PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17919343-1	2007	BACKGROUND: Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.	Hydrogen Peroxide	47-64	insulin receptor	Homo sapiens	144-160	
23730255-0	2012	H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria.	Hydrogen Peroxide	0-4	insulin receptor	Homo sapiens	51-67	
23730255-2	2012	Insulin-induced H2O2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H2O2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation.	Hydrogen Peroxide	16-20	insulin receptor	Homo sapiens	30-46	
23730255-2	2012	Insulin-induced H2O2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H2O2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation.	Hydrogen Peroxide	16-20	insulin receptor	Homo sapiens	203-219	
23730255-2	2012	Insulin-induced H2O2 promotes insulin receptor activation and the mitochondria act as the insulin-sensitive H2O2 source, providing a direct molecular link between mitochondrial dysfunction and irregular insulin receptor activation.	Hydrogen Peroxide	108-112	insulin receptor	Homo sapiens	203-219	
23730255-4	2012	Due to the high significance of insulin-induced H2O2 for insulin receptor activation, oxidative stress-induced upregulation of antioxidant enzymes, e.g., in AD brains, may represent another risk factor contributing to the development of insulin resistance.	Hydrogen Peroxide	48-52	insulin receptor	Homo sapiens	57-73	
23730255-5	2012	As insulin-induced H2O2 signalling requires fully functional mitochondria, pharmacological strategies based on activating mitochondria biogenesis in the brain are central to the treatment of diseases associated with dysfunctional insulin receptor signalling in this organ.	Hydrogen Peroxide	19-23	insulin receptor	Homo sapiens	230-246	
17919343-3	2007	The aim of the present study is to test the following hypotheses (1) whether insulin-induced H2O2 is required for insulin receptor autophosphorylation in neurons, and (2) whether mitochondrial respiratory chain is involved in insulin-stimulated H2O2 production, thus playing an integral role in insulin receptor autophosphorylation in neurons.	Hydrogen Peroxide	93-97	insulin receptor	Homo sapiens	114-130	
17919343-8	2007	CONCLUSION: Results of the present study suggest that insulin-induced H2O2 is required for the enhancement of insulin receptor autophosphorylation in neurons.	Hydrogen Peroxide	70-74	insulin receptor	Homo sapiens	110-126	
17919343-9	2007	The mitochondrial respiratory chain is involved in insulin-stimulated H2O2 production, thus playing an integral role in the insulin receptor autophosphorylation in neurons.	Hydrogen Peroxide	70-74	insulin receptor	Homo sapiens	124-140	
17919343-1	2007	BACKGROUND: Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.	Hydrogen Peroxide	66-70	insulin receptor	Homo sapiens	144-160	
15563471-2	2005	Using purified recombinant IRK fragments and the isolated intact insulin receptor, we show here that autophosphorylation is inhibited by ADP and that this effect is essentially reversed by hydrogen peroxide.	Hydrogen Peroxide	189-206	insulin receptor	Homo sapiens	65-81	
17179152-7	2007	Protein tyrosine phosphatases (PTPs) appear to be important for the IRS-1 cleavage because tyrosine phosphorylation of the insulin receptor was decreased in hypoxia and IRS-1 cleavage could be blocked either with H(2)O(2) or with vanadate, each of which inhibits PTPs.	Hydrogen Peroxide	213-221	insulin receptor	Homo sapiens	123-139	
16607115-7	2006	Another prominent case in point is insulin-independent "basal" insulin receptor kinase activity, which is strongly enhanced by hydrogen peroxide or by an oxidative shift in redox status.	Hydrogen Peroxide	127-144	insulin receptor	Homo sapiens	63-79	
12876303-8	2003	In addition, H2O2 inhibited insulin receptor binding partially and inhibited insulin receptor autophosphorylation almost completely.	Hydrogen Peroxide	13-17	insulin receptor	Homo sapiens	28-44	
12876303-8	2003	In addition, H2O2 inhibited insulin receptor binding partially and inhibited insulin receptor autophosphorylation almost completely.	Hydrogen Peroxide	13-17	insulin receptor	Homo sapiens	77-93	
6389223-8	1984	beta-Hydroxybutyrate also potentiated the effect of hydrogen peroxide (which acts at a level distal to the insulin receptor) even in cells that had been depleted of insulin receptors by trypsin treatment.	Hydrogen Peroxide	52-69	insulin receptor	Homo sapiens	107-123	
27422524-6	2016	Furthermore, beating-rate in Cor.4U( ) human cardiomyocytes, glucose uptake in HL-1 cells, and prevention from H2O2 induced caspase 3/7 activation in cardiac cells overexpressing the human insulin receptor (H9c2-E2) were analysed.	Hydrogen Peroxide	111-115	insulin receptor	Homo sapiens	189-205