PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34012878-1 2021 AIM: To investigate the protective effect of heme oxygenase-1 (HO-1) against H2O2-induced apoptosis in human ARPE-19 cells. Hydrogen Peroxide 77-81 heme oxygenase 1 Homo sapiens 45-61 34012878-1 2021 AIM: To investigate the protective effect of heme oxygenase-1 (HO-1) against H2O2-induced apoptosis in human ARPE-19 cells. Hydrogen Peroxide 77-81 heme oxygenase 1 Homo sapiens 63-67 34012878-2 2021 METHODS: The lentiviral vector expressing HO-1 was prepared and transfected into apoptotic ARPE-19 cells induced by H2O2. Hydrogen Peroxide 116-120 heme oxygenase 1 Homo sapiens 42-46 34012878-5 2021 It was found that exogenous HO-1 significantly ameliorated H2O2-induced loss of cell viability, apoptosis and intracellular levels of reactive oxygen species (ROS) in ARPE-19 cells. Hydrogen Peroxide 59-63 heme oxygenase 1 Homo sapiens 28-32 34012878-7 2021 Furthermore, HO-1 upregulation further inhibited H2O2-induced release of cysteinyl aspartate specific proteinase-3 (caspase-3). Hydrogen Peroxide 49-53 heme oxygenase 1 Homo sapiens 13-17 34012878-8 2021 CONCLUSION: Exogenous HO-1 protect ARPE-19 cells against H2O2-induced oxidative stress by regulating the expressions of Nrf2, HO-1, Bcl-2, and caspase-3. Hydrogen Peroxide 57-61 heme oxygenase 1 Homo sapiens 22-26 32623920-6 2020 We further showed that H2O2-induced oxidative stress was reduced by curcumin via the Nrf2/HO-1 pathway in human neuroblastoma cells. Hydrogen Peroxide 23-27 heme oxygenase 1 Homo sapiens 90-94 33270331-9 2021 Notably, the expression of antioxidant genes, such as HO-1, and the nuclear translocation of Nrf2 were further enhanced by F-FEJS in UVB/H2 O2 -treated cells. Hydrogen Peroxide 137-142 heme oxygenase 1 Homo sapiens 54-58 33915898-8 2021 Intriguingly, MiR-100 antagomir treatment exerted a cytoprotective effect against the H2O2-induced oxidative cell death through attenuating the oxidation-induced AMPK hyperphosphorylation, restoring cellular mTOR and p62/SQSTM1 levels and upregulating heme oxygenase-1 expression. Hydrogen Peroxide 86-90 heme oxygenase 1 Homo sapiens 252-268 33738869-9 2021 The effect of hydrogen peroxide was inhibited by HO-1 induction, whereas it was promoted by HO-1 knockdown. Hydrogen Peroxide 14-31 heme oxygenase 1 Homo sapiens 49-53 33256538-0 2022 Aloperine protects human retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through activation of Nrf2/HO-1 pathway. Hydrogen Peroxide 66-83 heme oxygenase 1 Homo sapiens 150-154 33256538-17 2022 In conclusion, these findings demonstrated that aloperine protected ARPE-19 cells from H2O2-induced oxidative stress and apoptosis in part via activating the Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 87-91 heme oxygenase 1 Homo sapiens 163-167 32204510-4 2020 Ectopic overexpression of HO-1 not only attenuated cell proliferation in vitro and in vivo, but also blocked the reactive oxygen species (ROS) induced by H2O2 and the pyocyanin in HepG2 or Hep3B cells. Hydrogen Peroxide 154-158 heme oxygenase 1 Homo sapiens 26-30 32712291-6 2020 In addition, hemistepsin A markedly promoted the activation of nuclear factor-erythroid-2-related factor 2 (Nrf2), which was associated with the enhanced expression and activity of heme oxygenase-1 (HO-1) in the presence of 500 muM H2O2. Hydrogen Peroxide 232-236 heme oxygenase 1 Homo sapiens 181-197 32712291-6 2020 In addition, hemistepsin A markedly promoted the activation of nuclear factor-erythroid-2-related factor 2 (Nrf2), which was associated with the enhanced expression and activity of heme oxygenase-1 (HO-1) in the presence of 500 muM H2O2. Hydrogen Peroxide 232-236 heme oxygenase 1 Homo sapiens 199-203 32854434-0 2020 Cudratricusxanthone O Inhibits H2O2-Induced Cell Damage by Activating Nrf2/HO-1 Pathway in Human Chondrocytes. Hydrogen Peroxide 31-35 heme oxygenase 1 Homo sapiens 75-79 32774685-6 2020 Additionally, H2O2 at 1 mM significantly decreased the mRNA expression levels of Nrf2, CAT, SOD1, SOD2, HO-1, GST-pi, NQO1, and GLCM in ARPE-19 cells; however, treatment with EE-TT reversed the downregulated mRNA expression levels of all these genes induced by H2O2. Hydrogen Peroxide 14-18 heme oxygenase 1 Homo sapiens 104-108 32695819-0 2020 Antioxidant Effects and Cytoprotective Potentials of Herbal Tea against H2O2-Induced Oxidative Damage by Activating Heme Oxygenase1 Pathway. Hydrogen Peroxide 72-76 heme oxygenase 1 Homo sapiens 116-131 32319555-5 2020 CA-mediated Nrf2/HO-1 activation protected the HUVECs from H2O2-induced oxidative stress, which promotes apoptosis. Hydrogen Peroxide 59-63 heme oxygenase 1 Homo sapiens 17-21 32630570-10 2020 After H2O2 treatment, translocation of Nrf2 into the nucleus and the subsequent increase of Heme Oxygenase-1 (HO-1) were observed earlier in CGA-treated cells. Hydrogen Peroxide 6-10 heme oxygenase 1 Homo sapiens 110-114 32410998-0 2020 Paeoniflorin Resists H2O2-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway. Hydrogen Peroxide 21-25 heme oxygenase 1 Homo sapiens 78-82 32410998-5 2020 Furthermore, PF activated c-Jun amino terminal kinase (JNK) and the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway to counteract H2O2-induced oxidative damage in PIG1 and PIG3V. Hydrogen Peroxide 156-160 heme oxygenase 1 Homo sapiens 110-126 32410998-5 2020 Furthermore, PF activated c-Jun amino terminal kinase (JNK) and the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway to counteract H2O2-induced oxidative damage in PIG1 and PIG3V. Hydrogen Peroxide 156-160 heme oxygenase 1 Homo sapiens 128-132 32410998-6 2020 Taken together, our study firstly demonstrates that PF resists H2O2-induced oxidative stress in melanocytes probably by activating JNK/Nrf2/HO-1 signaling, suggesting a potential therapeutic application of PF on vitiligo. Hydrogen Peroxide 63-67 heme oxygenase 1 Homo sapiens 140-144 32225089-7 2020 Oxidative stress response was also impaired in HACE1 fibroblasts, as shown by the reduced NQO1 and Hmox1 mRNA levels observed in H2O2-treated cells. Hydrogen Peroxide 129-133 heme oxygenase 1 Homo sapiens 99-104 33000859-10 2020 Furthermore, H2O2-induced increase in expression levels of HO-1 and nuclear Nrf2 were enhanced by MADE treatment. Hydrogen Peroxide 13-17 heme oxygenase 1 Homo sapiens 59-63 33000859-12 2020 In conclusion, these findings demonstrated that MADE protected ARPE-19 cells from H2O2-induced oxidative stress and apoptosis by inducing the activation of Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 82-86 heme oxygenase 1 Homo sapiens 161-165 32860873-4 2020 Among other pathways, HO-1 expression is stimulated by the Nrf2/Keap1 system which senses electrophilic compounds including alkylating agents and reactive oxygen species (ROS) such as superoxide or hydrogen peroxide. Hydrogen Peroxide 198-215 heme oxygenase 1 Homo sapiens 22-26 31902541-0 2020 Corrigendum to "Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2/HO-1 signaling pathway" [Biomed. Hydrogen Peroxide 78-95 heme oxygenase 1 Homo sapiens 186-190 31981961-8 2020 The miR-548a-3p might regulate the cellular response to hydrogen peroxide through HO-1 and HIF-1pathway. Hydrogen Peroxide 56-73 heme oxygenase 1 Homo sapiens 82-86 31076999-0 2019 Naringenin Inhibit the Hydrogen Peroxide-Induced SH-SY5Y Cells Injury Through Nrf2/HO-1 Pathway. Hydrogen Peroxide 23-40 heme oxygenase 1 Homo sapiens 83-87 31159593-8 2019 We found that H2O2 stimulation-evoked HUVECs oxidative damage meanwhile impeded HO-1 expression. Hydrogen Peroxide 14-18 heme oxygenase 1 Homo sapiens 80-84 31644887-0 2019 Quercetin, but not rutin, attenuated hydrogen peroxide-induced cell damage via heme oxygenase-1 induction in endothelial cells. Hydrogen Peroxide 37-54 heme oxygenase 1 Homo sapiens 79-95 31076999-9 2019 The HO-1 inhibitor ZnPP abolished the neuroprotective effect of NGN against H2O2-induced neurotoxicity. Hydrogen Peroxide 76-80 heme oxygenase 1 Homo sapiens 4-8 31076999-10 2019 Taken together, the present study demonstrates that regulation of Nrf2/HO-1 pathway through activation of ERK and PI3 K/Akt, and the inhibition of mitochondria-dependent apoptosis together may render NGN protect SH-SY5Y cells from H2O2-induced neurotoxicity. Hydrogen Peroxide 231-235 heme oxygenase 1 Homo sapiens 71-75 31219431-4 2019 Interestingly, the expressions of nuclear factor-erythroid-2-related factor 2 (Nrf2) and its active form, phosphorylated Nrf2, were strikingly promoted by coptisine in the presence of H2O2, which was associated with a marked increase in the expression of heme oxygenase-1 (HO-1). Hydrogen Peroxide 184-188 heme oxygenase 1 Homo sapiens 255-271 31219431-7 2019 Furthermore, the protective effects of coptisine against H2O2-induced cytotoxicity were abolished by ZnPP, indicating that coptisine protects keratinocytes against oxidative stress-induced injury through activation of the Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 57-61 heme oxygenase 1 Homo sapiens 227-231 31219431-4 2019 Interestingly, the expressions of nuclear factor-erythroid-2-related factor 2 (Nrf2) and its active form, phosphorylated Nrf2, were strikingly promoted by coptisine in the presence of H2O2, which was associated with a marked increase in the expression of heme oxygenase-1 (HO-1). Hydrogen Peroxide 184-188 heme oxygenase 1 Homo sapiens 273-277 31115551-0 2019 Glycyrrhizin protects human melanocytes from H2O2-induced oxidative damage via the Nrf2-dependent induction of HO-1. Hydrogen Peroxide 45-49 heme oxygenase 1 Homo sapiens 111-115 31115551-11 2019 The knockdown of Nrf2 by small interfering RNA or the inhibition of HO-1 by ZnPP reversed the protective effect of GR on melanocytes against H2O2-induced cytotoxicity and apoptosis. Hydrogen Peroxide 141-145 heme oxygenase 1 Homo sapiens 68-72 31013932-4 2019 The results showed that PG significantly inhibited the H2O2-induced growth inhibition in HaCaT cells, which was associated with increased expression of heme oxygenase-1 (HO-1) by the activation of nuclear factor erythroid 2-related factor-2 (Nrf2). Hydrogen Peroxide 55-59 heme oxygenase 1 Homo sapiens 152-168 31049492-0 2019 Wheat alkylresorcinols protect human retinal pigment epithelial cells against H2O2-induced oxidative damage through Akt-dependent Nrf2/HO-1 signaling. Hydrogen Peroxide 78-82 heme oxygenase 1 Homo sapiens 135-139 30576222-0 2019 Klotho protein inhibits H2O2-induced oxidative injury in endothelial cells via regulation of PI3K/AKT/Nrf2/HO-1 pathways. Hydrogen Peroxide 24-28 heme oxygenase 1 Homo sapiens 107-111 30576222-8 2019 Klotho protein enhanced the antioxidant defense ability of the cells by activating the PI3K/AKT pathway, which upregulated the expression of Nrf2/HO-1, thereby inhibiting H2O2-induced oxidative damage. Hydrogen Peroxide 171-175 heme oxygenase 1 Homo sapiens 146-150 31013932-4 2019 The results showed that PG significantly inhibited the H2O2-induced growth inhibition in HaCaT cells, which was associated with increased expression of heme oxygenase-1 (HO-1) by the activation of nuclear factor erythroid 2-related factor-2 (Nrf2). Hydrogen Peroxide 55-59 heme oxygenase 1 Homo sapiens 170-174 31013932-8 2019 However, the inhibition of HO-1 function using zinc protoporphyrin, a HO-1 inhibitor, markedly attenuated these protective effects of PG against H2O2. Hydrogen Peroxide 145-149 heme oxygenase 1 Homo sapiens 27-31 30594636-8 2019 This led to HO-1 protein downregulation in H2O2-treated human pancreatic beta-cells, which was also observed in NRF2-silenced beta-cells. Hydrogen Peroxide 43-47 heme oxygenase 1 Homo sapiens 12-16 30269355-8 2019 Moreover, TQ enhanced the activation of Nrf2/heme oxygenase 1 (HO-1) signaling pathway in H2 O2 -induced ARPE cells. Hydrogen Peroxide 90-95 heme oxygenase 1 Homo sapiens 40-61 30594624-7 2019 In addition, NO inhibited H2O2-induced endothelial dysfunction through activation of HO-1. Hydrogen Peroxide 26-30 heme oxygenase 1 Homo sapiens 85-89 30652259-0 2019 Carvacrol Depends on Heme Oxygenase-1 (HO-1) to Exert Antioxidant, Anti-inflammatory, and Mitochondria-Related Protection in the Human Neuroblastoma SH-SY5Y Cells Line Exposed to Hydrogen Peroxide. Hydrogen Peroxide 179-196 heme oxygenase 1 Homo sapiens 39-43 30652259-11 2019 Thus, it is suggested that CAR caused cytoprotective effects by an HO-1-dependent manner in SH-SY5Y cells exposed to H2O2. Hydrogen Peroxide 117-121 heme oxygenase 1 Homo sapiens 67-71 30269355-8 2019 Moreover, TQ enhanced the activation of Nrf2/heme oxygenase 1 (HO-1) signaling pathway in H2 O2 -induced ARPE cells. Hydrogen Peroxide 90-95 heme oxygenase 1 Homo sapiens 63-67 30269355-10 2019 These results suggested that TQ protected ARPE cells from H2 O2 -induced oxidative stress and apoptosis via the Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 58-63 heme oxygenase 1 Homo sapiens 117-121 31468438-6 2019 Moreover, APW increased the expressions of nuclear Nrf2 and cytosolic HO-1 in H2O2-treated hepatocytes. Hydrogen Peroxide 78-82 heme oxygenase 1 Homo sapiens 70-74 30709701-0 2019 Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway. Hydrogen Peroxide 60-77 heme oxygenase 1 Homo sapiens 138-142 30709701-9 2019 Oxy increased p-Akt and HO-1 expressions in H2O2-stimulated HLECs. Hydrogen Peroxide 44-48 heme oxygenase 1 Homo sapiens 24-28 30709701-10 2019 Akt and HO-1 expressions form a regulatory axis and Oxy activated the Akt/HO-1 pathway in H2O2-stimulated HLECs. Hydrogen Peroxide 90-94 heme oxygenase 1 Homo sapiens 8-12 30709701-10 2019 Akt and HO-1 expressions form a regulatory axis and Oxy activated the Akt/HO-1 pathway in H2O2-stimulated HLECs. Hydrogen Peroxide 90-94 heme oxygenase 1 Homo sapiens 74-78 30709701-11 2019 Inhibition of the Akt/HO-1 pathway by LY294002 or ZnPP attenuated the effects of Oxy on oxidative stress and apoptosis in H2O2-stimulated HLECs. Hydrogen Peroxide 122-126 heme oxygenase 1 Homo sapiens 22-26 30709701-12 2019 In conclusion, Oxy protected H2O2-induced oxidative stress and apoptosis through activating the Akt/HO-1 pathway, suggesting the protective effect of Oxy against H2O2-induced cataract. Hydrogen Peroxide 29-33 heme oxygenase 1 Homo sapiens 100-104 30709701-12 2019 In conclusion, Oxy protected H2O2-induced oxidative stress and apoptosis through activating the Akt/HO-1 pathway, suggesting the protective effect of Oxy against H2O2-induced cataract. Hydrogen Peroxide 162-166 heme oxygenase 1 Homo sapiens 100-104 30476559-4 2019 Only in thyrocytes, H2O2 up-regulated GPx activity and expression of HO-1 mRNA. Hydrogen Peroxide 20-24 heme oxygenase 1 Homo sapiens 69-73 29473125-0 2018 Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway. Hydrogen Peroxide 62-79 heme oxygenase 1 Homo sapiens 114-118 30272289-11 2018 The results revealed that treatment with TCSGs markedly induced Nrf2 nuclear translocation and upregulated the expression of heme oxygenase-1 (HO-1) in the L02 cells damaged by H2O2. Hydrogen Peroxide 177-181 heme oxygenase 1 Homo sapiens 125-141 30144404-8 2018 GLS1 inhibition also sensitized ECs to the cytotoxic effect of hydrogen peroxide and this was prevented by the overexpression of HO-1. Hydrogen Peroxide 63-80 heme oxygenase 1 Homo sapiens 129-133 30186615-9 2018 Results: Pretreatment with low-dose (1 and 5 muM) CAM for 72 h inhibited H2O2-induced reductions of GPx-1, GR, SOD, CAT and HO-1 activities, and mRNA expressions of GPx-1 and HO-1, and improved the GSH/GSSG ratio. Hydrogen Peroxide 73-77 heme oxygenase 1 Homo sapiens 124-128 30186615-9 2018 Results: Pretreatment with low-dose (1 and 5 muM) CAM for 72 h inhibited H2O2-induced reductions of GPx-1, GR, SOD, CAT and HO-1 activities, and mRNA expressions of GPx-1 and HO-1, and improved the GSH/GSSG ratio. Hydrogen Peroxide 73-77 heme oxygenase 1 Homo sapiens 175-179 29473125-8 2018 Therefore, SFN exerted an anti-inflammatory effect in H2O2-challenged SH-SY5Y cells by a mechanism dependent on the Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 54-58 heme oxygenase 1 Homo sapiens 121-125 30048241-4 2018 METHODS AND RESULTS: Upregulation of HO-1 by Hemin or adenovirus infection reversed H2O2-induced senescence in human umbilical vein endothelial cells (HUVECs); whereas depletion of HO-1 by siRNA or HO-1 inhibitor protoporphyrin IX zinc (II) (ZnPP) triggered HUVEC senescence. Hydrogen Peroxide 84-88 heme oxygenase 1 Homo sapiens 37-41 30048241-6 2018 Moreover, HO-1 induction prevented the decrease of eNOS dimer/monomer ratio stimulated by H2O2 via its antioxidant properties. Hydrogen Peroxide 90-94 heme oxygenase 1 Homo sapiens 10-14 30057686-7 2018 Silencing either Nrf2 or HO-1 was found to aggravate flutamide-induced hydrogen peroxide accumulation and mitochondrial dysfunction as well as inhibition of the Nrf2 pathway. Hydrogen Peroxide 71-88 heme oxygenase 1 Homo sapiens 25-29 29951371-6 2018 In addition, endogenous miR-494 inhibition in undifferentiated cells impairs HO-1 induction in response to exposure to 500 microM H2O2, reducing the number of viable cells. Hydrogen Peroxide 130-134 heme oxygenase 1 Homo sapiens 77-81 29951371-7 2018 The analysis of Bach1 expression did not reveal any significant modifications in any experimental conditions tested, proving that the impairment of HO-1 induction observed in cells treated with miR-494 inhibitor and exposed to H2O2 is independent from Bach1. Hydrogen Peroxide 227-231 heme oxygenase 1 Homo sapiens 148-152 29471244-11 2018 SIGNIFICANCE: DAs provided cytoprotective effects against H2O2-induced cytotoxicity by activation of the Nrf2/ARE/HO-1 pathway via phosphorylation of AMPKalpha and ERK. Hydrogen Peroxide 58-62 heme oxygenase 1 Homo sapiens 114-118 29874784-8 2018 In addition, EESS increased not only expression, but also phosphorylation of nuclear factor-erythroid 2 related factor 2 (Nrf2), and promoted the expression of heme oxygenase-1 (HO-1), a critical target enzyme of Nrf2, but decreased the expression of kelch-like ECH-associated protein-1; however, the inhibition of HO-1 activity by zinc protoporphyrin abolished the antioxidant potential induced by EESS against H2O2-mediated oxidative stress. Hydrogen Peroxide 412-416 heme oxygenase 1 Homo sapiens 160-176 29874784-8 2018 In addition, EESS increased not only expression, but also phosphorylation of nuclear factor-erythroid 2 related factor 2 (Nrf2), and promoted the expression of heme oxygenase-1 (HO-1), a critical target enzyme of Nrf2, but decreased the expression of kelch-like ECH-associated protein-1; however, the inhibition of HO-1 activity by zinc protoporphyrin abolished the antioxidant potential induced by EESS against H2O2-mediated oxidative stress. Hydrogen Peroxide 412-416 heme oxygenase 1 Homo sapiens 178-182 29051011-2 2018 Previously, we reported that heme oxygenase-1 can protect LECs from hydrogen peroxide (H2O2)-induced apoptosis and oxidative stress; however, to the best of our knowledge, these protection mechanisms have not yet been explained. Hydrogen Peroxide 87-91 heme oxygenase 1 Homo sapiens 29-45 28084593-12 2018 Overall, PB afforded cytoprotection by the Nrf2/HO-1 axis in H2O2-treated SH-SY5Y cells. Hydrogen Peroxide 61-65 heme oxygenase 1 Homo sapiens 48-52 29421327-1 2018 Our previous study has shown heme oxygenase-1 (HO-1) protects human lens epithelial cells (LECs) against H2O2-induced oxidative stress and apoptosis. Hydrogen Peroxide 105-109 heme oxygenase 1 Homo sapiens 29-45 29421327-1 2018 Our previous study has shown heme oxygenase-1 (HO-1) protects human lens epithelial cells (LECs) against H2O2-induced oxidative stress and apoptosis. Hydrogen Peroxide 105-109 heme oxygenase 1 Homo sapiens 47-51 29278300-6 2018 Pretreatment with the phenolic acids for 18 h results in a significant upregulation of the Nrf2-regulated antioxidant response proteins heme oxygenase 1 (HO-1) and glutamate-cysteine ligase modifier subunit (GCLM), following 6 h exposure to 2.5 mum H2 O2 . Hydrogen Peroxide 249-254 heme oxygenase 1 Homo sapiens 136-152 29278300-6 2018 Pretreatment with the phenolic acids for 18 h results in a significant upregulation of the Nrf2-regulated antioxidant response proteins heme oxygenase 1 (HO-1) and glutamate-cysteine ligase modifier subunit (GCLM), following 6 h exposure to 2.5 mum H2 O2 . Hydrogen Peroxide 249-254 heme oxygenase 1 Homo sapiens 154-158 29694447-8 2018 Furthermore, CRISPR/Cas9-mediated HO-1 depletion decreased 293T viability, growth, clonogenic potential and increased sensitivity to H2O2 treatment. Hydrogen Peroxide 133-137 heme oxygenase 1 Homo sapiens 34-38 29051011-2 2018 Previously, we reported that heme oxygenase-1 can protect LECs from hydrogen peroxide (H2O2)-induced apoptosis and oxidative stress; however, to the best of our knowledge, these protection mechanisms have not yet been explained. Hydrogen Peroxide 68-85 heme oxygenase 1 Homo sapiens 29-45 28790431-2 2017 The role played by the Nrf2/HO-1 system in favoring cell survival of neuroblastoma (NB) cells exposed to hydrogen peroxide (H2O2) has been investigated using undifferentiated or all-trans retinoic acid (ATRA) differentiated SH-SY5Y cells. Hydrogen Peroxide 105-122 heme oxygenase 1 Homo sapiens 28-32 28882558-5 2017 CA-mediated Nrf2/HO-1 activation reduced the level of reactive oxygen species and protected the hDPCs from H2O2-induced oxidative stress, which induces apoptosis. Hydrogen Peroxide 107-111 heme oxygenase 1 Homo sapiens 17-21 28583303-10 2017 HO-1, a major gene that is upregulated in RNA-sequencing using Keap1-silenced PHEMs, protected melanocytes against H2O2-induced cell death and upregulated MITF and beta-catenin expression. Hydrogen Peroxide 115-119 heme oxygenase 1 Homo sapiens 0-4 28912423-9 2017 In conclusion, FAEW counteracted H2O2-induced oxidative stress through KEAP1-NRF2/HO-1 pathway. Hydrogen Peroxide 33-37 heme oxygenase 1 Homo sapiens 82-86 28669729-7 2017 In addition, Nrf2 and its downstream target effectors (HO1, NQO1) were dramatically attenuated in MC3T3-E cells treatment with H2O2, while MAN can significantly increase the expression of Nrf2, HO1 and NQO1. Hydrogen Peroxide 127-131 heme oxygenase 1 Homo sapiens 55-58 28669729-7 2017 In addition, Nrf2 and its downstream target effectors (HO1, NQO1) were dramatically attenuated in MC3T3-E cells treatment with H2O2, while MAN can significantly increase the expression of Nrf2, HO1 and NQO1. Hydrogen Peroxide 127-131 heme oxygenase 1 Homo sapiens 194-197 28790431-4 2017 HO-1 silencing decreased undifferentiated cell viability when exposed to H2O2, proving the role of HO-1 in cell survival. Hydrogen Peroxide 73-77 heme oxygenase 1 Homo sapiens 0-4 28790431-5 2017 Conversely, ATRA differentiated cells exposed to H2O2 showed a significantly lower induction of HO-1, and only the supplementation with low doses of bilirubin (0,5-1 muM) restored viability. Hydrogen Peroxide 49-53 heme oxygenase 1 Homo sapiens 96-100 28790431-7 2017 Furthermore, Bach1 was displaced from HO-1 promoter in undifferentiated cells exposed to H2O2, enabling the binding of Nrf2. Hydrogen Peroxide 89-93 heme oxygenase 1 Homo sapiens 38-42 28790431-8 2017 On the contrary, in ATRA differentiated cells treated with H2O2, Bach1 displacement was impaired, preventing Nrf2 binding and limiting HO-1 transcription. Hydrogen Peroxide 59-63 heme oxygenase 1 Homo sapiens 135-139 28675952-4 2017 The expression of three antioxidant proteins, superoxide dismutase (SOD)-2, haem oxygenase (HO)-1, and sirtuin (SIRT) 1, was reduced upon H2O2 stimulation in miR-200c-overexpressed A549 cells. Hydrogen Peroxide 138-142 heme oxygenase 1 Homo sapiens 76-97 28224676-6 2017 RESULTS: Stimulation of hPVECs and human vaginal epithelial cell line, VK2/E6E7 with H2 O2 augmented the expression of Hb-alpha, Hb-beta, Nrf2, heme oxygenase-1 (HO-1), and reactive oxygen species (ROS). Hydrogen Peroxide 85-90 heme oxygenase 1 Homo sapiens 144-160 27725188-0 2016 Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway. Hydrogen Peroxide 97-114 heme oxygenase 1 Homo sapiens 19-35 28103505-0 2017 Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells. Hydrogen Peroxide 28-32 heme oxygenase 1 Homo sapiens 95-99 28694916-8 2017 To further investigate the mechanism of IAA, Nrf2-related antioxidant pathway was examined and the results showed that the level of Nrf2 and HO-1 expressions, stimulated by H2O2, decreased after treatment of IAA. Hydrogen Peroxide 173-177 heme oxygenase 1 Homo sapiens 141-145 28694916-9 2017 Moreover, IAA treatment protected hDPSCs against H2O2-induced oxidative stress via increased expression of Nrf2 and HO-1, mediated by the AKT pathway. Hydrogen Peroxide 49-53 heme oxygenase 1 Homo sapiens 116-120 27725188-12 2016 In conclusion, we provide evidence that OM transcriptionally induces HO-1 via AhR - and H2O2 - independent, but Nrf2 - dependent mechanisms. Hydrogen Peroxide 88-92 heme oxygenase 1 Homo sapiens 69-73 28513573-5 2017 Oxidative molecules were altered after the H2O2 exposure, whereby the signaling of Nrf2 was activated with an increase in its downstream effectors, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and gamma-glutamyl cysteine synthetase (gamma-GCS). Hydrogen Peroxide 43-47 heme oxygenase 1 Homo sapiens 148-164 28694915-3 2017 In the present study, we demonstrated that these halophenols exhibited significant protective effects against H2O2-induced injury in EA.hy926 cells by inhibition of apoptosis and ROS and TNF-alpha production, as well as induction of the upregulation of HO-1, the magnitude of which correlated with their cytoprotective actions. Hydrogen Peroxide 110-114 heme oxygenase 1 Homo sapiens 253-257 28255307-6 2017 Then, MSC or MSC-HO-1 was cocultured with retinal ganglion cells (RGC-5) in H2O2-simulated oxidative condition and their protection on RGC-5 was systemically valuated in vitro. Hydrogen Peroxide 76-80 heme oxygenase 1 Homo sapiens 17-21 28255307-7 2017 Compared with MSC, MSC-HO-1 significantly attenuated H2O2-induced injury of RGC-5, including decrease in cellular ROS level and apoptosis, activation of antiapoptotic proteins p-Akt and Bcl-2, and blockage of proapoptotic proteins cleaved caspase 3 and Bax. Hydrogen Peroxide 53-57 heme oxygenase 1 Homo sapiens 23-27 27725188-9 2016 Interestingly, the concentration at which OM induced HO-1 also increased H2O2 levels. Hydrogen Peroxide 73-77 heme oxygenase 1 Homo sapiens 53-57 27725188-10 2016 Furthermore, H2O2 independently augmented HO-1 expression. Hydrogen Peroxide 13-17 heme oxygenase 1 Homo sapiens 42-46 27418236-0 2016 Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling. Hydrogen Peroxide 42-46 heme oxygenase 1 Homo sapiens 91-95 27222475-1 2016 The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. Hydrogen Peroxide 191-196 heme oxygenase 1 Homo sapiens 134-150 27222475-1 2016 The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. Hydrogen Peroxide 191-196 heme oxygenase 1 Homo sapiens 152-157 27222475-1 2016 The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. Hydrogen Peroxide 191-196 heme oxygenase 1 Homo sapiens 161-165 27146412-9 2016 Moreover, Res which protected Caco-2 cells from H2O2-induced oxidative damage clearly reduced malondialdehyde level and intracellular reactive oxygen species accumulation, but increased the expression levels of superoxide dismutase and heme oxygenase-1 (HO-1). Hydrogen Peroxide 48-52 heme oxygenase 1 Homo sapiens 236-252 27146412-9 2016 Moreover, Res which protected Caco-2 cells from H2O2-induced oxidative damage clearly reduced malondialdehyde level and intracellular reactive oxygen species accumulation, but increased the expression levels of superoxide dismutase and heme oxygenase-1 (HO-1). Hydrogen Peroxide 48-52 heme oxygenase 1 Homo sapiens 254-258 26889770-3 2016 Our results showed that pretreatment with l-carnitine augmented Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells, although l-carnitine treatment alone had no effect on them. Hydrogen Peroxide 155-159 heme oxygenase 1 Homo sapiens 117-133 26969214-0 2016 Aspirin induces Nrf2-mediated transcriptional activation of haem oxygenase-1 in protection of human melanocytes from H2 O2 -induced oxidative stress. Hydrogen Peroxide 117-122 heme oxygenase 1 Homo sapiens 60-76 26969214-10 2016 In addition, knockdown of Nrf2 expression or pharmacological inhibition of HO-1 abrogated the protective action of ASA on melanocytes against H2 O2 -induced cytotoxicity and apoptosis. Hydrogen Peroxide 142-147 heme oxygenase 1 Homo sapiens 75-79 26969214-11 2016 These results suggest that ASA protects human melanocytes against H2 O2 -induced oxidative stress via Nrf2-driven transcriptional activation of HO-1. Hydrogen Peroxide 66-71 heme oxygenase 1 Homo sapiens 144-148 26889770-3 2016 Our results showed that pretreatment with l-carnitine augmented Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells, although l-carnitine treatment alone had no effect on them. Hydrogen Peroxide 155-159 heme oxygenase 1 Homo sapiens 135-139 26765462-5 2016 However, by pretreatment of zinc protoporphyrin (ZnPP), HO-1 inhibitor, ALA inhibition of ROS generation by H2O2 was abolished. Hydrogen Peroxide 108-112 heme oxygenase 1 Homo sapiens 56-60 26992777-0 2016 Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. Hydrogen Peroxide 80-97 heme oxygenase 1 Homo sapiens 0-16 26992777-0 2016 Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. Hydrogen Peroxide 80-97 heme oxygenase 1 Homo sapiens 18-22 26992777-0 2016 Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. Hydrogen Peroxide 99-103 heme oxygenase 1 Homo sapiens 0-16 26992777-0 2016 Heme oxygenase-1 (HO-1) protects human lens epithelial cells (SRA01/04) against hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis. Hydrogen Peroxide 99-103 heme oxygenase 1 Homo sapiens 18-22 26992777-1 2016 OBJECTIVES: This study aimed to investigate the protective role of heme oxygenase-1 (HO-1) in H2O2-induced oxidative stress and apoptosis in human lens epithelial cells (hLEC; SRA01/04). Hydrogen Peroxide 94-98 heme oxygenase 1 Homo sapiens 67-83 26992777-1 2016 OBJECTIVES: This study aimed to investigate the protective role of heme oxygenase-1 (HO-1) in H2O2-induced oxidative stress and apoptosis in human lens epithelial cells (hLEC; SRA01/04). Hydrogen Peroxide 94-98 heme oxygenase 1 Homo sapiens 85-89 26992777-12 2016 RESULTS: HO-1 significantly restored the cell viability under H2O2 injury via reducing the generation of ROS and increasing the levels of SOD and GSH activity. Hydrogen Peroxide 62-66 heme oxygenase 1 Homo sapiens 9-13 26992777-13 2016 Moreover, HO-1 also inhibited H2O2-induced caspase-8 and caspase-3 proteins, thus significantly reducing the apoptosis of SRA01/04. Hydrogen Peroxide 30-34 heme oxygenase 1 Homo sapiens 10-14 26992777-15 2016 CONCLUSIONS: These findings suggested that HO-1 protects human lens epithelial cells from H2O2-induced oxidant stress by upregulating antioxidant enzyme activity, reducing ROS generation, and thus inhibiting caspase family-dependent apoptosis. Hydrogen Peroxide 90-94 heme oxygenase 1 Homo sapiens 43-47 25615876-0 2015 Pretreatment with pPolyHb attenuates H2O2-induced endothelial cell injury through inhibition of JNK/p38 MAPK pathway by upregulation of heme oxygenase-1. Hydrogen Peroxide 37-41 heme oxygenase 1 Homo sapiens 136-152 26423448-6 2015 RNA interference of HO-1 makes the cell more susceptible to hydrogen peroxide, which can be rescued by forced expression of wild-type FHC but not mutants that lose the capacity of iron storage and ferroxidase activity. Hydrogen Peroxide 60-77 heme oxygenase 1 Homo sapiens 20-24 25917210-11 2015 CONCLUSIONS: These results demonstrated that geraniin induced Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death. Hydrogen Peroxide 210-214 heme oxygenase 1 Homo sapiens 110-114 25815672-8 2015 These data suggest that EPA protects against H(2)O(2)-induced oxidative stress in endothelial cells by activating Nrf2 and inducting HO-1 expression. Hydrogen Peroxide 45-53 heme oxygenase 1 Homo sapiens 133-137 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. Hydrogen Peroxide 226-230 heme oxygenase 1 Homo sapiens 51-67 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. Hydrogen Peroxide 226-230 heme oxygenase 1 Homo sapiens 69-73 25592228-8 2015 ZnPP, an HO-1 inhibitor, and transfection with HO-1 siRNA increased ROS levels and apoptosis, whereas hemin, an HO-1 activator, reduced ROS levels and apoptosis in H2O2-treated YZ5 cells. Hydrogen Peroxide 164-168 heme oxygenase 1 Homo sapiens 47-51 25652453-15 2015 In conclusion, our data suggest that 5-ALA and SFC protect HL-1 cells from H2O2-induced cardiac hypertrophy via activation of the MAPK/Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 75-79 heme oxygenase 1 Homo sapiens 140-144 25592228-7 2015 Transfection with ATM induced expression of HO-1 which was mediated by PKC-delta and NF-kappaB in H2O2-treated MOCK cells. Hydrogen Peroxide 98-102 heme oxygenase 1 Homo sapiens 44-48 25652453-0 2015 5-aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway. Hydrogen Peroxide 71-75 heme oxygenase 1 Homo sapiens 142-146 25592228-8 2015 ZnPP, an HO-1 inhibitor, and transfection with HO-1 siRNA increased ROS levels and apoptosis, whereas hemin, an HO-1 activator, reduced ROS levels and apoptosis in H2O2-treated YZ5 cells. Hydrogen Peroxide 164-168 heme oxygenase 1 Homo sapiens 47-51 25592228-9 2015 Rottlerin, a PKC-delta inhibitor, inhibited NF-kappaB activation and HO-1 expression in H2O2-treated YZ5 cells. Hydrogen Peroxide 88-92 heme oxygenase 1 Homo sapiens 69-73 25592228-11 2015 In addition, transfection with p65 siRNA increased ROS levels and DNA fragmentation, but decreased HO-1 protein levels in H2O2-treated YZ5 cells. Hydrogen Peroxide 122-126 heme oxygenase 1 Homo sapiens 99-103 24415199-5 2014 Our study demonstrated that DMSO pretreatment showed a cytoprotective effect against H2 O2 -induced oxidative damage (impaired cell viability, increased apopototic cells rate and caspase-3 level, and increased release of LDH and CK) and this process is partially mediated by HO-1 upregulation. Hydrogen Peroxide 85-90 heme oxygenase 1 Homo sapiens 275-279 24662764-3 2014 Our previous study showed that the nuclear factor E2-related factor 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HO-1) are crucial for melanocytes to cope with H2O2-induced oxidative damage. Hydrogen Peroxide 221-225 heme oxygenase 1 Homo sapiens 156-172 24662764-3 2014 Our previous study showed that the nuclear factor E2-related factor 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HO-1) are crucial for melanocytes to cope with H2O2-induced oxidative damage. Hydrogen Peroxide 221-225 heme oxygenase 1 Homo sapiens 174-178 24662764-5 2014 We found that vitiligo melanocytes exhibited hypersensitivity to H2O2-induced oxidative injury because of reduced Nrf2 nuclear translocation and transcriptional activity, which led to decreased HO-1 expression and aberrant redox balance. Hydrogen Peroxide 65-69 heme oxygenase 1 Homo sapiens 194-198 26269017-5 2015 For in vitro experiments, the transient-transfection assay was performed to explore the correlation between different lengths of (GT)n repeats and promoter activity by assessing the promoter activities of HO-1 gene in cultured Ecal09 cells treated with H2O2 by analysis of cariance. Hydrogen Peroxide 253-257 heme oxygenase 1 Homo sapiens 205-209 25176212-6 2014 The reactive oxygen species were detected in the HO-1-overexpression HEK293T cells and the normal cells after the adding of hydrogen peroxide. Hydrogen Peroxide 124-141 heme oxygenase 1 Homo sapiens 49-53 25176212-9 2014 The reactive oxygen species in the HO-1-overexpression HEK293T cells and human umbilical vein endothelial cells decreased obviously after exposure to hydrogen peroxide. Hydrogen Peroxide 150-167 heme oxygenase 1 Homo sapiens 35-39 24415199-0 2014 Dimethyl sulfoxide attenuates hydrogen peroxide-induced injury in cardiomyocytes via heme oxygenase-1. Hydrogen Peroxide 30-47 heme oxygenase 1 Homo sapiens 85-101 24415199-7 2014 This study reports for the first time that the cytoprotective effect of DMSO in cardiomyocytes is partially mediated by HO-1, which may further explain the mechanisms by which DMSO exerts cardioprotection on H2 O2 injury. Hydrogen Peroxide 208-213 heme oxygenase 1 Homo sapiens 120-124 24486344-7 2014 Both Nrf2 and HO-1 were required for Sal A-mediated cytoprotective effect, as Nrf2/HO-1 inhibition abolished Sal A-induced beneficial effects against H2O2. Hydrogen Peroxide 150-154 heme oxygenase 1 Homo sapiens 83-87 24500083-8 2014 Moreover, a regulatory role of ROS for HO-1 regulation in these cells is demonstrated by studies with the antioxidant N-acetylcysteine and exogenous hydrogenperoxide. Hydrogen Peroxide 149-165 heme oxygenase 1 Homo sapiens 39-43 25337552-9 2013 HO-1 inhibitor ZnPP attenuated the protective effect of morin against H2O2-induced cytotoxicity. Hydrogen Peroxide 70-74 heme oxygenase 1 Homo sapiens 0-4 23418094-0 2013 Caffeoylserotonin protects human keratinocyte HaCaT cells against H2 O2 -induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 pathway. Hydrogen Peroxide 66-71 heme oxygenase 1 Homo sapiens 136-140 24323422-9 2013 However, ferrous ion can react with hydrogen peroxide to produce pro-oxidant hydroxyl radicals which may explain the harmful role of HO-1 in intracerebral hemorrhage. Hydrogen Peroxide 36-53 heme oxygenase 1 Homo sapiens 133-137 23350672-4 2013 Heme-hemopexin is relatively resistant to damage by ROS and retains its ability to induce the cytoprotective HO1 after exposure to tert-butylhydroperoxide, although induction is impaired, but not eliminated, by exposure to high concentrations of H(2)O(2) in vitro. Hydrogen Peroxide 246-254 heme oxygenase 1 Homo sapiens 109-112 23691207-0 2013 Resveratrol protects C6 astrocyte cell line against hydrogen peroxide-induced oxidative stress through heme oxygenase 1. Hydrogen Peroxide 52-69 heme oxygenase 1 Homo sapiens 103-119 23328493-7 2013 Furthermore, the protective effect of DSC on H2O2-induced cell death was abolished by HO-1 inhibitor ZnPP, but was mimicked by carbon monoxide-releasing moiety CORM-3 or HO-1 by-product bilirubin. Hydrogen Peroxide 45-49 heme oxygenase 1 Homo sapiens 86-90 23691207-8 2013 In addition, HO1 signaling pathway is involved in the protective effect of resveratrol against H2O2-induced oxidative damage in astroglial cells. Hydrogen Peroxide 95-99 heme oxygenase 1 Homo sapiens 13-16 23261939-6 2013 The heme oxygenase-1 (HO-1) induction in response to H2O2 and MPP(+) treatment was impaired by the overexpression of the PINK1 P209A mutant. Hydrogen Peroxide 53-57 heme oxygenase 1 Homo sapiens 4-20 23261939-6 2013 The heme oxygenase-1 (HO-1) induction in response to H2O2 and MPP(+) treatment was impaired by the overexpression of the PINK1 P209A mutant. Hydrogen Peroxide 53-57 heme oxygenase 1 Homo sapiens 22-26 23328493-8 2013 Finally, DSC inhibited H2O2-induced changes of Bcl-2, Bax, and caspase-3 expression, and all of these effects were reversed by HO-1 silencing. Hydrogen Peroxide 23-27 heme oxygenase 1 Homo sapiens 127-131 22989377-3 2013 We investigated HO-1-overexpressing A549 cells and find that, as expected, HO-1-overexpressing cells are resistant to killing by hydrogen peroxide. Hydrogen Peroxide 129-146 heme oxygenase 1 Homo sapiens 75-79 23318726-0 2013 Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions. Hydrogen Peroxide 45-62 heme oxygenase 1 Homo sapiens 117-133 23318726-8 2013 In addition, butein-dependent HO-1 expression was required for the inhibition of H2O2-induced cell death and ROS generation. Hydrogen Peroxide 81-85 heme oxygenase 1 Homo sapiens 30-34 23143154-13 2013 Quercetin also reduced the CSE- and H(2)O(2)-induced upregulation of ROS and HO-1 protein in differentiated OFs and preadipocyte OFs. Hydrogen Peroxide 36-44 heme oxygenase 1 Homo sapiens 77-81 23131562-7 2013 Also, pretreatment with omega3-PUFA prevented H(2)O(2)-induced cytotoxicity in a HO-1 dependent manner. Hydrogen Peroxide 46-54 heme oxygenase 1 Homo sapiens 81-85 23255485-6 2013 In Caco-2 cells, treatment with genistein markedly attenuated H(2)O(2) -induced peroxide formation; this amelioration was reversed by buthionine sulfoximine(GCLC inhibitor) and zinc protoporphyrin(HO-1 inhibitor). Hydrogen Peroxide 62-70 heme oxygenase 1 Homo sapiens 197-201 23221079-8 2013 In contrast, HO-1 protein was upregulated by treatment with both hydrogen peroxide and light. Hydrogen Peroxide 65-82 heme oxygenase 1 Homo sapiens 13-17 23569422-0 2013 Propofol-induced protection of SH-SY5Y cells against hydrogen peroxide is associated with the HO-1 via the ERK pathway. Hydrogen Peroxide 53-70 heme oxygenase 1 Homo sapiens 94-98 23087099-6 2013 Such upregulated HO-1 levels were effective in conferring protection against H(2)O(2)-induced cell death and in promoting the proangiogenic phenotype of HMEC-1 cells. Hydrogen Peroxide 77-85 heme oxygenase 1 Homo sapiens 17-21 21552291-8 2011 Although p53 and its classical targets such as p21 and Mdm2 are activated by both H(2)O(2) and CDDP, we found that the expression of haeme-oxygenase-1 (HO-1)-an antioxidant and antiapoptotic protein-was directly induced only upon H(2)O(2) treatment in a p53-dependent manner. Hydrogen Peroxide 82-90 heme oxygenase 1 Homo sapiens 152-156 22392462-0 2012 Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells. Hydrogen Peroxide 21-38 heme oxygenase 1 Homo sapiens 93-109 22392462-10 2012 CONCLUSION: Cur protects human intestinal epithelial cells against H(2)O(2)-induced disruption of TJ and barrier dysfunction via the HO-1 pathway. Hydrogen Peroxide 67-75 heme oxygenase 1 Homo sapiens 133-137 21997482-10 2012 1,2-NQ exposure also causes marked expression of HO-1 that appears to be enhanced by suppression of H2O2. Hydrogen Peroxide 100-104 heme oxygenase 1 Homo sapiens 49-53 22142471-6 2012 The relevance of the Nrf2/HO-1 axis to antioxidant protection was further demonstrated by the finding that the HO-1 inhibitor stannous-mesoporphyrin abolished protection against hydrogen peroxide conferred by NDGA. Hydrogen Peroxide 178-195 heme oxygenase 1 Homo sapiens 26-30 22142471-6 2012 The relevance of the Nrf2/HO-1 axis to antioxidant protection was further demonstrated by the finding that the HO-1 inhibitor stannous-mesoporphyrin abolished protection against hydrogen peroxide conferred by NDGA. Hydrogen Peroxide 178-195 heme oxygenase 1 Homo sapiens 111-115 23071605-4 2012 Transduction of NPCCs with adenovirus containing hHO-1 gene significantly reduced apoptosis compared with the GFP-expressing adenovirus control after treatment with either hydrogen peroxide or hTNF-alpha and cycloheximide. Hydrogen Peroxide 172-189 heme oxygenase 1 Homo sapiens 49-54 23071605-9 2012 As expected, fibroblasts derived from the hHO-1 transgenic pigs were significantly resistant to both hydrogen peroxide damage and hTNF-alpha and cycloheximide-mediated apoptosis when compared with wild-type fibroblasts. Hydrogen Peroxide 101-118 heme oxygenase 1 Homo sapiens 42-47 21552291-8 2011 Although p53 and its classical targets such as p21 and Mdm2 are activated by both H(2)O(2) and CDDP, we found that the expression of haeme-oxygenase-1 (HO-1)-an antioxidant and antiapoptotic protein-was directly induced only upon H(2)O(2) treatment in a p53-dependent manner. Hydrogen Peroxide 230-238 heme oxygenase 1 Homo sapiens 133-150 21552291-8 2011 Although p53 and its classical targets such as p21 and Mdm2 are activated by both H(2)O(2) and CDDP, we found that the expression of haeme-oxygenase-1 (HO-1)-an antioxidant and antiapoptotic protein-was directly induced only upon H(2)O(2) treatment in a p53-dependent manner. Hydrogen Peroxide 230-238 heme oxygenase 1 Homo sapiens 152-156 21552291-11 2011 Finally, H(2)O(2)-mediated cell death was rescued significantly in p53-deficient cells by antioxidant treatment, as well as by bilirubin, a by-product of HO-1 metabolism. Hydrogen Peroxide 9-17 heme oxygenase 1 Homo sapiens 154-158 21172416-9 2011 siRNA knock down of HO-1, but not NQO1, enhanced Cd induced H(2)O(2) production and Cd induced toxicity. Hydrogen Peroxide 60-68 heme oxygenase 1 Homo sapiens 20-24 21520244-6 2011 In addition, fisetin pretreatment reduced hydrogen peroxide (H(2)O(2))-induced cell death, and this effect was reversed by ZnPP, an inhibitor of HO-1. Hydrogen Peroxide 42-59 heme oxygenase 1 Homo sapiens 145-149 21520244-6 2011 In addition, fisetin pretreatment reduced hydrogen peroxide (H(2)O(2))-induced cell death, and this effect was reversed by ZnPP, an inhibitor of HO-1. Hydrogen Peroxide 61-69 heme oxygenase 1 Homo sapiens 145-149 21520244-7 2011 In summary, these findings suggest that induction of HO-1 expression via Nrf2 activation may contribute to the cytoprotection exerted by fisetin against H(2)O(2) -induced oxidative stress in HUVECs. Hydrogen Peroxide 153-161 heme oxygenase 1 Homo sapiens 53-57 21412259-0 2011 Heme oxygenase-1 protects human melanocytes from H2O2-induced oxidative stress via the Nrf2-ARE pathway. Hydrogen Peroxide 49-53 heme oxygenase 1 Homo sapiens 0-16 21412259-8 2011 In addition, the H(2)O(2)-induced Nrf2-ARE/HO-1 pathway was confirmed in primary cultured human melanocytes by examining the expression and translocation of Nrf2 and HO-1. Hydrogen Peroxide 17-25 heme oxygenase 1 Homo sapiens 43-47 21412259-8 2011 In addition, the H(2)O(2)-induced Nrf2-ARE/HO-1 pathway was confirmed in primary cultured human melanocytes by examining the expression and translocation of Nrf2 and HO-1. Hydrogen Peroxide 17-25 heme oxygenase 1 Homo sapiens 166-170 21412259-9 2011 These data suggested that regulation of the Nrf2/HO-1 pathway can reduce H(2)O(2)-induced oxidative damage in human melanocytes. Hydrogen Peroxide 73-81 heme oxygenase 1 Homo sapiens 49-53 21199573-9 2011 Addition of resveratrol to the cell culture medium produced relatively low levels of hydrogen peroxide which may be a positive hormetic redox-signal for Nrf2 dependent gene expression thereby driving heme oxygenase-1 induction. Hydrogen Peroxide 85-102 heme oxygenase 1 Homo sapiens 200-216 20563825-3 2011 Astroglial induction of the Hmox1 gene by beta-amyloid, pro-inflammatory cytokines and hydrogen peroxide promotes mitochondrial sequestration of non-transferrin iron and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergy failure amply documented in AD-affected neural tissues. Hydrogen Peroxide 87-104 heme oxygenase 1 Homo sapiens 28-33 21099244-5 2011 Additionally, depletion of BLVRA reduced the H2O2-dependent induction of heme oxygenase-1 (HO-1) in young HDFs, but not in senescent cells, suggesting an aging-dependent differential modulation of responses to oxidative stress. Hydrogen Peroxide 45-49 heme oxygenase 1 Homo sapiens 73-89 20511222-6 2010 Treatment with hydrogen peroxide (H(2)O(2)) enhances the nuclear colocalization of NRF2 and NRP/B and induces heme oxygenase 1 (HO1). Hydrogen Peroxide 15-32 heme oxygenase 1 Homo sapiens 110-126 20950636-7 2011 ATO, on the other hand, induced heme oxygenase-1 (HO-1) to catalyze heme degradation, thereby provided ferrous iron for EGCG-induced hydrogen peroxide to precede Fenton reaction, which in turn generated deleterious reactive oxygen species to damage cell. Hydrogen Peroxide 133-150 heme oxygenase 1 Homo sapiens 32-48 20950636-7 2011 ATO, on the other hand, induced heme oxygenase-1 (HO-1) to catalyze heme degradation, thereby provided ferrous iron for EGCG-induced hydrogen peroxide to precede Fenton reaction, which in turn generated deleterious reactive oxygen species to damage cell. Hydrogen Peroxide 133-150 heme oxygenase 1 Homo sapiens 50-54 21112485-11 2010 24-hour treatment with 500 mumol/L H2O2 induced remarkable up-regulation of HO-1 and PARP-1 in ARPE-19 cells. Hydrogen Peroxide 35-39 heme oxygenase 1 Homo sapiens 76-80 20615462-7 2010 Inhibition of gamma-GCS or HO-1 prevented the inhibitory effect of FGF9 on MPP(+)-induced H(2)O(2) production and death in mesencephalic dopaminergic and cortical neurons. Hydrogen Peroxide 90-98 heme oxygenase 1 Homo sapiens 27-31 21223723-8 2010 The HO-1 mRNA expression and the generation of intracellular ROS were downregulated at a specific concentration of H2O2 in the ALDH2 gene transfected group. Hydrogen Peroxide 115-119 heme oxygenase 1 Homo sapiens 4-8 20511222-6 2010 Treatment with hydrogen peroxide (H(2)O(2)) enhances the nuclear colocalization of NRF2 and NRP/B and induces heme oxygenase 1 (HO1). Hydrogen Peroxide 15-32 heme oxygenase 1 Homo sapiens 128-131 20511222-6 2010 Treatment with hydrogen peroxide (H(2)O(2)) enhances the nuclear colocalization of NRF2 and NRP/B and induces heme oxygenase 1 (HO1). Hydrogen Peroxide 34-42 heme oxygenase 1 Homo sapiens 110-126 20511222-6 2010 Treatment with hydrogen peroxide (H(2)O(2)) enhances the nuclear colocalization of NRF2 and NRP/B and induces heme oxygenase 1 (HO1). Hydrogen Peroxide 34-42 heme oxygenase 1 Homo sapiens 128-131 20508205-5 2010 The presence of the S allele led to higher basal HO-1 expression and stronger induction in response to cobalt protoporphyrin, prostaglandin-J(2), hydrogen peroxide, and lipopolysaccharide. Hydrogen Peroxide 146-163 heme oxygenase 1 Homo sapiens 49-53 20806083-0 2010 Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression. Hydrogen Peroxide 57-61 heme oxygenase 1 Homo sapiens 122-126 20498371-8 2010 Also, 8-nitro-cGMP caused S-guanylation of KEAP1 in cells, which led to Nrf2 activation and subsequent induction of antioxidant enzymes, including heme oxygenase-1; thus, 8-nitro-cGMP protected cells against cytotoxic effects of hydrogen peroxide. Hydrogen Peroxide 229-246 heme oxygenase 1 Homo sapiens 147-163 20501657-3 2010 Oxidative stress induced by H(2)O(2) led to an increase in MARE activity and expression of heme oxygenase-1 (HO-1), an inducible antioxidant defense enzyme. Hydrogen Peroxide 28-36 heme oxygenase 1 Homo sapiens 91-107 20370564-3 2010 Cell treatment with H(2)O(2) (0.5 mM) resulted in a time- and dose-dependent response of HOX-1 and COX-2 mRNA and protein levels, with ERK1/2, p38-MAPK and MSK1 found to mediate these effects. Hydrogen Peroxide 20-28 heme oxygenase 1 Homo sapiens 89-94 20501657-3 2010 Oxidative stress induced by H(2)O(2) led to an increase in MARE activity and expression of heme oxygenase-1 (HO-1), an inducible antioxidant defense enzyme. Hydrogen Peroxide 28-36 heme oxygenase 1 Homo sapiens 109-113 20501657-6 2010 In contrast, Bach1 overexpression abolished HO-1 induction by H(2)O(2), which led to increased reactive oxygen species accumulation. Hydrogen Peroxide 62-70 heme oxygenase 1 Homo sapiens 44-48 20170153-0 2010 Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. Hydrogen Peroxide 53-70 heme oxygenase 1 Homo sapiens 23-39 19961840-0 2010 Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Hydrogen Peroxide 21-38 heme oxygenase 1 Homo sapiens 108-124 19245827-10 2009 In summary, these findings suggest that induction of HO-1 through a Smad-dependent mechanism is responsible for the cytoprotective effect of BMP6 in H(2)O(2)-mediated renal cell injury. Hydrogen Peroxide 149-157 heme oxygenase 1 Homo sapiens 53-57 20700711-3 2010 Quantitative PCR analysis as well as Western blotting demonstrated a specific upregulation of Hsp70 mRNA and protein after heat shock, while heme oxygenase 1 (HO1 or Hsp32) mRNA and protein was specifically upregulated following H2O2-induced oxidative stress. Hydrogen Peroxide 229-233 heme oxygenase 1 Homo sapiens 141-157 20700711-3 2010 Quantitative PCR analysis as well as Western blotting demonstrated a specific upregulation of Hsp70 mRNA and protein after heat shock, while heme oxygenase 1 (HO1 or Hsp32) mRNA and protein was specifically upregulated following H2O2-induced oxidative stress. Hydrogen Peroxide 229-233 heme oxygenase 1 Homo sapiens 159-162 20700711-3 2010 Quantitative PCR analysis as well as Western blotting demonstrated a specific upregulation of Hsp70 mRNA and protein after heat shock, while heme oxygenase 1 (HO1 or Hsp32) mRNA and protein was specifically upregulated following H2O2-induced oxidative stress. Hydrogen Peroxide 229-233 heme oxygenase 1 Homo sapiens 166-171 19131520-9 2009 These results not only show that HO-1-generated hydrogen peroxide leads to a decrease in HO-1 activity but also provide for a chemically defined system to be used to examine the function of full-length HO-1 in a membrane environment. Hydrogen Peroxide 48-65 heme oxygenase 1 Homo sapiens 33-37 19131520-9 2009 These results not only show that HO-1-generated hydrogen peroxide leads to a decrease in HO-1 activity but also provide for a chemically defined system to be used to examine the function of full-length HO-1 in a membrane environment. Hydrogen Peroxide 48-65 heme oxygenase 1 Homo sapiens 89-93 19131520-9 2009 These results not only show that HO-1-generated hydrogen peroxide leads to a decrease in HO-1 activity but also provide for a chemically defined system to be used to examine the function of full-length HO-1 in a membrane environment. Hydrogen Peroxide 48-65 heme oxygenase 1 Homo sapiens 89-93 18631371-6 2008 Additionally, H(2)O(2) treatment induced upregulation of CHOP, GRP78 and several representative endoplasmic reticulum (ER) stress-responsive proteins, including heme oxygenase-1. Hydrogen Peroxide 14-22 heme oxygenase 1 Homo sapiens 161-177 18952926-0 2009 Reactivation of optic nerve head astrocytes by TGF-beta2 and H2O2 is accompanied by increased Hsp32 and Hsp47 expression. Hydrogen Peroxide 61-65 heme oxygenase 1 Homo sapiens 94-99 18952926-8 2009 Exposure of the cells to H(2)O(2) could increase both Hsp32 and -47. Hydrogen Peroxide 25-33 heme oxygenase 1 Homo sapiens 54-59 21152244-9 2009 VEGF, MMP9 and HO-1 transcript levels were increased in ARPE19 cells under H(2)O(2) - induced oxidative stress. Hydrogen Peroxide 75-83 heme oxygenase 1 Homo sapiens 15-19 18776993-2 2008 The HO-1 isozyme is induced by a variety of factors such as heat, heme, ischemia, and hydrogen peroxide. Hydrogen Peroxide 86-103 heme oxygenase 1 Homo sapiens 4-8 18357586-3 2008 In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression. Hydrogen Peroxide 13-17 heme oxygenase 1 Homo sapiens 96-100 18712632-4 2008 The results show that alpha(1)-microglobulin prevents intracellular oxidation and up-regulation of heme oxygenase-1 induced by heme, hydrogen peroxide and Fenton reaction-generated hydroxyl radicals in the culture medium. Hydrogen Peroxide 133-150 heme oxygenase 1 Homo sapiens 99-115 18634931-0 2008 Hydrogen peroxide induces heme oxygenase-1 and dentin sialophosphoprotein mRNA in human pulp cells. Hydrogen Peroxide 0-17 heme oxygenase 1 Homo sapiens 26-42 18634931-1 2008 Although the induction of heme oxygenase-1 (HO-1) by hydrogen peroxide (H2O2) has been reported, the HO-1 and odontoblastic differentiation-inducing effects against H2O2 have not been clarified in human pulp cells. Hydrogen Peroxide 53-70 heme oxygenase 1 Homo sapiens 26-42 18634931-1 2008 Although the induction of heme oxygenase-1 (HO-1) by hydrogen peroxide (H2O2) has been reported, the HO-1 and odontoblastic differentiation-inducing effects against H2O2 have not been clarified in human pulp cells. Hydrogen Peroxide 53-70 heme oxygenase 1 Homo sapiens 44-48 18634931-1 2008 Although the induction of heme oxygenase-1 (HO-1) by hydrogen peroxide (H2O2) has been reported, the HO-1 and odontoblastic differentiation-inducing effects against H2O2 have not been clarified in human pulp cells. Hydrogen Peroxide 72-76 heme oxygenase 1 Homo sapiens 26-42 18634931-1 2008 Although the induction of heme oxygenase-1 (HO-1) by hydrogen peroxide (H2O2) has been reported, the HO-1 and odontoblastic differentiation-inducing effects against H2O2 have not been clarified in human pulp cells. Hydrogen Peroxide 72-76 heme oxygenase 1 Homo sapiens 44-48 18634931-3 2008 H2O2 decreased cell viability but increased HO-1 and DSPP expression in a concentration- and time-dependent manner. Hydrogen Peroxide 0-4 heme oxygenase 1 Homo sapiens 44-48 18634931-4 2008 Antioxidants and inhibitors of HO-1, phosphatidylinositol-3"-kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase blocked H2O2-induced cytotoxicity and the expression of HO-1 and DSPP mRNA in pulp cells. Hydrogen Peroxide 157-161 heme oxygenase 1 Homo sapiens 31-35 18634931-4 2008 Antioxidants and inhibitors of HO-1, phosphatidylinositol-3"-kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase blocked H2O2-induced cytotoxicity and the expression of HO-1 and DSPP mRNA in pulp cells. Hydrogen Peroxide 157-161 heme oxygenase 1 Homo sapiens 205-209 18634931-5 2008 These data suggest that the induction of HO-1 by H2O2 in pulp cells plays a protective role against the cytotoxic effects of H2O2 and stimulates DSPP expression, resulting in premature odontoblast differentiation through pathways that involve phosphatidylinositol-3"-kinase, p38, and extracellular signal-regulated kinase. Hydrogen Peroxide 49-53 heme oxygenase 1 Homo sapiens 41-45 18634931-5 2008 These data suggest that the induction of HO-1 by H2O2 in pulp cells plays a protective role against the cytotoxic effects of H2O2 and stimulates DSPP expression, resulting in premature odontoblast differentiation through pathways that involve phosphatidylinositol-3"-kinase, p38, and extracellular signal-regulated kinase. Hydrogen Peroxide 125-129 heme oxygenase 1 Homo sapiens 41-45 18487208-12 2008 The addition of NADPH-P450 reductase to the H2O2-generated hHO-1-isoporphyrin complex produced alpha-biliverdin, confirming its role as a reaction intermediate. Hydrogen Peroxide 44-48 heme oxygenase 1 Homo sapiens 59-64 18691515-7 2008 Dermal fibroblasts exposed to 25 micromol/L ferulic acid ethyl ester in the presence of 500 micromol/L hydrogen peroxide showed an increased level of both heme oxygenase-1 and heat shock protein-70 compared with dermal fibroblasts treated with hydrogen peroxide alone. Hydrogen Peroxide 103-120 heme oxygenase 1 Homo sapiens 155-197 17559630-0 2007 Defense mechanism of heme oxygenase-1 against cytotoxic and receptor activator of nuclear factor-kappaB ligand inducing effects of hydrogen peroxide in human periodontal ligament cells. Hydrogen Peroxide 131-148 heme oxygenase 1 Homo sapiens 21-37 18360685-8 2008 A minimal HO-1-inducing formulation was prepared and showed significant cytoprotection against H2O2-induced oxidative stress. Hydrogen Peroxide 95-99 heme oxygenase 1 Homo sapiens 10-14 17559630-6 2007 CONCLUSION: These data suggest that heme oxygenase-1 induction plays a protective role in periodontal ligament cells against the cytotoxic and RANKL-inducing effects of H2O2, through multiple signaling pathways. Hydrogen Peroxide 169-173 heme oxygenase 1 Homo sapiens 36-52 17559630-1 2007 BACKGROUND AND OBJECTIVE: Although induction of heme oxygenase-1 by H2O2 has been reported, the protective role of heme oxygenase-1 against the cytotoxic and osteoclastogenic effects of H2O2 have not been elucidated in human periodontal ligament cells. Hydrogen Peroxide 68-72 heme oxygenase 1 Homo sapiens 48-64 17559630-1 2007 BACKGROUND AND OBJECTIVE: Although induction of heme oxygenase-1 by H2O2 has been reported, the protective role of heme oxygenase-1 against the cytotoxic and osteoclastogenic effects of H2O2 have not been elucidated in human periodontal ligament cells. Hydrogen Peroxide 186-190 heme oxygenase 1 Homo sapiens 115-131 17559630-2 2007 The aim of this work was to investigate the defense mechanism of heme oxygenase-1 on H2O2-induced cytotoxicity and to analyze the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin as markers for osteoclast differentiation in periodontal ligament cells. Hydrogen Peroxide 85-89 heme oxygenase 1 Homo sapiens 65-81 17559630-4 2007 RESULTS: H2O2 produced a cytotoxic effect by reducing the cell viability and enhancing the expression of heme oxygenase-1 and RANKL mRNAs in a concentration- and time-dependent manner. Hydrogen Peroxide 9-13 heme oxygenase 1 Homo sapiens 105-121 17430897-9 2007 Nevertheless, nuclear HO-1 protected cells against hydrogen peroxide-mediated injury equally as well as cytoplasmic HO-1. Hydrogen Peroxide 51-68 heme oxygenase 1 Homo sapiens 22-26 16814105-8 2006 Inhibition of HO-1 with Sn protoporphyrin IX and blockage of Sp-1-mediatied upregulation of HO-1 with mithramycin attenuated antioxidant and cytoprotective functions of NGF against hydrogen peroxide. Hydrogen Peroxide 181-198 heme oxygenase 1 Homo sapiens 92-96 17339489-8 2007 The same low H(2)O(2) concentration also induced the anti-inflammatory gene coding for heme oxygenase-1 (HO-1) and IL-6. Hydrogen Peroxide 13-21 heme oxygenase 1 Homo sapiens 87-103 17339489-8 2007 The same low H(2)O(2) concentration also induced the anti-inflammatory gene coding for heme oxygenase-1 (HO-1) and IL-6. Hydrogen Peroxide 13-21 heme oxygenase 1 Homo sapiens 105-109 16840713-0 2006 Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Hydrogen Peroxide 54-58 heme oxygenase 1 Homo sapiens 117-129 16840713-9 2006 HO-1 reduced H2O2-induced OS and apoptosis. Hydrogen Peroxide 13-17 heme oxygenase 1 Homo sapiens 0-4 16840713-10 2006 Akt knockdown removed the protective effect of HO-1 on delta psi(m) during exposure to H2O2. Hydrogen Peroxide 87-91 heme oxygenase 1 Homo sapiens 47-51 16840713-12 2006 Inhibition of PI3K-Akt reduced induction of HO-1 protein expression by H2O2 and blocked its anti-apoptotic effects. Hydrogen Peroxide 71-75 heme oxygenase 1 Homo sapiens 44-48 16298686-4 2005 In neuron-glia cultures, we found that H2O2, a product of dopamine metabolism, or l-3,4-dihydroxyphenylalanine (L-DOPA), the dopamine precursor used in the therapy of PD, induced a fast up-regulation of HO-1 mRNA and protein levels, followed by a secondary down-regulation. Hydrogen Peroxide 39-43 heme oxygenase 1 Homo sapiens 203-207 16378625-10 2006 On the other hand, pretreatment of these cells with EGCG exerts significant cytoprotective effects against H2O2, suggesting that the induction of HO-1 is an important component in the protection against oxidative stress. Hydrogen Peroxide 107-111 heme oxygenase 1 Homo sapiens 146-150 16337498-7 2006 Coincubation of C (0.5-1.0-2.0 mM), AC (0.1-0.2-0.4 mM) and PC (0.05-0.1-0.2 mM) with H2O2 further increased HO-1 gene expression and not only normalized vs. H2O2 but even increased vs. basal ecNOS mRNA. Hydrogen Peroxide 86-90 heme oxygenase 1 Homo sapiens 109-113 16298686-5 2005 H2O2 and L-DOPA also increased HO-1 expression in astrocyte cultures, but with a delayed time course in H2O2-treated cultures. Hydrogen Peroxide 0-4 heme oxygenase 1 Homo sapiens 31-35 16298686-7 2005 Because exogenously applied GDNF prevented HO-1 up-regulation in cultures treated with H2O2 or l-DOPA, and antibody neutralization of GDNF prevented the secondary HO-1 down-regulation observed in neuron-glia cultures, we propose that GDNF negatively modulates HO-1 expression induced by oxidative stress. Hydrogen Peroxide 87-91 heme oxygenase 1 Homo sapiens 43-47 15542064-11 2004 The increase in HO-1 produced by DAS protected the HepG2 cells against toxicity by hydrogen peroxide or arachidonic acid. Hydrogen Peroxide 83-100 heme oxygenase 1 Homo sapiens 16-20 15589375-0 2005 Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. Hydrogen Peroxide 56-69 heme oxygenase 1 Homo sapiens 34-47 15207648-7 2004 We found that HO-1 induction in astrocytes is increased by combined exposure to Pb2+ and many other stresses, including heat, nitric oxide, H2O2, and superoxide. Hydrogen Peroxide 140-144 heme oxygenase 1 Homo sapiens 14-18 15378604-4 2004 Effect of HO-1 production on the cell injury induced by hydrogen peroxide was evaluated after hemin stimulation and after HO-1 gene transfection. Hydrogen Peroxide 56-73 heme oxygenase 1 Homo sapiens 10-14 15213272-5 2004 The presence of catalase significantly prevented the upregulation of HO-1 in SSAT overexpressing cells, indicating that generation of H2O2 is partially responsible for the induction of oxidative stress. Hydrogen Peroxide 134-138 heme oxygenase 1 Homo sapiens 69-73 11930234-5 2002 It was found that the HO-1 transfected-VSMCs presented dominant resistance to toxicity produced by exposure to H2O2, as a significant protective effect of HO-1 marked by cell survival and LDH leakage was observed when 200, 400 and 600 micromol/L of H2O2 were used. Hydrogen Peroxide 111-115 heme oxygenase 1 Homo sapiens 22-26 12118938-4 2002 However, the resistance of the HO-1 transfected VSMC against H2O2 was significantly raised. Hydrogen Peroxide 61-65 heme oxygenase 1 Homo sapiens 31-35 11930234-5 2002 It was found that the HO-1 transfected-VSMCs presented dominant resistance to toxicity produced by exposure to H2O2, as a significant protective effect of HO-1 marked by cell survival and LDH leakage was observed when 200, 400 and 600 micromol/L of H2O2 were used. Hydrogen Peroxide 111-115 heme oxygenase 1 Homo sapiens 155-159 11930234-5 2002 It was found that the HO-1 transfected-VSMCs presented dominant resistance to toxicity produced by exposure to H2O2, as a significant protective effect of HO-1 marked by cell survival and LDH leakage was observed when 200, 400 and 600 micromol/L of H2O2 were used. Hydrogen Peroxide 249-253 heme oxygenase 1 Homo sapiens 22-26 11171043-9 2001 H(2)O(2) also activated the CdRE-binding activity, and pretreatment with N-acetyl-L-cysteine, which replenishes the intracellular levels of GSH, suppressed, in TS-treated cells, both the CdRE-binding activity and the increased HO-1 expression. Hydrogen Peroxide 0-8 heme oxygenase 1 Homo sapiens 227-231 11581219-6 2001 Differentiated ARPE-19 cells treated with tBH or H2O2 resulted in upregulation of the HO-1 and FGFR1 transcripts. Hydrogen Peroxide 49-53 heme oxygenase 1 Homo sapiens 86-90 10425949-2 1999 Synthesis of the enzyme heme oxygenase-1 (HO-1) is increased after exposure of eukaryotic cells to conditions of oxidative stress (including H2O2) as a defense against the damaging effects of free radicals. Hydrogen Peroxide 141-145 heme oxygenase 1 Homo sapiens 24-40 10631150-8 2000 H2O2 exposure up-regulated the transcriptional activity of the HO-1 promoter/luciferase fusion genes with (GT)16 or (GT)20 but did not do so with (GT)29 or (GT)38. Hydrogen Peroxide 0-4 heme oxygenase 1 Homo sapiens 63-67 10513606-10 1999 Strain treatment, similar to H2O2 exposure, induced HO-1 expression in a time-dependent manner. Hydrogen Peroxide 29-33 heme oxygenase 1 Homo sapiens 52-56 10644516-6 2000 In contrast, HO-1 induction by the oxidants, H(2)O(2) and carbonyl cyanide m-chlorophenylhydrazone (CCCP) was significantly attenuated in the presence of free radical scavengers. Hydrogen Peroxide 45-53 heme oxygenase 1 Homo sapiens 13-17 10460761-9 1999 These findings suggest that HO-1 induction provides protection against H(2)O(2)-induced injury of the cultured human airway epithelial cells in part via the HO-bilirubin pathway. Hydrogen Peroxide 71-79 heme oxygenase 1 Homo sapiens 28-32 10409239-7 1999 The protective effect of enhancement of HO-1 activity against heme and H(2)O(2) was reversed by pretreatment with stannic mesoporphyrin, a competitive inhibitor of HO. Hydrogen Peroxide 71-79 heme oxygenase 1 Homo sapiens 40-44 10425949-2 1999 Synthesis of the enzyme heme oxygenase-1 (HO-1) is increased after exposure of eukaryotic cells to conditions of oxidative stress (including H2O2) as a defense against the damaging effects of free radicals. Hydrogen Peroxide 141-145 heme oxygenase 1 Homo sapiens 42-46 10218639-1 1999 Induction of heme oxygenase 1 transcription and enzymatic activity is a common response after exposure of cells to various forms of oxidative stress including ultraviolet A radiation (UVA) and hydrogen peroxide. Hydrogen Peroxide 193-210 heme oxygenase 1 Homo sapiens 13-29 10218639-4 1999 We also demonstrate a high degree of correlation between the amount of heme released and the degree of subsequent induction of heme oxygenase 1 transcription following UVA and hydrogen peroxide treatment. Hydrogen Peroxide 176-193 heme oxygenase 1 Homo sapiens 127-143 8783636-2 1996 BSC-1 cells adapted by long-term exposure to H2O2 exhibited a twofold increase in basal HO activity and expression of HO-1 mRNA as compared with their wild-type counterparts. Hydrogen Peroxide 45-49 heme oxygenase 1 Homo sapiens 118-122 9747510-7 1998 In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively. Hydrogen Peroxide 83-100 heme oxygenase 1 Homo sapiens 181-185 9747510-7 1998 In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively. Hydrogen Peroxide 102-106 heme oxygenase 1 Homo sapiens 181-185 9054378-1 1997 Conversion of heme to verdoheme by heme oxygenase-1 (HO-1) is thought to involve alpha-meso-hydroxylation and elimination of the meso-carbon as CO, a reaction supported by both H2O2 and NADPH-cytochrome P450 reductase/O2. Hydrogen Peroxide 177-181 heme oxygenase 1 Homo sapiens 35-51 8783636-3 1996 Exposure of both adapted and wild-type BSC-1 cells to H2O2 induced HO-1 mRNA. Hydrogen Peroxide 54-58 heme oxygenase 1 Homo sapiens 67-71 8783636-8 1996 In conclusion, two interrelated stressors, H2O2 and hemin, produced a stimulation of HO-1, and this was associated with a reduction in the viability of BSC-1 cells. Hydrogen Peroxide 43-47 heme oxygenase 1 Homo sapiens 85-89 34510844-10 2021 Moreover, H2O2 significantly reduced Nrf2 nuclear localization, as well as HO-1 and NQO1 expression, which could be reversed by Ech. Hydrogen Peroxide 10-14 heme oxygenase 1 Homo sapiens 75-79 8600294-9 1995 In addition, exposure to hydrogen peroxide (H2O2), cadmium (Cd), and lipopolysaccharide (LPS) stimulated a rise in HO-1 levels. Hydrogen Peroxide 25-42 heme oxygenase 1 Homo sapiens 115-119 8600294-9 1995 In addition, exposure to hydrogen peroxide (H2O2), cadmium (Cd), and lipopolysaccharide (LPS) stimulated a rise in HO-1 levels. Hydrogen Peroxide 44-48 heme oxygenase 1 Homo sapiens 115-119 33775716-0 2021 The signaling pathway PI3K/Akt/Nrf2/HO-1 plays a role in the mitochondrial protection promoted by astaxanthin in the SH-SY5Y cells exposed to hydrogen peroxide. Hydrogen Peroxide 142-159 heme oxygenase 1 Homo sapiens 36-40 33775716-9 2021 Inhibition of the PI3K/Akt or of the HO-1 enzyme abolished the AST-induced mitochondrial protection in cells challenged with H2O2. Hydrogen Peroxide 125-129 heme oxygenase 1 Homo sapiens 37-41 33775716-11 2021 Thus, we suggest that AST promotes mitochondrial protection by a mechanism dependent on the PI3K/Akt/Nrf2/HO-1 signaling pathway in SH-SY5Y cells exposed to H2O2. Hydrogen Peroxide 157-161 heme oxygenase 1 Homo sapiens 106-110 34876806-13 2021 Conclusion: Our results indicate that MeCbl attenuated the H2O2-induced oxidative stress in melanocytes by activating the Nrf2/HO-1 pathway, this suggests that MeCbl may be an effective treatment against vitiligo. Hydrogen Peroxide 59-63 heme oxygenase 1 Homo sapiens 127-131 34874275-8 2021 As an HO-1 inducer, cobalt protoporphyrin IX (CoPP) decreased ROS production and significantly reversed the inhibitory effect of H2O2 on cell viability. Hydrogen Peroxide 129-133 heme oxygenase 1 Homo sapiens 6-10 34558653-11 2021 In addition, RK1 treatment notably induced Nrf2 nuclear translocation, increased the protein expression levels of Nrf2 and HO-1, and the ratio of phosphorylated-AKT to AKT in the PIG1 cells exposed to H2O2. Hydrogen Peroxide 201-205 heme oxygenase 1 Homo sapiens 123-127 34476501-4 2021 The expression levels of apoptosis-related proteins, activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway induced by H2O2 and the effect of treatment with ANP on vertebral EPCs were detected by western blotting. Hydrogen Peroxide 175-179 heme oxygenase 1 Homo sapiens 122-138 34476501-4 2021 The expression levels of apoptosis-related proteins, activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway induced by H2O2 and the effect of treatment with ANP on vertebral EPCs were detected by western blotting. Hydrogen Peroxide 175-179 heme oxygenase 1 Homo sapiens 140-144 34476501-8 2021 Finally, ANP blocked H2O2-induced oxidative stress through activating the Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 21-25 heme oxygenase 1 Homo sapiens 79-83 34476501-9 2021 These findings suggested that ANP may effectively protect EPCs through inhibition of H2O2-induced oxidant injury and cell death by activating the Nrf2/HO-1 signaling pathway. Hydrogen Peroxide 85-89 heme oxygenase 1 Homo sapiens 151-155 34622673-10 2021 In eAAA, HO-1 expression was negatively correlated with aortic collagen content and oxidative stress parameters H2O2 release, oxidized proteins, and thiobarbituric acid reactive substances. Hydrogen Peroxide 112-116 heme oxygenase 1 Homo sapiens 9-13 35584686-7 2022 RESULTS: mRNA expression of HO-1, GCLC, HSPB1, VEGFA, PDGFA and PDGFB were significantly increased in ARPE-19 cells treated with H2O2 + hUCESC-CM compared to cells treated with H2O2 only. Hydrogen Peroxide 129-133 heme oxygenase 1 Homo sapiens 28-32 34566656-7 2021 In addition, JSH-23 attenuated H2O2-induced apoptosis and mineralization reduction in osteoblasts by reducing ROS production and enhancing Nrf2/HO-1 expression. Hydrogen Peroxide 31-35 heme oxygenase 1 Homo sapiens 144-148 34313971-12 2021 Moreover, A-EVs significantly upregulated the mRNA expression of Nrf2, HO-1, CAT, and SOD genes in H2O2-treated HaCaT cells. Hydrogen Peroxide 99-103 heme oxygenase 1 Homo sapiens 71-75 34228907-10 2021 Additionally, Isoeucommin A protected H2 O2 -stimulated renal tubular epithelial cells (RTECs) from oxidative stress and activated Nrf2/HO-1 signaling pathway in high glucose-stimulated human renal mesangial cells (HRMCs). Hydrogen Peroxide 38-43 heme oxygenase 1 Homo sapiens 136-140 34305600-6 2021 At the same time, the GN combination could also inhibit the H2O2-induced inflammatory response and apoptosis of human umbilical vein endothelial cells (HUVECs), which is mainly related to the activation of the AMPK/mTOR pathway by GN combination, which in turn induces the activation of Nrf2/HO-1 signal. Hydrogen Peroxide 60-64 heme oxygenase 1 Homo sapiens 292-296 34104310-8 2021 In particular, the methanol extract was the most effective in protecting neuron-like SH-SY5Y cells against H2O2-induced oxidative stress by upregulating endogenous antioxidant enzymes such as thioredoxin reductase, heme oxygenase 1, NADPH quinone oxidoreductase, and glutathione reductase. Hydrogen Peroxide 107-111 heme oxygenase 1 Homo sapiens 215-231 35620405-0 2022 11,12-Diacetyl-carnosol Protects SH-SY5Y Cells from Hydrogen Peroxide Damage through the Nrf2/HO-1 Pathway. Hydrogen Peroxide 52-69 heme oxygenase 1 Homo sapiens 94-98 35620405-9 2022 Conclusion: These results demonstrate that NO.20 protects SH-SY5Y cells from H2O2-induced neurotoxicity by activating the Nrf2/HO-1 pathway. Hydrogen Peroxide 77-81 heme oxygenase 1 Homo sapiens 127-131 35199318-8 2022 Both H2O2 and methemoglobin upregulated the expression of the HO-1 protein in the dTHP-1 monoculture; moreover, co-culture with endometriotic cells further enhanced HO-1 production. Hydrogen Peroxide 5-9 heme oxygenase 1 Homo sapiens 62-66 35306372-3 2022 Photochemical oxidation of isoprene leads to the formation of hydroperoxides, environmental oxidants that lead to inflammatory (IL-8) and adaptive (HMOX1) gene expression in human airway epithelial cells (HAEC). Hydrogen Peroxide 62-76 heme oxygenase 1 Homo sapiens 148-153 35480872-12 2022 These findings implicated that BV/BR redox pair protects LECs against H2O2-induced apoptosis by regulating NF-kappaB/iNOS and Nrf2/HO-1 pathways. Hydrogen Peroxide 70-74 heme oxygenase 1 Homo sapiens 131-135 35387349-0 2022 Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway. Hydrogen Peroxide 50-54 heme oxygenase 1 Homo sapiens 117-121 35387349-11 2022 In conclusion, our study revealed that metformin promoted osteogenic differentiation and H2O2-induced oxidative damage of osteoblasts via the PI3K/AKT/Nrf2/HO-1 pathway. Hydrogen Peroxide 89-93 heme oxygenase 1 Homo sapiens 156-160 35199318-8 2022 Both H2O2 and methemoglobin upregulated the expression of the HO-1 protein in the dTHP-1 monoculture; moreover, co-culture with endometriotic cells further enhanced HO-1 production. Hydrogen Peroxide 5-9 heme oxygenase 1 Homo sapiens 165-169 35222803-10 2022 As demonstrated by these data, KGF-2 resisted H2O2-mediated apoptosis and oxidative stress in HLECs through Nrf2/HO-1 and PI3K/Akt pathways, suggesting a potential protective effect against the formation of cataracts. Hydrogen Peroxide 46-50 heme oxygenase 1 Homo sapiens 113-117 34981336-10 2022 CONCLUSIONS: These findings suggest that WDR26 mediates H2O2-induced oxidative stress and cell injury, possibly by reducing the intrinsic apoptotic pathway and activating Nrf2 and HO-1 in astrocytes. Hydrogen Peroxide 56-60 heme oxygenase 1 Homo sapiens 180-184 35218032-6 2022 Furthermore, preincubation with Orz reduced H2 O2 -mediated the proapoptotic protein of Bak expression and the phosphorylation of ASK1, p38, JNK, and ERK, and increased the anti-apoptotic protein of Bcl-xl expression and anti-oxidative stress proteins of Nrf2 and HO-1 expression. Hydrogen Peroxide 44-49 heme oxygenase 1 Homo sapiens 264-268