PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35238277-10	2022	HMGB1 silencing reduced toll-like receptor 4 (TLR4) expression to promote proliferation and reduce apoptosis of H2O2-treated cardiomyocytes.	Hydrogen Peroxide	112-116	high mobility group box 1	Rattus norvegicus	0-5	
30517029-4	2019	HMGB1 was originally located within the nucleus and translocated to the cytoplasm of pulmonary artery smooth muscle cells (PASMCs) upon hypoxia exposure, a process that appeared to be mediated by endogenous H2O2.	Hydrogen Peroxide	207-211	high mobility group box 1	Rattus norvegicus	0-5	
19944723-8	2010	In these cells, HMGB1 siRNA delivery successfully reduced both basal and H(2)O(2)- or NMDA-induced HMGB1 levels, and as a result of that, neuronal cell death was significantly suppressed in both cases.	Hydrogen Peroxide	73-81	high mobility group box 1	Rattus norvegicus	16-21	
30111205-12	2018	RESULTS: In H2O2 model group, the LECs proliferation was significantly inhibited, the caspase-3 activity significantly increased, HMGB-1 mRNA and secretion significantly enhanced, NF-kappaB mRNA and protein levels significantly elevated, compared to the Control group (p < .05).	Hydrogen Peroxide	12-16	high mobility group box 1	Rattus norvegicus	130-136	
24681787-0	2014	H2O2 evokes injury of cardiomyocytes through upregulating HMGB1.	Hydrogen Peroxide	0-4	high mobility group box 1	Rattus norvegicus	58-63	
24681787-3	2014	This study aimed to investigate the role of high-mobility group box 1 protein (HMGB1) in cardiomyocytes undergoing H2O2 treatment.	Hydrogen Peroxide	115-119	high mobility group box 1	Rattus norvegicus	44-69	
24681787-3	2014	This study aimed to investigate the role of high-mobility group box 1 protein (HMGB1) in cardiomyocytes undergoing H2O2 treatment.	Hydrogen Peroxide	115-119	high mobility group box 1	Rattus norvegicus	79-84	
24681787-7	2014	RESULTS: H2O2-induced ROS significantly decreased cell viability, promoted the apoptosis of neonatal myocytes, and upregulated the expression of HMGB1 in a dose-dependent manner.	Hydrogen Peroxide	9-13	high mobility group box 1	Rattus norvegicus	145-150	
24681787-8	2014	However, NAC or HMGB1 neutralizing antibody suppressed the loss of cell viability and the rate of cell apoptosis induced by H2O2.	Hydrogen Peroxide	124-128	high mobility group box 1	Rattus norvegicus	16-21	
24681787-10	2014	CONCLUSION: The present study suggests that H2O2-induced ROS evoke injury to cardiomyocytes that may be associated with upregulating HMGB1.	Hydrogen Peroxide	44-48	high mobility group box 1	Rattus norvegicus	133-138	
19944723-8	2010	In these cells, HMGB1 siRNA delivery successfully reduced both basal and H(2)O(2)- or NMDA-induced HMGB1 levels, and as a result of that, neuronal cell death was significantly suppressed in both cases.	Hydrogen Peroxide	73-81	high mobility group box 1	Rattus norvegicus	99-104