PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26664016-7 2015 Hydrogen peroxide-induced the expression of phospho-Jun N-terminal kinases (p-JNK) and p-p38 proteins in HT22 cells; however CUIP and nobiletin suppressed p-JNK and p-p38 without changing JNK or p38. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Mus musculus 89-92 26664016-7 2015 Hydrogen peroxide-induced the expression of phospho-Jun N-terminal kinases (p-JNK) and p-p38 proteins in HT22 cells; however CUIP and nobiletin suppressed p-JNK and p-p38 without changing JNK or p38. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Mus musculus 167-170 26664016-7 2015 Hydrogen peroxide-induced the expression of phospho-Jun N-terminal kinases (p-JNK) and p-p38 proteins in HT22 cells; however CUIP and nobiletin suppressed p-JNK and p-p38 without changing JNK or p38. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Mus musculus 167-170 25435295-8 2015 In addition, we confirmed that H2O2 activated mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK) and p38 MAPK. Hydrogen Peroxide 31-35 mitogen-activated protein kinase 14 Mus musculus 178-186 25298527-9 2014 Angiotensin II and H2O2, but not IL-1 or lipopolysaccharide, induced p38 activation and upregulation of transforming growth factor-beta1, platelet-derived growth factor-B, and monocyte chemoattractant protein-1 production was suppressed in Ask1(-/-) tubular epithelial cells. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 14 Mus musculus 69-72 24812425-5 2014 In vitro, high glucose level, hydrogen peroxide, and oltipraz stimulated Nrf2 and Agt gene expression; these changes were blocked by trigonelline, small interfering RNAs of Nrf2, antioxidants, or pharmacological inhibitors of nuclear factor-kappaB and p38 mitogen-activated protein kinase. Hydrogen Peroxide 30-47 mitogen-activated protein kinase 14 Mus musculus 252-255 23746981-3 2013 SSCs depleted of ROS stopped proliferating, but they showed enhanced self-renewal when ROS levels were increased by the addition of hydrogen peroxide, which induced the phosphorylation of stress kinases p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK). Hydrogen Peroxide 132-149 mitogen-activated protein kinase 14 Mus musculus 203-206 23914844-7 2013 Moreover, OXO inhibited LPS-induced intracellular reactive oxygen species (ROS) production and co-incubation of OXO and hydrogen peroxide (H2O2) suppressed the phosphorylation of p38 in a concentration-dependent manner. Hydrogen Peroxide 120-137 mitogen-activated protein kinase 14 Mus musculus 179-182 23914844-7 2013 Moreover, OXO inhibited LPS-induced intracellular reactive oxygen species (ROS) production and co-incubation of OXO and hydrogen peroxide (H2O2) suppressed the phosphorylation of p38 in a concentration-dependent manner. Hydrogen Peroxide 139-143 mitogen-activated protein kinase 14 Mus musculus 179-182 23742763-0 2013 An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells. Hydrogen Peroxide 40-57 mitogen-activated protein kinase 14 Mus musculus 8-11 24260309-4 2013 TGF-beta1/H2O2/HOCl, but not TGF-beta1 or H2O2/HOCl, induced beta3 expression by triggering the enhanced activation of p38 MAPK. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 14 Mus musculus 119-127 24260309-6 2013 beta3 promoted TGF-beta1/H2O2/HOCl-induced expression of itself via positive feed-back effect on p38 MAPK activation, and also promoted TGF-beta1/H2O2/HOCl-induced expression of alpha3 and SNAI2 by enhancing the activation of ERK pathway, thus resulting in higher invasive capacity of HCC cells. Hydrogen Peroxide 25-29 mitogen-activated protein kinase 14 Mus musculus 97-100 23233790-0 2012 The D1 dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Hydrogen Peroxide 55-72 mitogen-activated protein kinase 14 Mus musculus 155-158 23582186-7 2013 Furthermore, CoQ10 strongly suppressed H2 O2 -induced IkappaBalpha, p38 signaling pathways for osteoclastogenesis. Hydrogen Peroxide 39-44 mitogen-activated protein kinase 14 Mus musculus 68-71 23613819-5 2013 Six-hour treatment of mouse primary cortical cells with 10-40 microM hydrogen peroxide did not significantly compromise cell viability but it did produce mild oxidative stress (mOS), as shown by the increased levels of reactive radical species and activation of p38 stress kinase. Hydrogen Peroxide 69-86 mitogen-activated protein kinase 14 Mus musculus 262-265 22493442-8 2012 Consistently, activation of p38 by H(2)O(2) inhibited syndecan-2 expression and cell migration, whereas inhibition of p38 activation enhanced syndecan-2 expression and cell migration. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 14 Mus musculus 28-31 21732361-9 2012 Inhibition of p38 attenuated H(2)O(2)-induced LMVEC apoptosis. Hydrogen Peroxide 29-37 mitogen-activated protein kinase 14 Mus musculus 14-17 21732361-11 2012 PKCdelta inhibition significantly attenuated H(2)O(2)-induced LMVEC p38 activation. Hydrogen Peroxide 45-53 mitogen-activated protein kinase 14 Mus musculus 68-71 21732361-12 2012 Conversely, overexpression of wild-type PKCdelta or the catalytically active PKCdelta cleavage product greatly increased H(2)O(2)-induced HMVEC caspase and p38 activation. Hydrogen Peroxide 121-129 mitogen-activated protein kinase 14 Mus musculus 156-159 23734265-5 2013 TLR4 ligand (LPS) and H2O2 cooperated with TGF-beta1 to enhance the sustained activation of non-Smad pathways, including p38MAPK, ERK, JNK, PI3K, and NF-kappaB. Hydrogen Peroxide 22-26 mitogen-activated protein kinase 14 Mus musculus 121-128 23233790-10 2012 CONCLUSIONS: We conclude that SKF83959 attenuates hydrogen peroxide-induced injury in RGC-5 cells via a mechanism involving activation of the ERK and p38 pathways and the D(1) receptor is a potential molecular target for developing neuroprotective drugs. Hydrogen Peroxide 50-67 mitogen-activated protein kinase 14 Mus musculus 150-153 22145029-5 2011 Increasing endogenous H(2)O(2) attenuates p38-MAPK activity in IFNgamma/LPS stimulated WT and p47(phox-/-) DC, which suggests that endogenous Nox 2-derived ROS functions as a secondary messenger in the activated p38-MAPK signaling pathway during IL-12 expression. Hydrogen Peroxide 22-30 mitogen-activated protein kinase 14 Mus musculus 42-45 21532881-6 2011 The ability of TGF-beta1 to activate Smad2/3 was unaffected by LOX inactivation in normal MECs, whereas the stimulation of p38 MAPK by TGF-beta1 was blunted by inhibiting LOX activity in malignant MECs or by inducing the degradation of hydrogen peroxide in both cell types. Hydrogen Peroxide 236-253 mitogen-activated protein kinase 14 Mus musculus 123-126 21711332-8 2011 Pretreatment of T lymphocytes with the MAPK p38 inhibitor SB203580 or the MEK1 inhibitor U0126 reduced the stimulatory effect of H2O2. Hydrogen Peroxide 129-133 mitogen-activated protein kinase 14 Mus musculus 44-47 22145029-5 2011 Increasing endogenous H(2)O(2) attenuates p38-MAPK activity in IFNgamma/LPS stimulated WT and p47(phox-/-) DC, which suggests that endogenous Nox 2-derived ROS functions as a secondary messenger in the activated p38-MAPK signaling pathway during IL-12 expression. Hydrogen Peroxide 22-30 mitogen-activated protein kinase 14 Mus musculus 212-215 19955483-3 2010 Treating cultured C2C12 myotubes with oxidant hydrogen peroxide (4 h) resulted in increased p38 phosphorylation and reduced FoxO3 phosphorylation along with induced Atg7 mRNA expression without activation of NF-kappaB or FoxO3a transcriptional activities. Hydrogen Peroxide 46-63 mitogen-activated protein kinase 14 Mus musculus 92-95 19557877-7 2009 Hydrogen peroxide treatment also induced phosphorylation of the mitogen-activated protein kinases (MAPKs), c-Jun terminal kinase (JNK), extracellular-regulated kinase (ERK) and p38, and activated caspase-3. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Mus musculus 177-180 19955483-4 2010 Furthermore, inhibition of p38alpha/beta by SB202190 blocked hydrogen peroxide-induced atrophy with diminished upregulation of Atg7 and atrogenes [muscle atrophy F-box protein (MAFbx/Atrogin-1), muscle ring finger protein 1 (MuRF-1), and Nedd4]. Hydrogen Peroxide 61-78 mitogen-activated protein kinase 14 Mus musculus 27-35 19996687-9 2009 Inhibition assays with SB203580 (10 microM, a specific inhibitor of p38) and PD98059 (10 microM, a specific inhibitor of MEK) clearly showed that astaxanthin can inhibit H2O2-mediated apoptotic death via modulation of p38 and MEK signaling pathways. Hydrogen Peroxide 170-174 mitogen-activated protein kinase 14 Mus musculus 218-221 19996687-0 2009 Astaxanthin inhibits H2O2-mediated apoptotic cell death in mouse neural progenitor cells via modulation of P38 and MEK signaling pathways. Hydrogen Peroxide 21-25 mitogen-activated protein kinase 14 Mus musculus 107-110 18716444-8 2008 H2O2 also increased the phosphorylation of p38 MAPK, SAPK/JNK and nuclear factor kappa B (NF-kappaB), but DHT blocked these effects. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Mus musculus 43-46 19376889-4 2009 In control HUVEC treated with H(2)O(2) or in WT mice exposed to 100% O(2), a marked induction of Bax translocation and dimerization was associated with increased JNK and p38 kinase activity. Hydrogen Peroxide 30-38 mitogen-activated protein kinase 14 Mus musculus 170-173 19199341-4 2009 Moreover, H(2)O(2) induced an increase in the phosphorylation of epidermal growth factor receptor (EGFR), which was blocked by the inhibition of p44/42 or p38 MAPKs. Hydrogen Peroxide 10-18 mitogen-activated protein kinase 14 Mus musculus 155-158 19038359-5 2009 H(2)O(2) rapidly activated the mitogen-activated protein kinases (MAPK) including extracellular signal-regulated kinase 1/2 (Erk1/2), c-Jun N-terminal kinase (JNK) and p38. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Mus musculus 168-171 19038359-9 2009 Overexpression of PP2A or PP5 partially prevented H(2)O(2)-activation of Erk/12, JNK and p38, as well as cell death. Hydrogen Peroxide 50-58 mitogen-activated protein kinase 14 Mus musculus 89-92 19038359-11 2009 The results suggest that H(2)O(2)-induction of ROS inhibit PP2A and PP5, leading to activation of Erk1/2, JNK and p38 pathways thereby resulting in neuronal apoptosis. Hydrogen Peroxide 25-33 mitogen-activated protein kinase 14 Mus musculus 114-117 19208854-6 2009 Upon various proinflammatory signals including LPS, free fatty acids, and hydrogen peroxide, BBR suppressed the phosphorylation of MAPKs, such as p38, ERK, and JNK, and the level of reactive oxygen species in macrophages. Hydrogen Peroxide 74-91 mitogen-activated protein kinase 14 Mus musculus 146-149 18854310-8 2008 In addition, LAR deficiency enhanced H(2)O(2)-induced phosphorylation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), and p38 mitogen-activated protein kinase (MAPK). Hydrogen Peroxide 37-45 mitogen-activated protein kinase 14 Mus musculus 160-163 18716444-11 2008 In conclusion, DHT may partially prevent H2O2-induced cell injury through inhibition of ROS and ROS-induced activation of p38 MAPK, SAPK/JNK and NF-kappaB in mouse ES cells. Hydrogen Peroxide 41-45 mitogen-activated protein kinase 14 Mus musculus 122-130 18339707-3 2008 H(2)O(2) exposure rapidly induced apoptosis, which was associated with sustained activation of apoptosis signal-regulating kinase-1 and stress-activated protein kinases, such as p38 MAPK and c-Jun N-terminal kinase. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Mus musculus 178-186 18330893-11 2008 H2O2 also increased the level of p38 MAPK, JNK/SAPK, and NF-kappaB phosphorylation, which were inhibited by the DHT pretreatment. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Mus musculus 33-41 18417530-4 2008 Treatment of these cells with superoxide, H(2)O(2) or 4-hydroxy-2-nonenal (HNE) significantly inhibited steroid production and increased phosphorylation and activation of p38 MAPK. Hydrogen Peroxide 42-50 mitogen-activated protein kinase 14 Mus musculus 171-179 18330893-13 2008 However, the flutamide treatment abolished the inhibitory effects of DHT on the H2O2-induced increase in the levels of p38 MAPK, JNK/SAPK, and NF-kappaB phosphorylation. Hydrogen Peroxide 80-84 mitogen-activated protein kinase 14 Mus musculus 119-127 18330893-16 2008 In conclusion, DHT prevents the H2O2-induced apoptotic cell death of mouse ES cells through the activation of catalase and the downregulation of p38 MAPK, JNK/SAPK, and NF-kappaB via the androgen receptor. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 14 Mus musculus 145-153 18562577-0 2008 Hydrogen peroxide induces the production of tumor necrosis factor-alpha in RAW 264.7 macrophage cells via activation of p38 and stress-activated protein kinase. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Mus musculus 120-123 18562577-9 2008 Therefore, H( 2) O(2) was suggested to induce TNF-alpha production in macrophages via activating p38 and SAPK/JNK as oxidative stress-related signal pathways. Hydrogen Peroxide 11-21 mitogen-activated protein kinase 14 Mus musculus 97-100 18451500-6 2008 Inhibition of p38 MAPK ablated LPS-mediated Prx I upregulation and sensitized the microglia to H(2)O(2)-mediated cell death. Hydrogen Peroxide 95-103 mitogen-activated protein kinase 14 Mus musculus 14-22 17686961-8 2007 Furthermore, cultured Mkk3-/- tubular epithelial cells showed resistance to H(2)O(2)-induced apoptosis, suggesting a direct role for MKK3-p38 signaling in tubular apoptosis. Hydrogen Peroxide 76-84 mitogen-activated protein kinase 14 Mus musculus 138-141 17975303-6 2007 H(2)O(2) also increased phosphorylation of p44/42 mitogen activated protein kinases (MAPKs), p38 MAPK, and stress-activated protein kinase/Jun-N-terminal kinase (SAPK/JNK). Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Mus musculus 93-101 17900993-8 2007 p38 and ERK 1/2MAPK inhibitors reduced the maximal response to H(2)O(2), whereas JNK inhibitor had no effect. Hydrogen Peroxide 63-71 mitogen-activated protein kinase 14 Mus musculus 0-3 16386719-7 2006 Elevated phosphorylation of ERK1/2 and p38 induced by cisplatin or H2O2 in NIH3T3 cells was lowered by AD4, AD7 and CB4 in a dose-dependent manner. Hydrogen Peroxide 67-71 mitogen-activated protein kinase 14 Mus musculus 39-42 16971657-6 2006 Simultaneous blocking of ERK and P38 completely abolished the effect of H(2)O(2) on c-Src expression in mouse collecting duct cells. Hydrogen Peroxide 72-80 mitogen-activated protein kinase 14 Mus musculus 33-36 15746179-5 2005 Intraperitoneal injection of TNF-alpha increased atrogin1/MAFbx mRNA in skeletal muscle of adult mice within 4 h. Exposing myotubes to either TNF-alpha or H2O2 also produced general activation of the mitogen-activated protein kinases (MAPKs): p38, ERK1/2, and JNK. Hydrogen Peroxide 155-159 mitogen-activated protein kinase 14 Mus musculus 243-246 16394011-5 2006 We found that hydrogen peroxide acted by inducing p38 MAPK activation, which then prevented the ERK activation and MAPK phosphatase-1 up-regulation normally induced by TGF-beta. Hydrogen Peroxide 14-31 mitogen-activated protein kinase 14 Mus musculus 50-53 15965073-7 2005 p38 mitogen-activated protein kinase (MAPK) and caspase-3 were also activated in BV-2 cells under H2O2 stress. Hydrogen Peroxide 98-102 mitogen-activated protein kinase 14 Mus musculus 0-3 15965073-8 2005 Sesamolin was able to inhibit H2O2-induced p38 MAPK and caspase-3 activation and cell death. Hydrogen Peroxide 30-34 mitogen-activated protein kinase 14 Mus musculus 43-46 15685690-7 2005 Cellular senescence of cultured mouse biliary epithelial cells was induced by treatment with H2O2 via the p38MAPK-dependent pathway and nitric oxide-augmented H2O2-induced cellular senescence. Hydrogen Peroxide 93-97 mitogen-activated protein kinase 14 Mus musculus 106-113 14556862-8 2003 Interestingly, hydrogen peroxide-induced oxidative apoptosis of MLE-12 cells, with a shrinking nuclear morphology and activated caspase-3 activity, is also mediated by AP-1, JNK, and p38. Hydrogen Peroxide 15-32 mitogen-activated protein kinase 14 Mus musculus 183-186 14656721-5 2004 Using exposure of murine bone marrow neutrophils to H2O2 as a model of oxidative stress, we found both strong and persistent activation of ERK1/2, p38, JNK, and PKB, but not the p21-activated kinase. Hydrogen Peroxide 52-56 mitogen-activated protein kinase 14 Mus musculus 147-150 33184449-6 2021 H2O2 incubation activated mitogen-activated protein kinases (MAPKs) pathways, including the extracellular signal-regulated kinase1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 pathways. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Mus musculus 178-181 14631147-9 2003 p38 MAPK inhibition reduced H2O2-induced apoptosis more in LD, diminishing the density-dependence of H2O2-induced apoptosis without altering that of spontaneous apoptosis. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 14 Mus musculus 0-3 14631147-9 2003 p38 MAPK inhibition reduced H2O2-induced apoptosis more in LD, diminishing the density-dependence of H2O2-induced apoptosis without altering that of spontaneous apoptosis. Hydrogen Peroxide 101-105 mitogen-activated protein kinase 14 Mus musculus 0-3 14631147-10 2003 Akt level and activity and Hsp72 level were increased in HD, but decreased in MD and LD cells, by H2O2, and the active p38 MAPK was enhanced by H2O2 in all groups. Hydrogen Peroxide 144-148 mitogen-activated protein kinase 14 Mus musculus 119-127 10945608-3 2000 Whereas H2O2 treatment of cells induced JNK, p38, and IKK activities, in the presence of H2O2 and elevated GSTp expression there was an additional increase in ERK, p38, and IKK activities and a decrease in JNK activity. Hydrogen Peroxide 8-12 mitogen-activated protein kinase 14 Mus musculus 45-48 10945608-4 2000 GSTp-mediated protection from H2O2-induced death was attenuated upon inhibition of p38, nuclear factor KB, or MAP kinase by dominant negative or pharmacological inhibitors. Hydrogen Peroxide 30-34 mitogen-activated protein kinase 14 Mus musculus 83-86 10514426-5 1999 Comparison of JNK/p38 activities in response to methyl methanesulfonate, hydrogen peroxide, UVC irradiation, sorbitol, and anisomycin treatment of gadd45(+/+) and gadd45(-/-) fibroblasts revealed no deficiency in JNK/p38 activation in gadd45(-/-) fibroblasts. Hydrogen Peroxide 73-90 mitogen-activated protein kinase 14 Mus musculus 18-21 34542904-7 2021 ROS production, CCL2 level, cardiomyocyte apoptosis, and expression of Bax, caspase-3, and p-p38 MAPK were significantly amplified by the administration of IL-39 combined with H2O2, and these processes were significantly alleviated by an antioxidant Trolox. Hydrogen Peroxide 176-180 mitogen-activated protein kinase 14 Mus musculus 93-101 32755658-12 2020 Moreover, p38 MAPK inhibitor SB203580 can effectively reverse the damage of pcDNA Gadd45alpha from H2O2-induced RGC-5 cells. Hydrogen Peroxide 99-103 mitogen-activated protein kinase 14 Mus musculus 10-18 12885591-6 2003 p38 was also activated by H2O2, but to a greater extent in old cells. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 14 Mus musculus 0-3 12180991-5 2002 Over-expression of Hsp105alpha enhanced hydrogen peroxide-induced apoptosis by enhancing the activation of caspase-3, poly(ADP-ribose)polymerase cleavage, cytochrome c release and activation of p38 mitogen-activated protein kinase (p38). Hydrogen Peroxide 40-57 mitogen-activated protein kinase 14 Mus musculus 194-197 12180991-5 2002 Over-expression of Hsp105alpha enhanced hydrogen peroxide-induced apoptosis by enhancing the activation of caspase-3, poly(ADP-ribose)polymerase cleavage, cytochrome c release and activation of p38 mitogen-activated protein kinase (p38). Hydrogen Peroxide 40-57 mitogen-activated protein kinase 14 Mus musculus 232-235 11266364-3 2001 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide 53-61 mitogen-activated protein kinase 14 Mus musculus 103-106 10936514-0 2000 Hydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C. This study examined the immunomodulatory effects of hydrogen peroxide (H(2)O(2)) in B6C3F1 mouse splenic lymphocytes. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Mus musculus 130-133 10936514-5 2000 In addition, H(2)O(2) pretreatment blocked the phosphorylation of two stress-activated mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase (JNK) and p38 by LPS in a concentration-dependent fashion. Hydrogen Peroxide 13-21 mitogen-activated protein kinase 14 Mus musculus 164-167 10936514-6 2000 Therefore, these data suggest that H(2)O(2) suppresses immune response through the desensitization of PKC, which subsequently results in inhibition of JNK and p38. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 14 Mus musculus 159-162 34374636-5 2021 At a concentration-dependent way, resveratrol reversed H2O2-induced increases in expressions of cleaved caspase-3 and cleaved caspase-9, production of ROS, loss of mitochondrial membrane potential and the expressions of p-p38, p-ERK, and p-JNK. Hydrogen Peroxide 55-59 mitogen-activated protein kinase 14 Mus musculus 222-225 34781017-7 2022 On the contrary, suppression/silencing of S1PR3 further promoted H2O2-induced endothelial hyperpermeability and ZO-1 redistribution, accompanied by the increased phosphorylation of p38, ERK and cPLA2. Hydrogen Peroxide 65-69 mitogen-activated protein kinase 14 Mus musculus 181-184 34542904-6 2021 IL-39 and H2O2 both significantly promoted the production of intracellular ROS, increased the level of intracellular CCL2, stimulated the apoptotic progress of cardiomyocytes, increased the mRNA and protein expression levels of Bax, caspase-3, and p-p38 MAPK, and decreased the mRNA and protein expression levels of Bcl-2. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 14 Mus musculus 250-258 35368107-6 2022 Furthermore, the trends of Nrf2, Keap1, p-ERK, p-JNK, p-p38, p-PI3K, and p-AKT levels in H2 O2 -induced RAW264.7 cells after AMP treatment were similar to the results in CCl4 -induced mice liver. Hydrogen Peroxide 89-94 mitogen-activated protein kinase 14 Mus musculus 56-59 30693443-5 2019 Interestingly, postmitotic cochlear cells exposed to H2O2 displayed key hallmarks of senescent cells, including dramatically increased levels of p21, p38, and p-p38 expression, concomitant with decreased p19 and BubR1 expression and positive senescence-associated beta-galactosidase labeling. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 14 Mus musculus 150-153 32667705-0 2020 Spinosin protects N2a cells from H2 O2 -induced neurotoxicity through inactivation of p38MAPK. Hydrogen Peroxide 33-38 mitogen-activated protein kinase 14 Mus musculus 86-93 32667705-9 2020 Notably, H2 O2 -increased p38MAPK activation was attenuated by SPI administration, and p38MAPK inhibitor BIRB796 markedly reduced H2 O2 -induced oxidative damage in N2a cells. Hydrogen Peroxide 9-14 mitogen-activated protein kinase 14 Mus musculus 26-33 32667705-9 2020 Notably, H2 O2 -increased p38MAPK activation was attenuated by SPI administration, and p38MAPK inhibitor BIRB796 markedly reduced H2 O2 -induced oxidative damage in N2a cells. Hydrogen Peroxide 130-135 mitogen-activated protein kinase 14 Mus musculus 87-94 32667705-10 2020 CONCLUSIONS: Our findings suggest that SPI protects N2a cells from H2 O2 -induced oxidative damage through inactivation of p38MAPK. Hydrogen Peroxide 67-72 mitogen-activated protein kinase 14 Mus musculus 123-130 31715260-3 2020 Recently we have demonstrated that the activation of extracellular signal-regulated kinase (Erk) 1/2 as well as p38 is required for hydrogen peroxide (H2O2)-increased cytosolic phospholipase A2 (cPLA2) phosphorylation in bEnd3 cells. Hydrogen Peroxide 132-149 mitogen-activated protein kinase 14 Mus musculus 112-115 30693443-5 2019 Interestingly, postmitotic cochlear cells exposed to H2O2 displayed key hallmarks of senescent cells, including dramatically increased levels of p21, p38, and p-p38 expression, concomitant with decreased p19 and BubR1 expression and positive senescence-associated beta-galactosidase labeling. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 14 Mus musculus 161-164 30351993-10 2019 Inhibiting Prx1/2 promoted neuronal apoptosis by increasing the hydrogen peroxide (H2O2) levels via the apoptosis signal-regulating kinase 1/p38 pathway. Hydrogen Peroxide 83-87 mitogen-activated protein kinase 14 Mus musculus 141-144 30810603-0 2019 Erratum for: "Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation" [Braz J Med Biol Res (2018) 51(10): e7439]. Hydrogen Peroxide 73-77 mitogen-activated protein kinase 14 Mus musculus 155-158 30290210-5 2019 Besides p38, extracellular signal-regulated kinase (Erk) 1/2 is required for H2O2-increased cPLA2 phosphorylation and endothelial permeability. Hydrogen Peroxide 77-81 mitogen-activated protein kinase 14 Mus musculus 8-11 29906250-5 2018 This TRPM2-dependent H2O2-mediated NET formation involved components of autophagy and activation of AMPK and p38 MAPK, but not PI3K and AKT. Hydrogen Peroxide 21-25 mitogen-activated protein kinase 14 Mus musculus 109-117 30156611-0 2018 Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation. Hydrogen Peroxide 59-63 mitogen-activated protein kinase 14 Mus musculus 141-144 30156611-10 2018 Additionally, phosphorylated p38 in LSECs exposed to H2O2 was elevated by GSTD. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 14 Mus musculus 29-32 30156611-11 2018 Inhibition of p38 phosphorylation by SB203580 did not induce Nrf2 and HO-1 expression after 1 or 10 microM GSTD treatment and the protective effect on cell viability and malondialdehyde reduction in H2O2-exposed LSECs was reduced. Hydrogen Peroxide 199-203 mitogen-activated protein kinase 14 Mus musculus 14-17 30156611-12 2018 The data conclusively demonstrated that GSTD-induced HO-1 and Nrf2 expression is involved in protection of LSECs from H2O2-induced oxidative injury, which may be regulated by p38 phosphorylation. Hydrogen Peroxide 118-122 mitogen-activated protein kinase 14 Mus musculus 175-178 29523818-5 2018 H2O2- and rotenone-induced cellular and intramitochondrial reactive oxygen species (ROS) activated oxidant-responsive kinases P38 and ERK1, and the translocation of Tdp1 from the nucleus to the mitochondria via the TIM/TOM complex. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Mus musculus 126-129 29385192-4 2018 Oxidant H2O2 and agonists of TLR4, Akt, p38/JNK and IKK/NF-kappaB could significantly antagonize the inhibitory effects of rhein on IAV-induced cytopathic effect (CPE) and IAV replication. Hydrogen Peroxide 8-12 mitogen-activated protein kinase 14 Mus musculus 40-43 29221988-3 2018 In NRVMs, TIIA treatment ameliorated H2O2-induced caspase-3/9 activations through the suppression of p38 and mTOR signaling pathways, where caspase-mediated cleavage of YY1 and PARP resulted in the defects in mitochondrial biogenesis and DNA repair, and this event finally led to cardiomyocyte apoptosis. Hydrogen Peroxide 37-41 mitogen-activated protein kinase 14 Mus musculus 101-104 28982666-6 2017 p38alpha/MAPK-activated protein kinase 2/heat shock protein 27 and p38alpha/cytosolic phospholipases A2 were the major pathways regulating receptor-mediated or hydrogen peroxide-induced platelet activation in an ischemic environment. Hydrogen Peroxide 160-177 mitogen-activated protein kinase 14 Mus musculus 0-8 28982666-6 2017 p38alpha/MAPK-activated protein kinase 2/heat shock protein 27 and p38alpha/cytosolic phospholipases A2 were the major pathways regulating receptor-mediated or hydrogen peroxide-induced platelet activation in an ischemic environment. Hydrogen Peroxide 160-177 mitogen-activated protein kinase 14 Mus musculus 67-75 28302174-6 2017 RESULTS: Treatment of Y1 cells with H2O2 greatly enhanced the phosphorylation of both p38 MAPK and CREB protein. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 14 Mus musculus 86-94 28283909-7 2017 Dephosphorylation of phospho-p38 by CacyBP/SIP in NB2a cells treated with hydrogen peroxide is much more effective than in control ones. Hydrogen Peroxide 74-91 mitogen-activated protein kinase 14 Mus musculus 29-32 29156799-13 2017 Mechanistically, AA attenuated I/R or LPS/H2O2-induced ROS production and phosphorylation level of JNK, p38 MAPK and IkappaBalpha but not ERK, a mechanism dependent on PPARgamma. Hydrogen Peroxide 42-46 mitogen-activated protein kinase 14 Mus musculus 104-112 27884794-7 2017 LPS-induced Muc5ac release was significantly inhibited by EGFR inhibitor, p38 inhibitor and JNK inhibitor, but not ERK1/2 inhibitor, indicating that the H2O2-EGFR-MAPK pathway is likely involved in the responses. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 14 Mus musculus 74-77 27391427-6 2016 Moreover, pretreatment of N2a cells with D609, an sphingomyelin synthase inhibitor, or SMS1-silencing RNA (siRNA) further increased ceramide and potentiated H2O2-induced apoptosis which could be reversed by SB203580 (a p38 inhibitor). Hydrogen Peroxide 157-161 mitogen-activated protein kinase 14 Mus musculus 219-222 28163684-12 2017 In addition, SDSS significantly attenuated H2O2-induced activation of p38-, ERK1/2-, and JNK-MAPKs. Hydrogen Peroxide 43-47 mitogen-activated protein kinase 14 Mus musculus 70-73 25982271-9 2016 Interestingly, other genotoxins such as cisplatin (CDDP), hydrogen peroxide and ultraviolet radiation also enhance XPC-dependent p38-SAPK phosphorylation. Hydrogen Peroxide 58-75 mitogen-activated protein kinase 14 Mus musculus 129-132