PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17222797-0 2007 Small heat shock protein alphaB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis. Hydrogen Peroxide 110-127 transformation related protein 53, pseudogene Mus musculus 52-55 17205518-7 2007 Other stressors like H2O2 also mediated a decrease in P53 concentration in p53 defective cells. Hydrogen Peroxide 21-25 transformation related protein 53, pseudogene Mus musculus 54-57 17205518-7 2007 Other stressors like H2O2 also mediated a decrease in P53 concentration in p53 defective cells. Hydrogen Peroxide 21-25 transformation related protein 53, pseudogene Mus musculus 75-78 10660095-3 1999 After exposure to gamma-ionizing radiation or hydrogen peroxide, DNA ladders and labeling of nucelosomal fragments were detected in cells with wild-type p53 gene, but not in p53 null cells or NLS-I deleted cells, suggesting that the NLS-I of p53 protein is necessary for apoptosis. Hydrogen Peroxide 46-63 transformation related protein 53, pseudogene Mus musculus 153-156 10748185-5 2000 Expression of N-JNK in cells that were treated with H(2)O(2) impaired transcriptional output as reflected in a delayed and lower level of c-Jun-, limited ATF2-, and reduced p53-transcriptional activities. Hydrogen Peroxide 52-60 transformation related protein 53, pseudogene Mus musculus 173-176 10748185-6 2000 N-JNK elicited an increase in H(2)O(2)-induced cell death, which is p53-dependent, because it was not seen in p53 null cells yet could be observed upon coexpression of p53 and N-JNK. Hydrogen Peroxide 30-38 transformation related protein 53, pseudogene Mus musculus 68-71 34285767-9 2021 Moreover, under H2O2 and juglone treatment, a large amount of ROS was produced, and phosphorylation of p53 was induced. Hydrogen Peroxide 16-20 transformation related protein 53, pseudogene Mus musculus 103-106 34223980-7 2021 Usp10 inhibition attenuated H2O2-induced senescence in MLO-Y4 cells, as indicated by p53/p21 quantification, a senescence-associated beta-galactosidase (SA-beta-gal) assay, and p53 localization visualization with a confocal microscope. Hydrogen Peroxide 28-32 transformation related protein 53, pseudogene Mus musculus 85-88 34223980-7 2021 Usp10 inhibition attenuated H2O2-induced senescence in MLO-Y4 cells, as indicated by p53/p21 quantification, a senescence-associated beta-galactosidase (SA-beta-gal) assay, and p53 localization visualization with a confocal microscope. Hydrogen Peroxide 28-32 transformation related protein 53, pseudogene Mus musculus 177-180 34679653-6 2021 Sesamol suppressed H2O2-induced expression of phospho-IKKalpha, p53, and caspase-3. Hydrogen Peroxide 19-23 transformation related protein 53, pseudogene Mus musculus 64-67 32943614-6 2020 Furthermore, 4-OI inhibited H2O2-induced programmed necrosis by suppressing mitochondrial depolarization, mitochondrial cyclophilin D-ANT1 (adenine nucleotide translocase 1)-p53 association, and cytosol lactate dehydrogenase release in osteoblasts. Hydrogen Peroxide 28-32 transformation related protein 53, pseudogene Mus musculus 174-177 35123567-15 2022 The HIF1alpha-p53 relationship was negative in YBMSCs and NAC-treated ABMSCs, but positive in ABMSCs and H2O2-treated YBMSCs. Hydrogen Peroxide 105-109 transformation related protein 53, pseudogene Mus musculus 14-17 34026845-10 2021 We found decreased intracellular p53 protein levels under glutamate and hydrogen peroxide treatment in KO cortical cells. Hydrogen Peroxide 72-89 transformation related protein 53, pseudogene Mus musculus 33-36 33475982-0 2021 MicroRNA-125b alleviates hydrogen-peroxide-induced abnormal mitochondrial dynamics in HT22 cells by inhibiting p53. Hydrogen Peroxide 25-42 transformation related protein 53, pseudogene Mus musculus 111-114 33475982-3 2021 Following stimulation with H2O2, we observed downregulation of miR-125b expression, upregulation of p53 expression, mitochondria were damaged and increased cell death. Hydrogen Peroxide 27-31 transformation related protein 53, pseudogene Mus musculus 100-103 33475982-6 2021 Thus, miR-125b alleviates abnormal mitochondrial homeostasis in H2O2-treated HT22 cells by suppressing p53 expression. Hydrogen Peroxide 64-68 transformation related protein 53, pseudogene Mus musculus 103-106 33569547-6 2021 Our findings suggest that H2O2 downregulates P53 by enhancing the P53 suppressor mouse double minute 2 homolog (MDM2), as well as by increasing the apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref1). Hydrogen Peroxide 26-30 transformation related protein 53, pseudogene Mus musculus 45-48 33569547-6 2021 Our findings suggest that H2O2 downregulates P53 by enhancing the P53 suppressor mouse double minute 2 homolog (MDM2), as well as by increasing the apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref1). Hydrogen Peroxide 26-30 transformation related protein 53, pseudogene Mus musculus 66-69 35101250-11 2022 The results demonstrated that EGb protection can effectively diminish H2O2-induced apoptosis by inhibiting p53 acetylation, reducing the ratio of Bax/Bcl-2 and suppressing the expression of specific cleavage of Caspase-9 and Caspase-3. Hydrogen Peroxide 70-74 transformation related protein 53, pseudogene Mus musculus 107-110 28127704-0 2017 Effect of potential role of p53 on embryo development arrest induced by H2O2 in mouse. Hydrogen Peroxide 72-76 transformation related protein 53, pseudogene Mus musculus 28-31 31144365-8 2019 In addition, the phosphorylation of p53, cathepsin B, and Bax/Bcl-2 protein levels, and the translocation of Bax from the cytosol to mitochondria induced by H2 O2 in C2C12 cells was significantly reduced by PTL. Hydrogen Peroxide 157-162 transformation related protein 53, pseudogene Mus musculus 36-39 30693443-4 2019 Our results revealed that sublethal concentrations of hydrogen peroxide (H2O2) exposure initiated a DNA damage response illustrated by increased gammaH2AX and 53BP1 expression and foci formation mainly in sensory hair cells, together with increased levels of p-Chk2 and p53. Hydrogen Peroxide 54-71 transformation related protein 53, pseudogene Mus musculus 270-273 30693443-4 2019 Our results revealed that sublethal concentrations of hydrogen peroxide (H2O2) exposure initiated a DNA damage response illustrated by increased gammaH2AX and 53BP1 expression and foci formation mainly in sensory hair cells, together with increased levels of p-Chk2 and p53. Hydrogen Peroxide 73-77 transformation related protein 53, pseudogene Mus musculus 270-273 28989026-8 2017 Under diabetic oxidative stress or H2O2 stimulation, nuclear beta-catenin accumulation upregulated downstream c-Myc and further facilitated DNA damage and p53-mediated apoptosis as well as cell viability reduction, followed by phenotypic changes of cardiac dysfunction, interstitial fibrosis deposition and myocardial atrophy. Hydrogen Peroxide 35-39 transformation related protein 53, pseudogene Mus musculus 155-158 28237267-8 2017 Expressions of endothelial nitric oxide synthase and silent information regulator protein 1 (SIRT1) were significantly up-regulated but those of P53 and P21 were markedly down-regulated both in aged mice and in hydrogen peroxide-treated MAECs in the absence of the TRPC5 gene. Hydrogen Peroxide 211-228 transformation related protein 53, pseudogene Mus musculus 145-148 26703444-3 2016 In the present study we observed that H2O2 induces the mitochondrial permeability transition pore (mPTP) opening and exerts p53 activation in a time-dependent way, with a maximum response after 1-2h of treatment. Hydrogen Peroxide 38-42 transformation related protein 53, pseudogene Mus musculus 124-127 27249370-4 2017 We report that E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 and FoxO transcription factors and then their target genes Bcl-2, Bim, Puma, PERP, and MDM2, without affecting Noxa gene. Hydrogen Peroxide 75-80 transformation related protein 53, pseudogene Mus musculus 92-95 22348305-3 2012 We found that the Bach1-p53 interaction was inhibited by oncogenic Ras, bleomycin, and hydrogen peroxide. Hydrogen Peroxide 87-104 transformation related protein 53, pseudogene Mus musculus 24-27 26406155-7 2015 And the chemical activation of Sirt 1 inhibited the H2O2-induced apoptosis via the downregulation of p53 acetylation. Hydrogen Peroxide 52-56 transformation related protein 53, pseudogene Mus musculus 101-104 25242411-7 2014 Moreover, the proanthocyanidins inhibit H2O2-induced apoptosis signaling which is mediated by p53. Hydrogen Peroxide 40-44 transformation related protein 53, pseudogene Mus musculus 94-97 24067374-5 2013 Furthermore, p53-dependent induction of Tpt1 was able to reduce oxidative stress, minimize apoptosis, and promote cell survival in response to H 2O2 challenge. Hydrogen Peroxide 143-148 transformation related protein 53, pseudogene Mus musculus 13-16 23533505-8 2013 These observations imply that gallic acid-mediated hydrogen peroxide formation acts as an initiator of JNK signaling pathways, leading to p53 activation and apoptosis in mouse lung fibroblasts. Hydrogen Peroxide 51-68 transformation related protein 53, pseudogene Mus musculus 138-141 25535325-5 2015 For this effect, H2O2 upregulated levels of p14, increased ubiquitin-dependent degradation of mouse double minute 2 (MDM2), and reduced the interaction between MDM2 and p53 to prevent p53 degradation, resulting in accumulation of p53 and subsequent activation of p53-dependent apoptotic pathways. Hydrogen Peroxide 17-21 transformation related protein 53, pseudogene Mus musculus 169-172 25535325-5 2015 For this effect, H2O2 upregulated levels of p14, increased ubiquitin-dependent degradation of mouse double minute 2 (MDM2), and reduced the interaction between MDM2 and p53 to prevent p53 degradation, resulting in accumulation of p53 and subsequent activation of p53-dependent apoptotic pathways. Hydrogen Peroxide 17-21 transformation related protein 53, pseudogene Mus musculus 184-187 25535325-5 2015 For this effect, H2O2 upregulated levels of p14, increased ubiquitin-dependent degradation of mouse double minute 2 (MDM2), and reduced the interaction between MDM2 and p53 to prevent p53 degradation, resulting in accumulation of p53 and subsequent activation of p53-dependent apoptotic pathways. Hydrogen Peroxide 17-21 transformation related protein 53, pseudogene Mus musculus 184-187 25535325-5 2015 For this effect, H2O2 upregulated levels of p14, increased ubiquitin-dependent degradation of mouse double minute 2 (MDM2), and reduced the interaction between MDM2 and p53 to prevent p53 degradation, resulting in accumulation of p53 and subsequent activation of p53-dependent apoptotic pathways. Hydrogen Peroxide 17-21 transformation related protein 53, pseudogene Mus musculus 184-187 25535325-6 2015 Interestingly, HCV core repressed p14 expression via promoter hypermethylation to abolish the potential of H2O2 to activate the p14-MDM2-p53 pathway. Hydrogen Peroxide 107-111 transformation related protein 53, pseudogene Mus musculus 137-140 25535325-7 2015 As a consequence, HCV core-expressing cells could overcome p53-mediated apoptosis provoked by H2O2. Hydrogen Peroxide 94-98 transformation related protein 53, pseudogene Mus musculus 59-62 26406155-4 2015 Results demonstrated that Sirt 1 and Bcl-2 were inhibited, whereas p53 acetylation, Bax, and caspase 9 were promoted by H2O2, as was aggravated by the Sirt 1 inhibitor, EX-527. Hydrogen Peroxide 120-124 transformation related protein 53, pseudogene Mus musculus 67-70 26406155-5 2015 Instead, RSV inhibited the H2O2-induced both p53 acetylation and the caspase 9 activation, whereas ameliorated the H2O2-induced Bcl-2 inhibition and apoptosis. Hydrogen Peroxide 27-31 transformation related protein 53, pseudogene Mus musculus 45-48 22922974-11 2012 Phosphorylated p53 protein was increased in MGFs subsequent to treatment with 20 microM H2O2, along with an upregulated transcription of p21 and Mdm2 mRNAs. Hydrogen Peroxide 88-92 transformation related protein 53, pseudogene Mus musculus 15-18 20136445-0 2010 Effects of various polyphenolics on hydrogen peroxide-induced p53 activity in NIH3T3 cells. Hydrogen Peroxide 36-53 transformation related protein 53, pseudogene Mus musculus 62-65 21527937-8 2011 The mechanism of H(2)O(2)-mediated miR-200c upregulation involves p53 and retinoblastoma proteins. Hydrogen Peroxide 17-25 transformation related protein 53, pseudogene Mus musculus 66-69 21654327-2 2011 In cultured endothelial cells, 2 atherogenic stimuli, hydrogen peroxide and tumor necrosis factor-alpha, increased the acetylation of p53 lysine-382, and caspase-3 cleavage, an indicator of apoptotic signaling. Hydrogen Peroxide 54-71 transformation related protein 53, pseudogene Mus musculus 134-137 21211512-6 2011 In addition, we show that ovarian carcinoma A2780 cells with Nrf2 shRNA expression displayed higher levels of p53 activation in response to hydrogen peroxide treatment, leading to increased cell death. Hydrogen Peroxide 140-157 transformation related protein 53, pseudogene Mus musculus 110-113 21799252-2 2011 We found that APO treatment ameliorated oxidative stress in an AD mouse model and specifically attenuated the hydrogen peroxide-induced p53-related apoptosis in the SH-SY5Y neuroblastoma cell line. Hydrogen Peroxide 110-127 transformation related protein 53, pseudogene Mus musculus 136-139 20136445-1 2010 A cell-based assay system was developed to evaluate the potential antioxidant and pro-oxidant effects of various dietary polyphenolic compounds based on the induction of p53 activity by hydrogen peroxide. Hydrogen Peroxide 186-203 transformation related protein 53, pseudogene Mus musculus 170-173 19887573-0 2010 Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line. Hydrogen Peroxide 40-44 transformation related protein 53, pseudogene Mus musculus 82-85 18753379-10 2008 In organotypic forebrain slice cultures treated with hydrogen peroxide, p53 is accumulated and colocalized with necdin and Sirt1 in cortical neurons. Hydrogen Peroxide 53-70 transformation related protein 53, pseudogene Mus musculus 72-75