PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29393339-5 2018 H2O2-exposed fibroblasts exhibited activated NALP3 inflammasomes via increased NALP3, apoptosis-associated Speck-like protein and caspase-1 expression and the secretion of interleukin-1beta. Hydrogen Peroxide 0-4 interleukin 1 beta Mus musculus 172-189 31060676-3 2019 Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.<b>Conclusion</b> CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1. Hydrogen Peroxide 29-33 interleukin 1 beta Mus musculus 116-124 31060676-3 2019 Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.<b>Conclusion</b> CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1. Hydrogen Peroxide 29-33 interleukin 1 beta Mus musculus 297-305 29859240-4 2018 We reported here that H2S attenuated hydrogen peroxide (H2O2)-induced NLRP3 inflammasome activation, which led to caspase-1 activation and IL-1beta production in macrophages. Hydrogen Peroxide 37-54 interleukin 1 beta Mus musculus 139-147 29859240-4 2018 We reported here that H2S attenuated hydrogen peroxide (H2O2)-induced NLRP3 inflammasome activation, which led to caspase-1 activation and IL-1beta production in macrophages. Hydrogen Peroxide 56-60 interleukin 1 beta Mus musculus 139-147 26688105-6 2016 Intragastric administration of H2O2 significantly up-regulated the expression of TNF-alpha,IL-1beta, and IL-5 (P<0.05). Hydrogen Peroxide 31-35 interleukin 1 beta Mus musculus 91-99 27864663-13 2017 It was found that BMSCs reduced H2O2-induced inflammatory factors IL-1beta and TNF-alpha, down-regulated intracellular oxidant factor MDA, up-regulated intracellular antioxidant factor SOD, and increased neurotrophins BDNF and CNTF expression. Hydrogen Peroxide 32-36 interleukin 1 beta Mus musculus 66-74 28752965-12 2017 in vitroexperiment, H2O2 increased NALP3 (P<0.05), ASC (P<0.01), caspase-1 (P<0.05) expressions and IL-1beta releasing (P<0.05)and promoted the expressions of collagen-1 and alpha-SMA in both gene and protein levels (P<0.05) in NIH-3T3. Hydrogen Peroxide 20-24 interleukin 1 beta Mus musculus 109-117 27749344-9 2017 Additionally we report, in vitro, that increased concentrations of active caspase-1 and interleukin-1beta are related to an increased concentration of hydrogen peroxide in bacterially infected glutathione peroxidase 1 macrophages and that restoring hydrogen peroxide antioxidant defenses suppressed this effect. Hydrogen Peroxide 151-168 interleukin 1 beta Mus musculus 88-105 27749344-9 2017 Additionally we report, in vitro, that increased concentrations of active caspase-1 and interleukin-1beta are related to an increased concentration of hydrogen peroxide in bacterially infected glutathione peroxidase 1 macrophages and that restoring hydrogen peroxide antioxidant defenses suppressed this effect. Hydrogen Peroxide 249-266 interleukin 1 beta Mus musculus 88-105 25218213-3 2014 Upregulation of TNF-alpha and IL-1beta mRNA in the brain parenchyma was independent of cerebrospinal fluid leukocytosis, pneumococcal pneumolysin and H2O2, but it was potently induced by pneumococcal cell wall (PCW) fragments. Hydrogen Peroxide 150-154 interleukin 1 beta Mus musculus 30-38 23938462-5 2014 The cascade involved prostaglandin E2 (PGE2) production from melanoma induced by IL-18-dependent tumor necrosis factor-alpha (TNFalpha); next, PGE2-induced IL-1beta via vascular endothelial growth factor (VEGF) secretion, which in turn induced VLA-4 activation via cyclooxygenase 2-dependent H2O2. Hydrogen Peroxide 292-296 interleukin 1 beta Mus musculus 156-164 34537189-7 2022 More importantly, transfection of keratinocytes with dsDNA synergized with TNF-alpha or H2O2 to induce STING-dependent activation of NF-kappaB and subsequent expression of Il1b, Ccl20, and Cxcl10. Hydrogen Peroxide 88-92 interleukin 1 beta Mus musculus 172-176 8613473-1 1996 We have examined H2O2 production by in vitro enriched hepatic sinusoidal endothelium (HSE) during interleukin-1 beta (IL-1 beta) stimulation and B16 melanoma cell adhesion. Hydrogen Peroxide 17-21 interleukin 1 beta Mus musculus 98-116 8613473-1 1996 We have examined H2O2 production by in vitro enriched hepatic sinusoidal endothelium (HSE) during interleukin-1 beta (IL-1 beta) stimulation and B16 melanoma cell adhesion. Hydrogen Peroxide 17-21 interleukin 1 beta Mus musculus 118-127 8613473-3 1996 Under IL-1 beta treatment there was a 6-fold increase in endothelial cells producing H2O2 (67%) and a 4-fold augmentation in the Kupffer cell population (86%). Hydrogen Peroxide 85-89 interleukin 1 beta Mus musculus 6-15 8613473-5 1996 In contrast to the homogeneity of Kupffer cells, H2O2 production intensity was largely heterogeneous in IL-1 beta-activated HSE. Hydrogen Peroxide 49-53 interleukin 1 beta Mus musculus 104-113 8613473-7 1996 The addition of increasing concentration of IL-1 beta to HSE for 4 h caused the progressive activation of H2O2 production by treated cells. Hydrogen Peroxide 106-110 interleukin 1 beta Mus musculus 44-53 8613473-8 1996 The addition of 80 M excess of IL-1 receptor antagonist (IL-1 Ra) 10 min before IL-1 beta treatment abrogated IL-1 beta-mediated enhancement of H2O2. Hydrogen Peroxide 144-148 interleukin 1 beta Mus musculus 80-89 8613473-8 1996 The addition of 80 M excess of IL-1 receptor antagonist (IL-1 Ra) 10 min before IL-1 beta treatment abrogated IL-1 beta-mediated enhancement of H2O2. Hydrogen Peroxide 144-148 interleukin 1 beta Mus musculus 110-119 8613473-12 1996 Preincubation of B16 melanoma cells in the presence of 5 micrograms/ml anti-mouse IL-1 beta neutralizing antibody reduced the melanoma cell-induced HSE production of H2O2 by 80%. Hydrogen Peroxide 166-170 interleukin 1 beta Mus musculus 82-91 18620044-3 2008 We found that the non-provitamin A carotenoid, lutein, decreased intracellular H(2)O(2) accumulation by scavenging superoxide and H(2)O(2) and the NF-kappaB-regulated inflammatory genes, iNOS, TNF-alpha, IL-1beta, and cyclooxygenase-2, in lipopolysaccharide (LPS)-stimulated macrophages. Hydrogen Peroxide 79-87 interleukin 1 beta Mus musculus 204-212 18383346-7 2008 As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release. Hydrogen Peroxide 291-299 interleukin 1 beta Mus musculus 97-105 35192424-6 2022 Enzyme-linked immunosorbent assays and Western blotting revealed that inflammatory cytokine (interleukin-1beta, interleukin-18 and C-C motif chemokine ligand 5) expression was induced by H2O2 treatment and that circ_0007059 repressed H2O2-induced inflammation. Hydrogen Peroxide 187-191 interleukin 1 beta Mus musculus 93-110 35192424-6 2022 Enzyme-linked immunosorbent assays and Western blotting revealed that inflammatory cytokine (interleukin-1beta, interleukin-18 and C-C motif chemokine ligand 5) expression was induced by H2O2 treatment and that circ_0007059 repressed H2O2-induced inflammation. Hydrogen Peroxide 234-238 interleukin 1 beta Mus musculus 93-110