PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33461096-5 2021 HMGB1 dimerization was positively modulated by CuCl2 and H2O2. Hydrogen Peroxide 57-61 high mobility group box 1 Homo sapiens 0-5 34696918-7 2022 Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2. Hydrogen Peroxide 15-19 high mobility group box 1 Homo sapiens 87-92 34696918-7 2022 Treatment with H2O2 + VD decreased gene/protein expression of NLRP1, NLRP3, caspase-1, HMGB1, IL-1beta, TNF-alpha and IL-18 in PE and NT explants with H2O2. Hydrogen Peroxide 151-155 high mobility group box 1 Homo sapiens 87-92 34696918-6 2022 Placental explants from NT cultured with H2O2 showed increased gene and protein expression of NLRP1, NLRP3, caspase-1, IL-1beta, TNF-alpha and HMGB1, while H2O2 was also able to increase TNF-alpha and caspase-1 gene expression in PE. Hydrogen Peroxide 41-45 high mobility group box 1 Homo sapiens 143-148 33461096-7 2021 Treatment of HEK293T cells with CuCl2 and H2O2 enhanced the oxidative self-dimerization of HMGB1, whereas this dimerization was inhibited in mutant HMGB1C106A cells. Hydrogen Peroxide 42-46 high mobility group box 1 Homo sapiens 91-96 30998983-6 2019 Furthermore, cultured normal human melanocytes could release HMGB1 under treatment with hydrogen peroxide. Hydrogen Peroxide 88-105 high mobility group box 1 Homo sapiens 61-66 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 12-29 high mobility group box 1 Homo sapiens 218-243 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 12-29 high mobility group box 1 Homo sapiens 245-250 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 31-35 high mobility group box 1 Homo sapiens 218-243 32347316-6 2020 RESULTS: In hydrogen peroxide (H2O2)-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1beta, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). Hydrogen Peroxide 31-35 high mobility group box 1 Homo sapiens 245-250 33841665-6 2021 RESULTS: Ectopic HESCs showed markedly decreased cell viability with the increased release of HMGB-1 following treatment with H2O2. Hydrogen Peroxide 126-130 high mobility group box 1 Homo sapiens 94-100 33732708-7 2021 The higher cell viability observed in the HMGB1 knocked-down group after stimulation with H2O2 indicated the possible negative effect of HMGB1 on cellular lifespan. Hydrogen Peroxide 90-94 high mobility group box 1 Homo sapiens 42-47 33732708-7 2021 The higher cell viability observed in the HMGB1 knocked-down group after stimulation with H2O2 indicated the possible negative effect of HMGB1 on cellular lifespan. Hydrogen Peroxide 90-94 high mobility group box 1 Homo sapiens 137-142 31115516-7 2019 Conversely, fr-HMGB1 upregulated the aforementioned factors only following treatment with H2O2. Hydrogen Peroxide 90-94 high mobility group box 1 Homo sapiens 15-20 30338917-0 2018 HMGB1 deficiency reduces H2 O2 -induced oxidative damage in human melanocytes via the Nrf2 pathway. Hydrogen Peroxide 25-30 high mobility group box 1 Homo sapiens 0-5 31019652-7 2019 Pre-miR-122 or siRNA SBP1 (si-SBP1) treatment ameliorated acute TNBS-induced colitis and H2O2-induced oxidative stress. Hydrogen Peroxide 89-93 high mobility group box 1 Homo sapiens 21-25 31019652-7 2019 Pre-miR-122 or siRNA SBP1 (si-SBP1) treatment ameliorated acute TNBS-induced colitis and H2O2-induced oxidative stress. Hydrogen Peroxide 89-93 high mobility group box 1 Homo sapiens 30-34 30502088-0 2019 MiR-216a-5p protects 16HBE cells from H2O2-induced oxidative stress through targeting HMGB1/NF-kB pathway. Hydrogen Peroxide 38-42 high mobility group box 1 Homo sapiens 86-91 30502088-4 2019 A significantly elevation of HMGB1 protein expression and a reduction of miR-216a-5p expression were observed in children with asthma as well as in H2O2 stimulated 16HBE cells. Hydrogen Peroxide 148-152 high mobility group box 1 Homo sapiens 29-34 30502088-6 2019 MiR-216a-5p repressed HMGB1 protein expression in H2O2 induced 16HBE cells. Hydrogen Peroxide 50-54 high mobility group box 1 Homo sapiens 22-27 30502088-9 2019 In conclusion, these results suggested that miR-216a-5p functions as a negative regulator of H2O2 induced 16HBE cell injury through targeting HMGB1/NF-kB pathway, provided a potential therapeutic target for asthma. Hydrogen Peroxide 93-97 high mobility group box 1 Homo sapiens 142-147 30338917-7 2018 H2 O2 treatment increased cytoplasmic translocation and extracellular release of HMGB1. Hydrogen Peroxide 0-5 high mobility group box 1 Homo sapiens 81-86 30338917-10 2018 The expression of Nrf2 and its downstream antioxidant genes was downregulated after the supernatant of H2 O2 -treated NHEMs was added to HMGB1-deficient cells. Hydrogen Peroxide 103-108 high mobility group box 1 Homo sapiens 137-142 27198223-0 2016 PKCalpha and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation. Hydrogen Peroxide 44-61 high mobility group box 1 Homo sapiens 13-18 27198223-8 2016 Together, these results identify PKCalpha and HMGB1 as important co-regulators involved in H2O2-induced PAR formation, a finding that may have important relevance for oxidative stress-associated pathophysiological conditions. Hydrogen Peroxide 91-95 high mobility group box 1 Homo sapiens 46-51 24070090-7 2014 Leukocyte activation abated in the presence of inhibitors of HMGB1 or of catalase, which catalyzes the dismutation of hydrogen peroxide into water and molecular oxygen. Hydrogen Peroxide 118-135 high mobility group box 1 Homo sapiens 61-66 22931605-0 2012 [Hydrogen peroxide induces high mobility group box 1 release in human bronchial epithelial cells]. Hydrogen Peroxide 1-18 high mobility group box 1 Homo sapiens 27-60 23244202-4 2013 To investigate these processes, the extracellular release of HMGB1 during necrosis was characterized in vitro using Jurkat T cell leukemia cells treated to induce necrosis by freeze-thaw, heat, hydrogen peroxide or ethanol. Hydrogen Peroxide 194-211 high mobility group box 1 Homo sapiens 61-66 24370952-6 2014 Concomitant exposure to 18% CS and oxidative stress (H2O2) augmented HMGB1 expression (~13 fold increase) whereas lipopolysaccharide (LPS) challenge increased HMGB1 expression in static EC, but not in 18% CS-challenged EC. Hydrogen Peroxide 53-57 high mobility group box 1 Homo sapiens 69-74 24370952-7 2014 In contrast, physiologic, low amplitude cyclic stretch (5% CS) attenuated both oxidative H2O2- and LPS-induced increases in HMGB1 expression, suggesting that physiologic mechanical stress is protective. Hydrogen Peroxide 89-93 high mobility group box 1 Homo sapiens 124-129 23647088-6 2013 After exposure to H2O2, a marked decrease in cell viability (<50%) was demonstrated, and this was significantly ameliorated upon culture at 32 C. Significantly intracellular damage was found to affect the 24-hour H2O2-exposed cells in 37 C (P < .05), including an increase in apoptosis and necrosis, intracellular ROS, caspase-3 activity, HMGB1 protein expression, and some alterations to the cell cycle. Hydrogen Peroxide 18-22 high mobility group box 1 Homo sapiens 345-350 23647088-6 2013 After exposure to H2O2, a marked decrease in cell viability (<50%) was demonstrated, and this was significantly ameliorated upon culture at 32 C. Significantly intracellular damage was found to affect the 24-hour H2O2-exposed cells in 37 C (P < .05), including an increase in apoptosis and necrosis, intracellular ROS, caspase-3 activity, HMGB1 protein expression, and some alterations to the cell cycle. Hydrogen Peroxide 216-220 high mobility group box 1 Homo sapiens 345-350 22931605-1 2012 OBJECTIVE: To investigate the effect of hydrogen dioxide (H(2)O(2)) on the release and translocation of high mobility group box 1 release (HMGB1) from normal human bronchiolar epithelial cells (HBE). Hydrogen Peroxide 40-56 high mobility group box 1 Homo sapiens 104-137 22931605-1 2012 OBJECTIVE: To investigate the effect of hydrogen dioxide (H(2)O(2)) on the release and translocation of high mobility group box 1 release (HMGB1) from normal human bronchiolar epithelial cells (HBE). Hydrogen Peroxide 40-56 high mobility group box 1 Homo sapiens 139-144 22931605-9 2012 CONCLUSION: H(2)O(2) can induce HMGB1 translocation and release in human bronchial epithelial cells, suggesting the involvement of HMGB1 in airway oxidative stress in chronic inflammatory diseases such as asthma and COPD. Hydrogen Peroxide 12-20 high mobility group box 1 Homo sapiens 32-37 22931605-9 2012 CONCLUSION: H(2)O(2) can induce HMGB1 translocation and release in human bronchial epithelial cells, suggesting the involvement of HMGB1 in airway oxidative stress in chronic inflammatory diseases such as asthma and COPD. Hydrogen Peroxide 12-20 high mobility group box 1 Homo sapiens 131-136 21487246-5 2011 Hydrogen peroxide (H 2O 2) and loss of superoxide dismutase 1 (SOD1)-mediated oxidative stress promotes cytosolic HMGB1 expression and extracellular release. Hydrogen Peroxide 0-17 high mobility group box 1 Homo sapiens 114-119 22246807-0 2012 Heat shock transcription factor 1 inhibits H2O2-induced cardiomyocyte death through suppression of high-mobility group box 1. Hydrogen Peroxide 43-47 high mobility group box 1 Homo sapiens 99-124 17513788-0 2007 Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. Hydrogen Peroxide 75-92 high mobility group box 1 Homo sapiens 102-107 20618458-6 2010 Extracellular HMGB-1 levels markedly increased after hydrogen peroxide stimulation, but did not change after STS stimulation. Hydrogen Peroxide 53-70 high mobility group box 1 Homo sapiens 14-20 17135572-0 2007 Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. Hydrogen Peroxide 0-17 high mobility group box 1 Homo sapiens 75-80 17135572-2 2007 Here, we demonstrated that a reactive oxygen species, hydrogen peroxide (H(2)O(2)), induces active and passive HMGB1 release from macrophage and monocyte cultures in a time- and dose-dependent manner. Hydrogen Peroxide 54-71 high mobility group box 1 Homo sapiens 111-116 17135572-2 2007 Here, we demonstrated that a reactive oxygen species, hydrogen peroxide (H(2)O(2)), induces active and passive HMGB1 release from macrophage and monocyte cultures in a time- and dose-dependent manner. Hydrogen Peroxide 73-81 high mobility group box 1 Homo sapiens 111-116 17135572-3 2007 At nontoxic doses (e.g., 0.0125-0.125 mM), H(2)O(2) induced HMGB1 cytoplasmic translocation and active release within 3-24 h. At higher concentrations (e.g., 0.25 mM), however, H(2)O(2) exhibited cytotoxicity to macrophage and monocyte cell cultures and consequently, triggered active and passive HMGB1 release. Hydrogen Peroxide 43-51 high mobility group box 1 Homo sapiens 60-65 17135572-3 2007 At nontoxic doses (e.g., 0.0125-0.125 mM), H(2)O(2) induced HMGB1 cytoplasmic translocation and active release within 3-24 h. At higher concentrations (e.g., 0.25 mM), however, H(2)O(2) exhibited cytotoxicity to macrophage and monocyte cell cultures and consequently, triggered active and passive HMGB1 release. Hydrogen Peroxide 43-51 high mobility group box 1 Homo sapiens 297-302 17135572-4 2007 In addition, H(2)O(2) stimulated potential interaction of HMGB1 with a nuclear export factor, chromosome region maintenance (CRM1), in macrophage/monocyte cultures. Hydrogen Peroxide 13-21 high mobility group box 1 Homo sapiens 58-63