PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10220113-3	1999	Additionally, IL1beta was found to elicit H2O2 synthesis in these cells.	Hydrogen Peroxide	42-46	interleukin 1 beta	Rattus norvegicus	14-21	
11786081-7	2002	Since MnTBAP, a superoxide dismutase mimetic, had no effects on the amplification of mRNA levels, we suggest that H2O2 is the candidate reactive oxygen species (ROS) responsible for the potentiation of IL-1beta-triggered tPA and PAI-1 expression.	Hydrogen Peroxide	114-118	interleukin 1 beta	Rattus norvegicus	202-210	
10220113-6	1999	Pretreatment of cells with either PBN or NAC at 1.0 mM suppressed IL1beta H2O2, and sorbitol-mediated activation of p38 and significantly increased phosphatase activity.	Hydrogen Peroxide	74-78	interleukin 1 beta	Rattus norvegicus	66-73	
10069792-8	1999	Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1beta-stimulated VSMCs.	Hydrogen Peroxide	26-43	interleukin 1 beta	Rattus norvegicus	83-91	
1884886-3	1991	Since cytotoxicity induced by free radicals and by heat may activate the same cellular repair mechanism (the heat shock response), the aim of this study was to investigate the pattern of protein synthesis in isolated islets after exposure to interleukin 1 beta (150 pg/ml, 24 h), tumour necrosis factor alpha (50 ng/ml, 24 h) heat shock (43 degrees C, 30 min) and H2O2 (0.1 mmol/l, 20 min).	Hydrogen Peroxide	364-368	interleukin 1 beta	Rattus norvegicus	242-260	
29649568-8	2018	Thus, our results demonstrate that honokiol inhibited the H2O2 induced apoptosis, oxidative stress, and inflammatory responses through the depression of TXNIP/NLRP3/caspase-1/ Interleukin - 1beta signaling axis and the activation of NF-kB and JNK.	Hydrogen Peroxide	58-62	interleukin 1 beta	Rattus norvegicus	176-195	
31184936-7	2019	The mRNA and protein expression levels of serine-threonine kinase 2 (RIP2) and interleukin-1beta (IL-1beta) were significantly increased in the I/R and H2O2 groups when compared with the controls; however, these levels were significantly decreased after l-NAT intervention.	Hydrogen Peroxide	152-156	interleukin 1 beta	Rattus norvegicus	79-96	
30557884-10	2018	Hesperidin also reversed the activity of H2O2 on inhibiting the Col2a1, aggrecan, and SOX9 gene expression and increasing the gene expression of caspase 3, IL-1beta, TNFalpha, iNOS, and MMP13.	Hydrogen Peroxide	41-45	interleukin 1 beta	Rattus norvegicus	156-164	
30111205-13	2018	While the TNF-alpha and IL-1beta secretions significantly up-regulated in H2O2 model group compared to the Control group (p < .05).	Hydrogen Peroxide	74-78	interleukin 1 beta	Rattus norvegicus	24-32	
28605990-10	2018	miR-25 protected PC-12 cells against H2O2-induced oxidative damage, as evidenced by significant suppression in cell apoptosis, increase in cell viability, decrease in the level of ROS, HIF-alpha and gammaH2A, and decrease in inflammatory mediators (IL-1beta, TNF-alpha, IL-6, and MCP-1).	Hydrogen Peroxide	37-41	interleukin 1 beta	Rattus norvegicus	249-257	
29273374-11	2018	GSH also decreased H2O2-mediated increases in interleukin 1 beta secretion, cleaved caspase-3 activation, and apoptosis in IEC-6 cells.	Hydrogen Peroxide	19-23	interleukin 1 beta	Rattus norvegicus	46-64	
27430346-10	2016	Pre-treatment with cannabidiol suppressed the promotion of COX-2, iNOS, IL-1beta and IL-6 expression in the nucleus pulposus cells following H2O2 exposure.	Hydrogen Peroxide	141-145	interleukin 1 beta	Rattus norvegicus	72-80	
26330101-7	2015	We found that H2O2 stimulated the production of IL-6, IL-1beta, TNF-alpha and NO, which could be reduced by pretreatment with FA through inhibiting the p-NF-kappaB as well as the iNOS expression.	Hydrogen Peroxide	14-18	interleukin 1 beta	Rattus norvegicus	54-62	
16393992-8	2006	In conclusion, these findings indicate that microglial proliferation in response to IL-1beta or TNF-alpha is mediated by hydrogen peroxide from NADPH oxidase.	Hydrogen Peroxide	121-138	interleukin 1 beta	Rattus norvegicus	84-92	
15683716-3	2005	We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase.	Hydrogen Peroxide	72-89	interleukin 1 beta	Rattus norvegicus	14-31	
15683716-3	2005	We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase.	Hydrogen Peroxide	72-89	interleukin 1 beta	Rattus norvegicus	33-41	
15683716-3	2005	We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase.	Hydrogen Peroxide	91-95	interleukin 1 beta	Rattus norvegicus	14-31	
15683716-3	2005	We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase.	Hydrogen Peroxide	91-95	interleukin 1 beta	Rattus norvegicus	33-41	
15683716-3	2005	We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase.	Hydrogen Peroxide	152-156	interleukin 1 beta	Rattus norvegicus	14-31	
15683716-3	2005	We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase.	Hydrogen Peroxide	152-156	interleukin 1 beta	Rattus norvegicus	33-41	
27445100-0	2016	Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit.	Hydrogen Peroxide	92-96	interleukin 1 beta	Rattus norvegicus	126-134	
22642771-7	2012	Telmisartan reduced the IL-1beta-induced increase in IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression, NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide-induced COX-2 gene expression.	Hydrogen Peroxide	170-187	interleukin 1 beta	Rattus norvegicus	24-32	
16393992-5	2006	IL-1beta and TNF-alpha rapidly stimulated the rate of hydrogen peroxide produced by isolated microglia, and this was inhibited by diphenylene iodonium, implying that the cytokines were acting directly on microglia to stimulate the NADPH oxidase.	Hydrogen Peroxide	54-71	interleukin 1 beta	Rattus norvegicus	0-8