PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15705590-4 2005 Furthermore, we found that PLD2 was associated with Pyk2 and Src, and that activation of PLD2 was required for H(2)O(2)-enhanced association of Src with Pyk2 leading to full activation of Pyk2. Hydrogen Peroxide 111-119 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 61-64 15705590-4 2005 Furthermore, we found that PLD2 was associated with Pyk2 and Src, and that activation of PLD2 was required for H(2)O(2)-enhanced association of Src with Pyk2 leading to full activation of Pyk2. Hydrogen Peroxide 111-119 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 144-147 15644319-6 2005 The effect of H(2)O(2) on c-Src expression was completely abolished with cyclohexamide or actinomycin D. Hydrogen Peroxide 14-22 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 26-31 11782488-0 2002 Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. Hydrogen Peroxide 0-17 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 29-34 11782488-8 2002 Transfection of kinase-inactive Src also inhibited H(2)O(2)-induced BMK1 activation. Hydrogen Peroxide 51-59 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 32-35 11782488-11 2002 These findings suggest that c-Src mediated BMK1 activation by H(2)O(2) may counteract ischemic cellular damage probably through the activation of MEF2C transcription factor. Hydrogen Peroxide 62-70 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 28-33 11100733-6 2000 The G betagamma-responsive ERK activation induced by H2O2 is independent of ligands binding to Gi-coupled receptors, but requires phosphatidylinositol-3-kinase and Src activation. Hydrogen Peroxide 53-57 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 164-167 2833239-5 1988 The kinase activity of the WGA-purified receptor preparation obtained from H2O2-treated cells, as measured by phosphorylation of src-related synthetic peptide, was increased about 4-fold over control cells. Hydrogen Peroxide 75-79 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 129-132 30939252-9 2019 Pharmacological blockade or silencing of c-Src resulted in significant suppression of H2O2-induced Egr-1 expression as well as Akt and CREB phosphorylation. Hydrogen Peroxide 86-90 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 41-46 30939252-10 2019 These data show that H2O2 enhances the expression of Egr-1, which was associated with increased phosphorylation of Akt, and H2O2 triggers its effects on Egr-1 expression through c-Src-mediated Akt and CREB-dependent signaling events in VSMCs. Hydrogen Peroxide 21-25 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 178-183 30939252-10 2019 These data show that H2O2 enhances the expression of Egr-1, which was associated with increased phosphorylation of Akt, and H2O2 triggers its effects on Egr-1 expression through c-Src-mediated Akt and CREB-dependent signaling events in VSMCs. Hydrogen Peroxide 124-128 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 178-183 30510405-0 2018 Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells. Hydrogen Peroxide 84-88 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 38-41 30510405-9 2018 Under the stimulation of H2O2, MAPKs (ERK, JNK, and p38), AKT, and Src signaling proteins in PC12 cells were activated in a time-dependent manner. Hydrogen Peroxide 25-29 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 67-70 30510405-10 2018 The application of inhibitors that were specific for MAPKs, AKT, and Src effectively alleviated H2O2-induced cell apoptosis. Hydrogen Peroxide 96-100 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 69-72 30510405-12 2018 More importantly, orientin effectively decreased H2O2-induced phosphorylation of MAPKs, AKT, and Src signaling proteins. Hydrogen Peroxide 49-53 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 97-100 30510405-14 2018 In addition, ROS inhibitors blocked the Src-MAPKs/AKT signaling pathway-dependent cell apoptosis stimulated by H2O2. Hydrogen Peroxide 111-115 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 40-43 30510405-15 2018 Conclusion: These results indicate that alleviation of H2O2-induced cell apoptosis by orientin is Src-MAPKs/AKT dependent. Hydrogen Peroxide 55-59 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 98-101 30510405-16 2018 Overall, our study confirms that orientin alleviates H2O2-induced cell apoptosis by inhibiting the ROS-mediated activation of Src-MAPKs/AKT signaling. Hydrogen Peroxide 53-57 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 126-129 28673614-6 2017 H2O2 and the superoxide-generating quinoledione LY83583 both induced c-Src oxidation, SrcFK auto-phosphorylation and contraction in IPA. Hydrogen Peroxide 0-4 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 69-74 25380156-0 2015 c-Src, ERK1/2 and Rho kinase mediate hydrogen peroxide-induced vascular contraction in hypertension: role of TXA2, NAD(P)H oxidase and mitochondria. Hydrogen Peroxide 37-54 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-5 25380156-5 2015 The c-Src inhibitor PP1 reduced H2O2 and U46619-induced contraction and TXA2 release in both strains. Hydrogen Peroxide 32-36 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 4-9 25380156-11 2015 The effects induced by H2O2 were abolished by inhibitors of TXA2 synthase, ERK1/2 and c-Src. Hydrogen Peroxide 23-27 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 86-91 25380156-13 2015 CONCLUSION: In arteries from WKY, c-Src mediates H2O2 contractile responses by modulating TXA2 release and TXA2 effect. Hydrogen Peroxide 49-53 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 34-39 25380156-14 2015 In SHR, H2O2 induces c-Src dependent TXA2 release that provokes vascular contractile responses through Rho kinase, c-Src and O2 from NAD(P)H Oxidase and mitochondria. Hydrogen Peroxide 8-12 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 21-26 25380156-14 2015 In SHR, H2O2 induces c-Src dependent TXA2 release that provokes vascular contractile responses through Rho kinase, c-Src and O2 from NAD(P)H Oxidase and mitochondria. Hydrogen Peroxide 8-12 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 115-120 21597237-5 2011 In this study, we investigated the involvement of BMK1 and Src in H(2)O(2)-induced cell death using cultured rat aortic smooth muscle cells (RASMCs). Hydrogen Peroxide 66-74 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 59-62 21258655-2 2011 Application of hydrogen peroxide to PC12 cells activated multiple tyrosine kinases (c-Src, epidermal growth factor receptor (EGFR), and Pyk2) and the serine-threonine kinase ERK1/2. Hydrogen Peroxide 15-32 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 84-89 18083901-4 2008 We identified the expression of the paxillin homologue hydrogen peroxide-inducible clone-5 (Hic-5) and showed its activation by norepinephrine (NE) in a Src-dependent manner. Hydrogen Peroxide 55-72 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 153-156 17164397-5 2007 Because a previous study showed that H(2)O(2) stimulated the expression of Src family protein tyrosine kinase (PTK) which inhibited SK channels (3), we explored the role of PTK in mediating the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 37-45 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 75-78 17164397-5 2007 Because a previous study showed that H(2)O(2) stimulated the expression of Src family protein tyrosine kinase (PTK) which inhibited SK channels (3), we explored the role of PTK in mediating the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 204-212 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 75-78 17003231-0 2007 Cyclooxygenase, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase MAPK, Rho kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava. Hydrogen Peroxide 133-150 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 121-124