleted cells, and by a Src inhibitor (2 microM PP2). Hydrogen Peroxide 41-49 Rous sarcoma oncogene Mus musculus 162-165 14975446-9 2004 Upstream pathways of H2O2-mediated ERK1/2 activation and cell death involved both tyrosine kinase (PDGFbeta receptor and Src) and PKCdelta, while in HSP25-overexpressed cells these kinases did not respond to H2O2 treatment. Hydrogen Peroxide 21-25 Rous sarcoma oncogene Mus musculus 121-124 9252345-4 1997 Therefore, the role of Src kinase family members (c-Src and Fyn) in activation of the BMK1 by H2O2 in mouse fibroblasts was studied. Hydrogen Peroxide 94-98 Rous sarcoma oncogene Mus musculus 23-26 9252345-6 1997 First, H2O2 stimulated c-Src activity rapidly in fibroblasts (peak at 5 min), which preceded peak activity of BMK1 (20 min). Hydrogen Peroxide 7-11 Rous sarcoma oncogene Mus musculus 25-28