PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32141401-7	2020	The C3 G liposomes can obviously increased T-AOC and decreased the MDA content.Collectively, C3 G liposomes protected human GES-1 cells from gastric mucosal injury induced by H2O2 by activating the related antioxidant pathway.	Hydrogen Peroxide	175-179	Rap guanine nucleotide exchange factor 1	Homo sapiens	4-8	
12747740-4	2003	Protective effects were exerted, in a dose-dependent manner, by C-3-G also in 2 mM hydrogen peroxide-treated human erythrocytes.	Hydrogen Peroxide	83-100	Rap guanine nucleotide exchange factor 1	Homo sapiens	64-69	
34614009-8	2021	Additionally, treatment with C3G resulted in a significant reduction in the protein expression of inflammatory markers IL-1beta and NLRP3 (p<0.01) as well as an increase in LC3 autophagic marker (p<0.05) in human islets treated with amylin, Abeta1-42, rapamycin, or H2O2.	Hydrogen Peroxide	266-270	Rap guanine nucleotide exchange factor 1	Homo sapiens	29-32	
20958056-3	2010	This study demonstrates that C3G is able to protect human endothelial cells against alterations induced by TNF-alpha, including the activation of NF-kappaB, increased gene expression of adhesion molecules, leukocyte adhesion to endothelium, and intracellular accumulation of H2O2 and lipid peroxidation byproducts.	Hydrogen Peroxide	275-279	Rap guanine nucleotide exchange factor 1	Homo sapiens	29-32	
19925863-3	2010	In contrast, in response to H2O2, C3G behaves as a pro-apoptotic molecule, as its knock-down or knock-out enhances survival through up-regulation of p38alpha activation, which plays an anti-apoptotic role under these conditions.	Hydrogen Peroxide	28-32	Rap guanine nucleotide exchange factor 1	Homo sapiens	34-37	
19925863-7	2010	In addition, the increase in BNIP-3 levels induced by C3G knock-down in wt cells treated with H2O2 might play a role preventing cell death.	Hydrogen Peroxide	94-98	Rap guanine nucleotide exchange factor 1	Homo sapiens	54-57	
15701043-4	2005	We also investigated antioxidant properties of C-3-G in HaCaT cells against ROS formation at apoptotic doses of UVA; C-3-G inhibited hydrogen peroxide (H2O2) release (an indicator of cellular ROS formation) after UVA irradiation.	Hydrogen Peroxide	133-150	Rap guanine nucleotide exchange factor 1	Homo sapiens	117-122	
15701043-4	2005	We also investigated antioxidant properties of C-3-G in HaCaT cells against ROS formation at apoptotic doses of UVA; C-3-G inhibited hydrogen peroxide (H2O2) release (an indicator of cellular ROS formation) after UVA irradiation.	Hydrogen Peroxide	152-156	Rap guanine nucleotide exchange factor 1	Homo sapiens	117-122	
15701043-5	2005	Further confirmation of the potential of C-3-G to counteract UVA-induced ROS formation comes from our demonstration of its ability to enhance the resistance of HaCaT cells to the apoptotic effects of both H2O2 and the superoxide anion (O2*-), two ROS involved in UVA-oxidative stress.	Hydrogen Peroxide	205-209	Rap guanine nucleotide exchange factor 1	Homo sapiens	41-46	
32141401-7	2020	The C3 G liposomes can obviously increased T-AOC and decreased the MDA content.Collectively, C3 G liposomes protected human GES-1 cells from gastric mucosal injury induced by H2O2 by activating the related antioxidant pathway.	Hydrogen Peroxide	175-179	Rap guanine nucleotide exchange factor 1	Homo sapiens	93-97	
31141616-6	2019	The C3G and C3G liposomes can enhance the activities of GSH, SOD, and T-AOC but decrease the MDA content after H2 O2 treatment, while the changes were different in 2D and 3D cells culture models.	Hydrogen Peroxide	111-116	Rap guanine nucleotide exchange factor 1	Homo sapiens	4-7	
31141616-6	2019	The C3G and C3G liposomes can enhance the activities of GSH, SOD, and T-AOC but decrease the MDA content after H2 O2 treatment, while the changes were different in 2D and 3D cells culture models.	Hydrogen Peroxide	111-116	Rap guanine nucleotide exchange factor 1	Homo sapiens	12-15