PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34087234-9 2021 Activation of PKA by forskolin or isoproterenol almost completely abolished hydrogen peroxide-induced p62 phosphorylation. Hydrogen Peroxide 76-93 nucleoporin 62 Homo sapiens 102-105 34973945-5 2022 In vitro, The results revealed that IL-10 had inhibitory effects on hydrogen peroxide (H2O2)-induced autophagy, as evidenced by the decreased LC3II/I ratio and Beclin1 expression, increased p62 expression, reduced numbers of autophagosomes, and blocked autophagy initiation in HSCs. Hydrogen Peroxide 68-85 nucleoporin 62 Homo sapiens 190-193 34973945-5 2022 In vitro, The results revealed that IL-10 had inhibitory effects on hydrogen peroxide (H2O2)-induced autophagy, as evidenced by the decreased LC3II/I ratio and Beclin1 expression, increased p62 expression, reduced numbers of autophagosomes, and blocked autophagy initiation in HSCs. Hydrogen Peroxide 87-91 nucleoporin 62 Homo sapiens 190-193 32963595-8 2020 In addition, the effects of miR-210 on the expression of the autophagy-related proteins Beclin1 and p62 in H2O2-treated MG63 cells were detected by western blotting. Hydrogen Peroxide 107-111 nucleoporin 62 Homo sapiens 100-103 35605921-16 2022 In addition, YJZYD weakened H2O2-induced mitophagy by compromising the expression of PINK1, Parkin, Beclin1 and P62. Hydrogen Peroxide 28-32 nucleoporin 62 Homo sapiens 112-115 32963595-14 2020 In addition, miR-210 elevated Beclin1 expression and decreased p62 expression in H2O2-treated MG63 cells. Hydrogen Peroxide 81-85 nucleoporin 62 Homo sapiens 63-66 32305648-8 2020 SPD also rescued the impaired autophagic flux consequent to H2O2 exposure by increasing mRNA and protein expression of LC3-II and p62. Hydrogen Peroxide 60-64 nucleoporin 62 Homo sapiens 130-133 28186139-7 2017 Noteworthily, upregulation of the Nrf2-p62 pathway or p62 reduced H2O2-induced oxidative damage of vitiligo melanocytes. Hydrogen Peroxide 66-70 nucleoporin 62 Homo sapiens 54-57 33418754-4 2018 Exposure of H2O2 increased p62 level and blocked the fusion of autophagosomes with lysosomes, indicating of impaired autophagic flux in senescent endothelial cells. Hydrogen Peroxide 12-16 nucleoporin 62 Homo sapiens 27-30 31263165-9 2019 The detrimental effects of H2O2-induced oxidative stress were increased in autophagy-deficient cells via reduced expression of Atg7 and the Keap1-Nrf2-p62 autophagy pathway. Hydrogen Peroxide 27-31 nucleoporin 62 Homo sapiens 151-154 30221706-8 2018 The data from the present study also demonstrated that LC3II/LC3-I and p62, members of autophagy-related genes, were increased and decreased in cells treated with H2O2 + TM compared with cells treated with H2O2, respectively, indicating that autophagy was stimulated by ERS. Hydrogen Peroxide 163-167 nucleoporin 62 Homo sapiens 71-74 30221706-8 2018 The data from the present study also demonstrated that LC3II/LC3-I and p62, members of autophagy-related genes, were increased and decreased in cells treated with H2O2 + TM compared with cells treated with H2O2, respectively, indicating that autophagy was stimulated by ERS. Hydrogen Peroxide 206-210 nucleoporin 62 Homo sapiens 71-74 30013443-4 2018 We found pretreatment with trehalose not only prevented H2O2-induced death in SH-SY5Y cells, but also reversed H2O2-induced upregulation of LC3II, Beclin1 and ATG5 and downregulation of p62. Hydrogen Peroxide 111-115 nucleoporin 62 Homo sapiens 186-189 23705001-9 2013 Cell death induced by H2O2 or NaIO3 was preceded by mitochondrial dysfunction and by p62 upregulation, both of which were attenuated by PCM and/or by IFNgamma+TNFalpha. Hydrogen Peroxide 22-26 nucleoporin 62 Homo sapiens 85-88 26890602-6 2016 Importantly, AMPK activation prevented hydrogen peroxide-induced impairment of the autophagic flux in senescent cells, evidenced by the decreased p62 degradation, GFP-RFP-LC3 cancellation, and activity of lysosomal hydrolases. Hydrogen Peroxide 39-56 nucleoporin 62 Homo sapiens 146-149 22622204-4 2012 Exposed to H 2O 2, curcumin-treated HUVECs upregulate the level of microtubule-associated protein 1 light chain 3-II (LC3-II), the number of autophagosomes, and the degradation of p62. Hydrogen Peroxide 11-17 nucleoporin 62 Homo sapiens 180-183 19010391-0 2009 p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway. Hydrogen Peroxide 49-53 nucleoporin 62 Homo sapiens 0-3 19010391-5 2009 In addition, p62 showed neuroprotective effects against H(2)O(2)-induced cell death in differentiated SH-SY5Y cells. Hydrogen Peroxide 56-64 nucleoporin 62 Homo sapiens 13-16 19010391-6 2009 p62 expression prolonged Akt phosphorylation during the later stages of H(2)O(2)-induced cell death. Hydrogen Peroxide 72-80 nucleoporin 62 Homo sapiens 0-3