PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33418754-4	2018	Exposure of H2O2 increased p62 level and blocked the fusion of autophagosomes with lysosomes, indicating of impaired autophagic flux in senescent endothelial cells.	Hydrogen Peroxide	12-16	nucleoporin 62	Homo sapiens	27-30	
34973945-5	2022	In vitro, The results revealed that IL-10 had inhibitory effects on hydrogen peroxide (H2O2)-induced autophagy, as evidenced by the decreased LC3II/I ratio and Beclin1 expression, increased p62 expression, reduced numbers of autophagosomes, and blocked autophagy initiation in HSCs.	Hydrogen Peroxide	68-85	nucleoporin 62	Homo sapiens	190-193	
34973945-5	2022	In vitro, The results revealed that IL-10 had inhibitory effects on hydrogen peroxide (H2O2)-induced autophagy, as evidenced by the decreased LC3II/I ratio and Beclin1 expression, increased p62 expression, reduced numbers of autophagosomes, and blocked autophagy initiation in HSCs.	Hydrogen Peroxide	87-91	nucleoporin 62	Homo sapiens	190-193	
34087234-9	2021	Activation of PKA by forskolin or isoproterenol almost completely abolished hydrogen peroxide-induced p62 phosphorylation.	Hydrogen Peroxide	76-93	nucleoporin 62	Homo sapiens	102-105	
32963595-8	2020	In addition, the effects of miR-210 on the expression of the autophagy-related proteins Beclin1 and p62 in H2O2-treated MG63 cells were detected by western blotting.	Hydrogen Peroxide	107-111	nucleoporin 62	Homo sapiens	100-103	
32963595-14	2020	In addition, miR-210 elevated Beclin1 expression and decreased p62 expression in H2O2-treated MG63 cells.	Hydrogen Peroxide	81-85	nucleoporin 62	Homo sapiens	63-66	
35605921-16	2022	In addition, YJZYD weakened H2O2-induced mitophagy by compromising the expression of PINK1, Parkin, Beclin1 and P62.	Hydrogen Peroxide	28-32	nucleoporin 62	Homo sapiens	112-115	
32305648-8	2020	SPD also rescued the impaired autophagic flux consequent to H2O2 exposure by increasing mRNA and protein expression of LC3-II and p62.	Hydrogen Peroxide	60-64	nucleoporin 62	Homo sapiens	130-133	
31263165-9	2019	The detrimental effects of H2O2-induced oxidative stress were increased in autophagy-deficient cells via reduced expression of Atg7 and the Keap1-Nrf2-p62 autophagy pathway.	Hydrogen Peroxide	27-31	nucleoporin 62	Homo sapiens	151-154	
30221706-8	2018	The data from the present study also demonstrated that LC3II/LC3-I and p62, members of autophagy-related genes, were increased and decreased in cells treated with H2O2 + TM compared with cells treated with H2O2, respectively, indicating that autophagy was stimulated by ERS.	Hydrogen Peroxide	163-167	nucleoporin 62	Homo sapiens	71-74	
30221706-8	2018	The data from the present study also demonstrated that LC3II/LC3-I and p62, members of autophagy-related genes, were increased and decreased in cells treated with H2O2 + TM compared with cells treated with H2O2, respectively, indicating that autophagy was stimulated by ERS.	Hydrogen Peroxide	206-210	nucleoporin 62	Homo sapiens	71-74	
30013443-4	2018	We found pretreatment with trehalose not only prevented H2O2-induced death in SH-SY5Y cells, but also reversed H2O2-induced upregulation of LC3II, Beclin1 and ATG5 and downregulation of p62.	Hydrogen Peroxide	111-115	nucleoporin 62	Homo sapiens	186-189	
28186139-7	2017	Noteworthily, upregulation of the Nrf2-p62 pathway or p62 reduced H2O2-induced oxidative damage of vitiligo melanocytes.	Hydrogen Peroxide	66-70	nucleoporin 62	Homo sapiens	54-57	
26890602-6	2016	Importantly, AMPK activation prevented hydrogen peroxide-induced impairment of the autophagic flux in senescent cells, evidenced by the decreased p62 degradation, GFP-RFP-LC3 cancellation, and activity of lysosomal hydrolases.	Hydrogen Peroxide	39-56	nucleoporin 62	Homo sapiens	146-149	
23705001-9	2013	Cell death induced by H2O2 or NaIO3 was preceded by mitochondrial dysfunction and by p62 upregulation, both of which were attenuated by PCM and/or by IFNgamma+TNFalpha.	Hydrogen Peroxide	22-26	nucleoporin 62	Homo sapiens	85-88	
19010391-0	2009	p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway.	Hydrogen Peroxide	49-53	nucleoporin 62	Homo sapiens	0-3	
19010391-5	2009	In addition, p62 showed neuroprotective effects against H(2)O(2)-induced cell death in differentiated SH-SY5Y cells.	Hydrogen Peroxide	56-64	nucleoporin 62	Homo sapiens	13-16	
19010391-6	2009	p62 expression prolonged Akt phosphorylation during the later stages of H(2)O(2)-induced cell death.	Hydrogen Peroxide	72-80	nucleoporin 62	Homo sapiens	0-3	
22622204-4	2012	Exposed to H 2O 2, curcumin-treated HUVECs upregulate the level of microtubule-associated protein 1 light chain 3-II (LC3-II), the number of autophagosomes, and the degradation of p62.	Hydrogen Peroxide	11-17	nucleoporin 62	Homo sapiens	180-183