PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24184207-4 2014 Previous studies suggested that superoxide anion and H2O2 generation are involved in T cell receptor (TCR)-dependent signaling. Hydrogen Peroxide 53-57 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 85-100 24184207-4 2014 Previous studies suggested that superoxide anion and H2O2 generation are involved in T cell receptor (TCR)-dependent signaling. Hydrogen Peroxide 53-57 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 102-105 11781366-0 2002 Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. Hydrogen Peroxide 38-55 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 59-74 23880762-0 2013 Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction. Hydrogen Peroxide 21-38 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 60-75 23880762-1 2013 T cell receptor (TCR)-initiated signal transduction is reported to increase production of intracellular reactive oxygen species, such as superoxide (O2 (-)) and hydrogen peroxide (H2O2), as second messengers. Hydrogen Peroxide 161-178 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-15 23880762-1 2013 T cell receptor (TCR)-initiated signal transduction is reported to increase production of intracellular reactive oxygen species, such as superoxide (O2 (-)) and hydrogen peroxide (H2O2), as second messengers. Hydrogen Peroxide 161-178 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 17-20 23880762-1 2013 T cell receptor (TCR)-initiated signal transduction is reported to increase production of intracellular reactive oxygen species, such as superoxide (O2 (-)) and hydrogen peroxide (H2O2), as second messengers. Hydrogen Peroxide 180-184 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-15 23880762-1 2013 T cell receptor (TCR)-initiated signal transduction is reported to increase production of intracellular reactive oxygen species, such as superoxide (O2 (-)) and hydrogen peroxide (H2O2), as second messengers. Hydrogen Peroxide 180-184 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 17-20 23880762-2 2013 Although H2O2 can modulate signal transduction by inactivating protein phosphatases, the mechanism and the subcellular localization of intracellular H2O2 as a second messenger of the TCR are not known. Hydrogen Peroxide 149-153 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 183-186 23880762-8 2013 As mitochondria translocate to the immunological synapse during TCR activation, we hypothesize this translocation provides the effective concentration of H2O2 required to selectively modulate downstream signal transduction pathways. Hydrogen Peroxide 154-158 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 64-67 18548611-7 2008 In addition, using Phospho-Flow we discovered that H(2)O(2)-induced phosphorylation of TCR signaling proteins was inhibited by small molecular weight kinase inhibitors far more potently than OKT3-triggered protein phosphorylation, despite a superior induction of phosphorylation by H(2)O(2). Hydrogen Peroxide 51-59 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 87-90 18548611-7 2008 In addition, using Phospho-Flow we discovered that H(2)O(2)-induced phosphorylation of TCR signaling proteins was inhibited by small molecular weight kinase inhibitors far more potently than OKT3-triggered protein phosphorylation, despite a superior induction of phosphorylation by H(2)O(2). Hydrogen Peroxide 282-290 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 87-90 12899942-3 2003 TcR cross-linking of primary human T blasts and Jurkat human T cells rapidly activated the ERK, JNK, p38 and Akt kinases within minutes, and was temporally associated with TcR-stimulated production of hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 201-218 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-3 12899942-3 2003 TcR cross-linking of primary human T blasts and Jurkat human T cells rapidly activated the ERK, JNK, p38 and Akt kinases within minutes, and was temporally associated with TcR-stimulated production of hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 201-218 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 172-175 12899942-4 2003 TcR-induced activation of ERK was selectively augmented and sustained in the presence of pharmacologic antioxidants that can quench or inhibit H(2)O(2) production (NAC, MnTBAP and Ebselen, but not DPI), while activation of JNK and Akt were largely unaffected. Hydrogen Peroxide 143-151 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 0-3 12899942-6 2003 Molecular targeting of H(2)O(2) by overexpression of peroxiredoxin II, a thioredoxin dependent peroxidase, also increased and sustained ERK and MEK activation upon TcR cross-linking. Hydrogen Peroxide 23-31 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 164-167 12899942-8 2003 Thus, the data suggest that TcR-stimulated production of hydrogen peroxide negatively feeds back to dampen antigen-stimulated ERK activation and this redox-dependent regulation may serve to modulate key steps in TcR signaling. Hydrogen Peroxide 57-74 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 28-31 12899942-8 2003 Thus, the data suggest that TcR-stimulated production of hydrogen peroxide negatively feeds back to dampen antigen-stimulated ERK activation and this redox-dependent regulation may serve to modulate key steps in TcR signaling. Hydrogen Peroxide 57-74 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 212-215 11781366-3 2002 Furthermore, the data suggest the novel observation that superoxide anion and hydrogen peroxide are produced separately by distinct TCR-stimulated pathways. Hydrogen Peroxide 78-95 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 132-135 11781366-4 2002 Unexpectedly, TCR-stimulated activation of the Fas ligand (FasL) promoter and subsequent cell death was dependent upon superoxide anion, but independent of hydrogen peroxide, while nuclear factor of activated T cells (NFAT) activation or interleukin 2 transcription was independent of all ROS. Hydrogen Peroxide 156-173 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 14-17 11781366-2 2002 In this study, we have shown for the first time that TCR cross-linking induced rapid (within 15 min) generation of both hydrogen peroxide and superoxide anion, as defined with oxidation-sensitive dyes, selective pharmacologic antioxidants, and overexpression of specific antioxidant enzymes. Hydrogen Peroxide 120-137 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 53-56 10213852-8 1999 These results suggest that the decreased expression of TCR zeta molecules in peripheral T cells was induced by surgical stress, and was mediated by hydrogen peroxide derived from monocytes. Hydrogen Peroxide 148-165 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 55-58