PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34959841-0 2021 Gongjin-Dan Enhances Neurite Outgrowth of Cortical Neuron by Ameliorating H2O2-Induced Oxidative Damage via Sirtuin1 Signaling Pathway. Hydrogen Peroxide 74-78 sirtuin 1 Homo sapiens 108-116 34959841-7 2021 GJD effectively ameliorated H2O2-induced neuronal death against oxidative damage through Sirtuin1 activation. Hydrogen Peroxide 28-32 sirtuin 1 Homo sapiens 89-97 34829709-8 2021 To validate the possible mechanism of GF, we used HepG2 cells with hydrogen peroxide treated oxidative stress and chronic exposure conditions via deteriorations of cellular SIRT1. Hydrogen Peroxide 67-84 sirtuin 1 Homo sapiens 173-178 34155600-12 2021 Moreover, the H2O2 treatment group showed significantly downregulated expression of SIRT1 (P < 0.01) but significantly upregulated expressions of p53 and Caspase3 (P < 0.01) compared to the control group. Hydrogen Peroxide 14-18 sirtuin 1 Homo sapiens 84-89 34187948-4 2021 Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependent manners and it has protective role against H2O2-induced cellular senescence by upregulation of sirtuin 1 (SIRT1). Hydrogen Peroxide 141-145 sirtuin 1 Homo sapiens 204-209 34724621-13 2021 In conclusion, Res had a protective effect against the H2O2-induced LGCs, and the mechanism may be associated with Sirt1. Hydrogen Peroxide 55-59 sirtuin 1 Homo sapiens 115-120 34155600-14 2021 This study suggests that SPPA inhibits H2O2-induced human KGN cell apoptosis through antioxidation, and the SIRT1/p53 signal pathway mediates the antioxidation. Hydrogen Peroxide 39-43 sirtuin 1 Homo sapiens 108-113 35105933-0 2022 Tetrahydroxy stilbene glycoside attenuates endothelial cell premature senescence induced by H2O2 through the microRNA-34a/SIRT1 pathway. Hydrogen Peroxide 92-96 sirtuin 1 Homo sapiens 122-127 35105933-2 2022 Our previous results confirmed that Tetrahydroxy stilbene glycoside (TSG) can alleviate the human umbilical vein endothelial cells (HUVECs) senescence induced by H2O2 through SIRT1. Hydrogen Peroxide 162-166 sirtuin 1 Homo sapiens 175-180 33576462-7 2021 Through downregulating SIRT1 and activating p53 signaling, miR-138-5p induced apoptosis in H2O2-induced AC-16 and HCM cells. Hydrogen Peroxide 91-95 sirtuin 1 Homo sapiens 23-28 33882455-6 2021 The activation of SIRT1 significantly attenuated UV- and H2O2-induced cytotoxic damage by inhibiting oxidative stress and promoting the activation of autophagy. Hydrogen Peroxide 57-61 sirtuin 1 Homo sapiens 18-23 32910941-3 2020 Here, we established an RPE model of H2O2-induced oxidative stress and found that Sirtuin 1 (Sirt1)-mediated deacetylation of E2F transcription factor 1 (E2F1) was required for oxidation resistance in RPE cells. Hydrogen Peroxide 37-41 sirtuin 1 Homo sapiens 82-91 32402066-5 2021 Using H2O2 as a model of oxidative stress-induced DNA damage, pharmacological activation of SIRT1 reduced H2O2 DNA damage induced calcification, prevented not only DNA damage, as shown by reduced comet tail length, but also decreased yH2AX foci formation, and attenuated calcification. Hydrogen Peroxide 6-10 sirtuin 1 Homo sapiens 92-97 32402066-5 2021 Using H2O2 as a model of oxidative stress-induced DNA damage, pharmacological activation of SIRT1 reduced H2O2 DNA damage induced calcification, prevented not only DNA damage, as shown by reduced comet tail length, but also decreased yH2AX foci formation, and attenuated calcification. Hydrogen Peroxide 106-110 sirtuin 1 Homo sapiens 92-97 33111210-0 2021 6,4"-dihydroxy-7-methoxyflavanone protects against H2O2-induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. Hydrogen Peroxide 51-55 sirtuin 1 Homo sapiens 96-101 33078415-12 2020 DFG also upregulated SIRT-1 and PCG-1alpha expression level obviously in H2 O2 -stimulated ARPE-19 cells (to 134.4% and 127.1%, respectively) and in acute ethanol stimulated mouse eyes (to 135.1% and 111.5%, respectively) and liver (to 123.3% and 113.6%, respectively). Hydrogen Peroxide 73-78 sirtuin 1 Homo sapiens 21-27 33834065-13 2021 Overexpressed Sirt-1 scavenged reactive oxygen species (ROS) production in SK-N-SH with H2O2. Hydrogen Peroxide 88-92 sirtuin 1 Homo sapiens 14-20 33488795-13 2021 In addition, miR-34a upregulation was accompanied with reduced SIRT1 expression in HUVECs, following H2O2 treatment. Hydrogen Peroxide 101-105 sirtuin 1 Homo sapiens 63-68 32910941-3 2020 Here, we established an RPE model of H2O2-induced oxidative stress and found that Sirtuin 1 (Sirt1)-mediated deacetylation of E2F transcription factor 1 (E2F1) was required for oxidation resistance in RPE cells. Hydrogen Peroxide 37-41 sirtuin 1 Homo sapiens 93-98 32901866-5 2020 In addition, the SIRT1 activator, resveratrol, or the SIRT1 inhibitor, Ex527, reduced or elevated H2O2-induced COV434 cell apoptosis, respectively. Hydrogen Peroxide 98-102 sirtuin 1 Homo sapiens 17-22 32901866-5 2020 In addition, the SIRT1 activator, resveratrol, or the SIRT1 inhibitor, Ex527, reduced or elevated H2O2-induced COV434 cell apoptosis, respectively. Hydrogen Peroxide 98-102 sirtuin 1 Homo sapiens 54-59 32901866-7 2020 Moreover, OTS514 further decreased the SIRT1 transcriptional activity decreased by H2O2, but promoted the H2O2-induced p53 or p21 transcriptional activity. Hydrogen Peroxide 83-87 sirtuin 1 Homo sapiens 39-44 32901866-9 2020 Taken together, the findings of the present study demonstrate that TOPK inhibition promotes p53-mediated granulosa cell apoptosis through SIRT1 downregulation in response to H2O2. Hydrogen Peroxide 174-178 sirtuin 1 Homo sapiens 138-143 32901866-10 2020 Therefore, it can be concluded that TOPK suppresses H2O2-induced apoptosis through the modulation of the p53/SIRT1 axis, suggesting a potential role of TOPK in the regulation of human granulosa cell apoptosis, leading to the promotion of abnormal follicular development. Hydrogen Peroxide 52-56 sirtuin 1 Homo sapiens 109-114 32412821-0 2020 Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1. Hydrogen Peroxide 28-45 sirtuin 1 Homo sapiens 130-135 32412821-9 2020 Conclusion: Kaempferol protective effect against H2O2-induced ARPE-19 damage involves antioxidant and anti-inflammatory effects mediated, at least, by stimulating the nuclear accumulation, activation, and deacetylase ability of SIRT1 and concurrent inhibition of PARP1. Hydrogen Peroxide 49-53 sirtuin 1 Homo sapiens 228-233 32692720-7 2020 Pretreatment with selisistat (Sirt1-specific inhibitor) or compound C (AMPK antagonist) significantly reduced the viability and mitochondrial function in H2O2-treated Mst1-silenced RA-FLSs by inhibiting Sirt1 function or Sirt1 expression, respectively. Hydrogen Peroxide 154-158 sirtuin 1 Homo sapiens 203-208 32732457-7 2020 A NAD+ precursor restored autophagy and protected mitochondria in ARPE-19 cells by preserving SIRT1 activity upon H2O2. Hydrogen Peroxide 114-118 sirtuin 1 Homo sapiens 94-99 32692720-6 2020 Sirt1 expression was significantly reduced in the H2O2-treated RA-FLSs, but was higher in the H2O2-treated Mst1-silenced RA-FLSs. Hydrogen Peroxide 50-54 sirtuin 1 Homo sapiens 0-5 32377712-0 2020 Ginsenoside Rb1 reduces H2O2-induced HUVEC dysfunction by stimulating the sirtuin-1/AMP-activated protein kinase pathway. Hydrogen Peroxide 24-28 sirtuin 1 Homo sapiens 74-83 32692720-6 2020 Sirt1 expression was significantly reduced in the H2O2-treated RA-FLSs, but was higher in the H2O2-treated Mst1-silenced RA-FLSs. Hydrogen Peroxide 94-98 sirtuin 1 Homo sapiens 0-5 32692720-7 2020 Pretreatment with selisistat (Sirt1-specific inhibitor) or compound C (AMPK antagonist) significantly reduced the viability and mitochondrial function in H2O2-treated Mst1-silenced RA-FLSs by inhibiting Sirt1 function or Sirt1 expression, respectively. Hydrogen Peroxide 154-158 sirtuin 1 Homo sapiens 30-35 32692720-7 2020 Pretreatment with selisistat (Sirt1-specific inhibitor) or compound C (AMPK antagonist) significantly reduced the viability and mitochondrial function in H2O2-treated Mst1-silenced RA-FLSs by inhibiting Sirt1 function or Sirt1 expression, respectively. Hydrogen Peroxide 154-158 sirtuin 1 Homo sapiens 203-208 32377712-4 2020 It was demonstrated that Sirtuin-1 (SIRT1) was activated by Rb1 to protect HUVECs from H2O2-induced senescence. Hydrogen Peroxide 87-91 sirtuin 1 Homo sapiens 25-34 32377712-4 2020 It was demonstrated that Sirtuin-1 (SIRT1) was activated by Rb1 to protect HUVECs from H2O2-induced senescence. Hydrogen Peroxide 87-91 sirtuin 1 Homo sapiens 36-41 32377712-6 2020 The present study examined the role of AMP-activated protein kinase (AMPK), an energy sensor of cellular metabolism, in the signaling pathway of SIRT1 during H2O2-stimulated HUVEC aging. Hydrogen Peroxide 158-162 sirtuin 1 Homo sapiens 145-150 32377712-7 2020 It was identified that Rb1 restored the H2O2-induced reduction of SIRT1 expression, which was consistent with our previous study, together with the activation of AMPK phosphorylation. Hydrogen Peroxide 40-44 sirtuin 1 Homo sapiens 66-71 32377712-10 2020 Taken together, these results provide new insights into the possible molecular mechanisms by which Rb1 protects against H2O2-induced HUVEC senescence via the SIRT1/AMPK pathway. Hydrogen Peroxide 120-124 sirtuin 1 Homo sapiens 158-163 30818884-8 2019 A reduction of Sirt-1 expression under UVB- and H2O2-treated conditions was recovered in HaCaT cells by Pm-ME. Hydrogen Peroxide 48-52 sirtuin 1 Homo sapiens 15-21 31750822-0 2019 [Tanshinone IIA attenuates hydrogen peroxide-induced senescence of human umbilical vein endothelial cells through activating SIRT1/eNOS pathway]. Hydrogen Peroxide 27-44 sirtuin 1 Homo sapiens 125-130 32061777-4 2020 In mouse embryonic fibroblast (MEF) cells and human foreskin fibroblast (HFF) cells, senescence, induced by either progressive passage or treatment with hydrogen peroxide (H2O2), led to augmented lysine acetylation of MRTF-A paralleling down-regulation of collagen type I and SIRT1, a lysine deacetylase. Hydrogen Peroxide 153-170 sirtuin 1 Homo sapiens 276-281 32061777-4 2020 In mouse embryonic fibroblast (MEF) cells and human foreskin fibroblast (HFF) cells, senescence, induced by either progressive passage or treatment with hydrogen peroxide (H2O2), led to augmented lysine acetylation of MRTF-A paralleling down-regulation of collagen type I and SIRT1, a lysine deacetylase. Hydrogen Peroxide 172-176 sirtuin 1 Homo sapiens 276-281 31535381-8 2020 Additionally, LG suppressed the expressions of sirtuin 1 (Sirt1) in cortical neurons exposed to H2 O2 . Hydrogen Peroxide 96-101 sirtuin 1 Homo sapiens 47-56 31535381-8 2020 Additionally, LG suppressed the expressions of sirtuin 1 (Sirt1) in cortical neurons exposed to H2 O2 . Hydrogen Peroxide 96-101 sirtuin 1 Homo sapiens 58-63 31535381-9 2020 Furthermore, knockdown of Sirt1 by short interfering RNA facilitated the LG-mediated mitochondrial protection in cortical neurons under H2 O2 . Hydrogen Peroxide 136-141 sirtuin 1 Homo sapiens 26-31 30988280-6 2019 H2O2 activated AMPK, which then phosphorylated SIRT1 and inhibited its deacetylation activity toward p53 in A549 cells or FOXO1 in NCI-H1299 cells. Hydrogen Peroxide 0-4 sirtuin 1 Homo sapiens 47-52 29803744-3 2018 Oxidative stress has long been considered to be harmful to cells, nevertheless, in this study, we found that lower concentration of hydrogen peroxide (H2O2) decreased the number of SA-betagal-immunopositive cells, which was ameliorated by inhibition of SIRT1. Hydrogen Peroxide 132-149 sirtuin 1 Homo sapiens 253-258 29803744-3 2018 Oxidative stress has long been considered to be harmful to cells, nevertheless, in this study, we found that lower concentration of hydrogen peroxide (H2O2) decreased the number of SA-betagal-immunopositive cells, which was ameliorated by inhibition of SIRT1. Hydrogen Peroxide 151-155 sirtuin 1 Homo sapiens 253-258 29803744-5 2018 SIRT1 protein level in ADSCs was increased by the treatment with H2O2, meanwhile, H2O2 activated p53-depended apoptosis in high concentration. Hydrogen Peroxide 65-69 sirtuin 1 Homo sapiens 0-5 29803744-5 2018 SIRT1 protein level in ADSCs was increased by the treatment with H2O2, meanwhile, H2O2 activated p53-depended apoptosis in high concentration. Hydrogen Peroxide 82-86 sirtuin 1 Homo sapiens 0-5 29803744-10 2018 These results suggest that SIRT1 had a pivotally protective role in the regulation of ADSCs aging and apoptosis induced by H2O2. Hydrogen Peroxide 123-127 sirtuin 1 Homo sapiens 27-32 29380418-8 2018 Activation of SIRT1 by resveratrol rescued the effect of H2 O2 on early-differentiated BM-MSCs and inhibition of SIRT1 by nicotinamide intensified the effect of H2 O2 on late-differentiated BM-MSCs, indicating that the SIRT1-mediated pathway was actively involved in MSC osteogenesis and antioxidant mechanisms. Hydrogen Peroxide 57-62 sirtuin 1 Homo sapiens 14-19 29992759-5 2018 Kallistatin reversed H2 O2 -mediated inhibition of endothelial nitric oxide synthase (eNOS), SIRT1, catalase and superoxide dismutase (SOD)-2 expression, and kallistatin alone stimulated the synthesis of these antioxidant enzymes. Hydrogen Peroxide 21-26 sirtuin 1 Homo sapiens 93-98 30093944-3 2018 In this work, we comparatively investigated nanostructured CaP, MgP and calcium magnesium phosphate (CMP) for the delivery of SRT1720, which is a silent information regulator (SIRT1) specific activator with pro-angiogenic and anti-aging properties in response to hydrogen peroxide (H2O2)-induced endothelial senescence. Hydrogen Peroxide 263-280 sirtuin 1 Homo sapiens 176-181 30093944-3 2018 In this work, we comparatively investigated nanostructured CaP, MgP and calcium magnesium phosphate (CMP) for the delivery of SRT1720, which is a silent information regulator (SIRT1) specific activator with pro-angiogenic and anti-aging properties in response to hydrogen peroxide (H2O2)-induced endothelial senescence. Hydrogen Peroxide 282-286 sirtuin 1 Homo sapiens 176-181 29380418-9 2018 Our findings uncovered the relationship between SIRT1 and resistance to H2 O2 -induced oxidative stress during BM-MSC osteogenesis, which could provide a new strategy for protecting MSCs from extracellular oxidative stress. Hydrogen Peroxide 72-77 sirtuin 1 Homo sapiens 48-53 29380418-8 2018 Activation of SIRT1 by resveratrol rescued the effect of H2 O2 on early-differentiated BM-MSCs and inhibition of SIRT1 by nicotinamide intensified the effect of H2 O2 on late-differentiated BM-MSCs, indicating that the SIRT1-mediated pathway was actively involved in MSC osteogenesis and antioxidant mechanisms. Hydrogen Peroxide 161-166 sirtuin 1 Homo sapiens 113-118 29380418-8 2018 Activation of SIRT1 by resveratrol rescued the effect of H2 O2 on early-differentiated BM-MSCs and inhibition of SIRT1 by nicotinamide intensified the effect of H2 O2 on late-differentiated BM-MSCs, indicating that the SIRT1-mediated pathway was actively involved in MSC osteogenesis and antioxidant mechanisms. Hydrogen Peroxide 161-166 sirtuin 1 Homo sapiens 113-118 29417471-7 2018 Pretreated SH-SY5Y cells with phenolic compounds also helped to upregulate H2O2-induced depletion of the expressions of sirtuin-1 (SIRT1) and forkhead box O (FoxO) 3a as well as induce the levels of antioxidant (superoxide dismutase (SOD) 2 and catalase) and antiapoptotic B-cell lymphoma 2 (Bcl-2) proteins. Hydrogen Peroxide 75-79 sirtuin 1 Homo sapiens 120-129 29579543-9 2018 However, the expression level of SIRT-1 was decreased in senescent and H2O2-induced old cells compared to young cells. Hydrogen Peroxide 71-75 sirtuin 1 Homo sapiens 33-39 29512706-0 2018 Upregulation of SIRT1 inhibits H2O2-induced osteoblast apoptosis via FoxO1/beta-catenin pathway. Hydrogen Peroxide 31-35 sirtuin 1 Homo sapiens 16-21 29512706-7 2018 The results demonstrated that OB apoptosis and elevated oxidative stress in cells were simulated by H2O2, which was inhibited by moderate SIRT1 overexpression through reducing the oxidative stress. Hydrogen Peroxide 100-104 sirtuin 1 Homo sapiens 138-143 29417471-7 2018 Pretreated SH-SY5Y cells with phenolic compounds also helped to upregulate H2O2-induced depletion of the expressions of sirtuin-1 (SIRT1) and forkhead box O (FoxO) 3a as well as induce the levels of antioxidant (superoxide dismutase (SOD) 2 and catalase) and antiapoptotic B-cell lymphoma 2 (Bcl-2) proteins. Hydrogen Peroxide 75-79 sirtuin 1 Homo sapiens 131-136 29600625-1 2018 This study aimed to investigate the effect of notoginsenoside R1 in delaying H2O2-induced vascular endothelial cell senescence through microRNA-34a/SIRT1/p53 signal pathway. Hydrogen Peroxide 77-81 sirtuin 1 Homo sapiens 148-153 28975701-5 2018 In addition, H2 O2 decreased the activities of SIRT1, a histone deacetylase and longevity gene. Hydrogen Peroxide 13-18 sirtuin 1 Homo sapiens 47-52 28975701-6 2018 By silencing and reconstituting SIRT1 in MSCs, we demonstrated that H2 O2 exerted its disparate effects on adipogenic/osteoblastic lineage commitment mainly through modulating SIRT1 expression levels. Hydrogen Peroxide 68-73 sirtuin 1 Homo sapiens 32-37 28975701-6 2018 By silencing and reconstituting SIRT1 in MSCs, we demonstrated that H2 O2 exerted its disparate effects on adipogenic/osteoblastic lineage commitment mainly through modulating SIRT1 expression levels. Hydrogen Peroxide 68-73 sirtuin 1 Homo sapiens 176-181 29600625-14 2018 The possible mechanism is that notoginsenoside R1 can delay the senescence process of vascular endothelial cells induced by H2O2 by regulating microRNA-34a/SIRT1/p53 signal pathway. Hydrogen Peroxide 124-128 sirtuin 1 Homo sapiens 156-161 29118911-0 2017 Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1. Hydrogen Peroxide 96-100 sirtuin 1 Homo sapiens 138-143 29039587-11 2017 Furthermore, RA suppressed H2O2-induced inflammation in NHDFs and significantly rescued H2O2-induced downregulation of sirtuin 1. Hydrogen Peroxide 88-92 sirtuin 1 Homo sapiens 119-128 29118911-7 2017 Transient knockdown of SIRT1 in HUVECs significantly suppressed the protective effects of FGF21 for the rescue of H2O2-induced premature senescence and DNA damage, which suggests that the anti-senescence effect of FGF21 on HUVECs is SIRT1-dependent. Hydrogen Peroxide 114-118 sirtuin 1 Homo sapiens 23-28 29118911-7 2017 Transient knockdown of SIRT1 in HUVECs significantly suppressed the protective effects of FGF21 for the rescue of H2O2-induced premature senescence and DNA damage, which suggests that the anti-senescence effect of FGF21 on HUVECs is SIRT1-dependent. Hydrogen Peroxide 114-118 sirtuin 1 Homo sapiens 233-238 28981116-5 2017 Moreover, we identified that Sirtuin 1 (SIRT1), a deacetylase that suppresses FoxO1 acetylation in GCs, was downregulated by miR-181a and reversed the promoting effects of H2O2 and miR-181a on FoxO1 acetylation and GC apoptosis. Hydrogen Peroxide 172-176 sirtuin 1 Homo sapiens 29-38 28981116-5 2017 Moreover, we identified that Sirtuin 1 (SIRT1), a deacetylase that suppresses FoxO1 acetylation in GCs, was downregulated by miR-181a and reversed the promoting effects of H2O2 and miR-181a on FoxO1 acetylation and GC apoptosis. Hydrogen Peroxide 172-176 sirtuin 1 Homo sapiens 40-45 27925196-7 2017 Our results demonstrate that SIRT1-silenced cells are more resistant to H2 O2 and etoposide treatment showing decreased ROS accumulation, gamma-H2AX phosphorylation, caspase-3 activation and PARP cleavage. Hydrogen Peroxide 72-77 sirtuin 1 Homo sapiens 29-34 29108229-5 2017 By using western blot and real-time PCR, we found that the expression levels of MeCP2 were up-regulated and SIRT1 were down-regulated with replicative senescence and H2O2-induced senescence. Hydrogen Peroxide 166-170 sirtuin 1 Homo sapiens 108-113 28627707-0 2017 Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1. Hydrogen Peroxide 46-63 sirtuin 1 Homo sapiens 127-132 28627707-11 2017 These results indicated that TFPS alleviated hydrogen peroxide-induced oxidative stress and apoptosis in skin fibroblasts via upregulation of SIRT1 expression, indicating that TFPS may act as a potential therapeutic agent for oxidative-stress-associated skin diseases and aging. Hydrogen Peroxide 45-62 sirtuin 1 Homo sapiens 142-147 28808424-6 2017 Our analyses also indicate that hydrogen peroxide induces deacetylase SIRT1 which decreases chromatin affinity and the activity of histone acetyltransferase hMOF toward H4K16ac and results in decreased transcriptional expression of DNA repair genes. Hydrogen Peroxide 32-49 sirtuin 1 Homo sapiens 70-75 27914878-9 2017 MiR-9 and SIRT-1 levels showed opposite changes in chondrocytes following H2O2 and HT treatment. Hydrogen Peroxide 74-78 sirtuin 1 Homo sapiens 10-16 28675952-4 2017 The expression of three antioxidant proteins, superoxide dismutase (SOD)-2, haem oxygenase (HO)-1, and sirtuin (SIRT) 1, was reduced upon H2O2 stimulation in miR-200c-overexpressed A549 cells. Hydrogen Peroxide 138-142 sirtuin 1 Homo sapiens 112-119 27914878-10 2017 Moreover mir-9 silencing inhibited cell death induced by H2O2 partly through down-regulation of SIRT-1, whereas miR-9 overexpression markedly reduced the protective effect of HT. Hydrogen Peroxide 57-61 sirtuin 1 Homo sapiens 96-102 29050034-12 2017 SIRT1 silencing rescues cell viability of H2O2 treated cells. Hydrogen Peroxide 42-46 sirtuin 1 Homo sapiens 0-5 28139552-0 2017 Inhibition of Hydrogen Peroxide-Induced Human Umbilical Vein Endothelial Cells Aging by Allicin Depends on Sirtuin1 Activation. Hydrogen Peroxide 14-31 sirtuin 1 Homo sapiens 107-115 28139552-12 2017 Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) analysis showed that H2O2 attenuated the phosphorylation and activation of Sirt1 and increased the expression of plasminogen activator inhibitor-1(PAI-1) protein. Hydrogen Peroxide 97-101 sirtuin 1 Homo sapiens 151-156 28139552-16 2017 CONCLUSIONS Overall, the results demonstrated that allicin protects HUVECs from H2O2-induced oxidative stress and aging via the activation of Sirt1. Hydrogen Peroxide 80-84 sirtuin 1 Homo sapiens 142-147 29050034-13 2017 Also, SIRT1 inhibition blocked cell apoptosis induced by H2O2 as well as reduced intracellular ROS levels. Hydrogen Peroxide 57-61 sirtuin 1 Homo sapiens 6-11 29050034-14 2017 CONCLUSION: Together, our findings indicated that the miR-29b/SIRT1 axis has a protective effect against H2O2-induced damage of cell viability and oxidative stress and may provide novel options for miR-29b-based therapeutic approaches for EOC treatment. Hydrogen Peroxide 105-109 sirtuin 1 Homo sapiens 62-67 28751929-0 2017 The Preconditioning of Berberine Suppresses Hydrogen Peroxide-Induced Premature Senescence via Regulation of Sirtuin 1. Hydrogen Peroxide 44-61 sirtuin 1 Homo sapiens 109-118 27840925-10 2016 In addition, the H2O2-induced increase in apoptotic markers (caspase-3 and caspase-9) and H2O2-induced reduction in sirtuin 1 levels were significantly reversed following pretreatment of cells with monotropein. Hydrogen Peroxide 17-21 sirtuin 1 Homo sapiens 116-125 27840925-10 2016 In addition, the H2O2-induced increase in apoptotic markers (caspase-3 and caspase-9) and H2O2-induced reduction in sirtuin 1 levels were significantly reversed following pretreatment of cells with monotropein. Hydrogen Peroxide 90-94 sirtuin 1 Homo sapiens 116-125 27332950-0 2016 Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways. Hydrogen Peroxide 32-36 sirtuin 1 Homo sapiens 107-112 27767101-2 2016 Here, we show that oxidative stress (hydrogen peroxide) selectively elevates microRNA-34a (miR-34a) but not the related miR-34b/c, with concomitant reduction of SIRT1/-6 in bronchial epithelial cells (BEAS2B), which was also observed in peripheral lung samples from patients with COPD. Hydrogen Peroxide 37-54 sirtuin 1 Homo sapiens 161-166 26918354-0 2016 Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway. Hydrogen Peroxide 42-59 sirtuin 1 Homo sapiens 88-93 27508009-0 2016 SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium. Hydrogen Peroxide 47-51 sirtuin 1 Homo sapiens 11-16 27508009-2 2016 The purpose of this study was to examine whether SIRT1 specific activator SRT1720 would exhibit pro-angiogenic and anti-aging properties in response to hydrogen peroxide (H2O2)-induced endothelial senescence, and determine the underlying mechanisms. Hydrogen Peroxide 152-169 sirtuin 1 Homo sapiens 49-54 27508009-2 2016 The purpose of this study was to examine whether SIRT1 specific activator SRT1720 would exhibit pro-angiogenic and anti-aging properties in response to hydrogen peroxide (H2O2)-induced endothelial senescence, and determine the underlying mechanisms. Hydrogen Peroxide 171-175 sirtuin 1 Homo sapiens 49-54 26716364-7 2016 RESULTS: SIRT1 expressions significantly increased with H2O2 treatment and further increased with RES treatment in a dose-dependent manner. Hydrogen Peroxide 56-60 sirtuin 1 Homo sapiens 9-14 26918354-6 2016 And we found the inhibition of sirt1 using sirtinol and sirt1 siRNA reversed the protective effects of melatonin and induces the autophagy process in H2O2-treated cells. Hydrogen Peroxide 150-154 sirtuin 1 Homo sapiens 31-36 26918354-6 2016 And we found the inhibition of sirt1 using sirtinol and sirt1 siRNA reversed the protective effects of melatonin and induces the autophagy process in H2O2-treated cells. Hydrogen Peroxide 150-154 sirtuin 1 Homo sapiens 56-61 26918354-7 2016 This is the first report demonstrating that autophagy flux activated by melatonin protects human keratinocytes through sirt1 pathway against hydrogen peroxide-induced damages. Hydrogen Peroxide 141-158 sirtuin 1 Homo sapiens 119-124 26059423-0 2015 Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway. Hydrogen Peroxide 45-62 sirtuin 1 Homo sapiens 115-120 26208454-3 2015 Exogenous H2O2 tended to promote SIRT1 expression and induce more autophagy through mTOR pathway in control ph ESCs, by contrast more apoptosis via activation of p53 and caspase-3 in SIRT1-knockdown ph ESCs. Hydrogen Peroxide 10-14 sirtuin 1 Homo sapiens 33-38 26208454-3 2015 Exogenous H2O2 tended to promote SIRT1 expression and induce more autophagy through mTOR pathway in control ph ESCs, by contrast more apoptosis via activation of p53 and caspase-3 in SIRT1-knockdown ph ESCs. Hydrogen Peroxide 10-14 sirtuin 1 Homo sapiens 183-188 25640014-4 2015 In the present study, we investigated whether SIRT1 exerted a protective effect on hydrogen peroxide (H(2)O(2))-induced EPCs apoptosis and, if so, what the underlying mechanism might be. Hydrogen Peroxide 83-100 sirtuin 1 Homo sapiens 46-51 25640014-4 2015 In the present study, we investigated whether SIRT1 exerted a protective effect on hydrogen peroxide (H(2)O(2))-induced EPCs apoptosis and, if so, what the underlying mechanism might be. Hydrogen Peroxide 102-110 sirtuin 1 Homo sapiens 46-51 25640014-7 2015 SIRT1 protein level in EPCs was increased by the treatment with H(2)O(2) for 24 h. Incubation of EPCs with H(2)O(2) dose dependently induced EPCs apoptosis. Hydrogen Peroxide 64-72 sirtuin 1 Homo sapiens 0-5 25640014-7 2015 SIRT1 protein level in EPCs was increased by the treatment with H(2)O(2) for 24 h. Incubation of EPCs with H(2)O(2) dose dependently induced EPCs apoptosis. Hydrogen Peroxide 107-115 sirtuin 1 Homo sapiens 0-5 25975679-0 2015 Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway. Hydrogen Peroxide 19-24 sirtuin 1 Homo sapiens 89-94 25975679-3 2015 In this study, we hypothesized that melatonin could protect MSCs from premature senescence induced by hydrogen peroxide (H2 O2 ) via the silent information regulator type 1 (SIRT1)-dependent pathway. Hydrogen Peroxide 102-119 sirtuin 1 Homo sapiens 137-172 25975679-3 2015 In this study, we hypothesized that melatonin could protect MSCs from premature senescence induced by hydrogen peroxide (H2 O2 ) via the silent information regulator type 1 (SIRT1)-dependent pathway. Hydrogen Peroxide 102-119 sirtuin 1 Homo sapiens 174-179 25975679-3 2015 In this study, we hypothesized that melatonin could protect MSCs from premature senescence induced by hydrogen peroxide (H2 O2 ) via the silent information regulator type 1 (SIRT1)-dependent pathway. Hydrogen Peroxide 121-126 sirtuin 1 Homo sapiens 137-172 25975679-3 2015 In this study, we hypothesized that melatonin could protect MSCs from premature senescence induced by hydrogen peroxide (H2 O2 ) via the silent information regulator type 1 (SIRT1)-dependent pathway. Hydrogen Peroxide 121-126 sirtuin 1 Homo sapiens 174-179 25975679-8 2015 We also found that melatonin attenuated the H2 O2 -stimulated phosphorylation of p38 mitogen-activated protein kinase, decreased expression of the senescence-associated protein p16(INK) (4alpha) , and increased SIRT1. Hydrogen Peroxide 44-49 sirtuin 1 Homo sapiens 211-216 26059423-7 2015 As expected, SIRT1 suppression by Ex527 (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) and siRNA-mediated SIRT1 silencing (si-SIRT1) significantly aggravated the H2O2-induced increased level of cleaved caspase-3 but greatly reduced the decreased expression of MnSOD and Bcl-xL. Hydrogen Peroxide 172-176 sirtuin 1 Homo sapiens 13-18 26059423-7 2015 As expected, SIRT1 suppression by Ex527 (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) and siRNA-mediated SIRT1 silencing (si-SIRT1) significantly aggravated the H2O2-induced increased level of cleaved caspase-3 but greatly reduced the decreased expression of MnSOD and Bcl-xL. Hydrogen Peroxide 172-176 sirtuin 1 Homo sapiens 116-121 26059423-7 2015 As expected, SIRT1 suppression by Ex527 (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) and siRNA-mediated SIRT1 silencing (si-SIRT1) significantly aggravated the H2O2-induced increased level of cleaved caspase-3 but greatly reduced the decreased expression of MnSOD and Bcl-xL. Hydrogen Peroxide 172-176 sirtuin 1 Homo sapiens 116-121 26059423-9 2015 Collectively, the present study indicated that CA can alleviate H2O2-induced hepatocyte damage through the SIRT1 pathway. Hydrogen Peroxide 64-68 sirtuin 1 Homo sapiens 107-112 26059423-6 2015 Considering the above results, we hypothesized that SIRT1 may play important roles in the protective effects of CA in injury induced by H2O2. Hydrogen Peroxide 136-140 sirtuin 1 Homo sapiens 52-57 25557764-3 2015 As predicted, ASA and salicylic acid (SA) treatment resulted in generation of H2O2, which is known to be an inducer of mitochondrial gene Sirt4 and other downstream target genes of Sirt1. Hydrogen Peroxide 78-82 sirtuin 1 Homo sapiens 181-186 25461268-9 2015 Treatment with NaSH (100 micromol/L) could increase the expression of SIRT1 in time dependent manner, which decreased by different concentration of H2O2. Hydrogen Peroxide 148-152 sirtuin 1 Homo sapiens 70-75 26583059-5 2015 H2O2 treatment increased PRMT1 and PRMT4 expression but decreased SIRT1 expression. Hydrogen Peroxide 0-4 sirtuin 1 Homo sapiens 66-71 26235577-0 2015 Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence via the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells. Hydrogen Peroxide 20-37 sirtuin 1 Homo sapiens 89-94 26235577-8 2015 Treatment of HUVECs with H2O2 also down-regulated the phosphorylation of endothelial nitric oxide synthase (eNOS), decreased the level of nitric oxide in the culture medium, and inhibited the protein expression and enzymatic activity of silent information regulator 1 (SIRT1), while pretreatment with curcumin partly reversed these effects (all p<0.05). Hydrogen Peroxide 25-29 sirtuin 1 Homo sapiens 237-267 26235577-8 2015 Treatment of HUVECs with H2O2 also down-regulated the phosphorylation of endothelial nitric oxide synthase (eNOS), decreased the level of nitric oxide in the culture medium, and inhibited the protein expression and enzymatic activity of silent information regulator 1 (SIRT1), while pretreatment with curcumin partly reversed these effects (all p<0.05). Hydrogen Peroxide 25-29 sirtuin 1 Homo sapiens 269-274 26235577-10 2015 The inhibition of SIRT1 using SIRT1 short interfering RNA (siRNA) could decrease the expression and phosphorylation of eNOS and abrogate the protective effect of curcumin on H2O2-induced premature senescence. Hydrogen Peroxide 174-178 sirtuin 1 Homo sapiens 18-23 26235577-10 2015 The inhibition of SIRT1 using SIRT1 short interfering RNA (siRNA) could decrease the expression and phosphorylation of eNOS and abrogate the protective effect of curcumin on H2O2-induced premature senescence. Hydrogen Peroxide 174-178 sirtuin 1 Homo sapiens 30-35 26583059-7 2015 Moreover, the H2O2-induced RPE cell damage was attenuated by PRMT1 or PRMT4 knockdown and SIRT1 overexpression. Hydrogen Peroxide 14-18 sirtuin 1 Homo sapiens 90-95 25386949-0 2014 Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway. Hydrogen Peroxide 25-29 sirtuin 1 Homo sapiens 70-79 25386949-3 2014 The purpose of this study was to explore whether Sirt1 is involved in the action of Ginsenoside Rb1 regarding protection against H2O2-induced HUVEC Senescence. Hydrogen Peroxide 129-133 sirtuin 1 Homo sapiens 49-54 24449278-6 2014 High concentrations of H2O2 (1 mM) induced more apoptosis in Sirt1-/-, than in WT mESCs. Hydrogen Peroxide 23-27 sirtuin 1 Homo sapiens 61-66 25128742-3 2014 Here, we show that SIRT1 essentially mediates hydrogen peroxide (H2O2)-induced cytotoxicity in human umbilical vein endothelial cell (HUVEC). Hydrogen Peroxide 46-63 sirtuin 1 Homo sapiens 19-24 25128742-3 2014 Here, we show that SIRT1 essentially mediates hydrogen peroxide (H2O2)-induced cytotoxicity in human umbilical vein endothelial cell (HUVEC). Hydrogen Peroxide 65-69 sirtuin 1 Homo sapiens 19-24 25128742-4 2014 In HUVECs, SIRT1 protein expression was significantly increased in a dose-dependent manner after H2O2 treatment, whereas the acetylation levels of the NF-kappaB p65 subunit and p53 were decreased. Hydrogen Peroxide 97-101 sirtuin 1 Homo sapiens 11-16 25128742-5 2014 EX527 (a specific SIRT1 inhibitor) conferred protection to the HUVECs against H2O2, as indicated by an improved cell viability, adhesion, an enhanced migratory ability, a decreased apoptotic index, decreased reactive oxygen species (ROS) production and reductions in several biochemical parameters. Hydrogen Peroxide 78-82 sirtuin 1 Homo sapiens 18-23 25128742-6 2014 Immunofluorescence and Western blot analyses demonstrated that H2O2 treatment up-regulated SIRT1, phosphorylated-JNK (p-JNK), p-p38MAPK, and p-ERK expression. Hydrogen Peroxide 63-67 sirtuin 1 Homo sapiens 91-96 24449278-5 2014 Exogenous H2 O2 (1 mM) induced apoptosis and autophagy in wild-type (WT) and Sirt1-/- mESCs. Hydrogen Peroxide 10-15 sirtuin 1 Homo sapiens 77-82 25032863-4 2014 We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases. Hydrogen Peroxide 14-31 sirtuin 1 Homo sapiens 81-86 25032863-5 2014 Both SIRT1 and SIRT5 are required for H2O2-mediated deacetylation of PML and accumulation of nuclear PML protein in HeLa cells. Hydrogen Peroxide 38-42 sirtuin 1 Homo sapiens 5-10 25032863-6 2014 Knockdown of SIRT1 reduces the number of H2O2-induced PML-nuclear bodies (NBs) and increases the survival of HeLa cells. Hydrogen Peroxide 41-45 sirtuin 1 Homo sapiens 13-18 25032863-7 2014 Ectopic expression of wild-type PML but not the K487R mutant rescues H2O2-induced cell death in SIRT1 knockdown cells. Hydrogen Peroxide 69-73 sirtuin 1 Homo sapiens 96-101 25032863-8 2014 Furthermore, ectopic expression of wild-type SIRT5 but not a catalytic defective mutant can also restore H2O2-induced cell death in SIRT1 knockdown cells. Hydrogen Peroxide 105-109 sirtuin 1 Homo sapiens 132-137 24449278-7 2014 However, addition of 3-methyladenine, a widely used autophagy inhibitor, in combination with H2O2 induced more cell death in WT than in Sirt1-/- mESCs. Hydrogen Peroxide 93-97 sirtuin 1 Homo sapiens 136-141 24449278-9 2014 H2O2 induced autophagy with loss of mitochondrial membrane potential and disruption of mitochondrial dynamics in Sirt1-/- mESCs. Hydrogen Peroxide 0-4 sirtuin 1 Homo sapiens 113-118 24449278-11 2014 Consistent with effects in mESCs, inhibition of SIRT1 using Lentivirus-mediated SIRT1 shRNA in hESCs demonstrated that knockdown of SIRT1 decreased H2O2-induced autophagy. Hydrogen Peroxide 148-152 sirtuin 1 Homo sapiens 48-53 23588928-0 2013 Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation. Hydrogen Peroxide 26-30 sirtuin 1 Homo sapiens 100-105 24451382-3 2014 We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inactivated SirT1 by reversible oxidative post-translational modifications (OPTMs) on three cysteines. Hydrogen Peroxide 79-96 sirtuin 1 Homo sapiens 11-16 24451382-3 2014 We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inactivated SirT1 by reversible oxidative post-translational modifications (OPTMs) on three cysteines. Hydrogen Peroxide 79-96 sirtuin 1 Homo sapiens 164-169 25147862-4 2014 Further results indicated that Vit C caused the dysregulation of some stress responses factors (SIRT1, p53 and FOXO3) in ARPE-19 cells response to H2O2. Hydrogen Peroxide 147-151 sirtuin 1 Homo sapiens 96-101 23247634-6 2013 Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2. Hydrogen Peroxide 145-149 sirtuin 1 Homo sapiens 111-117 22507555-5 2012 Incubation of cells with melatonin decreased H(2) O(2) -induced Sirtuin 1 (SIRT1) mRNA and protein expression. Hydrogen Peroxide 45-54 sirtuin 1 Homo sapiens 64-73 23228932-5 2013 As predicted, ASA and SA treatment resulted in the production of H(2)O(2), a known inducer of Sirt1 and confirmed in the current studies. Hydrogen Peroxide 65-73 sirtuin 1 Homo sapiens 94-99 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Hydrogen Peroxide 18-27 sirtuin 1 Homo sapiens 162-167 23247634-0 2013 Vitamin D protects human endothelial cells from H2O2 oxidant injury through the Mek/Erk-Sirt1 axis activation. Hydrogen Peroxide 48-52 sirtuin 1 Homo sapiens 88-93 22628222-0 2013 Hepatoprotection of berberine against hydrogen peroxide-induced apoptosis by upregulation of Sirtuin 1. Hydrogen Peroxide 38-55 sirtuin 1 Homo sapiens 93-102 22628222-5 2013 A significant change in the expression levels of sirtuin 1 (SIRT1) and apoptosis-related proteins was also observed in the BBR-pretreated hepatocytes under exposure to H2 O2 . Hydrogen Peroxide 168-173 sirtuin 1 Homo sapiens 49-58 22628222-5 2013 A significant change in the expression levels of sirtuin 1 (SIRT1) and apoptosis-related proteins was also observed in the BBR-pretreated hepatocytes under exposure to H2 O2 . Hydrogen Peroxide 168-173 sirtuin 1 Homo sapiens 60-65 22628222-7 2013 This study demonstrated that the protective effect of BBR against H2 O2 -induced apoptosis was associated with regulation of SIRT1 in hepatic cell line L02, which provided a possible explanation for its antioxidant activity, and implied an application of BBR for the therapeutic relevance in oxidative-stress-related liver diseases. Hydrogen Peroxide 66-71 sirtuin 1 Homo sapiens 125-130 22507555-5 2012 Incubation of cells with melatonin decreased H(2) O(2) -induced Sirtuin 1 (SIRT1) mRNA and protein expression. Hydrogen Peroxide 45-54 sirtuin 1 Homo sapiens 75-80 22219708-9 2010 Importantly, the anti-oxidant effects of resveratrol in H(2)O(2)-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1). Hydrogen Peroxide 56-64 sirtuin 1 Homo sapiens 137-142 20533910-6 2010 These results indicate that the effect of icariin on H(2) O(2) -induced neurotoxicity is dependent on increasing SIRT1 and provides a potentially novel pharmacological strategy for stroke prevention and/or treatment. Hydrogen Peroxide 53-62 sirtuin 1 Homo sapiens 113-118 21909125-12 2011 H2O2 (100 mumol/L) significantly decreased Sirt1 expression, and induced up-regulation of p53 acetylation and p16(INK4a), which were blocked by pre-treatment with RHL (10 mumol/L). Hydrogen Peroxide 0-4 sirtuin 1 Homo sapiens 43-48 20644332-0 2010 Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation. Hydrogen Peroxide 44-52 sirtuin 1 Homo sapiens 97-102 20644332-11 2010 Importantly, the treatment effect of RV was significantly abolished in the oxidative effects of H(2)O(2)-treated HUVECs by siRNA-SirT1. Hydrogen Peroxide 96-104 sirtuin 1 Homo sapiens 129-134 22219708-9 2010 Importantly, the anti-oxidant effects of resveratrol in H(2)O(2)-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1). Hydrogen Peroxide 56-64 sirtuin 1 Homo sapiens 158-163 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Hydrogen Peroxide 49-57 sirtuin 1 Homo sapiens 14-19 18681908-0 2009 SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. Hydrogen Peroxide 42-46 sirtuin 1 Homo sapiens 0-5 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Hydrogen Peroxide 49-57 sirtuin 1 Homo sapiens 128-133 18681908-7 2009 SIRT1 activator, resveratrol, which has been considered as an important antioxidant, protects against UV- and H(2)O(2)-induced cell death, whereas SIRT inhibitors such as sirtinol and nicotinamide enhance cell death. Hydrogen Peroxide 110-118 sirtuin 1 Homo sapiens 0-5 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Hydrogen Peroxide 49-57 sirtuin 1 Homo sapiens 128-133 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Hydrogen Peroxide 156-164 sirtuin 1 Homo sapiens 14-19 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Hydrogen Peroxide 156-164 sirtuin 1 Homo sapiens 128-133 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Hydrogen Peroxide 156-164 sirtuin 1 Homo sapiens 128-133 16785031-6 2006 H(2)O(2)-induced apoptosis was significantly attenuated in SIRT1-overexpressing MMCs, but enhanced in SIRT1-knockdown MMCs. Hydrogen Peroxide 0-8 sirtuin 1 Homo sapiens 59-64 17595514-0 2007 H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion. Hydrogen Peroxide 0-4 sirtuin 1 Homo sapiens 103-108 18485895-4 2008 When apoptosis was induced with H(2)O(2), Sirt1 was upregulated with the concomitant increase in catalase expression. Hydrogen Peroxide 32-40 sirtuin 1 Homo sapiens 42-47 18485895-5 2008 Sirt1 overexpression rescued H(2)O(2)-induced apoptosis through the upregulation of catalase. Hydrogen Peroxide 29-37 sirtuin 1 Homo sapiens 0-5 17916362-9 2007 Conversely, overexpression of Sirt1 prevented hydrogen peroxide-induced SA-beta-gal activity, morphological changes and deranged expression of PAI-1 and eNOS. Hydrogen Peroxide 46-63 sirtuin 1 Homo sapiens 30-35 16785031-6 2006 H(2)O(2)-induced apoptosis was significantly attenuated in SIRT1-overexpressing MMCs, but enhanced in SIRT1-knockdown MMCs. Hydrogen Peroxide 0-8 sirtuin 1 Homo sapiens 102-107 16785031-7 2006 Although SIRT1 did not affect H(2)O(2)-mediated phosphorylation of mitogen-activated protein (MAP) kinase, it interacted with p53 and inhibited H(2)O(2)-mediated p53 acetylation but not phosphorylation in MMCs. Hydrogen Peroxide 144-152 sirtuin 1 Homo sapiens 9-14