PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10676651-1	2000	Xanthine oxidase (XO) mediates anticancer activity because of its ability to generate cytotoxic reactive oxygen species (ROS), including superoxide anion radical and hydrogen peroxide.	Hydrogen Peroxide	166-183	xanthine dehydrogenase	Mus musculus	0-16	
10788668-5	2000	Although EDTA is commonly included in this assay to eliminate undesirable Fenton side-reactions with H(2)O(2) (a co-product of reactions that use xanthine oxidase to produce O(2)(-&z.rad;)), we found that catalase, but not EDTA, blocked suicide elimination of cytochrome c from the reaction.	Hydrogen Peroxide	101-109	xanthine dehydrogenase	Mus musculus	146-162	
34309015-6	2021	In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function.	Hydrogen Peroxide	213-218	xanthine dehydrogenase	Mus musculus	176-199	
8902218-2	1996	Sperm were treated with superoxide and hydrogen peroxide generated by addition of xanthine oxidase (XO: 10-200 mlU/ml) to hypoxanthine (HX: 1 mM).	Hydrogen Peroxide	39-56	xanthine dehydrogenase	Mus musculus	82-98	
7820952-7	1995	Pretreatment of tumor cells with H2O2 or hypoxanthanine and xanthine oxidase (to generate superoxide radical and H2O2) prior to intravenous injection, enhanced experimental lung tumor colony formation.	Hydrogen Peroxide	113-117	xanthine dehydrogenase	Mus musculus	60-76	
8055654-1	1994	Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide.	Hydrogen Peroxide	248-265	xanthine dehydrogenase	Mus musculus	137-153	
8396508-5	1993	Xanthine oxidase in the presence of xanthine, H2O2, HOCl, and NH2Cl induced cessation of spontaneous beating followed by cessation of electrical stimulation-elicited beating but did not induce an increase in [Ca2+]i.	Hydrogen Peroxide	46-50	xanthine dehydrogenase	Mus musculus	0-16	
1664322-5	1991	The evidence suggests that superoxide, and thereby H2O2, is produced by the xanthine/xanthine oxidase system, but an involvement of the other superoxide generating systems has not been excluded.	Hydrogen Peroxide	51-55	xanthine dehydrogenase	Mus musculus	85-101	
34309015-6	2021	In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function.	Hydrogen Peroxide	213-218	xanthine dehydrogenase	Mus musculus	201-204	
31022672-1	2019	In the present study, we show that cholesterol crystals induce NFkappaB activation, and ICAM1 and VCAM1 expression via xanthine oxidase-mediated H2O2 production and PP2A inhibition in influencing endothelial cell and monocyte interactions and all these adverse effects of cholesterol crystals could be attenuated by proresolving lipid mediator RvD1.	Hydrogen Peroxide	145-149	xanthine dehydrogenase	Mus musculus	119-135	
3677084-1	1987	Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide.	Hydrogen Peroxide	258-275	xanthine dehydrogenase	Mus musculus	151-167	
3338107-4	1988	In order to mimick AO released by phagocytes we used xanthine/xanthine oxidase as a source of extracellular superoxide and hydrogen peroxide.	Hydrogen Peroxide	123-140	xanthine dehydrogenase	Mus musculus	62-78	
20660016-6	2010	We show that reactive oxygen species (ROS) such as H(2)O(2) and superoxide anion (via the xanthine/xanthine oxidase reaction) as well as the FFA palmitate augment TRB3 expression in podocytes.	Hydrogen Peroxide	51-59	xanthine dehydrogenase	Mus musculus	99-115	
29782988-3	2018	In addition, cholesterol crystals induced tyrosine phosphorylation of VE-cadherin and alpha-catenin, disrupting endothelial AJ and its barrier function and these effects required xanthine oxidase-mediated H2O2 production, SHP2 inactivation and Frk activation.	Hydrogen Peroxide	205-209	xanthine dehydrogenase	Mus musculus	179-195	
21530649-9	2011	Our results show that compared to control conditions, suppression of xanthine oxidase activity by allopurinol reduced xanthine oxidase activity, H2O2 levels, lipid peroxidation, and caspase-3 activity; prevented the in situ electrically stimulated isometric contraction-induced loss of glutathione; prevented the increase in catalase and copper-zinc superoxide dismutase activities; and increased maximal isometric force in the plantar flexor muscles of aged mice after repetitive electrically evoked contractions.	Hydrogen Peroxide	145-149	xanthine dehydrogenase	Mus musculus	69-85	
17447855-2	2007	For this purpose, the effect of heating on the activity of xanthine oxidase (XOD) in tumor cells upon their photosensitization with HPD was examined; this enzyme is participated in purine catabolism and has the ability to generate O2-*, a precursor of H2O2 and very cytotoxic hydroxyl radical.	Hydrogen Peroxide	252-256	xanthine dehydrogenase	Mus musculus	59-75	
17189252-8	2007	Superoxide and hydrogen peroxide generated by xanthine oxidase did not significantly decrease complex I function.	Hydrogen Peroxide	15-32	xanthine dehydrogenase	Mus musculus	46-62	
17447855-2	2007	For this purpose, the effect of heating on the activity of xanthine oxidase (XOD) in tumor cells upon their photosensitization with HPD was examined; this enzyme is participated in purine catabolism and has the ability to generate O2-*, a precursor of H2O2 and very cytotoxic hydroxyl radical.	Hydrogen Peroxide	252-256	xanthine dehydrogenase	Mus musculus	77-80