PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25236746-0	2014	Mechanism of oxidative inactivation of human presequence protease by hydrogen peroxide.	Hydrogen Peroxide	69-86	prolyl endopeptidase	Homo sapiens	45-65	
33838285-8	2021	We studied the impact of a PREP inhibitor, KYP-2047, on hydrogen peroxide and ferrous chloride induced ROS production and on cellular antioxidant response in HEK-293 and SH-SY5Y cells.	Hydrogen Peroxide	56-73	prolyl endopeptidase	Homo sapiens	27-31	
23041349-3	2012	In this study, we have investigated the effects of a biologically relevant oxidant, hydrogen peroxide (H(2)O(2)), on the activity of recombinant human PreP (hPreP).	Hydrogen Peroxide	84-101	prolyl endopeptidase	Homo sapiens	151-155	
23041349-3	2012	In this study, we have investigated the effects of a biologically relevant oxidant, hydrogen peroxide (H(2)O(2)), on the activity of recombinant human PreP (hPreP).	Hydrogen Peroxide	84-101	prolyl endopeptidase	Homo sapiens	157-162	
23041349-4	2012	H(2)O(2) inhibited hPreP activity in a concentration-dependent manner, resulting in oxidation of amino acid residues (detected by carbonylation) and lowered protein stability.	Hydrogen Peroxide	0-8	prolyl endopeptidase	Homo sapiens	19-24	
23041349-6	2012	The activity of hPreP oxidized at low concentrations of H(2)O(2) could be restored by methionine sulfoxide reductase A (MsrA), an enzyme that localizes to the mitochondrial matrix, suggesting that hPreP constitutes a substrate for MsrA.	Hydrogen Peroxide	56-64	prolyl endopeptidase	Homo sapiens	16-21	
23041349-6	2012	The activity of hPreP oxidized at low concentrations of H(2)O(2) could be restored by methionine sulfoxide reductase A (MsrA), an enzyme that localizes to the mitochondrial matrix, suggesting that hPreP constitutes a substrate for MsrA.	Hydrogen Peroxide	56-64	prolyl endopeptidase	Homo sapiens	197-202	
10522802-5	1999	RESULTS: Addition of PEP 1261 effectively blocked the H2O2 and O2*- release, decreased the levels of MPO levels (p< 0.01) and lysosomal enzymes (p < 0.05) as compared to PMA stimulated human neutrophils.	Hydrogen Peroxide	54-58	prolyl endopeptidase	Homo sapiens	21-24	
10522802-6	1999	PEP 1261 was also observed to inhibit the levels of H2O2, O2*-, MPO and lysosomal enzymes (p < 0.05) as compared to PMA stimulated control rat neutrophils and neutrophils from arthritic rats.	Hydrogen Peroxide	52-56	prolyl endopeptidase	Homo sapiens	0-3