PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8185323-1	1994	The contribution of xanthine oxidoreductase (XDH + XO) to the extracellular release of hydrogen peroxide (H2O2) and intracellular H2O2 concentration in cultured bovine aortic endothelial cells (BAEC) was determined.	Hydrogen Peroxide	87-104	xanthine dehydrogenase	Bos taurus	20-43	
8185323-1	1994	The contribution of xanthine oxidoreductase (XDH + XO) to the extracellular release of hydrogen peroxide (H2O2) and intracellular H2O2 concentration in cultured bovine aortic endothelial cells (BAEC) was determined.	Hydrogen Peroxide	87-104	xanthine dehydrogenase	Bos taurus	45-48	
8185323-1	1994	The contribution of xanthine oxidoreductase (XDH + XO) to the extracellular release of hydrogen peroxide (H2O2) and intracellular H2O2 concentration in cultured bovine aortic endothelial cells (BAEC) was determined.	Hydrogen Peroxide	106-110	xanthine dehydrogenase	Bos taurus	20-43	
8185323-1	1994	The contribution of xanthine oxidoreductase (XDH + XO) to the extracellular release of hydrogen peroxide (H2O2) and intracellular H2O2 concentration in cultured bovine aortic endothelial cells (BAEC) was determined.	Hydrogen Peroxide	106-110	xanthine dehydrogenase	Bos taurus	45-48	
8185323-1	1994	The contribution of xanthine oxidoreductase (XDH + XO) to the extracellular release of hydrogen peroxide (H2O2) and intracellular H2O2 concentration in cultured bovine aortic endothelial cells (BAEC) was determined.	Hydrogen Peroxide	130-134	xanthine dehydrogenase	Bos taurus	45-48	
15905466-2	2005	We postulated that H2O2 may modulate the irreversible conversion of xanthine dehydrogenase (XDH) to XO and sought to examine mechanisms involved.	Hydrogen Peroxide	19-23	xanthine dehydrogenase	Bos taurus	68-90	
15905466-2	2005	We postulated that H2O2 may modulate the irreversible conversion of xanthine dehydrogenase (XDH) to XO and sought to examine mechanisms involved.	Hydrogen Peroxide	19-23	xanthine dehydrogenase	Bos taurus	92-95	
15905466-3	2005	METHODS AND RESULTS: H2O2 (100 micromol/L) decreased bovine aortic endothelial cell (BAEC) XDH protein expression, and metabolic labeling studies indicated that H2O2 stimulated conversion of XDH to XO.	Hydrogen Peroxide	21-25	xanthine dehydrogenase	Bos taurus	91-94	
15905466-3	2005	METHODS AND RESULTS: H2O2 (100 micromol/L) decreased bovine aortic endothelial cell (BAEC) XDH protein expression, and metabolic labeling studies indicated that H2O2 stimulated conversion of XDH to XO.	Hydrogen Peroxide	21-25	xanthine dehydrogenase	Bos taurus	191-194	
15905466-3	2005	METHODS AND RESULTS: H2O2 (100 micromol/L) decreased bovine aortic endothelial cell (BAEC) XDH protein expression, and metabolic labeling studies indicated that H2O2 stimulated conversion of XDH to XO.	Hydrogen Peroxide	161-165	xanthine dehydrogenase	Bos taurus	91-94	
15905466-3	2005	METHODS AND RESULTS: H2O2 (100 micromol/L) decreased bovine aortic endothelial cell (BAEC) XDH protein expression, and metabolic labeling studies indicated that H2O2 stimulated conversion of XDH to XO.	Hydrogen Peroxide	161-165	xanthine dehydrogenase	Bos taurus	191-194	
15905466-5	2005	BAPTA-AM prevented the decline in XDH by H2O2, indicating that it was calcium-dependent.	Hydrogen Peroxide	41-45	xanthine dehydrogenase	Bos taurus	34-37	
15905466-6	2005	In keeping with calcium acting downstream of H2O2, the calcium ionophore A23187 (1 micromol/L) caused XDH-to-XO conversion, and this was not prevented by the antioxidants.	Hydrogen Peroxide	45-49	xanthine dehydrogenase	Bos taurus	102-105	
15905466-8	2005	CONCLUSIONS: Endothelial XO and XDH expression are strongly dependent on H2O2 and calcium.	Hydrogen Peroxide	73-77	xanthine dehydrogenase	Bos taurus	32-35	
15905466-9	2005	Stimulation of XDH conversion to XO may represent a feed-forward mechanism whereby H2O2 can stimulate further production of ROS.	Hydrogen Peroxide	83-87	xanthine dehydrogenase	Bos taurus	15-18