PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15998242-1	2005	This study shows that the combination of glutathione (GSH) plus hydrogen peroxide (H2O2) promotes the S-glutathionylation of ryanodine receptor type 1 (RyR1) Ca2+ release channels, and confirms their joint S-glutathionylation and S-nitrosylation by S-nitrosoglutathione (GSNO).	Hydrogen Peroxide	64-81	ryanodine receptor 1	Homo sapiens	125-150	
17237236-3	2007	The reactivity of these thiol groups was very sensitive to oxidation by naphthoquinone, H2O2, NO, or O2, all known modulators of the RyR1 channel complex.	Hydrogen Peroxide	88-92	ryanodine receptor 1	Homo sapiens	133-137	
16321793-8	2005	The effects of reactive oxygen/nitrogen species on RyR channels from neurons and RyR-mediated sequential activation of neuronal ERK1/2 and CREB produced by hydrogen peroxide and other stimuli will be discussed as well.	Hydrogen Peroxide	156-173	ryanodine receptor 1	Homo sapiens	81-84	
15998242-4	2005	RyR1 S-glutathionylation (induced by GSH plus H2O2) or RyR1 S-nitrosylation (produced by NOR-3) increased by approximately six- or twofold, respectively, the Kd of apocalmodulin (apoCaM) or Ca2+-calmodulin (CaCaM) binding to triads.	Hydrogen Peroxide	46-50	ryanodine receptor 1	Homo sapiens	0-4	
15998242-1	2005	This study shows that the combination of glutathione (GSH) plus hydrogen peroxide (H2O2) promotes the S-glutathionylation of ryanodine receptor type 1 (RyR1) Ca2+ release channels, and confirms their joint S-glutathionylation and S-nitrosylation by S-nitrosoglutathione (GSNO).	Hydrogen Peroxide	64-81	ryanodine receptor 1	Homo sapiens	152-156	
15998242-1	2005	This study shows that the combination of glutathione (GSH) plus hydrogen peroxide (H2O2) promotes the S-glutathionylation of ryanodine receptor type 1 (RyR1) Ca2+ release channels, and confirms their joint S-glutathionylation and S-nitrosylation by S-nitrosoglutathione (GSNO).	Hydrogen Peroxide	83-87	ryanodine receptor 1	Homo sapiens	125-150	
15998242-1	2005	This study shows that the combination of glutathione (GSH) plus hydrogen peroxide (H2O2) promotes the S-glutathionylation of ryanodine receptor type 1 (RyR1) Ca2+ release channels, and confirms their joint S-glutathionylation and S-nitrosylation by S-nitrosoglutathione (GSNO).	Hydrogen Peroxide	83-87	ryanodine receptor 1	Homo sapiens	152-156	
23798702-2	2013	S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4.	Hydrogen Peroxide	97-114	ryanodine receptor 1	Homo sapiens	15-19	
16036616-9	2005	Results showing that reactive oxygen/nitrogen species modify RyR channels from neurons and the RyR-mediated sequential activation of neuronal ERKs and CREB produced by hydrogen peroxide and other stimuli will be also discussed.	Hydrogen Peroxide	168-185	ryanodine receptor 1	Homo sapiens	95-98	
23798702-9	2013	Thus, physiological redox regulation of RyR1 by endogenously generated hydrogen peroxide is exerted through dynamic disulfide formation involving multiple Cys residues.	Hydrogen Peroxide	71-88	ryanodine receptor 1	Homo sapiens	40-44	
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Hydrogen Peroxide	66-83	ryanodine receptor 1	Homo sapiens	141-145