PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27677209-3 2016 Among potential endogenous agonists of TRPA1 is H2O2 generated by d-amino acid oxidase (DAAO) in astrocytes. Hydrogen Peroxide 48-52 D-amino-acid oxidase Rattus norvegicus 66-86 26922555-3 2016 Since the astrocyte-DAAO pathway generates hydrogen peroxide, an agonist of the TRPA1 channel expressed spinally on nociceptive nerve terminals and astrocytes, we tested a hypothesis that the spinal TRPA1 contributes to antinociceptive tolerance to prolonged spinal morphine treatment. Hydrogen Peroxide 43-60 D-amino-acid oxidase Rattus norvegicus 20-24 26922555-12 2016 This finding suggests that spinal TRPA1 may contribute, at least partly, to facilitation of morphine antinociceptive tolerance through mechanisms that possibly involve TRPA1-mediated up-regulation of the astroglial DAAO, a generator of hydrogen peroxide, a pronociceptive compound acting also on TRPA1. Hydrogen Peroxide 236-253 D-amino-acid oxidase Rattus norvegicus 215-219 27677209-3 2016 Among potential endogenous agonists of TRPA1 is H2O2 generated by d-amino acid oxidase (DAAO) in astrocytes. Hydrogen Peroxide 48-52 D-amino-acid oxidase Rattus norvegicus 88-92 23928652-0 2014 Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathway involved in morphine antinociceptive tolerance. Hydrogen Peroxide 77-94 D-amino-acid oxidase Rattus norvegicus 56-76 23928652-2 2014 DAAO catalyzes oxidation of D-amino acids to hydrogen peroxide, which is a stable and less active reactive oxygen species, and may represent a final form of reactive oxygen species. Hydrogen Peroxide 45-62 D-amino-acid oxidase Rattus norvegicus 0-4 23928652-3 2014 This study tested the hypothesis that the spinal astroglial DAAO-hydrogen peroxide pathway plays an important role in the development of morphine antinociceptive tolerance. Hydrogen Peroxide 65-82 D-amino-acid oxidase Rattus norvegicus 60-64 23958579-11 2013 The results indicate that among spinal pain facilitatory mechanisms that contribute to the sleep deprivation-induced mechanical pain hypersensitivity is DAAO, presumably due to production of reactive oxygen species, such as hydrogen peroxide, an endogenous agonist of the pronociceptive TRPA1 ion channel. Hydrogen Peroxide 224-241 D-amino-acid oxidase Rattus norvegicus 153-157 23928652-8 2014 Intrathecal 5-chloro-benzo[d]isoxazol-3-ol and small interfering RNA/DAAO completely prevented increased spinal hydrogen peroxide levels after chronic morphine treatment. Hydrogen Peroxide 112-129 D-amino-acid oxidase Rattus norvegicus 69-73 23928652-11 2014 CONCLUSIONS: For the first time, the authors" result identify a novel spinal astroglial DAAO-hydrogen peroxide pathway that is critically involved in the initiation and maintenance of morphine antinociceptive tolerance, and suggest that this pathway is of potential utility for the management of morphine tolerance and chronic pain. Hydrogen Peroxide 93-110 D-amino-acid oxidase Rattus norvegicus 88-92 18636195-1 2008 D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino acids, such as D-alanine, to the corresponding amino acids and is then reoxidized by molecular oxygen to yield hydrogen peroxide, a reactive oxygen species, which reacts with DNA, lipids and protein, inducing cell death. Hydrogen Peroxide 183-200 D-amino-acid oxidase Rattus norvegicus 0-20 21921941-4 2012 OSED utilizes D-amino acid oxidase (DAO), which is a promising therapeutic protein that induces oxidative stress and apoptosis through generating hydrogen peroxide (H2O2). Hydrogen Peroxide 146-163 D-amino-acid oxidase Rattus norvegicus 14-34 21921941-4 2012 OSED utilizes D-amino acid oxidase (DAO), which is a promising therapeutic protein that induces oxidative stress and apoptosis through generating hydrogen peroxide (H2O2). Hydrogen Peroxide 146-163 D-amino-acid oxidase Rattus norvegicus 36-39 21921941-4 2012 OSED utilizes D-amino acid oxidase (DAO), which is a promising therapeutic protein that induces oxidative stress and apoptosis through generating hydrogen peroxide (H2O2). Hydrogen Peroxide 165-169 D-amino-acid oxidase Rattus norvegicus 14-34 21921941-4 2012 OSED utilizes D-amino acid oxidase (DAO), which is a promising therapeutic protein that induces oxidative stress and apoptosis through generating hydrogen peroxide (H2O2). Hydrogen Peroxide 165-169 D-amino-acid oxidase Rattus norvegicus 36-39 22996731-1 2012 D-Amino acid oxidase (DAAO), a FAD-dependent peroxisomal flavoenzyme that catalyzes oxidation of D-amino acids to hydrogen peroxide, is distributed in the spinal cord almost exclusively expressed within astrocytes. Hydrogen Peroxide 114-131 D-amino-acid oxidase Rattus norvegicus 0-20 22996731-1 2012 D-Amino acid oxidase (DAAO), a FAD-dependent peroxisomal flavoenzyme that catalyzes oxidation of D-amino acids to hydrogen peroxide, is distributed in the spinal cord almost exclusively expressed within astrocytes. Hydrogen Peroxide 114-131 D-amino-acid oxidase Rattus norvegicus 22-26 22996731-8 2012 Our results provide the first evidence that spinal DAAO contributes to the development of morphine tolerance to analgesia and bone cancer pain accounting for 40-50 % pain status, probably via production of hydrogen peroxide leading to activation of astrocytes. Hydrogen Peroxide 206-223 D-amino-acid oxidase Rattus norvegicus 51-55 18636195-1 2008 D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino acids, such as D-alanine, to the corresponding amino acids and is then reoxidized by molecular oxygen to yield hydrogen peroxide, a reactive oxygen species, which reacts with DNA, lipids and protein, inducing cell death. Hydrogen Peroxide 183-200 D-amino-acid oxidase Rattus norvegicus 22-26 16452318-10 2006 Overall, we consider that extracellular D-serine can gain access to intracellular DAO, being metabolized to produce H(2)O(2). Hydrogen Peroxide 116-124 D-amino-acid oxidase Rattus norvegicus 82-85 35089810-3 2022 When DAAO-infected animals are fed the DAAO substrate D-alanine, the enzyme generates hydrogen peroxide (H2O2) in the cardiac myocytes, leading to dilated cardiomyopathy. Hydrogen Peroxide 86-103 D-amino-acid oxidase Rattus norvegicus 5-9 7903300-2 1993 D-Amino acids administered to animals are absorbed by the intestine and transported through the blood-stream to solid tissues where they are oxidized in vivo by D-amino acid oxidase and D-aspartate oxidase to produce the same compounds they do in vitro; i.e. NH3, H2O2, and the keto acid corresponding to the amino acid ingested. Hydrogen Peroxide 264-268 D-amino-acid oxidase Rattus norvegicus 161-181 8104917-1 1993 D-Amino acid oxidase activity was demonstrated in peroxisomes of rat liver using unfixed cryostat sections and a histochemical technique using cerium ions as capture reagent for hydrogen peroxide and diaminobenzidine, cobalt ions and exogenous hydrogen peroxide to visualize the final reaction product for light microscopical analysis. Hydrogen Peroxide 178-195 D-amino-acid oxidase Rattus norvegicus 0-20 8104917-1 1993 D-Amino acid oxidase activity was demonstrated in peroxisomes of rat liver using unfixed cryostat sections and a histochemical technique using cerium ions as capture reagent for hydrogen peroxide and diaminobenzidine, cobalt ions and exogenous hydrogen peroxide to visualize the final reaction product for light microscopical analysis. Hydrogen Peroxide 244-261 D-amino-acid oxidase Rattus norvegicus 0-20 35089810-6 2022 Rats infected with recombinant cardiotropic AAV9 expressing DAAO or control AAV9 were treated for 7 weeks with D-alanine to stimulate chemogenetic H2O2 production by DAAO and generate dilated cardiomyopathy. Hydrogen Peroxide 147-151 D-amino-acid oxidase Rattus norvegicus 166-170 35089810-3 2022 When DAAO-infected animals are fed the DAAO substrate D-alanine, the enzyme generates hydrogen peroxide (H2O2) in the cardiac myocytes, leading to dilated cardiomyopathy. Hydrogen Peroxide 86-103 D-amino-acid oxidase Rattus norvegicus 39-43 35089810-3 2022 When DAAO-infected animals are fed the DAAO substrate D-alanine, the enzyme generates hydrogen peroxide (H2O2) in the cardiac myocytes, leading to dilated cardiomyopathy. Hydrogen Peroxide 105-109 D-amino-acid oxidase Rattus norvegicus 5-9 35089810-3 2022 When DAAO-infected animals are fed the DAAO substrate D-alanine, the enzyme generates hydrogen peroxide (H2O2) in the cardiac myocytes, leading to dilated cardiomyopathy. Hydrogen Peroxide 105-109 D-amino-acid oxidase Rattus norvegicus 39-43 35089810-6 2022 Rats infected with recombinant cardiotropic AAV9 expressing DAAO or control AAV9 were treated for 7 weeks with D-alanine to stimulate chemogenetic H2O2 production by DAAO and generate dilated cardiomyopathy. Hydrogen Peroxide 147-151 D-amino-acid oxidase Rattus norvegicus 60-64