PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20085765-3	2010	This effect was inhibited by overexpression of human Bcl-2, by silencing of cytochrome c, and by ablation of Bax/Bak, indicating that H(2)O(2)-induced apoptosis was mediated by the mitochondrial pathway in Jurkat cells.	Hydrogen Peroxide	134-142	BCL2 antagonist/killer 1	Homo sapiens	113-116	
17991745-0	2008	Stimulatory heterotrimeric GTP-binding protein inhibits hydrogen peroxide-induced apoptosis by repressing BAK induction in SH-SY5Y human neuroblastoma cells.	Hydrogen Peroxide	56-73	BCL2 antagonist/killer 1	Homo sapiens	106-109	
18929848-13	2008	In addition, pharmacological scavenging study of ROS, including H2O2, revealed that cytotoxicity was achieved by generation of ROS, which might modulate Bak protein expression and mitochondrial dysfunction.	Hydrogen Peroxide	64-68	BCL2 antagonist/killer 1	Homo sapiens	153-156	
18929848-16	2008	Apoptosis was also achieved by generation of H2O2, which modulated Bak protein expression and mitochondrial dysfunction.	Hydrogen Peroxide	45-49	BCL2 antagonist/killer 1	Homo sapiens	67-70	
17991745-5	2008	Exogenous Bak expression abolished these inhibitory effects of Galpha(s)QL, but Bak small interfering RNA decreased hydrogen peroxide-induced apoptosis.	Hydrogen Peroxide	116-133	BCL2 antagonist/killer 1	Homo sapiens	80-83	
17991745-6	2008	Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT.	Hydrogen Peroxide	20-37	BCL2 antagonist/killer 1	Homo sapiens	46-49	
17991745-6	2008	Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT.	Hydrogen Peroxide	20-37	BCL2 antagonist/killer 1	Homo sapiens	96-99	
17991745-6	2008	Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT.	Hydrogen Peroxide	148-165	BCL2 antagonist/killer 1	Homo sapiens	46-49	
17991745-6	2008	Galpha(s) repressed hydrogen peroxide-induced Bak expression by inhibiting the transcription of Bak mRNA, which resulted from the inhibition of the hydrogen peroxide-induced activation of transcription factors such as AP1, NF-kappaB, and NFAT.	Hydrogen Peroxide	148-165	BCL2 antagonist/killer 1	Homo sapiens	96-99	
17991745-7	2008	Moreover, Galpha(s) also inhibited the hydrogen peroxide-induced binding of AP1, NF-kappaB, and NFAT to the Bak promoter.	Hydrogen Peroxide	39-56	BCL2 antagonist/killer 1	Homo sapiens	108-111	
17991745-9	2008	From the results, we conclude that Galpha(s) protects neuroblastoma cells from hydrogen peroxide-induced apoptosis by repressing Bak induction, which is mediated by the inhibition of the hydrogen peroxide-induced activations of AP1, NF-kappaB, and NFAT through cAMP-PKA-CREB signaling system.	Hydrogen Peroxide	187-204	BCL2 antagonist/killer 1	Homo sapiens	129-132	
35218032-6	2022	Furthermore, preincubation with Orz reduced H2 O2 -mediated the proapoptotic protein of Bak expression and the phosphorylation of ASK1, p38, JNK, and ERK, and increased the anti-apoptotic protein of Bcl-xl expression and anti-oxidative stress proteins of Nrf2 and HO-1 expression.	Hydrogen Peroxide	44-49	BCL2 antagonist/killer 1	Homo sapiens	88-91	
9890630-5	1999	After treatment with H2O2, p53 protein was highly expressed and protein levels of Bak, p21WAF1/CIP1 and GADD45 were also enhanced.	Hydrogen Peroxide	21-25	BCL2 antagonist/killer 1	Homo sapiens	82-85	
35380485-9	2022	HIF-1alpha reduces H2O2-induced apoptosis by upregulating Bcl-2 and Bcl-XL, downregulating Bax, Bak, and caspase-9, stabilizing intracellular ROS levels, and promoting the repair of H2O2-induced DNA damage to reduce apoptosis.	Hydrogen Peroxide	19-23	BCL2 antagonist/killer 1	Homo sapiens	96-99